Invitrogen

FGF9 Polyclonal Antibody

View all (12) FGF9 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-50202

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Fusion protein corresponding to a region derived from internal residues of human fibroblast growth factor 9

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.6 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 40% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2635655

Product Specific Information

The antibody detects endogenous levels of total FGF9 protein.

Target Information

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: elbow knee synostosis; FGF; FGF-9; Fibroblast growth factor; Fibroblast growth factor 9; fibroblast growth factor 9 (glia-activating factor); GAF; glia activating factor; Glia-activating factor; HBGF-9; Heparin-binding growth factor 9; M-FGF-9

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Gene Aliases: Eks; FGF-9; FGF9; GAF; HBFG-9; HBGF-9; SYNS3

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UniProt ID: (Human) P31371, (Rat) P36364, (Mouse) P54130

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Entrez Gene ID: (Human) 2254, (Rat) 25444, (Mouse) 14180

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Function(s)
protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity fibroblast growth factor receptor binding growth factor activity heparin binding 1-phosphatidylinositol-3-kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis osteoblast differentiation positive regulation of mesenchymal cell proliferation chondrocyte differentiation protein import into nucleus cell-cell signaling positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway male gonad development positive regulation of gene expression substantia nigra development negative regulation of Wnt signaling pathway male sex determination lung development embryonic limb morphogenesis positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of activin receptor signaling pathway inner ear morphogenesis positive regulation of MAPK cascade positive regulation of smoothened signaling pathway regulation of timing of cell differentiation embryonic digestive tract development embryonic skeletal system development positive regulation of epithelial cell proliferation positive regulation of cell division positive regulation of cardiac muscle cell proliferation lung-associated mesenchyme development positive regulation of canonical Wnt signaling pathway cardiac left ventricle morphogenesis cardiac ventricle development multicellular organism development cell differentiation positive regulation of transcription, DNA-templated vasculogenesis involved in coronary vascular morphogenesis MAPK cascade eye development signal transduction regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation phosphatidylinositol-3-phosphate biosynthetic process positive regulation of GTPase activity phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling
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