Invitrogen

FGFR1 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA1-24762

Applications
Tested Dilution
Publications

Western Blot (WB)

1:400
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunocytochemistry (ICC/IF)

Assay-Dependent
-

Immunoprecipitation (IP)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acid residues 360-373 of the extracellular region of human FGFR-1 conjugated to KLH with glutaraldehyde, and with a C-terminally added lysine.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

15mM sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_780610

Product Specific Information

PA1-24762 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology.

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.10.1; Basic fibroblast growth factor receptor 1; BFGFR; CD331; CD331 antigen; FGF Receptor; FGFR; fgfr 1; FGFR-1; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; N-sam; Proto-oncogene c-Fgr

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Gene Aliases: bFGF-R-1; BFGFR; CD331; CEK; ECCL; FGFBR; FGFR-1; FGFR1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; KAL2; N-SAM; OGD

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UniProt ID: (Human) P11362

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Entrez Gene ID: (Human) 2260

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Function(s)
glycoprotein binding protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding heparin binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding protein complex binding identical protein binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development angiogenesis ureteric bud development in utero embryonic development organ induction neuron migration positive regulation of mesenchymal cell proliferation chondrocyte differentiation transcription, DNA-templated protein phosphorylation sensory perception of sound positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of phospholipase activity positive regulation of phospholipase C activity positive regulation of neuron projection development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling cell migration peptidyl-tyrosine phosphorylation stem cell population maintenance motogenic signaling involved in postnatal olfactory bulb interneuron migration ventricular zone neuroblast division embryonic limb morphogenesis midbrain development neuron projection development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development phosphatidylinositol-3-phosphate biosynthetic process inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis chordate embryonic development positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of GTPase activity regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of cell cycle protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation skeletal system morphogenesis mesenchymal cell differentiation regulation of sensory perception of pain positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling regulation of stem cell proliferation positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway positive regulation of endothelial cell chemotaxis to fibroblast growth factor regulation of extrinsic apoptotic signaling pathway in absence of ligand
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