Invitrogen

FGFR3 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-81390

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to the center region of the Mouse FGFR3

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS, pH 7

Contains

0.03% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2788602

Product Specific Information

This antibody has specificity for Mouse FGFR3.

Target Information

FGFR3 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FGF Receptor; FGFR; FGFR3deltaTM; fibroblast growth factor receptor 3; heparin-binding growth factor receptor

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Gene Aliases: CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3; sam3

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Entrez Gene ID: (Mouse) 14184

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Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups fibroblast growth factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development positive regulation of endothelial cell proliferation morphogenesis of an epithelium lens morphogenesis in camera-type eye protein phosphorylation apoptotic process cell-cell signaling positive regulation of cell proliferation negative regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of phospholipase activity oligodendrocyte development phosphorylation peptidyl-tyrosine phosphorylation substantia nigra development central nervous system myelination cell differentiation bone mineralization forebrain development positive regulation of protein ubiquitination somatic stem cell population maintenance post-anal tail morphogenesis positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of MAPK cascade positive regulation of neuron apoptotic process positive regulation of phosphatidylinositol 3-kinase activity positive regulation of cell differentiation negative regulation of mitotic nuclear division negative regulation of smoothened signaling pathway protein autophosphorylation digestive tract morphogenesis negative regulation of developmental growth response to axon injury negative regulation of astrocyte differentiation inner ear development negative regulation of epithelial cell proliferation positive regulation of peptidyl-tyrosine phosphorylation cartilage development inner ear receptor cell differentiation bone morphogenesis axonogenesis involved in innervation alveolar secondary septum development lens fiber cell development positive regulation of ERK1 and ERK2 cascade bone maturation epithelial cell fate commitment positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway cochlea development positive regulation of canonical Wnt signaling pathway fibroblast growth factor receptor apoptotic signaling pathway
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