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Invitrogen
FGFR5 Polyclonal Antibody
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FGFR5 Antibody (PA5-47218) in IHC (F)
Immunohistochemical analysis of FGFR5 in perfusion fixed frozen sections of mouse lung. Samples were incubated in FGFR5 polyclonal antibody (Product # PA5-47218) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane and cytoplasm of al... View More
Product Details
PA5-47218
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse FGF R5 beta Ala21-Pro374
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606312
Product Specific Information
In Western blots, less than 5% cross-reactivity with recombinant human (rh) FGF R1 alpha (IIIb), recombinant mouse (rm) FGF R2 beta (IIIc), rmFGF R3 alpha (IIIb), rhFGF R3 alpha (IIIc), rhFGF R1 beta (IIIc), rmFGF R2 beta (IIIb), rhFGF R1 alpha (IIIc), rmFGF R2 alpha (IIIc), rhFGF R1 beta (IIIb), rmFGF R2 alpha (IIIb), rmFGF R2, and rmFGF R4 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF receptor-like protein 1; FGFR-5; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor-like 1
Gene Aliases: FGFR5; FGFR5beta; FGFR5gamma; Fgfrl1
UniProt ID: (Mouse) Q91V87
Entrez Gene ID: (Mouse) 116701
skeletal system development
heart valve morphogenesis
cell surface receptor signaling pathway
negative regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
peptidyl-tyrosine phosphorylation
negative regulation of fibroblast growth factor receptor signaling pathway
protein homooligomerization
ventricular septum morphogenesis
diaphragm development
cell-cell adhesion via plasma-membrane adhesion molecules
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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