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Invitrogen
FGR Recombinant Rabbit Monoclonal Antibody (13H37L5)
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FIGURE: 1 / 3
FGR Antibody (703189) in WB
Western blot analysis was performed on Membrane enriched extracts (30 µg lysate) of Daudi (Lane 1) Raji (Lane 2), Ramos (Lane 3), human PBMCs (Lane 4), HL-60 (Lane 5) and HL-60 treated with Retinoic Acid (1µM, 48 hr) (Lane 6). The blot was probed with Anti-FGR Recombinant Rabbit Monoclonal Antibody (Product # 703189, 1:500 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 60 kDa band corresponding to FGR (tyr... View More
Product Details
703189
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Insect
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
13H37L5
Immunogen
Protein corresponding to human FGR [aa1-aa76]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2734808
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Horse.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: c-fgr protooncogene; c-src-2 proto-oncogene; EC 2.7.10.2; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR protein; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55-c-fgr protein; p55-Fgr; p58-Fgr; p58c-Fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; Tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
Gene Aliases: c-fgr; c-src2; FGR; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2
UniProt ID: (Human) P09769
Entrez Gene ID: (Human) 2268
immune response-regulating cell surface receptor signaling pathway
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
regulation of cell shape
response to virus
positive regulation of phosphatidylinositol 3-kinase signaling
cell migration
peptidyl-tyrosine phosphorylation
cell differentiation
positive regulation of cell migration
peptidyl-tyrosine autophosphorylation
Fc-gamma receptor signaling pathway involved in phagocytosis
regulation of cell proliferation
positive regulation of mast cell degranulation
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of innate immune response
regulation of protein kinase activity
protein autophosphorylation
positive regulation of cytokine secretion
regulation of phagocytosis
defense response to Gram-positive bacterium
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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