Proteintech

FHL3 Polyclonal Antibody

FHL3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FHL3 Antibody (11028-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human ovary tumor using 11028-2-AP (FHL3 antibody) at dilution of 1:50 (under 40x lens).

FHL3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11028-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FHL3 Fusion Protein Ag1495 (1-280 aa encoded by BC011697)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes specifically the 34 kDa FHL3 protein.

Immunogen sequence: MSESFDCAK CNESLYGRKY IQTDSGPYCV PCYDNTFANT CAECQQLIGH DSRELFYEDR HFHEGCFRCC RCQRSLADEP FTCQDSELLC NDCYCSAFSS QCSACGETVM PGSRKLEYGG QTWHEHCFLC SGCEQPLGSR SFVPDKGAHY CVPCYENKFA PRCARCSKTL TQGGVTYRDQ PWHRECLVCT GCQTPLAGQQ FTSRDEDPYC VACFGELFAP KCSSCKRPIV GLGGGKYVSF EDRHWHHNCF SCARCSTSLV GQGFVPDGDQ VLCQGCSQAG P (1-280 aa encoded by BC011697)

Target Information

LIM proteins are defined by the possession of a highly conserved double zinc finger motif called the LIM domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

High-throughput proteomics profiling-derived signature associated with chemotherapy response and survival for stage II/III colorectal cancer.

NPJ precision oncology

Ye SB,Cheng YK,Li PS,Zhang L,Zhang LH,Huang Y,Chen P,Wang Y,Wang C,Peng JH,Shi LS,Ling L,Wu XJ,Qin J,Yang ZH,Lan P

Wed May 31 00:00:00 UTC 2023

FHL3 Contributes to EMT and Chemotherapy Resistance Through Up-Regulation of Slug and Activation of TGFβ/Smad-Independent Pathways in Gastric Cancer.

Frontiers in oncology

Cao G,Li P,He X,Jin M,Li M,Chen S,Xu X,Sun Q,Xiong M,Chen B

Sun Apr 24 00:00:00 UTC 2022

FHL3 promotes pancreatic cancer invasion and metastasis through preventing the ubiquitination degradation of EMT associated transcription factors.

Aging

Li P,Cao G,Zhang Y,Shi J,Cai K,Zhen L,He X,Zhou Y,Li Y,Zhu Y,Xiong M,Wu Y

Mon Jan 13 00:00:00 UTC 2020

FHL3 promotes pancreatic cancer invasion and metastasis through preventing the ubiquitination degradation of EMT associated transcription factors.

Aging

Li P,Cao G,Zhang Y,Shi J,Cai K,Zhen L,He X,Zhou Y,Li Y,Zhu Y,Xiong M,Wu Y

Mon Jan 13 00:00:00 UTC 2020

FHL3 promotes pancreatic cancer invasion and metastasis through preventing the ubiquitination degradation of EMT associated transcription factors.

Aging

Li P,Cao G,Zhang Y,Shi J,Cai K,Zhen L,He X,Zhou Y,Li Y,Zhu Y,Xiong M,Wu Y

Mon Jan 13 00:00:00 UTC 2020

FHL3 links cell growth and self-renewal by modulating SOX4 in glioma.

Cell death and differentiation

Han W,Hu P,Wu F,Wang S,Hu Y,Li S,Jiang T,Qiang B,Peng X

Wed May 01 00:00:00 UTC 2019

FHL3 links cell growth and self-renewal by modulating SOX4 in glioma.

Cell death and differentiation

Han W,Hu P,Wu F,Wang S,Hu Y,Li S,Jiang T,Qiang B,Peng X

Wed May 01 00:00:00 UTC 2019

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

Nature communications

Xu X,Fan Z,Liang C,Li L,Wang L,Liang Y,Wu J,Chang S,Yan Z,Lv Z,Fu J,Liu Y,Jin S,Wang T,Hong T,Dong Y,Ding L,Cheng L,Liu R,Fu S,Jiao S,Ye Q

Tue Jan 17 00:00:00 UTC 2017

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

Nature communications

Xu X,Fan Z,Liang C,Li L,Wang L,Liang Y,Wu J,Chang S,Yan Z,Lv Z,Fu J,Liu Y,Jin S,Wang T,Hong T,Dong Y,Ding L,Cheng L,Liu R,Fu S,Jiao S,Ye Q

Tue Jan 17 00:00:00 UTC 2017

Ribotrap analysis of proteins associated with FHL3 3'untranslated region in glioma cells.

Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih

Han W,Xia Q,Yin B,Peng XZ

Sun Jun 01 00:00:00 UTC 2014

Identification and characterization of MT-1X as a novel FHL3-binding partner.

PloS one

Cai X,Wang J,Huang X,Fu W,Xia W,Zou M,Wang Y,Wang J,Xu D

Tue Jun 09 00:00:00 UTC 2015

Identification and characterization of MT-1X as a novel FHL3-binding partner.

PloS one

Cai X,Wang J,Huang X,Fu W,Xia W,Zou M,Wang Y,Wang J,Xu D

Tue Jun 09 00:00:00 UTC 2015

RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3.

The Journal of clinical investigation

Han W,Xin Z,Zhao Z,Bao W,Lin X,Yin B,Zhao J,Yuan J,Qiang B,Peng X

Wed May 01 00:00:00 UTC 2013

RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3.

The Journal of clinical investigation

Han W,Xin Z,Zhao Z,Bao W,Lin X,Yin B,Zhao J,Yuan J,Qiang B,Peng X

Wed May 01 00:00:00 UTC 2013

RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3.

The Journal of clinical investigation

Han W,Xin Z,Zhao Z,Bao W,Lin X,Yin B,Zhao J,Yuan J,Qiang B,Peng X

Wed May 01 00:00:00 UTC 2013

RNA-binding protein PCBP2 modulates glioma growth by regulating FHL3.

The Journal of clinical investigation

Han W,Xin Z,Zhao Z,Bao W,Lin X,Yin B,Zhao J,Yuan J,Qiang B,Peng X

Wed May 01 00:00:00 UTC 2013

The four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoprotein.

Journal of virology

McCabe Á,Hashimoto K,Hall WW,Sheehy N

Mon Jul 01 00:00:00 UTC 2013

The four and a half LIM family members are novel interactants of the human T-cell leukemia virus type 1 Tax oncoprotein.

Journal of virology

McCabe Á,Hashimoto K,Hall WW,Sheehy N

Mon Jul 01 00:00:00 UTC 2013

FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.

IUBMB life

Lin J,Qin X,Zhu Z,Mu J,Zhu L,Wu K,Jiao H,Xu X,Ye Q

Thu Nov 01 00:00:00 UTC 2012

FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.

IUBMB life

Lin J,Qin X,Zhu Z,Mu J,Zhu L,Wu K,Jiao H,Xu X,Ye Q

Thu Nov 01 00:00:00 UTC 2012

Identification and characterization of FHL3 as a novel angiogenin-binding partner.

Gene

Xia W,Fu W,Cai L,Kong H,Cai X,Liu J,Wang Y,Zou M,Xu D

Fri Aug 10 00:00:00 UTC 2012

Identification and characterization of FHL3 as a novel angiogenin-binding partner.

Gene

Xia W,Fu W,Cai L,Kong H,Cai X,Liu J,Wang Y,Zou M,Xu D

Fri Aug 10 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: FHL-3; Four and a half LIM domains protein 3; LIM-only protein FHL3; MGC23614; MGC8696; Skeletal muscle LIM-protein 2; SLIM-2

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Gene Aliases: FHL3; SLIM2

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UniProt ID: (Human) Q13643, (Mouse) Q9R059

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Entrez Gene ID: (Human) 2275, (Rat) 313582, (Mouse) 14201

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Function(s)

actin binding protein binding zinc ion binding metal ion binding

Process(es)

muscle organ development actin cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FHL3 Polyclonal Antibody

FHL3 Antibody (11028-2-AP) in IHC (P)

Product Details

11028-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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