Bioss

FIG4/SAC3 Polyclonal Antibody

View all (5) FIG4 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

BS-11690R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human FIG4, amino acids 1-100.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FIG4 homolog, SAC domain containing lipid phosphatase; FIG4 homolog, SAC1 domain containing lipid phosphatase; FIG4 homolog, SAC1 lipid phosphatase domain containing; Phosphatidylinositol 3,5-bisphosphate 5-phosphatase; Polyphosphoinositide phosphatase; RP1-249I4.1; Sac domain-containing inositol phosphatase 3; SAC domain-containing protein 3; Serine-protein phosphatase FIG4

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Gene Aliases: A530089I17Rik; AI326867; ALS11; BTOP; CMT4J; dJ249I4.1; FIG4; KIAA0274; RGD1311375; SAC3; YVS

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UniProt ID: (Human) Q92562, (Mouse) Q91WF7

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Entrez Gene ID: (Human) 9896, (Rat) 309855, (Mouse) 103199

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Function(s)
phosphatidylinositol-3-phosphatase activity protein binding phosphatidylinositol-4-phosphate phosphatase activity phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity phosphatidylinositol bisphosphate phosphatase activity protein tyrosine/serine/threonine phosphatase activity protein tyrosine/threonine phosphatase activity JUN kinase phosphatase activity phosphohistidine phosphatase activity inositol bisphosphate phosphatase activity hydrolase activity MAP kinase tyrosine/serine/threonine phosphatase activity inositol-1,3,4-trisphosphate 4-phosphatase activity NADP phosphatase activity transmembrane receptor protein phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity inositol-4,5-bisphosphate 5-phosphatase activity phosphoric ester hydrolase activity 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity inositol phosphate phosphatase activity inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity inositol-3,4-bisphosphate 4-phosphatase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity IDP phosphatase activity
Process(es)
phosphatidylinositol biosynthetic process vacuole organization locomotory behavior positive regulation of neuron projection development dephosphorylation negative regulation of myelination myelin assembly phosphatidylinositol-3-phosphate biosynthetic process pigmentation neuron development phosphatidylinositol metabolic process
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