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Invitrogen
FK506 Monoclonal Antibody (4C12)
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Product Details
MA5-49653
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chemical
Host/Isotype
Mouse
/ IgG
Class
Monoclonal
Type
Antibody
Clone
4C12
Immunogen
Conjugate of TRL hapten and KLH
Conjugate
Form
Liquid
Concentration
4.2 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3090304
Product Specific Information
Antibody tested in indirect ELISA
Target Information
Tacrolimus is a macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro. Tacrolimus binds to the FKBP-12 protein and forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. [National Center for Biotechnology Information. PubChem Compound Database; CID=445643].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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