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Bethyl Laboratories
FKBP-135 Polyclonal Antibody
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FIGURE: 1 / 2
FKBP-135 Antibody (A300-209A) in WB
Detection of human and mouse FKPB-135 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and mouse NIH 3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-FKPB-135 antibody (Product # A300-209A) (lot A300-209A-2) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A300-209A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 50 and 100 of human FK506-binding protein 135.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 133 kDa FK506-binding protein; 133 kDa FKBP; FK506 binding protein 15, 133kDa; FK506-binding protein 133; FK506-binding protein 133kDa; FK506-binding protein 15; FKBP-133; FKBP-15; protein phosphatase 1, regulatory subunit 76; WAFL; WASP and FKBP-like; WASP and FKBP-like protein; WASP- and FKBP-like protein
Gene Aliases: BB131447; C430014M02Rik; FKBO133; FKBP-133; FKBP-15; FKBP133; FKBP15; KIAA0674; mKIAA0674; PPP1R76
UniProt ID: (Human) Q5T1M5, (Mouse) Q6P9Q6
Entrez Gene ID: (Human) 23307, (Mouse) 338355
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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