Invitrogen

FKBP12 Recombinant Superclonal™ Antibody (1 HCLC)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

711275

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

1 HCLC

Immunogen

Peptides corresponding to human FKBP12 (aa72-85, 55-66)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662724

Product Specific Information

This antibody is predicted to react with Monkey, Pig, Cat

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 12 kDa FK506-binding protein; 12 kDa FKBP; calstabin 1; Calstabin-1; EC 5.2.1.8; FK506 binding protein 1A, 12kDa; FK506 binding protein 2 (13 kDa); FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 1 (12kD); FK506-binding protein 12; FK506-binding protein 1A; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD; FKBP-12; FKBP-1A; FKBP12-Exip3; Immunophilin FKBP12; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; protein kinase C inhibitor 2; Rotamase

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Gene Aliases: Fkbp; FKBP-12; FKBP-1A; FKBP1; FKBP12; FKBP1A; Fkbp2; PKC12; PKCI2; PPIASE

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UniProt ID: (Human) P62942, (Mouse) P26883, (Rat) Q62658

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Entrez Gene ID: (Human) 2280, (Mouse) 14225, (Rat) 25639

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Function(s)
peptidyl-prolyl cis-trans isomerase activity signal transducer activity transforming growth factor beta receptor binding protein binding macrolide binding FK506 binding calcium channel inhibitor activity type I transforming growth factor beta receptor binding ion channel binding SMAD binding activin binding drug binding enzyme binding Hsp70 protein binding protein homodimerization activity
Process(es)
protein peptidyl-prolyl isomerization heart morphogenesis protein folding 'de novo' protein folding transforming growth factor beta receptor signaling pathway SMAD protein complex assembly protein maturation by protein folding positive regulation of protein ubiquitination positive regulation of protein binding negative regulation of protein phosphatase type 2B activity regulation of protein localization regulation of activin receptor signaling pathway protein refolding T cell activation positive regulation of I-kappaB kinase/NF-kappaB signaling extracellular fibril organization regulation of immune response negative regulation of release of sequestered calcium ion into cytosol ventricular cardiac muscle tissue morphogenesis regulation of ryanodine-sensitive calcium-release channel activity negative regulation of ryanodine-sensitive calcium-release channel activity heart trabecula formation chaperone-mediated protein folding calcium ion transmembrane transport regulation of amyloid precursor protein catabolic process amyloid fibril formation negative regulation of protein phosphorylation muscle contraction response to iron ion cytokine-mediated signaling pathway response to caffeine T cell proliferation release of sequestered calcium ion into cytosol
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