Invitrogen

FKBP12 Recombinant Rabbit Monoclonal Antibody (JM11-09)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-32611

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Mouse, Rat, Human

Published species

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JM11-09

Immunogen

Synthetic peptide within Human FKBP12 aa 76-108
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 40% Glycerol, 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2809888

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 12 kDa FK506-binding protein; 12 kDa FKBP; calstabin 1; Calstabin-1; EC 5.2.1.8; FK506 binding protein 1A, 12kDa; FK506 binding protein 2 (13 kDa); FK506 binding protein12; FK506-binding protein 1; FK506-binding protein 1 (12kD); FK506-binding protein 12; FK506-binding protein 1A; FK506-binding protein 1A (12kD); FK506-binding protein, T-cell, 12-kD; FKBP-12; FKBP-1A; FKBP12-Exip3; Immunophilin FKBP12; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; protein kinase C inhibitor 2; Rotamase

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Gene Aliases: Fkbp; FKBP-12; FKBP-1A; FKBP1; FKBP12; FKBP1A; Fkbp2; PKC12; PKCI2; PPIASE

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UniProt ID: (Human) P62942, (Mouse) P26883, (Rat) Q62658

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Entrez Gene ID: (Human) 2280, (Mouse) 14225, (Rat) 25639

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Function(s)
peptidyl-prolyl cis-trans isomerase activity signal transducer activity transforming growth factor beta receptor binding protein binding macrolide binding FK506 binding calcium channel inhibitor activity type I transforming growth factor beta receptor binding ion channel binding SMAD binding activin binding drug binding enzyme binding Hsp70 protein binding protein homodimerization activity
Process(es)
protein peptidyl-prolyl isomerization heart morphogenesis protein folding 'de novo' protein folding transforming growth factor beta receptor signaling pathway SMAD protein complex assembly protein maturation by protein folding positive regulation of protein ubiquitination positive regulation of protein binding negative regulation of protein phosphatase type 2B activity regulation of protein localization regulation of activin receptor signaling pathway protein refolding T cell activation positive regulation of I-kappaB kinase/NF-kappaB signaling extracellular fibril organization regulation of immune response negative regulation of release of sequestered calcium ion into cytosol ventricular cardiac muscle tissue morphogenesis regulation of ryanodine-sensitive calcium-release channel activity negative regulation of ryanodine-sensitive calcium-release channel activity heart trabecula formation chaperone-mediated protein folding calcium ion transmembrane transport regulation of amyloid precursor protein catabolic process amyloid fibril formation negative regulation of protein phosphorylation muscle contraction response to iron ion cytokine-mediated signaling pathway response to caffeine T cell proliferation release of sequestered calcium ion into cytosol
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