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Invitrogen
FKBP4 Monoclonal Antibody (Hi52C), FITC
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FIGURE: 1 / 3
FKBP4 Antibody (MA5-45164) in IHC (P)
Immunohistochemistry analysis using backskin. Fixation involved Bouins Fixative and paraffin-embedded. Samples were incubated with FKBP52 monoclonal antibody (Product # MA5-45164) at 1:100 for 1 hour at RT, followed by FITC Goat Anti-Mouse (green) at 1:50 for 1 hour at RT. Localization: Epidermis.
Product Details
MA5-45164
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Hamster,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
Hi52C
Immunogen
Synthetic peptide corresponding to the residues of human FKBP52
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
9.1mM sodium bicarbonate/PBS with 640.91mM DMSO, 136.36mM ethanolamine
Contains
no preservative
Storage conditions
4°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2931618
Product Specific Information
0.5 µg/mL was sufficient for detection of FKBP52 in 20 µg total protein using WB by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.|Detects approximately 52kDa. Heavy chain migrates close to FKBP52 on SDS PAGE.
Target Information
FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506 binding protein 52; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP51; FKBP52 protein; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Immunophilin FKBP52; p59; Peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; PPIase FKBP4; Rotamase; T-cell FK506-binding protein, 59kD
Gene Aliases: 59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP4; FKBP51; FKBP52; FKBP59; FKPB52; HBI; Hsp56; I79_001345; p52; p59; PPIase
UniProt ID: (Human) Q02790, (Mouse) P30416, (Rat) Q9QVC8
Entrez Gene ID: (Dog) 477726, (Human) 2288, (Mouse) 14228, (Chinese hamster) 100762395, (Rat) 260321
protein peptidyl-prolyl isomerization
protein folding
steroid hormone receptor complex assembly
copper ion transport
embryo implantation
androgen receptor signaling pathway
prostate gland development
negative regulation of microtubule polymerization
protein complex localization
male sex differentiation
reproductive structure development
chaperone-mediated protein folding
negative regulation of neuron projection development
negative regulation of microtubule polymerization or depolymerization
regulation of cellular response to heat
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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