Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
FKBP52 Monoclonal Antibody (1B5F1), CoraLite® Plus 488
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
CL488-66040
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1B5F1
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW LLDGTKFDSS LDRKDKFSFD LGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKD KLFDQRELRF EIGEGENLDL PYGLERAIQR MEKGEHSIVY LKPSYAFGSV GKEKFQIPPN AELKYELHLK SFEKAKESWE MNSEEKLEQS TIVKERGTVY FKEGKY
Target Information
FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP51; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Immunophilin FKBP52; p59; Peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; PPIase FKBP4; Rotamase; T-cell FK506-binding protein, 59kD
Gene Aliases: FKBP4; FKBP51; FKBP52; FKBP59; HBI; Hsp56; p52; PPIase
UniProt ID: (Human) Q02790
Entrez Gene ID: (Human) 2288
protein peptidyl-prolyl isomerization
protein folding
steroid hormone receptor complex assembly
copper ion transport
embryo implantation
negative regulation of neuron projection development
androgen receptor signaling pathway
prostate gland development
negative regulation of microtubule polymerization or depolymerization
negative regulation of microtubule polymerization
protein complex localization
male sex differentiation
chaperone-mediated protein folding
regulation of cellular response to heat
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support