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Immunogen sequence: SALNQGVLE GDDAPGQSLY ERLSQRMLDI SGDRGVLKDV IREGAGDLVA PDASVLVKYS GYLEHMDRPF DSNYFRKTPR LMKLGEDITL WGMELGLLSM RRGELARFLF KPNYAYGTLG CPPLIPPNTT VLFEIELLDF LDCAESDKFC ALSAEQQDQF PLQKVLKVAA TEREFGNYLF RQNRFYDAKV RYKRALLLLR RRSAPPEEQH LVEAAKLPVL LNLSFTYLKL DRPTIALCYG EQALIIDQKN AKALFRCGQA CLLLTEYQKA RDFLVRAQKE QPFNHDINNE LKKLASCYRD YVDKEKEMWH RMFAPCGDGS TAGES (4-327 aa encoded by BC036817)
FKBP6 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP6 is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin.This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. This protein is involved in palate formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 36 kDa FK506-binding protein; 36 kDa FKBP; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FK506-binding protein 6 (36kD); FKBP-6; Immunophilin FKBP36; Inactive peptidyl-prolyl cis-trans isomerase FKBP6; Inactive PPIase FKBP6; MGC87179; peptidyl-prolyl cis-trans isomerase FKBP6; PPIase FKBP6; rotamase
Gene Aliases: 1700008G22Rik; 36kDa; AU017274; D5Ertd724e; FKBP-36; FKBP-6; FKBP36; FKBP6
UniProt ID: (Human) O75344, (Mouse) Q91XW8
Entrez Gene ID: (Human) 8468, (Mouse) 94244
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