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Invitrogen
FLAP Polyclonal Antibody
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Product Details
PA5-103074
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ALOX5AP(Accession P20292), corresponding to amino acid residues A83-Y133.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852444
Product Specific Information
Antibody detects endogenous levels of total ALOX5AP.
Target Information
ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 5-lipoxygenase-activating protein FLAP; Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
Gene Aliases: ALOX5AP; FLAP
UniProt ID: (Human) P20292, (Rat) P20291
Entrez Gene ID: (Human) 241, (Rat) 29624
glutathione transferase activity
leukotriene-C4 synthase activity
glutathione peroxidase activity
protein binding
enzyme activator activity
protein N-terminus binding
arachidonic acid binding
arachidonate 5-lipoxygenase activity
enzyme binding
protein homodimerization activity
protein heterodimerization activity
leukotriene production involved in inflammatory response
positive regulation of acute inflammatory response
leukotriene biosynthetic process
lipoxygenase pathway
positive regulation of catalytic activity
oxidation-reduction process
protein homotrimerization
cellular response to calcium ion
leukotriene metabolic process
lipoxin metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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