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ALOX5AP is a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Arachidonate 5-lipoxygenase-activating protein; FLAP; MK-886-binding protein
Gene Aliases: ALOX5AP; FLAP
UniProt ID: (Human) P20292
Entrez Gene ID: (Human) 241
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