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Bioss
FLASH/CASP8AP2 Polyclonal Antibody
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Product Details
BS-3657R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FLASH/CASP8AP2, amino acids 1861-1982.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CASP8 associated protein 2; CASP8-associated protein 2; CASP8AP2; FLASH homolog RIP25; FLICE associated huge; FLICE-associated huge protein; FLJ11208; human FLASH; RP11-63K6.3
Gene Aliases: AA387232; CASP8AP2; CED-4; D4Ertd659e; FLASH; KIAA1315; mKIAA1315; RIP25
UniProt ID: (Human) Q9UKL3, (Mouse) Q9WUF3
Entrez Gene ID: (Human) 9994, (Rat) 313128, (Mouse) 26885
DNA binding
transcription corepressor activity
death receptor binding
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
peptidase activator activity involved in apoptotic process
SUMO polymer binding
protease binding
molecular_function
identical protein binding
activation of cysteine-type endopeptidase activity involved in apoptotic process
biological_process
extrinsic apoptotic signaling pathway via death domain receptors
Fas signaling pathway
cellular response to mechanical stimulus
negative regulation of nucleic acid-templated transcription
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
signal transduction
apoptotic signaling pathway
apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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