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FLCN Polyclonal Antibody

FLCN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FLCN Antibody (11236-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human ovary tumor using 11236-2-AP (FLCN antibody) at dilution of 1:50 (under 40x lens).

FLCN Antibody in Immunoprecipitation (IP)

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Product Details

11236-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FLCN Fusion Protein Ag1746 (1-342 aa encoded by BC015687)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize all the 3 isoforms of FLCN (38-45 kDa,64 kDa,20-26 kDa).

Immunogen sequence: MNAIVALCH FCELHGPRTL FCTEVLHAPL PQGDGNEDSP GQGEQAEEEE GGIQMNSRMR AHSPAEGASV ESSSPGPKKS DMCEGCRSLA AGHPGYISHD KETSIKYVSH QHPSHPQLFS IVRQACVRSL SCEVCPGREG PIFFGDEQHG FVFSHTFFIK DSLARGFQRW YSIITIMMDR IYLINSWPFL LGKVRGIIDE LQGKALKVFE AEQFGCPQRA QRMNTAFTPF LHQRNGNAAR SLTSLTSDDN LWACLHTSFA WLLKACGSRL TEKLLEGAPT EDTLVQMEKL AGEAGVLLPG PWPGWPWGGT SCLLSWQESL REGNAALNQP RTSLREAHPP ISV (1-342 aa encoded by BC015687)

Target Information

This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Methionine-chelated Zn promotes anabolism by integrating mTOR signal and autophagy pathway in juvenile yellow catfish.

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

Wu K,Chen GH,Hogstrand C,Ling SC,Wu LX,Luo Z

Sat May 01 00:00:00 UTC 2021

FLCN Regulates HIF2α Nuclear Import and Proliferation of Clear Cell Renal Cell Carcinoma.

Frontiers in molecular biosciences

Zhao X,Ma Y,Cui J,Zhao H,Liu L,Wang Y,Min P,Zhang L,Chen Y,Du J,Zhang Y,Gu L

Mon Sep 28 00:00:00 UTC 2020

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Collodet C,Foretz M,Deak M,Bultot L,Metairon S,Viollet B,Lefebvre G,Raymond F,Parisi A,Civiletto G,Gut P,Descombes P,Sakamoto K

Fri Nov 01 00:00:00 UTC 2019

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Collodet C,Foretz M,Deak M,Bultot L,Metairon S,Viollet B,Lefebvre G,Raymond F,Parisi A,Civiletto G,Gut P,Descombes P,Sakamoto K

Fri Nov 01 00:00:00 UTC 2019

Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis.

Biochemical and biophysical research communications

Sano S,Sakagami R,Sekiguchi M,Hidaka M

Fri Jan 11 00:00:00 UTC 2013

Stabilization of MAPO1 by specific binding with folliculin and AMP-activated protein kinase in O⁶-methylguanine-induced apoptosis.

Biochemical and biophysical research communications

Sano S,Sakagami R,Sekiguchi M,Hidaka M

Fri Jan 11 00:00:00 UTC 2013

Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.

DNA repair

Lim TH,Fujikane R,Sano S,Sakagami R,Nakatsu Y,Tsuzuki T,Sekiguchi M,Hidaka M

Thu Mar 01 00:00:00 UTC 2012

Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.

DNA repair

Lim TH,Fujikane R,Sano S,Sakagami R,Nakatsu Y,Tsuzuki T,Sekiguchi M,Hidaka M

Thu Mar 01 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; Birt-Hogg-Dube syndrome protein homolog; Folliculin

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Gene Aliases: AU014660; B430214A04Rik; BHD; FLCL; FLCN

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UniProt ID: (Human) Q8NFG4, (Mouse) Q8QZS3, (Rat) Q76JQ2

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Entrez Gene ID: (Human) 201163, (Mouse) 216805, (Rat) 303185

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Function(s)

guanyl-nucleotide exchange factor activity protein binding protein complex binding molecular_function

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FLCN Polyclonal Antibody

FLCN Antibody (11236-2-AP) in IHC (P)

Product Details

11236-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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