Proteintech

FLI1 Polyclonal Antibody

FLI1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

FLI1 Antibody (11347-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lymphoma tissue slide using 11347-1-AP ( FLI1 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

11347-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FLI1 Fusion Protein Ag1899 (103-452 aa encoded by BC010115)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.53 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: NSYMDEKNG PPPPNMTTNE RRVIVPADPT LWTQEHVRQW LEWAIKEYSL MEIDTSFFQN MDGKELCKMN KEDFLRATTL YNTEVLLSHL SYLRESSLLA YNTTSHTDQS SRLSVKEDPS YDSVRRGAWG NNMNSGLNKS PPLGGAQTIS KNTEQRPQPD PYQILGPTSS RLANPGSGQI QLWQFLLELL SDSANASCIT WEGTNGEFKM TDPDEVARRW GERKSKPNMN YDKLSRALRY YYDKNIMTKV HGKRYAYKFD FHGIAQALQP HPTESSMYKY PSDISYMPSY HAHQQKVNFV PPHPSSMPVT SSSFFGAASQ YWTSPTGGIY PNPNVPRHPN THVPSHLGSY Y (103-452 aa encoded by BC010115)

Target Information

ETS-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. This family of genes currently includes ETS-1, ETS-2, ERG-1, ERG-2, ELK, E74, FLI-1, PU. 1 and PEA3. Members of the ETS gene family exhibit varied pattern of tissue expression, and share a highly conserved carboxy terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Li P,Wu Y,Hamlett ED,Goodwin AJ,Halushka PV,Carroll SL,Liu M,Fan H

Wed Apr 06 00:00:00 UTC 2022

circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression.

Molecular therapy. Nucleic acids

Chen Z,Xu W,Zhang D,Chu J,Shen S,Ma Y,Wang Q,Liu G,Yao T,Huang Y,Ye H,Wang J,Ma J,Fan S

Fri Mar 05 00:00:00 UTC 2021

Fli‑1 promotes metastasis by regulating MMP2 signaling in hepatocellular carcinoma.

Molecular medicine reports

Wang H,Ou Y,Ou J,Jian Z

Mon Jan 01 00:00:00 UTC 2018

Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral Epithelial Cells.

Frontiers in cellular and infection microbiology

Geng F,Liu J,Guo Y,Li C,Wang H,Wang H,Zhao H,Pan Y

Tue Sep 19 00:00:00 UTC 2017

Persistent Exposure to Porphyromonas gingivalis Promotes Proliferative and Invasion Capabilities, and Tumorigenic Properties of Human Immortalized Oral Epithelial Cells.

Frontiers in cellular and infection microbiology

Geng F,Liu J,Guo Y,Li C,Wang H,Wang H,Zhao H,Pan Y

Tue Sep 19 00:00:00 UTC 2017

Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene.

Cancer

Zhang J,Guo H,Zhang H,Wang H,Qian G,Fan X,Hoffman AR,Hu JF,Ge S

Sat Jan 01 00:00:00 UTC 2011

Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene.

Cancer

Zhang J,Guo H,Zhang H,Wang H,Qian G,Fan X,Hoffman AR,Hu JF,Ge S

Sat Jan 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: Ewing sarcoma breakpoint region 2; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; Retroviral integration site protein Fli-1; Transcription factor ERGB

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Gene Aliases: EWSR2; Fli-1; FLI1; SIC-1; Sic1

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UniProt ID: (Human) Q01543, (Mouse) P26323

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Entrez Gene ID: (Human) 2313, (Mouse) 14247

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Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding

Process(es)

regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter hemostasis blood circulation organ morphogenesis cell differentiation megakaryocyte development positive regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated cellular process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FLI1 Polyclonal Antibody

FLI1 Antibody (11347-1-AP) in IHC (P)

Product Details

11347-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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