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Invitrogen
FLT3 Monoclonal Antibody (4G7E6B7)
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Product Details
MA5-30601
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4G7E6B7
Immunogen
Recombinant Human FLT3 protein (aa 1-541).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2786310
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human FLT3/FLK2/CD135.
Target Information
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD135; CD135 antigen; fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK-2; FLT-3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; Stem cell tyrosine kinase 1; STK-1
Gene Aliases: CD135; FLK-2; FLK2; FLT3; STK1
UniProt ID: (Human) P36888
Entrez Gene ID: (Human) 2322
leukocyte homeostasis
myeloid progenitor cell differentiation
pro-B cell differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
response to organonitrogen compound
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
hemopoiesis
B cell differentiation
organ regeneration
common myeloid progenitor cell proliferation
vascular endothelial growth factor signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of phosphatidylinositol 3-kinase activity
lymphocyte proliferation
protein autophosphorylation
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
dendritic cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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