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Abnova
FMN2 Monoclonal Antibody (1C2)
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Product Details
H00056776-M06
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1C2
Immunogen
FMN2 (AAH14364.2, 144 a.a. approximately 243 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: DQEAEENSLT ETHKCFLETT AYFFMKPKLG EKEVSPNAFF SIWHEFSSDF KDFWKKENKL LLQERVKEAE EVCRQKKGKS LYKIKPRHDS GIKAKISMKT
Target Information
FMN2, a novel formin homology protein of the cappuccino subfamily, is highly conserved between evolutionarily diverse vertebrates. FMN2 bears a high degree of similarity to formin-1 which is the founding member of formin homology proteins. FMN2 plays a crucial role in maintenance of the meiotic spindle. The protein is widely expressed in human fetal brain, adult whole brain, hypothalamus, retina, pancreatic islet and germinal-center B cells. Pathological role of the protein is identified in various tumors like parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma. FMN2 mutations are often a cause of unexplained infertility in women. The gene encoding for human FMN2 is localized in the chromosomal region 1q43.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Formin-2; RP11-90L13.1
Gene Aliases: FMN2
UniProt ID: (Human) Q9NZ56
Entrez Gene ID: (Human) 56776
cellular response to DNA damage stimulus
multicellular organism development
protein transport
vesicle-mediated transport
intracellular signal transduction
polar body extrusion after meiotic divisions
negative regulation of protein catabolic process
negative regulation of apoptotic process
intracellular transport
oogenesis
establishment of meiotic spindle localization
homologous chromosome movement towards spindle pole involved in homologous chromosome segregation
formin-nucleated actin cable assembly
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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