Invitrogen

FMRP Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-96505

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 500-600 of human FMRP (NP_0020151)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.02 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2808307

Product Specific Information

Immunogen sequence: SETESDHRDE LSDWSLAPTE EERESFLRRG DGRRRGGGGR GQGGRGRGGG FKGNDDHSRT DNRPRNPREA KGRTTDGSLQ IRVDCNNERS VHTKTLQNTS S; Positive Samples: U-251MG, HeLa, Rat brain; Cellular Location: Cytoplasm, Nucleus, nucleolus

Target Information

FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FMRP; fragile X mental retardation protein 1; fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; Fragile X messenger ribonucleoprotein; Fragile X messenger ribonucleoprotein 1; MGC87458; Protein FMR-1; ragile X mental retardation protein

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Gene Aliases: Fmr-1; FMR1; FMRP; FRAXA; POF; POF1

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UniProt ID: (Human) Q06787, (Rat) Q80WE1

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Entrez Gene ID: (Human) 2332, (Rat) 24948, (Mouse) 14265

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Function(s)
G-quadruplex RNA binding chromatin binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding microtubule binding poly(U) RNA binding translation repressor activity translation initiation factor binding RNA strand annealing activity poly(G) binding methylated histone binding siRNA binding miRNA binding RNA stem-loop binding identical protein binding protein homodimerization activity ribosome binding ion channel binding poly(A) RNA binding dynein binding protein heterodimerization activity mRNA 5'-UTR binding sequence-specific mRNA binding nucleic acid binding
Process(es)
regulation of translation central nervous system development negative regulation of translation negative regulation of translational initiation mRNA transport transport dendritic spine development regulation of alternative mRNA splicing, via spliceosome positive regulation of receptor internalization mRNA processing cellular response to DNA damage stimulus glutamate receptor signaling pathway RNA splicing gene silencing by RNA positive regulation of histone phosphorylation cellular response to UV regulation of mRNA stability modulation by host of viral RNA genome replication positive regulation of translation regulation of neurotransmitter secretion regulation of filopodium assembly positive regulation of filopodium assembly regulation of gene silencing by miRNA regulation of dendritic spine development positive regulation of dendritic spine development cellular response to hydroxyurea cellular response to virus regulation of neuronal action potential negative regulation of long term synaptic depression positive regulation of intracellular transport of viral material negative regulation of voltage-gated calcium channel activity positive regulation of proteasomal protein catabolic process positive regulation of mRNA binding negative regulation of synaptic vesicle exocytosis positive regulation of gene silencing by miRNA negative regulation of cytoplasmic translation positive regulation of response to DNA damage stimulus
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