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Proteintech
FN3KRP Polyclonal Antibody
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Product Details
16312-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FN3KRP Fusion Protein Ag9347 (1-309 aa encoded by BC014408)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Product # 16312-1-AP is a rabbit polyclonal antibody raised against the full-length of human FN3KRP. The MW of this protein is 34 kDa, and this antibody specifically recognizes the 34 kDa protein.
Immunogen sequence: MEELLRREL GCSSVRATGH SGGGCISQGR SYDTDQGRVF VKVNPKAEAR RMFEGEMASL TAILKTNTVK VPKPIKVLDA PGGGSVLVME HMDMRHLSSH AAKLGAQLAD LHLDNKKLGE MRLKEAGTVG RGGGQEERPF VARFGFDVVT CCGYLPQVND WQEDWVVFYA RQRIQPQMDM VEKESGDREA LQLWSALQLK IPDLFRDLEI IPALLHGDLW GGNVAEDSSG PVIFDPASFY GHSEYELAIA GMFGGFSSSF YSAYHGKIPK APGFEKRLQL YQLFHYLNHW NHFGSGYRGS SLNIMRNLVK (1-309 aa encoded by BC014408)
Target Information
Fructosamine-3-kinase related protein (FN3KRP) is located on chromosome 17q25.3, approximately 8 kb upstream of the FN3K gene. It shares 65% amino acid identity with FN3K and possesses an identical genomic organization, implying functional similarities; FN3KRP is suggested to play a role in enzymatic deglycation. Unlike FN3K, FN3KRP is more ancient, present in diverse organisms such as cyanobacteria, echinoderms, plants, and cold-blooded vertebrates. Studies have discovered a significant association between rs1046896 in FN3KRP and longevity, where the longevity allele C is linked to increased FN3KRP expression in whole blood. FN3KRP is hypothesized to phosphorylate glucitolamines, products of non-enzymatic glycation, indicating its involvement in crucial metabolic processes. The regulation of both FN3K and FN3KRP is notable for TATA-less and CAAT-less promoters, featuring homologous CpG islands and Sp1 binding sites. Meanwhile, both genes are widely expressed across human tissues, but FN3K demonstrates significantly higher levels in tissues prone to glycation-related complications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FN3K-related protein; FN3K-RP; fructosamine 3-kinase-related protein; Fructosamine-3-kinase-related protein; Ketosamine-3-kinase; ortholog of human fructosamine-3-kinase-related protein FN3KRP; Protein-psicosamine 3-kinase FN3KRP; testis secretory sperm-binding protein Li 211a
Gene Aliases: FN3K-RP; FN3KL; FN3KRP; RGD1304570
UniProt ID: (Human) Q9HA64, (Mouse) Q8K274
Entrez Gene ID: (Human) 79672, (Rat) 303755, (Mouse) 238024
kinase activity
molecular_function
phosphofructokinase activity
phosphorylase kinase regulator activity
cobinamide kinase activity
phytol kinase activity
phosphatidylinositol phosphate kinase activity
cyclin-dependent protein serine/threonine kinase regulator activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phenol kinase activity
cyclin-dependent protein kinase activating kinase regulator activity
inositol tetrakisphosphate 2-kinase activity
heptose 7-phosphate kinase activity
aminoglycoside phosphotransferase activity
phosphatidylinositol 3-kinase activity
eukaryotic elongation factor-2 kinase regulator activity
eukaryotic elongation factor-2 kinase activator activity
LPPG:FO 2-phospho-L-lactate transferase activity
cytidine kinase activity
glycerate 2-kinase activity
(S)-lactate 2-kinase activity
phosphoserine:homoserine phosphotransferase activity
L-seryl-tRNA(Sec) kinase activity
phosphocholine transferase activity
polynucleotide 5'-hydroxyl-kinase activity
ATP-dependent polynucleotide kinase activity
GTP-dependent polynucleotide kinase activity
farnesol kinase activity
CTP:2-trans,-6-trans-farnesol kinase activity
geraniol kinase activity
geranylgeraniol kinase activity
CTP:geranylgeraniol kinase activity
prenol kinase activity
1-phosphatidylinositol-5-kinase activity
1-phosphatidylinositol-3-phosphate 4-kinase activity
phosphatidylinositol-3,4-bisphosphate 5-kinase activity
phosphatidylinositol bisphosphate kinase activity
inositol-3,4,6-trisphosphate 1-kinase activity
inositol 5-diphosphate pentakisphosphate 5-kinase activity
inositol diphosphate tetrakisphosphate kinase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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