Invitrogen

FN3KRP Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-109734

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human FN3KRP (NP_078895.2).
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.62 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855145

Product Specific Information

Immunogen sequence: MEELLRRELG CSSVRATGHS GGGCISQGRS YDTDQGRVFV KVNPKAEARR MFEGEMASLT AILKTNTVKV PKPIKVLDAP GGGSVLVMEH MDMRHLSSHA AKLGAQLADL HLDNKKLGEM RLKEAGTVGR GGGQEERPFV ARFGFDVVTC CGYLPQVNDW QEDWVVFYAR QRIQPQMDMV EKESGDREAL QLWSALQLKI PDLFRDLEII PALLHGDLWG GNVAEDSSGP VIFDPASFYG HSEYELAIAG MFGGFSSSFY SAYHGKIPKA PGFEKRLQLY QLFHYLNHWN HFGSGYRGSS LNIMRNLVK

Target Information

Fructosamine-3-kinase related protein (FN3KRP) is located on chromosome 17q25.3, approximately 8 kb upstream of the FN3K gene. It shares 65% amino acid identity with FN3K and possesses an identical genomic organization, implying functional similarities; FN3KRP is suggested to play a role in enzymatic deglycation. Unlike FN3K, FN3KRP is more ancient, present in diverse organisms such as cyanobacteria, echinoderms, plants, and cold-blooded vertebrates. Studies have discovered a significant association between rs1046896 in FN3KRP and longevity, where the longevity allele C is linked to increased FN3KRP expression in whole blood. FN3KRP is hypothesized to phosphorylate glucitolamines, products of non-enzymatic glycation, indicating its involvement in crucial metabolic processes. The regulation of both FN3K and FN3KRP is notable for TATA-less and CAAT-less promoters, featuring homologous CpG islands and Sp1 binding sites. Meanwhile, both genes are widely expressed across human tissues, but FN3K demonstrates significantly higher levels in tissues prone to glycation-related complications.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FN3K-related protein; FN3K-RP; fructosamine 3-kinase-related protein; Fructosamine-3-kinase-related protein; Ketosamine-3-kinase; ortholog of human fructosamine-3-kinase-related protein FN3KRP; Protein-psicosamine 3-kinase FN3KRP; testis secretory sperm-binding protein Li 211a

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Gene Aliases: FN3K-RP; FN3KL; FN3KRP; RGD1304570

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UniProt ID: (Human) Q9HA64, (Mouse) Q8K274

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Entrez Gene ID: (Human) 79672, (Rat) 303755, (Mouse) 238024

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Function(s)
kinase activity molecular_function phosphofructokinase activity phosphorylase kinase regulator activity cobinamide kinase activity phytol kinase activity phosphatidylinositol phosphate kinase activity cyclin-dependent protein serine/threonine kinase regulator activity transferase activity transferase activity, transferring phosphorus-containing groups phenol kinase activity cyclin-dependent protein kinase activating kinase regulator activity inositol tetrakisphosphate 2-kinase activity heptose 7-phosphate kinase activity aminoglycoside phosphotransferase activity phosphatidylinositol 3-kinase activity eukaryotic elongation factor-2 kinase regulator activity eukaryotic elongation factor-2 kinase activator activity LPPG:FO 2-phospho-L-lactate transferase activity cytidine kinase activity glycerate 2-kinase activity (S)-lactate 2-kinase activity phosphoserine:homoserine phosphotransferase activity L-seryl-tRNA(Sec) kinase activity phosphocholine transferase activity polynucleotide 5'-hydroxyl-kinase activity ATP-dependent polynucleotide kinase activity GTP-dependent polynucleotide kinase activity farnesol kinase activity CTP:2-trans,-6-trans-farnesol kinase activity geraniol kinase activity geranylgeraniol kinase activity CTP:geranylgeraniol kinase activity prenol kinase activity 1-phosphatidylinositol-5-kinase activity 1-phosphatidylinositol-3-phosphate 4-kinase activity phosphatidylinositol-3,4-bisphosphate 5-kinase activity phosphatidylinositol bisphosphate kinase activity inositol-3,4,6-trisphosphate 1-kinase activity inositol 5-diphosphate pentakisphosphate 5-kinase activity inositol diphosphate tetrakisphosphate kinase activity
Process(es)
phosphorylation post-translational protein modification biological_process
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