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Invitrogen
FN3KRP Polyclonal Antibody
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Product Details
PA5-64249
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FN3KRP
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2641691
Product Specific Information
Immunogen sequence: GSVLVMEHMD MRHLSSHAAK LGAQLADLHL DNKKLGEMRL KEAGTVGRGG GQEERPFVAR FGFDVVTCCG YLPQVNDWQE DWVVFYARQR IQPQMD
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 83%.
Target Information
Fructosamine-3-kinase related protein (FN3KRP) is located on chromosome 17q25.3, approximately 8 kb upstream of the FN3K gene. It shares 65% amino acid identity with FN3K and possesses an identical genomic organization, implying functional similarities; FN3KRP is suggested to play a role in enzymatic deglycation. Unlike FN3K, FN3KRP is more ancient, present in diverse organisms such as cyanobacteria, echinoderms, plants, and cold-blooded vertebrates. Studies have discovered a significant association between rs1046896 in FN3KRP and longevity, where the longevity allele C is linked to increased FN3KRP expression in whole blood. FN3KRP is hypothesized to phosphorylate glucitolamines, products of non-enzymatic glycation, indicating its involvement in crucial metabolic processes. The regulation of both FN3K and FN3KRP is notable for TATA-less and CAAT-less promoters, featuring homologous CpG islands and Sp1 binding sites. Meanwhile, both genes are widely expressed across human tissues, but FN3K demonstrates significantly higher levels in tissues prone to glycation-related complications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FN3K-related protein; FN3K-RP; Fructosamine-3-kinase-related protein; Ketosamine-3-kinase; Protein-psicosamine 3-kinase FN3KRP; testis secretory sperm-binding protein Li 211a
Gene Aliases: FN3KL; FN3KRP
UniProt ID: (Human) Q9HA64
Entrez Gene ID: (Human) 79672
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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