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Invitrogen
FNIP1 Polyclonal Antibody
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FIGURE: 1 / 2
FNIP1 Antibody (PA5-77778) in ICC/IF
Immunofluorescent analysis of FNIP1 in mouse C2C12 cells (mouse myoblast cell line). Sample was incubated with FNIP1 polyclonal antibody (Product # PA5-77778) using a dilution of 1:100 (1 hour at RT), and followed by Goat Anti-Mouse 488, Phalloidin Texas Red and DAPI secondary antibody at a dilution of 1:200 (1 hour at RT).
Product Details
PA5-77778
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide from the mid-protein of Human FNIP1 (C-ahx-SKDEDENNKFNE) (aa 339-350).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2735782
Product Specific Information
A 1:1,000 dilution of PA5-77778 was sufficient for detection of FNIP1 in 15 µg of mouse kidney cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.|Detects approximately 130 kDa.
Target Information
FNIP1 encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. Diseases associated with FNIP1 include Birt-Hogg-Dube Syndrome and Pleural Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Folliculin-interacting protein 1
Gene Aliases: A730024A03Rik; AI838773; AW557298; FNIP1; KIAA1961
UniProt ID: (Human) Q8TF40, (Mouse) Q68FD7
Entrez Gene ID: (Human) 96459, (Mouse) 216742, (Rat) 100362347
negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
positive regulation of protein phosphorylation
immature B cell differentiation
positive regulation of B cell apoptotic process
cellular response to starvation
TOR signaling
negative regulation of TOR signaling
positive regulation of peptidyl-serine phosphorylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of GTPase activity
regulation of pro-B cell differentiation
positive regulation of protein complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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