Invitrogen

FOXA2 Recombinant Rabbit Monoclonal Antibody (9O4M2)

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-42678

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-

Immunoprecipitation (IP)

0.5 µg-4 µg antibody for 200 µg-400 µg extracts of
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Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

9O4M2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HNF3β/FOXA2 (Q9Y261)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2911819

Product Specific Information

Positive test controls include: HepG2, Rat lung. The target is usually found in the following locations: Cytoplasm, Nucleus.

Immunogen sequence: MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA

Target Information

FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; WHN

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Gene Aliases: FOXA2; HNF3B; Tcf-3b; TCF3B

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UniProt ID: (Human) Q9Y261, (Rat) P32182

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Entrez Gene ID: (Human) 3170, (Rat) 25099

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding protein domain specific binding transcription regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding double-stranded DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding kinase binding sequence-specific DNA binding SMAD binding
Process(es)
positive regulation of transcription from RNA polymerase II promoter by glucose negative regulation of transcription from RNA polymerase II promoter by glucose cell fate specification transcription, DNA-templated regulation of transcription from RNA polymerase II promoter adult locomotory behavior negative regulation of epithelial to mesenchymal transition covalent chromatin modification regulation of blood coagulation endocrine pancreas development negative regulation of glucokinase activity positive regulation of embryonic development negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of insulin secretion involved in cellular response to glucose stimulus response to interleukin-6 dopaminergic neuron differentiation primitive streak formation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of gastrulation negative regulation of detection of glucose in utero embryonic development ectoderm formation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter pattern specification process anatomical structure morphogenesis anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression chromatin modification regulation of lipid metabolic process regulation of steroid metabolic process cell differentiation in hindbrain dorsal/ventral neural tube patterning signal transduction involved in regulation of gene expression lung development somite rostral/caudal axis specification response to insulin negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase III promoter cell development anatomical structure formation involved in morphogenesis neuron fate specification epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation connective tissue development
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