Invitrogen

FOXC1/FOXC2 Polyclonal Antibody

View all (2) FOXC1/FOXC2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-36261

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 100-150 of human FoxC1
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553446

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 57 kDa.

Purity is >95% by SDS-PAGE.

Target Information

The forkhead transcription factor genes FOXC1 (Mf1) and FOXC2 (Mfh1) interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop. The genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels and somites. Both FOXC1 and FOXC2 are expressed in the mesenchyme from which the ocular drainage structures derive. FOXC1 and FOXC2 also interact in kidney and heart development. Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility of glaucoma, including juvenile glaucoma. Functional regions in FOXC1 are required for nuclear localization and transcriptional regulation. Specifically, two regions in the FOXC1 forkhead domain, one rich in basic amino acid residues, and a second, highly conserved among all FOX proteins, are necessary for nuclear localization of the FOXC1 protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BF-3; Brain factor 3; congenital hydrocephalus; forkhead box C1 protein; forkhead box C2 (MFH-1 mesenchyme forkhead 1); forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C1; Forkhead box protein C2; forkhead homolog 14; forkhead, Drosophila, homolog-like 14; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL14; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FREAC-3; HFH-BF-3; Mesenchyme fork head protein 1; mesenchyme forkhead 1; Mesoderm/mesenchyme forkhead 1; MF-1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; myeloid factor-delta; Transcription factor FKH-1; Transcription factor FKH-14

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Gene Aliases: ARA; ch; fkh-1; Fkh1; Fkh14; FKHL14; FKHL7; FOXC1; FOXC2; FREAC-3; FREAC3; frkhda; Hfhbf3; IGDA; IHG1; IRID1; LD; Mf1; Mf4; MFH-1; MFH1; RIEG3

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UniProt ID: (Human) Q12948, (Human) Q99958, (Mouse) Q61572, (Rat) Q63246, (Mouse) Q61850

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Entrez Gene ID: (Human) 2296, (Human) 2303, (Mouse) 17300, (Rat) 364706, (Rat) 171356, (Mouse) 14234

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding DNA binding, bending sequence-specific DNA binding transcription regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin DNA binding identical protein binding molecular_function
Process(es)
skeletal system development ossification ovarian follicle development eye development ureteric bud development in utero embryonic development somitogenesis lymph vessel development blood vessel remodeling regulation of transcription, DNA-templated transcription from RNA polymerase II promoter Notch signaling pathway brain development heart development cell proliferation germ cell migration mesenchymal cell development neural crest cell development cell migration negative regulation of angiogenesis collagen fibril organization glycosaminoglycan metabolic process lacrimal gland development embryonic heart tube development maintenance of lens transparency vascular endothelial growth factor signaling pathway odontogenesis of dentin-containing tooth camera-type eye development positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesoderm formation artery morphogenesis regulation of blood vessel size ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation negative regulation of lymphangiogenesis positive regulation of hematopoietic progenitor cell differentiation positive regulation of hematopoietic stem cell differentiation negative regulation of apoptotic process involved in outflow tract morphogenesis negative regulation of transcription from RNA polymerase II promoter blood vessel development patterning of blood vessels metanephros development kidney development lymphangiogenesis heart morphogenesis regulation of transcription from RNA polymerase II promoter insulin receptor signaling pathway response to hormone positive regulation of endothelial cell migration positive regulation of cell adhesion mediated by integrin positive regulation of vascular wound healing paraxial mesodermal cell fate commitment embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis glomerular endothelium development glomerular visceral epithelial cell differentiation glomerular mesangial cell development positive regulation of cell migration involved in sprouting angiogenesis transcription, DNA-templated positive regulation of gene expression mesenchymal cell differentiation mesoderm development biological_process multicellular organism development positive regulation of integrin activation
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