Invitrogen

FOXL2 Recombinant Rabbit Monoclonal Antibody (4H5X3)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-38083

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4H5X3

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOXL2 (P58012)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.28 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2898001

Product Specific Information

Positive Samples: HeLa, K-562, Mouse testis, Rat testis, Rat ovary

Immunogen sequence: MMASYPEPED AAGALLAPET GRTVKEPEGP PPSPGKGGGG GGGTAPEKPD PAQKPPYSYV ALIAMAIRES AEKRLTLSGI YQYIIAKFPF YEKNKKGWQN

Target Information

FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical role evolutionarily, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and in further follicle development and/or maintenance. Immunohistochemical data shows that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo any major posttranslational modifications. FOXL2 is also found to be associated with blepharo-phimosis/ptosis/epicanthus inverses syndrome (BPES). There are two forms of BPES. Type I BPES shows eyelid abnormal-ities that are associated with ovarian failure. In type II BPES, only eyelid defects are found. Studies have shown that FOXL2 is expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Blepharophimosis; epicanthus inversus; forkhead box L2; Forkhead box protein L2; forkhead transcription factor FOXL2; LUSTR2; MGC14393; P-Frk; Pituitary forkhead factor; putative transcription factor foxl2

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Gene Aliases: AU045128; BPES; BPES1; FOXL2; PFRK; PINTO; POF3

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UniProt ID: (Human) P58012, (Mouse) O88470

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Entrez Gene ID: (Human) 668, (Mouse) 26927, (Rat) 367152

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding estrogen receptor binding ubiquitin conjugating enzyme binding cysteine-type endopeptidase regulator activity involved in apoptotic process sequence-specific DNA binding molecular_function
Process(es)
negative regulation of transcription from RNA polymerase II promoter ovarian follicle development extraocular skeletal muscle development apoptotic DNA fragmentation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter female somatic sex determination cell differentiation menstruation positive regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic eye morphogenesis granulosa cell differentiation regulation of transcription from RNA polymerase II promoter biological_process oocyte growth single fertilization positive regulation of luteinizing hormone secretion positive regulation of transcription, DNA-templated positive regulation of follicle-stimulating hormone secretion uterus development
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