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NeoBiotechnologies
FOXL2 Monoclonal Antibody (PCRP-FOXL2-1B4)
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Product Details
668-MSM1-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2c
Class
Monoclonal
Type
Antibody
Clone
PCRP-FOXL2-1B4
Immunogen
Protein domain of FOXL2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
Positive Control:Nuclear expression in ovarian follicular and stromal cells. HeLa cells.
Cellular Location: Nucleus.
Target Information
FOXL2 is a winged helix/forkhead transcription factor that is highly conserved in human, goat, mouse, and certain aquatic species. Given its cross-species conservation, it appears to play a critical role evolutionarily, likely in ovarian differentiation in mammals and in ovarian somatic cell differentiation and in further follicle development and/or maintenance. Immunohistochemical data shows that FOXL2 is a nuclear protein specifically expressed in eyelids and in fetal and adult ovarian follicular cells. It does not undergo any major posttranslational modifications. FOXL2 is also found to be associated with blepharo-phimosis/ptosis/epicanthus inverses syndrome (BPES). There are two forms of BPES. Type I BPES shows eyelid abnormal-ities that are associated with ovarian failure. In type II BPES, only eyelid defects are found. Studies have shown that FOXL2 is expressed in the mesenchyme of developing mouse eyelids and in adult ovarian follicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Blepharophimosis; epicanthus inversus; Forkhead box protein L2; forkhead transcription factor FOXL2; LUSTR2; MGC14393
Gene Aliases: BPES; BPES1; FOXL2; PFRK; PINTO; POF3
UniProt ID: (Human) P58012
Entrez Gene ID: (Human) 668
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
estrogen receptor binding
ubiquitin conjugating enzyme binding
cysteine-type endopeptidase regulator activity involved in apoptotic process
negative regulation of transcription from RNA polymerase II promoter
ovarian follicle development
oocyte growth
extraocular skeletal muscle development
apoptotic DNA fragmentation
transcription from RNA polymerase II promoter
single fertilization
female somatic sex determination
cell differentiation
positive regulation of luteinizing hormone secretion
menstruation
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of follicle-stimulating hormone secretion
embryonic eye morphogenesis
granulosa cell differentiation
uterus development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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