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Invitrogen
FOXN1 Polyclonal Antibody
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FOXN1 Antibody (PA5-18191) in IHC (P)
Immunohistochemistry analysis of FOXN1 in human thymus, medulla. Samples were incubated with FOXN1 polyclonal antibody (Product # PA5-18191) using a dilution of 20 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18191
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (SVYLSPSSKPVALA) corresponding to the C-terminus amino acids of FOXN1 (aa 635-648).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10977719
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
FOXN1 is a 648 amino acid protein belonging to the winged helix/forkhead family It contains 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. FOXN1 is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicles and nail apparatus and its defects lead to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Forkhead box protein N1; JTK1; Rowett nude; winged helix nude; winged-helix nude; Winged-helix transcription factor nude
Gene Aliases: FKHL20; FOXN1; RONU; WHN
UniProt ID: (Human) O15353
Entrez Gene ID: (Human) 8456
hair follicle development
T cell lineage commitment
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
defense response
epidermis development
organ morphogenesis
keratinocyte differentiation
positive regulation of epithelial cell differentiation
nail development
T cell homeostasis
blood vessel morphogenesis
epithelial cell proliferation
positive regulation of hair follicle development
lymphoid lineage cell migration into thymus
thymus epithelium morphogenesis
regulation of positive thymic T cell selection
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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