Bioss

FOXO1 + FOXO4 Polyclonal Antibody

View all (2) FOXO1/FOXO4 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-2766R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

synthetic peptide from human FOXO4 conjugated to KLH.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

These genes encode a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. Multiple transcript variants encoding different isoforms have been found for these genes. Both function as transcription factors involved in the regulation of the insulin signaling pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Afxh; Fork head domain transcription factor AFX1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O4; Forkhead in rhabdomyosarcoma; forkhead protein; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7

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Gene Aliases: AFX; AFX1; Afxh; AI876417; FKH1; FKHR; Fkhr1; Fkhr3; FOXO1; FOXO1A; FOXO4; MLLT7; RGD1561201

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UniProt ID: (Human) Q12778, (Human) P98177, (Rat) G3V7R4, (Mouse) Q9R1E0, (Mouse) Q9WVH3

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Entrez Gene ID: (Human) 2308, (Human) 4303, (Rat) 84482, (Mouse) 56458, (Rat) 302415, (Mouse) 54601

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, transcription factor binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator binding chromatin binding protein binding beta-catenin binding ubiquitin protein ligase binding sequence-specific DNA binding protein phosphatase 2A binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding enzyme binding identical protein binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Process(es)
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell cycle arrest mitotic G2 DNA damage checkpoint negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of angiogenesis positive regulation of transcription, DNA-templated stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition negative regulation of transcription from RNA polymerase II promoter blood vessel development autophagy apoptotic process cellular response to DNA damage stimulus cellular response to starvation positive regulation of autophagy cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade cellular response to oxidative stress regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of cell proliferation glucose homeostasis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process positive regulation of transcription from RNA polymerase II promoter cellular response to hyperoxia cellular response to nitric oxide negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance regulation of nucleic acid-templated transcription regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process transcription, DNA-templated anatomical structure morphogenesis cell differentiation temperature homeostasis cellular glucose homeostasis protein acetylation endocrine pancreas development fat cell differentiation negative regulation of transcription, DNA-templated enamel mineralization cellular response to hydrogen peroxide cellular response to cold cellular response to dexamethasone stimulus response to fluoride regulation of energy homeostasis cell cycle multicellular organism development muscle organ development positive regulation of cell cycle arrest
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