Proteintech

FOXO4 Polyclonal Antibody

FOXO4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FOXO4 Antibody (21535-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney using 21535-1-AP (FOXO4 antibody) at dilution of 1:100 (under 40x lens).

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Product Details

21535-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Dog, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FOXO4 Fusion Protein Ag16169 (198-505 aa encoded by BC106761)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDSSSKLLR GRSKAPKKKP SVLPAPPEGA TPTSPVGHFA KWSGSPCSRN REEADMWTTF RPRSSSNASS VSTRLSPLRP ESEVLAEEIP ASVSSYAGGV PPTLNEGLEL LDGLNLTSSH SLLSRSGLSG FSLQHPGVTG PLHTYSSSLF SPAEGPLSAG EGCFSSSQAL EALLTSDTPP PPADVLMTQV DPILSQAPTL LLLGGLPSSS KLATGVGLCP KPLEAPGPSS LVPTLSMIAP PPVMASAPIP KALGTPVLTP PTEAASQDRM PQDLDLDMYM ENLECDMDNI ISDLMDEGEG LDFNFEPDP (198-505 aa encoded by BC106761)

Target Information

FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6. FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Tue Jan 31 00:00:00 UTC 2023

SGK2 promotes prostate cancer metastasis by inhibiting ferroptosis via upregulating GPX4.

Cell death & disease

Cheng L,He Q,Liu B,Chen L,Lv F,Li X,Li Y,Liu C,Song Y,Xing Y

Tue Jan 31 00:00:00 UTC 2023

Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence.

Materials today. Bio

Han J,Wang J,Shi H,Li Q,Zhang S,Wu H,Li W,Gan L,Brown-Borg HM,Feng W,Chen Y,Zhao RC

Sat Apr 01 00:00:00 UTC 2023

Tumor-derived extracellular vesicles delivering TNF-α promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23.

Archives of biochemistry and biophysics

Xie BW,Guan B,Chen W,Zhou M,Gu Q,Liu Y,Yan D

Thu Jun 01 00:00:00 UTC 2023

Tumor-derived extracellular vesicles delivering TNF-α promotes colorectal cancer metastasis via the NF-kB/LAMB3/AKT axis by targeting SNAP23.

Archives of biochemistry and biophysics

Xie BW,Guan B,Chen W,Zhou M,Gu Q,Liu Y,Yan D

Thu Jun 01 00:00:00 UTC 2023

Virus-induced FoxO factor facilitates replication of human cytomegalovirus.

Archives of virology

Sleman S

Sat Jan 01 00:00:00 UTC 2022

Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction.

Redox biology

Li H,Zhu J,Xu YW,Mou FF,Shan XL,Wang QL,Liu BN,Ning K,Liu JJ,Wang YC,Mi JX,Wei X,Shao SJ,Cui GH,Lu R,Guo HD

Mon Aug 01 00:00:00 UTC 2022

Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.

Virulence

Jie W,Rui-Fen Z,Zhong-Xiang H,Yan W,Wei-Na L,Yong-Ping M,Jing S,Jing-Yi C,Wan-Hong L,Xiao-Hua H,Zhi L,Yan S

Thu Dec 01 00:00:00 UTC 2022

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.

Nature communications

Xia W,Xie J,Cai Z,Liu X,Wen J,Cui ZK,Zhao R,Zhou X,Chen J,Mao X,Gu Z,Zou Z,Zou Z,Zhang Y,Zhao M,Mac M,Song Q,Bai X

Fri Oct 15 00:00:00 UTC 2021

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.

Nature communications

Xia W,Xie J,Cai Z,Liu X,Wen J,Cui ZK,Zhao R,Zhou X,Chen J,Mao X,Gu Z,Zou Z,Zou Z,Zhang Y,Zhao M,Mac M,Song Q,Bai X

Fri Oct 15 00:00:00 UTC 2021

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.

Nature communications

Xia W,Xie J,Cai Z,Liu X,Wen J,Cui ZK,Zhao R,Zhou X,Chen J,Mao X,Gu Z,Zou Z,Zou Z,Zhang Y,Zhao M,Mac M,Song Q,Bai X

Fri Oct 15 00:00:00 UTC 2021

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.

Nature communications

Xia W,Xie J,Cai Z,Liu X,Wen J,Cui ZK,Zhao R,Zhou X,Chen J,Mao X,Gu Z,Zou Z,Zou Z,Zhang Y,Zhao M,Mac M,Song Q,Bai X

Fri Oct 15 00:00:00 UTC 2021

FOXO4 expression associates with glioblastoma development and FOXO4 expression inhibits cell malignant phenotypes in vitro and in vivo.

Life sciences

Qi M,Sun LA,Jiang XC,Han YL,Wang L,Niu WH,Fei MX,Zhaba WD,Zheng LR,Zhou ML

Wed Apr 15 00:00:00 UTC 2020

Grandmaternal betaine supplementation enhances hepatic IGF2 expression in F2 rat offspring through modification of promoter DNA methylation.

Journal of the science of food and agriculture

Yang S,Zhao N,Sun B,Yang Y,Hu Y,Zhao R

Sun Mar 15 00:00:00 UTC 2020

miR-762 Promotes Malignant Development of Head and Neck Squamous Cell Carcinoma by Targeting PHLPP2 and FOXO4.

OncoTargets and therapy

Chen S,Zhang JY,Sun LS,Li XF,Bai JY,Zhang HY,Li TJ

Tue Apr 12 00:00:00 UTC 2022

Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies.

Circulation research

Auguste G,Gurha P,Lombardi R,Coarfa C,Willerson JT,Marian AJ

Fri Mar 02 00:00:00 UTC 2018

Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies.

Circulation research

Auguste G,Gurha P,Lombardi R,Coarfa C,Willerson JT,Marian AJ

Fri Mar 02 00:00:00 UTC 2018

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 UTC 2018

Mitotically Stable Modification of DNA Methylation in IGF2/H19 Imprinting Control Region Is Associated with Activated Hepatic IGF2 Expression in Offspring Rats from Betaine-Supplemented Dams.

Journal of agricultural and food chemistry

Yang S,Zhao N,Yang Y,Hu Y,Dong H,Zhao R

Wed Mar 21 00:00:00 UTC 2018

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 UTC 2016

Folate deprivation induces cell cycle arrest at G0/G1 phase and apoptosis in hippocampal neuron cells through down-regulation of IGF-1 signaling pathway.

The international journal of biochemistry & cell biology

Yang Y,Li X,Sun Q,He B,Jia Y,Cai D,Zhao R

Sat Oct 01 00:00:00 UTC 2016

Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.

The Journal of clinical investigation

Xu X,Fan Z,Kang L,Han J,Jiang C,Zheng X,Zhu Z,Jiao H,Lin J,Jiang K,Ding L,Zhang H,Cheng L,Fu H,Song Y,Jiang Y,Liu J,Wang R,Du N,Ye Q

Fri Feb 01 00:00:00 UTC 2013

Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis.

The Journal of clinical investigation

Xu X,Fan Z,Kang L,Han J,Jiang C,Zheng X,Zhu Z,Jiao H,Lin J,Jiang K,Ding L,Zhang H,Cheng L,Fu H,Song Y,Jiang Y,Liu J,Wang R,Du N,Ye Q

Fri Feb 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Afxh; AFXzeta; Fork head domain transcription factor AFX1; Forkhead box protein O4; forkhead protein; FOXO4b; MGC120490; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; OTTHUMP00000023497

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Gene Aliases: AFX; AFX1; Afxh; Fkhr3; FOXO4; MLLT7; RGD1561201

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UniProt ID: (Human) P98177, (Mouse) Q9WVH3

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Entrez Gene ID: (Human) 4303, (Rat) 302415, (Mouse) 54601

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Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding transcription factor binding enzyme binding identical protein binding sequence-specific DNA binding

Process(es)

regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell cycle arrest mitotic G2 DNA damage checkpoint negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of angiogenesis positive regulation of transcription, DNA-templated stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition transcription, DNA-templated cell cycle multicellular organism development muscle organ development anatomical structure morphogenesis cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of cell cycle arrest

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FOXO4 Polyclonal Antibody

FOXO4 Antibody (21535-1-AP) in IHC (P)

Product Details

21535-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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