Invitrogen

FOXP1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-118588

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FOXP1(Accession Q9H334), corresponding to amino acid residues V630-E677.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2903088

Product Specific Information

Antibody detects endogenous levels of total FOXP1.

Target Information

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ23741; Fork head related protein like B; fork head-related protein like B; Forkhead box protein P1; Forkhead box protein P1 (FOXP1); Forkhead-related transcription factor 1; Glutamine rich factor 1; glutamine-rich factor 1; Mac-1-regulated forkhead; MFH; MGC12942; MGC88572; MGC99551

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Gene Aliases: 12CC4; 3110052D19Rik; 4932443N09Rik; AI461938; AW494214; FOXP1; hFKH1B; HSPC215; MFH; QRF1

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UniProt ID: (Human) Q9H334, (Rat) Q498D1, (Mouse) P58462

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Entrez Gene ID: (Human) 27086, (Rat) 297480, (Mouse) 108655

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding protein self-association metal ion binding androgen receptor binding RNA polymerase II core promoter proximal region sequence-specific DNA binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein homodimerization activity protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development positive regulation of mesenchymal cell proliferation pre-B cell differentiation positive regulation of immunoglobulin production negative regulation of B cell apoptotic process regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter heart development skeletal muscle tissue development motor neuron axon guidance positive regulation of endothelial cell migration ventral spinal cord development osteoclast differentiation lung development response to lipopolysaccharide regulation of tumor necrosis factor production immunoglobulin V(D)J recombination chemokine (C-C motif) ligand 2 secretion osteoclast development macrophage activation monocyte activation endothelial cell activation sarcomere organization regulation of monocyte differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation smooth muscle tissue development positive regulation of epithelial cell proliferation regulation of interleukin-1 beta secretion regulation of inflammatory response cardiac muscle cell differentiation regulation of cardiac muscle cell proliferation negative regulation of androgen receptor signaling pathway lung secretory cell differentiation T follicular helper cell differentiation cardiovascular system development interleukin-21 secretion regulation of defense response to bacterium regulation of lung goblet cell differentiation negative regulation of lung goblet cell differentiation regulation of macrophage colony-stimulating factor production regulation of endothelial tube morphogenesis positive regulation of cardiac muscle cell differentiation regulation of interleukin-12 secretion transcription, DNA-templated regulation of transcription, DNA-templated anatomical structure morphogenesis embryo development
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