Product References
Changes of T Lymphocyte Subsets in Peripheral Blood of Patients with Intermediate and Advanced Cervical Cancer before and after Nimotuzumab Combined with Chemoradiotherapy.
International archives of allergy and immunology
Teng F,Cui G,Qian L,Zhao L
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Thu Jan 05 00:00:00 UTC 2023
The immune microenvironment after neoadjuvant therapy compared to upfront surgery in patients with pancreatic cancer.
Journal of cancer research and clinical oncology
Zwart ES,van Ee T,Doppenberg D,Farina A,Wilmink JW,Versteijne E,Busch OR,Besselink MG,Meijer LL,van Kooyk Y,Mebius RE,Kazemier G
14-4777-82 was used in Immunohistochemistry to analyzed the immune microenvironment in pancreatic cancer tumor tissue samples from patients treated with neoadjuvant therapy compared to patients after upfront surgery to gain knowledge about the immunological environment after therapy.
Wed Nov 01 00:00:00 UTC 2023
Tumor microenvironment shows an immunological abscopal effect in patients with NSCLC treated with pembrolizumab-radiotherapy combination.
Journal for immunotherapy of cancer
van der Woude LL,Gorris MAJ,Wortel IMN,Creemers JHA,Verrijp K,Monkhorst K,Grünberg K,van den Heuvel MM,Textor J,Figdor CG,Piet B,Theelen WSME,de Vries IJM
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Immunohistochemistry
Sat Oct 01 00:00:00 UTC 2022
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments.
Immunity
Jiang S,Chan CN,Rovira-Clavé X,Chen H,Bai Y,Zhu B,McCaffrey E,Greenwald NF,Liu C,Barlow GL,Weirather JL,Oliveria JP,Nakayama T,Lee IT,Matter MS,Carlisle AE,Philips D,Vazquez G,Mukherjee N,Busman-Sahay K,Nekorchuk M,Terry M,Younger S,Bosse M,Demeter J,Rodig SJ,Tzankov A,Goltsev Y,McIlwain DR,Angelo M,Estes JD,Nolan GP
14-4777-82 was used in Immunocytochemistry to simultaneously quantify DNA, RNA, and protein levels within these tissue compartments.
Tue Jun 14 00:00:00 UTC 2022
An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer.
Cell reports. Medicine
Johnson BE,Creason AL,Stommel JM,Keck JM,Parmar S,Betts CB,Blucher A,Boniface C,Bucher E,Burlingame E,Camp T,Chin K,Eng J,Estabrook J,Feiler HS,Heskett MB,Hu Z,Kolodzie A,Kong BL,Labrie M,Lee J,Leyshock P,Mitri S,Patterson J,Riesterer JL,Sivagnanam S,Somers J,Sudar D,Thibault G,Weeder BR,Zheng C,Nan X,Thompson RF,Heiser LM,Spellman PT,Thomas G,Demir E,Chang YH,Coussens LM,Guimaraes AR,Corless C,Goecks J,Bergan R,Mitri Z,Mills GB,Gray JW
14-4777-82 was used in Flow Cytometry to present illustrative examples of how integrative analyses of data reveal potential mechanisms of response and resistance and suggest novel therapeutic vulnerabilities.
Tue Feb 15 00:00:00 UTC 2022
Feasibility of Intratumoral Anti-PD1 as Treatment of Human Basal Cell Carcinoma: An Explorative Study with Adjuvant Ablative Fractional Laser.
Cancers
Omland SH,Ejlertsen JS,Krustrup D,Christensen RL,Svane IM,Olesen UH,Hædersdal M
14-4777-82 was used in Immunohistochemistry to explore intratumoral injection of anti-PD1 with and without AFL in basal cell carcinoma (BCC), exploring anti-PD1 concentration, immune cell infiltration, tumor response, and safety.
Fri Nov 25 00:00:00 UTC 2022
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions.
Immunity
Schwabenland M,Salié H,Tanevski J,Killmer S,Lago MS,Schlaak AE,Mayer L,Matschke J,Püschel K,Fitzek A,Ondruschka B,Mei HE,Boettler T,Neumann-Haefelin C,Hofmann M,Breithaupt A,Genc N,Stadelmann C,Saez-Rodriguez J,Bronsert P,Knobeloch KP,Blank T,Thimme R,Glatzel M,Prinz M,Bengsch B
14-4777-82 was used in Mass cytometry to identify profound neuroinflammation with activation of innate and adaptive immune cells as correlates of COVID-19 neuropathology, with implications for potential therapeutic strategies.
Tue Jul 13 00:00:00 UTC 2021
Analysis of Expression of Different Histone Deacetylases in Autoimmune Thyroid Disease.
The Journal of clinical endocrinology and metabolism
Sacristán-Gómez P,Serrano-Somavilla A,González-Amaro R,Martínez-Hernández R,Marazuela M
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Thu Oct 21 00:00:00 UTC 2021
Immune cell composition in the endometrium of patients with a complete molar pregnancy: Effects on outcome.
Gynecologic oncology
Hoeijmakers YM,Gorris MAJ,Sweep FCGJ,Bulten J,Eysbouts YK,Massuger LFAG,Ottevanger PB,de Vries JIJM
14-4777 was used in Immunohistochemistry to analyse immune cell composition and density in curettaged endometrium of patients with CHM which spontaneously regressed, and of patients with CHM which progressed to post-molar GTN.
Mon Feb 01 00:00:00 UTC 2021
Common clonal origin of conventional T cells and induced regulatory T cells in breast cancer patients.
Nature communications
Xydia M,Rahbari R,Ruggiero E,Macaulay I,Tarabichi M,Lohmayer R,Wilkening S,Michels T,Brown D,Vanuytven S,Mastitskaya S,Laidlaw S,Grabe N,Pritsch M,Fronza R,Hexel K,Schmitt S,Müller-Steinhardt M,Halama N,Domschke C,Schmidt M,von Kalle C,Schütz F,Voet T,Beckhove P
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Immunohistochemistry
Thu Feb 18 00:00:00 UTC 2021
Increased CD3+, CD8+, or FoxP3+ T Lymphocyte Infiltrations Are Associated with the Pathogenesis of Colorectal Cancer but Not with the Overall Survival of Patients.
Biology
Barbosa AM,Martinho O,Nogueira R,Campos J,Lobo L,Pinto H,Longatto-Filho A,Castro AG,Martins SF,Torrado E
14-4777-82 was used in Immunohistochemistry to show that the presence of CD3+, CD8+, or FoxP3+T lymphocyte infiltrates in the tumor margins are associated with the pathogenesis of CRC, but only high Foxp3+ T lymphocyte infiltrations in the tumor invasive margins are inclined to indicate favorable prognosis.
Fri Aug 20 00:00:00 UTC 2021
Increased CD3+, CD8+, or FoxP3+ T Lymphocyte Infiltrations Are Associated with the Pathogenesis of Colorectal Cancer but Not with the Overall Survival of Patients.
Biology
Barbosa AM,Martinho O,Nogueira R,Campos J,Lobo L,Pinto H,Longatto-Filho A,Castro AG,Martins SF,Torrado E
14-4777-82 was used in Immunohistochemistry to show that the presence of CD3+, CD8+, or FoxP3+T lymphocyte infiltrates in the tumor margins are associated with the pathogenesis of CRC, but only high Foxp3+ T lymphocyte infiltrations in the tumor invasive margins are inclined to indicate favorable prognosis.
Fri Aug 20 00:00:00 UTC 2021
Multiple Immunostainings with Different Epitope Retrievals-The FOLGAS Protocol.
International journal of molecular sciences
von Schoenfeld A,Bronsert P,Poc M,Fuller A,Filby A,Kraft S,Kurowski K,Sörensen K,Huber J,Pfeiffer J,Proietti M,Stehl V,Werner M,Seidl M
14-4777-82 was used in Immunohistochemistry to describe a sequential multistaining protocol for immunohistochemistry, immunofluorescence and CyTOF imaging for formalin-fixed, paraffin-embedded specimens (FFPE) in the formalin gas-phase (FOLGAS), enabling sequential multistaining, independent from the primary and secondary antibodies and retrieval.
Sat Dec 25 00:00:00 UTC 2021
Multiple Immunostainings with Different Epitope Retrievals-The FOLGAS Protocol.
International journal of molecular sciences
von Schoenfeld A,Bronsert P,Poc M,Fuller A,Filby A,Kraft S,Kurowski K,Sörensen K,Huber J,Pfeiffer J,Proietti M,Stehl V,Werner M,Seidl M
14-4777-82 was used in Immunohistochemistry to describe a sequential multistaining protocol for immunohistochemistry, immunofluorescence and CyTOF imaging for formalin-fixed, paraffin-embedded specimens (FFPE) in the formalin gas-phase (FOLGAS), enabling sequential multistaining, independent from the primary and secondary antibodies and retrieval.
Sat Dec 25 00:00:00 UTC 2021
Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma.
Nature communications
Phillips D,Matusiak M,Gutierrez BR,Bhate SS,Barlow GL,Jiang S,Demeter J,Smythe KS,Pierce RH,Fling SP,Ramchurren N,Cheever MA,Goltsev Y,West RB,Khodadoust MS,Kim YH,Schürch CM,Nolan GP
14-4777-82 was used in Immunohistochemistry to study the spatial organization of the cutaneous T cell lymphomas microenvironment in a cohort of patients enrolled in a previously published pembrolizumab clinical trial, which failed to identify a predictive biomarker of response.
Thu Nov 18 00:00:00 UTC 2021
Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma.
Nature communications
Phillips D,Matusiak M,Gutierrez BR,Bhate SS,Barlow GL,Jiang S,Demeter J,Smythe KS,Pierce RH,Fling SP,Ramchurren N,Cheever MA,Goltsev Y,West RB,Khodadoust MS,Kim YH,Schürch CM,Nolan GP
14-4777-82 was used in Immunohistochemistry to study the spatial organization of the cutaneous T cell lymphomas microenvironment in a cohort of patients enrolled in a previously published pembrolizumab clinical trial, which failed to identify a predictive biomarker of response.
Thu Nov 18 00:00:00 UTC 2021
Heme Oxygenase-1 Inhibition Potentiates the Effects of Nab-Paclitaxel-Gemcitabine and Modulates the Tumor Microenvironment in Pancreatic Ductal Adenocarcinoma.
Cancers
Ahmad IM,Dafferner AJ,O'Connell KA,Mehla K,Britigan BE,Hollingsworth MA,Abdalla MY
14-4777-82 was used in Immunohistochemistry (Paraffin) to to show that HO-1 inhibition abrogated the influx of macrophages and FoxP3+ cells, while increasing the proportion of CD8+ infiltration in the pancreatic tumors.
Sat May 08 00:00:00 UTC 2021
A Four-Chemokine Signature Is Associated with a T-cell-Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Romero JM,Grünwald B,Jang GH,Bavi PP,Jhaveri A,Masoomian M,Fischer SE,Zhang A,Denroche RE,Lungu IM,De Luca A,Bartlett JMS,Xu J,Li N,Dhaliwal S,Liang SB,Chadwick D,Vyas F,Bronsert P,Khokha R,McGaha TL,Notta F,Ohashi PS,Done SJ,O'Kane GM,Wilson JM,Knox JJ,Connor A,Wang Y,Zogopoulos G,Gallinger S
14-4777-82 was used in Immunocytochemistry to elucidate the molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma.
Wed Apr 15 00:00:00 UTC 2020
Metformin Abrogates Age-Associated Ovarian Fibrosis.
Clinical cancer research : an official journal of the American Association for Cancer Research
McCloskey CW,Cook DP,Kelly BS,Azzi F,Allen CH,Forsyth A,Upham J,Rayner KJ,Gray DA,Boyd RW,Murugkar S,Lo B,Trudel D,Senterman MK,Vanderhyden BC
14-4777 was used in Immunohistochemistry to assesse the effects of age and ovulation on the ovarian microenvironment underlie ovarian cancer risk.
Sat Feb 01 00:00:00 UTC 2020
Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans.
Molecular therapy : the journal of the American Society of Gene Therapy
Gernoux G,Gruntman AM,Blackwood M,Zieger M,Flotte TR,Mueller C
14-4777 was used in Immunohistochemistry to show that persisting transgene expression after gene transfer in muscle is mediated by Tregs and exhausted T cells.
Wed Mar 04 00:00:00 UTC 2020
Muscle-Directed Delivery of an AAV1 Vector Leads to Capsid-Specific T Cell Exhaustion in Nonhuman Primates and Humans.
Molecular therapy : the journal of the American Society of Gene Therapy
Gernoux G,Gruntman AM,Blackwood M,Zieger M,Flotte TR,Mueller C
14-4777 was used in Immunohistochemistry to show that persisting transgene expression after gene transfer in muscle is mediated by Tregs and exhausted T cells.
Wed Mar 04 00:00:00 UTC 2020
Mitochondrial transfer from MSCs to T cells induces Treg differentiation and restricts inflammatory response.
EMBO reports
Court AC,Le-Gatt A,Luz-Crawford P,Parra E,Aliaga-Tobar V,Bátiz LF,Contreras RA,Ortúzar MI,Kurte M,Elizondo-Vega R,Maracaja-Coutinho V,Pino-Lagos K,Figueroa FE,Khoury M
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Wed Feb 05 00:00:00 UTC 2020
Single-cell multi-omics analysis presents the landscape of peripheral blood T-cell subsets in human chronic prostatitis/chronic pelvic pain syndrome.
Journal of cellular and molecular medicine
Zhang M,Liu Y,Chen J,Chen L,Meng J,Yang C,Yin S,Zhang X,Zhang L,Hao Z,Chen X,Liang C
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Tue Dec 01 00:00:00 UTC 2020
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells.
Nature communications
Gómez-Aleza C,Nguyen B,Yoldi G,Ciscar M,Barranco A,Hernández-Jiménez E,Maetens M,Salgado R,Zafeiroglou M,Pellegrini P,Venet D,Garaud S,Trinidad EM,Benítez S,Vuylsteke P,Polastro L,Wildiers H,Simon P,Lindeman G,Larsimont D,Van den Eynden G,Velghe C,Rothé F,Willard-Gallo K,Michiels S,Muñoz P,Walzer T,Planelles L,Penninger J,Azim HA,Loi S,Piccart M,Sotiriou C,González-Suárez E
14-4777 was used in Immunohistochemistry to investigate the effects of inhibiting the RANK signalling pathway on immune activation.
Thu Dec 10 00:00:00 UTC 2020
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells.
Nature communications
Gómez-Aleza C,Nguyen B,Yoldi G,Ciscar M,Barranco A,Hernández-Jiménez E,Maetens M,Salgado R,Zafeiroglou M,Pellegrini P,Venet D,Garaud S,Trinidad EM,Benítez S,Vuylsteke P,Polastro L,Wildiers H,Simon P,Lindeman G,Larsimont D,Van den Eynden G,Velghe C,Rothé F,Willard-Gallo K,Michiels S,Muñoz P,Walzer T,Planelles L,Penninger J,Azim HA,Loi S,Piccart M,Sotiriou C,González-Suárez E
14-4777 was used in Immunohistochemistry to investigate the effects of inhibiting the RANK signalling pathway on immune activation.
Thu Dec 10 00:00:00 UTC 2020
Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs.
Genes
Scherer A,Stephens VR,McGivney GR,Gutierrez WR,Laverty EA,Knepper-Adrian V,Dodd RD
14-4777 was used in Immunohistochemistry to highlight important strain-specific phenotypes of genomically-matched malignant peripheral nerve sheath tumors (MPNSTs) that have implications for the design of future studies using similar in vivo gene editing approaches.
Sat May 23 00:00:00 UTC 2020
Distinct Tumor Microenvironments Are a Defining Feature of Strain-Specific CRISPR/Cas9-Induced MPNSTs.
Genes
Scherer A,Stephens VR,McGivney GR,Gutierrez WR,Laverty EA,Knepper-Adrian V,Dodd RD
14-4777 was used in Immunohistochemistry to highlight important strain-specific phenotypes of genomically-matched malignant peripheral nerve sheath tumors (MPNSTs) that have implications for the design of future studies using similar in vivo gene editing approaches.
Sat May 23 00:00:00 UTC 2020
hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts.
EBioMedicine
Todorova D,Zhang Y,Chen Q,Liu J,He J,Fu X,Xu Y
14-4777 was used in Immunohistochemistry to investigate whether the adoptive transfer of CTLA4-Ig/PD-L1 knock-in dendritic cell-like cells(CP DCLs) can induce long-term immune tolerance of parental human embryonic stem cells(hESC)-derived smooth muscle and cardiomyocyte allografts.
Tue Dec 01 00:00:00 UTC 2020
hESC-derived immune suppressive dendritic cells induce immune tolerance of parental hESC-derived allografts.
EBioMedicine
Todorova D,Zhang Y,Chen Q,Liu J,He J,Fu X,Xu Y
14-4777 was used in Immunohistochemistry to investigate whether the adoptive transfer of CTLA4-Ig/PD-L1 knock-in dendritic cell-like cells(CP DCLs) can induce long-term immune tolerance of parental human embryonic stem cells(hESC)-derived smooth muscle and cardiomyocyte allografts.
Tue Dec 01 00:00:00 UTC 2020
Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer.
Frontiers in physiology
Mi H,Gong C,Sulam J,Fertig EJ,Szalay AS,Jaffee EM,Stearns V,Emens LA,Cimino-Mathews AM,Popel AS
14-4777 was used in Immunohistochemistry to provide key information about the spatial heterogeneity within the TME.
Wed Nov 18 00:00:00 UTC 2020
Digital Pathology Analysis Quantifies Spatial Heterogeneity of CD3, CD4, CD8, CD20, and FoxP3 Immune Markers in Triple-Negative Breast Cancer.
Frontiers in physiology
Mi H,Gong C,Sulam J,Fertig EJ,Szalay AS,Jaffee EM,Stearns V,Emens LA,Cimino-Mathews AM,Popel AS
14-4777 was used in Immunohistochemistry to provide key information about the spatial heterogeneity within the TME.
Wed Nov 18 00:00:00 UTC 2020
Biomarker recommendation for PD-1/PD-L1 immunotherapy development in pediatric cancer based on digital image analysis of PD-L1 and immune cells.
The journal of pathology. Clinical research
Silva MA,Triltsch N,Leis S,Kanchev I,Tan TH,Van Peel B,Van Kerckhoven M,Deschoolmeester V,Zimmermann J
14-4777 was used in Immunohistochemistry to unveil whether - or which of - the pediatric tumors might be potentially eligible for anti-PD-1/PD-L1 checkpoint inhibition immunotherapy.
Wed Apr 01 00:00:00 UTC 2020
Biomarker recommendation for PD-1/PD-L1 immunotherapy development in pediatric cancer based on digital image analysis of PD-L1 and immune cells.
The journal of pathology. Clinical research
Silva MA,Triltsch N,Leis S,Kanchev I,Tan TH,Van Peel B,Van Kerckhoven M,Deschoolmeester V,Zimmermann J
14-4777 was used in Immunohistochemistry to unveil whether - or which of - the pediatric tumors might be potentially eligible for anti-PD-1/PD-L1 checkpoint inhibition immunotherapy.
Wed Apr 01 00:00:00 UTC 2020
Tumour immune microenvironment in primary and metastatic papillary renal cell carcinoma.
Histopathology
Eich ML,Chaux A,Mendoza Rodriguez MA,Guner G,Taheri D,Rodriguez Pena MDC,Sharma R,Allaf ME,Netto GJ
14-4777-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to find PD-L1 expression in up to one-quarter of primary and metastatic papillary RCC.
Sat Feb 01 00:00:00 UTC 2020
Inhibitory activity of FOXP3+ regulatory T cells reveals high specificity for displaying immune tolerance in remission state rheumatoid arthritis.
Scientific reports
Kanjana K,Chevaisrakul P,Matangkasombut P,Paisooksantivatana K,Lumjiaktase P
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Fri Nov 13 00:00:00 UTC 2020
Clusters of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Pregnant Uterus.
Cell reports
Benner M,Feyaerts D,García CC,Inci N,López SC,Fasse E,Shadmanfar W,van der Heijden OWH,Gorris MAJ,Joosten I,Ferwerda G,van der Molen RG
14-4777-82 was used in Flow Cytometry to suggest a role for B cells in healthy pregnancy.
Tue Sep 29 00:00:00 UTC 2020
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.
Cell research
Zhang Y,Du X,Liu M,Tang F,Zhang P,Ai C,Fields JK,Sundberg EJ,Latinovic OS,Devenport M,Zheng P,Liu Y
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Thu Aug 01 00:00:00 UTC 2019
Immunotherapy Targeting HPV16/18 Generates Potent Immune Responses in HPV-Associated Head and Neck Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Aggarwal C,Cohen RB,Morrow MP,Kraynyak KA,Sylvester AJ,Knoblock DM,Bauml JM,Weinstein GS,Lin A,Boyer J,Sakata L,Tan S,Anton A,Dickerson K,Mangrolia D,Vang R,Dallas M,Oyola S,Duff S,Esser M,Kumar R,Weiner D,Csiki I,Bagarazzi ML
14-4777 was used in Immunohistochemistry to demonstrate that MEDI0457 can generate durable HPV16/18 antigen-specific peripheral and tumor immune responses.
Tue Jan 01 00:00:00 UTC 2019
GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon.
Cancer research
Salem M,Wallace C,Velegraki M,Li A,Ansa-Addo E,Metelli A,Kwon H,Riesenberg B,Wu B,Zhang Y,Guglietta S,Sun S,Liu B,Li Z
14-4777-82 was used in Flow Cytometry to demonstrate that loss of GARP in Treg cells leads to spontaneous inflammation with highly activated CD4+ and CD8+ T cells and development of enteritis.
Fri Mar 15 00:00:00 UTC 2019
Poor Response to Neoadjuvant Chemotherapy Correlates with Mast Cell Infiltration in Inflammatory Breast Cancer.
Cancer immunology research
Reddy SM,Reuben A,Barua S,Jiang H,Zhang S,Wang L,Gopalakrishnan V,Hudgens CW,Tetzlaff MT,Reuben JM,Tsujikawa T,Coussens LM,Wani K,He Y,Villareal L,Wood A,Rao A,Woodward WA,Ueno NT,Krishnamurthy S,Wargo JA,Mittendorf EA
14-4777-82 was used in Immunohistochemistry to highlight the strong association of mast cell infiltration with poor response to NAC, suggesting a mechanism of treatment resistance and a potential therapeutic target in IBC.
Sat Jun 01 00:00:00 UTC 2019
CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.
The American journal of pathology
Strainic MG,Liu J,An F,Bailey E,Esposito A,Hamann J,Heeger PS,Medof ME
14-4777 was used in Immuno-assay to study the importance of DAF in enabling processes that program tolerance in the gut and the eye.
Mon Jul 01 00:00:00 UTC 2019
Molecular profiling of primary uveal melanomas with tumor-infiltrating lymphocytes.
Oncoimmunology
Triozzi PL,Schoenfield L,Plesec T,Saunthararajah Y,Tubbs RR,Singh AD
14-4777-82 was used in Immunohistochemistry to investigate how tumor-infiltrating lymphocytes (TILs) promote disease progression and what regulates their infiltration.
Wed Feb 03 00:00:00 UTC 2021
Molecular profiling of primary uveal melanomas with tumor-infiltrating lymphocytes.
Oncoimmunology
Triozzi PL,Schoenfield L,Plesec T,Saunthararajah Y,Tubbs RR,Singh AD
14-4777-82 was used in Immunohistochemistry to investigate how tumor-infiltrating lymphocytes (TILs) promote disease progression and what regulates their infiltration.
Wed Feb 03 00:00:00 UTC 2021
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody.
Oncoimmunology
Dao T,Mun SS,Scott AC,Jarvis CA,Korontsvit T,Yang Z,Liu L,Klatt MG,Guerreiro M,Selvakumar A,Brea EJ,Oh C,Liu C,Scheinberg DA
14-4777-82 was used in Flow cytometry/Cell sorting to generate a T cell receptor mimic antibody, "Foxp3-#32," recognizing a Foxp3-derived epitope in the context of HLA-A*02:01.
Tue Mar 19 00:00:00 UTC 2024
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.
Cell
Wagner J,Rapsomaniki MA,Chevrier S,Anzeneder T,Langwieder C,Dykgers A,Rees M,Ramaswamy A,Muenst S,Soysal SD,Jacobs A,Windhager J,Silina K,van den Broek M,Dedes KJ,Rodríguez Martínez M,Weber WP,Bodenmiller B
14-4777-82 was used in Flow Cytometry to characterise features of breast cancer ecosystems and their associations with clinical data.
Thu May 16 00:00:00 UTC 2019
Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data.
Genome medicine
Finotello F,Mayer C,Plattner C,Laschober G,Rieder D,Hackl H,Krogsdam A,Loncova Z,Posch W,Wilflingseder D,Sopper S,Ijsselsteijn M,Brouwer TP,Johnson D,Xu Y,Wang Y,Sanders ME,Estrada MV,Ericsson-Gonzalez P,Charoentong P,Balko J,de Miranda NFDCC,Trajanoski Z
14-4777-82 was used in Immunohistochemistry to validate quanTIseq, a method to quantify the fractions of ten immune cell types from bulk RNA-sequencing data, and show how kinase inhibitors modulate the immune contexture and to reveal immune-cell types that underlie differential patients' responses to checkpoint blockers.
Fri May 24 00:00:00 UTC 2019
HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.
The Journal of allergy and clinical immunology
Konvinse KC,Trubiano JA,Pavlos R,James I,Shaffer CM,Bejan CA,Schutte RJ,Ostrov DA,Pilkinton MA,Rosenbach M,Zwerner JP,Williams KB,Bourke J,Martinez P,Rwandamuriye F,Chopra A,Watson M,Redwood AJ,White KD,Mallal SA,Phillips EJ
14-4777-82 was used in Immunohistochemistry to determine whether variation in the HLA region is associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms (DRESS).
Mon Jul 01 00:00:00 UTC 2019
Undernutrition is associated with perturbations in T cell-, B cell-, monocyte- and dendritic cell- subsets in latent Mycobacterium tuberculosis infection.
PloS one
Rajamanickam A,Munisankar S,Dolla CK,Babu S
14-4777 was used in Flow cytometry/Cell sorting to demonstrate that coexistent undernutrition in LTBI is characterized by the occurrence of a significant modulation in the frequency of innate and adaptive immune cell subsets.
Mon Apr 06 00:00:00 UTC 2020
Alternative Splicing of FOXP3 Controls Regulatory T Cell Effector Functions and Is Associated With Human Atherosclerotic Plaque Stability.
Circulation research
Joly AL,Seitz C,Liu S,Kuznetsov NV,Gertow K,Westerberg LS,Paulsson-Berne G,Hansson GK,Andersson J
14-4777 was used in Flow cytometry/Cell sorting to define the regulation and functions of the 2 major FOXP3 isoforms, FOXP3fl and FOXP3Δ2, as well as to establish whether their expression is associated with the ischemic atherosclerotic disease.
Fri May 11 00:00:00 UTC 2018
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells.
The Journal of experimental medicine
Seki A,Rutz S
14-4777 was used in Flow cytometry/Cell sorting to develop an optimised approach for Cas9/RNP transfection of primary mouse and human T cells without TCR stimulation, that results in near complete loss of target gene expression at the population level.
Mon Mar 05 00:00:00 UTC 2018
Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells.
The Journal of allergy and clinical immunology
Schulten V,Tripple V,Seumois G,Qian Y,Scheuermann RH,Fu Z,Locci M,Rosales S,Vijayanand P,Sette A,Alam R,Crotty S,Peters B
14-4777 was used in Flow cytometry/Cell sorting to show balancing Tfh and Tfr cells in circulation can be mediated by allergen-specific immunotherapy.
Thu Feb 01 00:00:00 UTC 2018
Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kugel CH,Douglass SM,Webster MR,Kaur A,Liu Q,Yin X,Weiss SA,Darvishian F,Al-Rohil RN,Ndoye A,Behera R,Alicea GM,Ecker BL,Fane M,Allegrezza MJ,Svoronos N,Kumar V,Wang DY,Somasundaram R,Hu-Lieskovan S,Ozgun A,Herlyn M,Conejo-Garcia JR,Gabrilovich D,Stone EL,Nowicki TS,Sosman J,Rai R,Carlino MS,Long GV,Marais R,Ribas A,Eroglu Z,Davies MA,Schilling B,Schadendorf D,Xu W,Amaravadi RK,Menzies AM,McQuade JL,Johnson DB,Osman I,Weeraratna AT
14-4777 was used in Immunohistochemistry to analyse the intratumoural immune microenvironment in young versus aged mice models of melanoma.
Thu Nov 01 00:00:00 UTC 2018
Increased circulating regulatory T cells in medicated people with schizophrenia.
Psychiatry research
Kelly DL,Li X,Kilday C,Feldman S,Clark S,Liu F,Buchanan RW,Tonelli LH
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Thu Nov 01 00:00:00 UTC 2018
Spontaneous Regression of Ovarian Carcinoma After Septic Peritonitis; A Unique Case Report.
Frontiers in oncology
Roelofsen T,Wefers C,Gorris MAJ,Textor JC,Massuger LFAG,de Vries IJM,van Altena AM
14-4777 was used in Immunohistochemistry to study a unique case of spontaneous regression of ovarian carcinoma after septic peritonitis.
Wed Oct 04 00:00:00 UTC 2023
FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer.
The Prostate
Davidsson S,Andren O,Ohlson AL,Carlsson J,Andersson SO,Giunchi F,Rider JR,Fiorentino M
14-4777 was used in Immunohistochemistry to evaluate the prevalance of regulatory T cells in normal, post atrophic hyperplasia (PAH), prostatic intraepithelial neoplasia (PIN), and tumor lesions in men with and without prostate cancer, and propose a possible mechanism by which PAH develops directly into prostate cancer in the presence of CD4+ Tregs.
Mon Jan 01 00:00:00 UTC 2018
Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer.
Oncotarget
Onion D,Isherwood M,Shridhar N,Xenophontos M,Craze ML,Day LJ,García-Márquez MA,Pineda RG,Reece-Smith AM,Saunders JH,Duffy JP,Argent RH,Grabowska AM
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Immunohistochemistry
Fri Jan 05 00:00:00 UTC 2018
Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement.
JCI insight
Johnson DB,Nixon MJ,Wang Y,Wang DY,Castellanos E,Estrada MV,Ericsson-Gonzalez PI,Cote CH,Salgado R,Sanchez V,Dean PT,Opalenik SR,Schreeder DM,Rimm DL,Kim JY,Bordeaux J,Loi S,Horn L,Sanders ME,Ferrell PB,Xu Y,Sosman JA,Davis RS,Balko JM
14-4777-82 was used in Immunohistochemistry to suggest a MHC-II-mediated context-dependent mechanism of adaptive resistance to PD-1-targeting immunotherapy.
Thu Dec 20 00:00:00 UTC 2018
Dynamic evaluation of the immune infiltrate and immune function genes as predictive markers for neoadjuvant chemotherapy in hormone receptor positive, HER2 negative breast cancer.
Oncoimmunology
Matikas A,Lövrot J,Ramberg A,Eriksson M,Lindsten T,Lekberg T,Hedenfalk I,Loman N,Bergh J,Hatschek T,Erlandsson A,Foukakis T
14-4777 was used in Immunohistochemistry to explore the predictive value of tumour infiltrating lymphocytes in hormone receptor positive, HER2 negative breast cancer, measured both at baseline and after short exposure to chemotherapy.
Tue Nov 12 00:00:00 UTC 2024
Blocking the recruitment of naive CD4+ T cells reverses immunosuppression in breast cancer.
Cell research
Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Sat Apr 01 00:00:00 UTC 2017
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Immunity
Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Tue Nov 21 00:00:00 UTC 2017
TGF-β1 secreted by Tregs in lymph nodes promotes breast cancer malignancy via up-regulation of IL-17RB.
EMBO molecular medicine
Huang SC,Wei PC,Hwang-Verslues WW,Kuo WH,Jeng YM,Hu CM,Shew JY,Huang CS,Chang KJ,Lee EY,Lee WH
14-4777 was used in Immunohistochemistry on paraffin embedded tissues to investigate the role that regulatory T cells (in tumour-draining lymph nodes) play in modulating the malignancy of breast cancer cells for distant metastasis.
Fri Dec 01 00:00:00 UTC 2017
PD-L1 expression and the immune microenvironment in primary invasive lobular carcinomas of the breast.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Thompson ED,Taube JM,Asch-Kendrick RJ,Ogurtsova A,Xu H,Sharma R,Meeker A,Argani P,Emens LA,Cimino-Mathews A
14-4777 was used in Immunohistochemistry to investigate the tumour microenvironment of primary invasive lobular carcinomas.
Wed Nov 01 00:00:00 UTC 2017
ICOS+ Foxp3+ TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori.
International journal of cancer
Nagase H,Takeoka T,Urakawa S,Morimoto-Okazawa A,Kawashima A,Iwahori K,Takiguchi S,Nishikawa H,Sato E,Sakaguchi S,Mori M,Doki Y,Wada H
14477782 was used in flow cytometry and immunohistochemistry - paraffin section to establish the T Cell receptor-inducible costimulator as a promising target for direct T regulatory cell-targeting therapeutic agents for gastric cancer
Wed Feb 01 00:00:00 UTC 2017
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Zanin-Zhorov A,Weiss JM,Trzeciak A,Chen W,Zhang J,Nyuydzefe MS,Arencibia C,Polimera S,Schueller O,Fuentes-Duculan J,Bonifacio KM,Kunjravia N,Cueto I,Soung J,Fleischmann RM,Kivitz A,Lebwohl M,Nunez M,Woodson J,Smith SL,West RF,Berger M,Krueger JG,Ryan JL,Waksal SD
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Radioimmune Assays
Mon May 15 00:00:00 UTC 2017
Cutting Edge: Selective Oral ROCK2 Inhibitor Reduces Clinical Scores in Patients with Psoriasis Vulgaris and Normalizes Skin Pathology via Concurrent Regulation of IL-17 and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Zanin-Zhorov A,Weiss JM,Trzeciak A,Chen W,Zhang J,Nyuydzefe MS,Arencibia C,Polimera S,Schueller O,Fuentes-Duculan J,Bonifacio KM,Kunjravia N,Cueto I,Soung J,Fleischmann RM,Kivitz A,Lebwohl M,Nunez M,Woodson J,Smith SL,West RF,Berger M,Krueger JG,Ryan JL,Waksal SD
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Radioimmune Assays
Mon May 15 00:00:00 UTC 2017
Clinical, Genetic and Innate Immunity Characteristics of Melanoma in Organ Transplant Recipients.
Acta dermato-venereologica
Brocard A,Knol AC,Bossard C,Denis MG,Quéreux G,Saint-Jean M,Peuvrel L,Khammari A,Blancho G,Dantal J,Dréno B
14-4777 was used in Immunohistochemistry to determine the clinical and histological characteristics of melanoma in transplant recipients, the mutation profile (BRAF, NRAS and c-KIT genes), and the immune tolerance of the tumour microenvironment.
Thu Apr 06 00:00:00 UTC 2017
A novel method for assaying human regulatory T cell direct suppression of B cell effector function.
Journal of immunological methods
Weingartner E,Courneya JP,Keegan A,Golding A
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Wed Feb 01 00:00:00 UTC 2017
Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment.
Oncoimmunology
Jiang X,Seo YD,Chang JH,Coveler A,Nigjeh EN,Pan S,Jalikis F,Yeung RS,Crispe IN,Pillarisetty VG
14-4777 was used in Immunohistochemistry on paraffin embedded tissues to demonstrate the potential of using tumour slice cultures to study the immune microenvironment of pancreatic ductal adenocarcinoma.
Sat Nov 04 00:00:00 UTC 2023
Long-lived pancreatic ductal adenocarcinoma slice cultures enable precise study of the immune microenvironment.
Oncoimmunology
Jiang X,Seo YD,Chang JH,Coveler A,Nigjeh EN,Pan S,Jalikis F,Yeung RS,Crispe IN,Pillarisetty VG
14-4777 was used in Immunohistochemistry on paraffin embedded tissues to demonstrate the potential of using tumour slice cultures to study the immune microenvironment of pancreatic ductal adenocarcinoma.
Sat Nov 04 00:00:00 UTC 2023
Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment.
Oncotarget
Syed Khaja AS,Toor SM,El Salhat H,Faour I,Ul Haq N,Ali BR,Elkord E
Tue May 16 00:00:00 UTC 2017
Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment.
Oncotarget
Syed Khaja AS,Toor SM,El Salhat H,Faour I,Ul Haq N,Ali BR,Elkord E
Tue May 16 00:00:00 UTC 2017
HDAC inhibition potentiates immunotherapy in triple negative breast cancer.
Oncotarget
Terranova-Barberio M,Thomas S,Ali N,Pawlowska N,Park J,Krings G,Rosenblum MD,Budillon A,Munster PN
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Tue Dec 26 00:00:00 UTC 2017
Microenvironment inflammatory infiltrate drives growth speed and outcome of hepatocellular carcinoma: a prospective clinical study.
Cell death & disease
Critelli R,Milosa F,Faillaci F,Condello R,Turola E,Marzi L,Lei B,Dituri F,Andreani S,Sighinolfi P,Manni P,Maiorana A,Caporali C,di Benedetto F,Del Buono M,De Maria N,Schepis F,Martinez-Chantar ML,Giannelli G,Villa E
14-4777 was used in Immunohistochemistry to identify the circulating and tissue components of the microenvironment immune-mediated response affecting the aggressiveness of hepatocellular carcinoma.
Thu Aug 24 00:00:00 UTC 2017
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.
Nature medicine
Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA
14-4777 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.
Thu Sep 01 00:00:00 UTC 2016
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
Gut
Fischer A,Zundler S,Atreya R,Rath T,Voskens C,Hirschmann S,López-Posadas R,Watson A,Becker C,Schuler G,Neufert C,Atreya I,Neurath MF
14-4777 was used in Flow cytometry/Cell sorting to analyse the homing of effector and regulatory T-cells to the inflamed gut via α4β7 and GPR15.
Sat Oct 01 00:00:00 UTC 2016
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
Gut
Fischer A,Zundler S,Atreya R,Rath T,Voskens C,Hirschmann S,López-Posadas R,Watson A,Becker C,Schuler G,Neufert C,Atreya I,Neurath MF
14-4777 was used in Flow cytometry/Cell sorting to analyse the homing of effector and regulatory T-cells to the inflamed gut via α4β7 and GPR15.
Sat Oct 01 00:00:00 UTC 2016
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor.
The Journal of clinical investigation
MacDonald KG,Hoeppli RE,Huang Q,Gillies J,Luciani DS,Orban PC,Broady R,Levings MK
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Fri Apr 01 00:00:00 UTC 2016
Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy.
Cancer research
Le KS,Thibult ML,Just-Landi S,Pastor S,Gondois-Rey F,Granjeaud S,Broussais F,Bouabdallah R,Colisson R,Caux C,Ménétrier-Caux C,Leroux D,Xerri L,Olive D
14-4777 was used in Immunohistochemistry to highlight a role for regulatory T-cells in follicular lymphoma pathogenesis and suggest the ICOS/ICOSL pathway as an immunotherapy target.
Mon Aug 15 00:00:00 UTC 2016
Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Zwang NA,Zhang R,Germana S,Fan MY,Hastings WD,Cao A,Turka LA
14477782 was used in flow cytometry to study the pharmacologic inhibition of PI3K and MEK pathways in mixed cultures of human mononuclear cells.
Thu Sep 01 00:00:00 UTC 2016
The immune microenvironment of breast ductal carcinoma in situ.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Thompson E,Taube JM,Elwood H,Sharma R,Meeker A,Warzecha HN,Argani P,Cimino-Mathews A,Emens LA
Tue Mar 01 00:00:00 UTC 2016
Clinical efficacy of a new CD28-targeting antagonist of T cell co-stimulation in a non-human primate model of collagen-induced arthritis.
Clinical and experimental immunology
Vierboom MP,Breedveld E,Kap YS,Mary C,Poirier N,'t Hart BA,Vanhove B
14477782 was used in flow cytometry to describe a selective CD28 antagonist for treatment of rheumatoid arthritis
Tue Mar 01 00:00:00 UTC 2016
Effects of conventional immunosuppressive treatment on CD244+ (CD28null) and FOXP3+ T cells in the inflamed muscle of patients with polymyositis and dermatomyositis.
Arthritis research & therapy
Pandya JM,Loell I,Hossain MS,Zong M,Alexanderson H,Raghavan S,Lundberg IE,Malmström V
14-4777 was used in Immunohistochemistry to investigate to what extent persistent T cells in affected muscle were FOXP3+ or CD244+ and whether their presence correlated to clinical outcome.
Fri Apr 01 00:00:00 UTC 2016
Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis.
International journal of molecular medicine
Liang DY,Hou YQ,Luo LJ,Ao L
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Fri Jul 01 00:00:00 UTC 2016
PD-L1 (B7-H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas.
Human pathology
Cimino-Mathews A,Thompson E,Taube JM,Ye X,Lu Y,Meeker A,Xu H,Sharma R,Lecksell K,Cornish TC,Cuka N,Argani P,Emens LA
14-4777 was used in Immunohistochemistry to evaluate the expression of Programmed death ligand 1 and the immune tumour microenvironment in primary and metastatic breast carcinomas.
Fri Jan 01 00:00:00 UTC 2016
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
The Journal of biological chemistry
Ghosh S,Taylor A,Chin M,Huang HR,Conery AR,Mertz JA,Salmeron A,Dakle PJ,Mele D,Cote A,Jayaram H,Setser JW,Poy F,Hatzivassiliou G,DeAlmeida-Nagata D,Sandy P,Hatton C,Romero FA,Chiang E,Reimer T,Crawford T,Pardo E,Watson VG,Tsui V,Cochran AG,Zawadzke L,Harmange JC,Audia JE,Bryant BM,Cummings RT,Magnuson SR,Grogan JL,Bellon SF,Albrecht BK,Sims RJ,Lora JM
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Fri Jun 17 00:00:00 UTC 2016
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
The Journal of biological chemistry
Ghosh S,Taylor A,Chin M,Huang HR,Conery AR,Mertz JA,Salmeron A,Dakle PJ,Mele D,Cote A,Jayaram H,Setser JW,Poy F,Hatzivassiliou G,DeAlmeida-Nagata D,Sandy P,Hatton C,Romero FA,Chiang E,Reimer T,Crawford T,Pardo E,Watson VG,Tsui V,Cochran AG,Zawadzke L,Harmange JC,Audia JE,Bryant BM,Cummings RT,Magnuson SR,Grogan JL,Bellon SF,Albrecht BK,Sims RJ,Lora JM
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Fri Jun 17 00:00:00 UTC 2016
Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition.
The Journal of biological chemistry
Ghosh S,Taylor A,Chin M,Huang HR,Conery AR,Mertz JA,Salmeron A,Dakle PJ,Mele D,Cote A,Jayaram H,Setser JW,Poy F,Hatzivassiliou G,DeAlmeida-Nagata D,Sandy P,Hatton C,Romero FA,Chiang E,Reimer T,Crawford T,Pardo E,Watson VG,Tsui V,Cochran AG,Zawadzke L,Harmange JC,Audia JE,Bryant BM,Cummings RT,Magnuson SR,Grogan JL,Bellon SF,Albrecht BK,Sims RJ,Lora JM
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Fri Jun 17 00:00:00 UTC 2016
The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder.
Oncoimmunology
Baras AS,Drake C,Liu JJ,Gandhi N,Kates M,Hoque MO,Meeker A,Hahn N,Taube JM,Schoenberg MP,Netto G,Bivalacqua TJ
14-4777 was used in Immunohistochemistry to quantify tumour cell PD-L1 expression and CD8(+) and Treg infiltration in chemotherapy-naive biopsy tissues from patients with muscle-invasive bladder cancer.
Sun May 01 00:00:00 UTC 2016
The ratio of CD8 to Treg tumor-infiltrating lymphocytes is associated with response to cisplatin-based neoadjuvant chemotherapy in patients with muscle invasive urothelial carcinoma of the bladder.
Oncoimmunology
Baras AS,Drake C,Liu JJ,Gandhi N,Kates M,Hoque MO,Meeker A,Hahn N,Taube JM,Schoenberg MP,Netto G,Bivalacqua TJ
14-4777 was used in Immunohistochemistry to quantify tumour cell PD-L1 expression and CD8(+) and Treg infiltration in chemotherapy-naive biopsy tissues from patients with muscle-invasive bladder cancer.
Sun May 01 00:00:00 UTC 2016
Differential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer.
Journal of translational medicine
Miyan M,Schmidt-Mende J,Kiessling R,Poschke I,de Boniface J
14-4777 was used in Blocking experiments to study how immunological patterns with functional implications within each subtype are associated with prognostic factors.
Fri Jul 29 00:00:00 UTC 2016
Differential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer.
Journal of translational medicine
Miyan M,Schmidt-Mende J,Kiessling R,Poschke I,de Boniface J
14-4777 was used in Blocking experiments to study how immunological patterns with functional implications within each subtype are associated with prognostic factors.
Fri Jul 29 00:00:00 UTC 2016
Differential tumor infiltration by T-cells characterizes intrinsic molecular subtypes in breast cancer.
Journal of translational medicine
Miyan M,Schmidt-Mende J,Kiessling R,Poschke I,de Boniface J
14-4777 was used in Blocking experiments to study how immunological patterns with functional implications within each subtype are associated with prognostic factors.
Fri Jul 29 00:00:00 UTC 2016
Fine needle aspirate flow cytometric phenotyping characterizes immunosuppressive nature of the mesothelioma microenvironment.
Scientific reports
Lizotte PH,Jones RE,Keogh L,Ivanova E,Liu H,Awad MM,Hammerman PS,Gill RR,Richards WG,Barbie DA,Bass AJ,Bueno R,English JM,Bittinger M,Wong KK
14-4777 was used in Flow cytometry/Cell sorting to develop a fine needle aspirate biopsy platform to perform immune profiling on thoracic malignancies.
Fri Aug 19 00:00:00 UTC 2016
Low density of FOXP3-positive T cells in normal colonic mucosa is related to the presence of beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer.
Oncoimmunology
Echterdiek F,Janikovits J,Staffa L,Müller M,Lahrmann B,Frühschütz M,Hartog B,Nelius N,Benner A,Tariverdian M,von Knebel Doeberitz M,Grabe N,Kloor M
14-4777 was used in Immunohistochemistry to investigate whether Beta2-microglobulin mutations in Lynch syndrome-associated colorectal cancer result from immunoediting.
Mon Feb 01 00:00:00 UTC 2016
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.
PloS one
Goldstein JD,Burlion A,Zaragoza B,Sendeyo K,Polansky JK,Huehn J,Piaggio E,Salomon BL,Marodon G
14477782 was used in flow cytometry to explore the role of the JAK/STAT pathway in controlling Foxp3 in regulatory T cells
Thu Aug 25 00:00:00 UTC 2016
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Nature immunology
Finkin S,Yuan D,Stein I,Taniguchi K,Weber A,Unger K,Browning JL,Goossens N,Nakagawa S,Gunasekaran G,Schwartz ME,Kobayashi M,Kumada H,Berger M,Pappo O,Rajewsky K,Hoshida Y,Karin M,Heikenwalder M,Ben-Neriah Y,Pikarsky E
14-4777 was used in Immunohistochemistry to reveal the function of ectopic lymphoid-like structures in cancer.
Tue Dec 01 00:00:00 UTC 2015
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations.
Blood
Milner JD,Vogel TP,Forbes L,Ma CA,Stray-Pedersen A,Niemela JE,Lyons JJ,Engelhardt KR,Zhang Y,Topcagic N,Roberson ED,Matthews H,Verbsky JW,Dasu T,Vargas-Hernandez A,Varghese N,McClain KL,Karam LB,Nahmod K,Makedonas G,Mace EM,Sorte HS,Perminow G,Rao VK,O'Connell MP,Price S,Su HC,Butrick M,McElwee J,Hughes JD,Willet J,Swan D,Xu Y,Santibanez-Koref M,Slowik V,Dinwiddie DL,Ciaccio CE,Saunders CJ,Septer S,Kingsmore SF,White AJ,Cant AJ,Hambleton S,Cooper MA
14-4777 was used in Flow cytometry/Cell sorting to suggest that there is a broad range of autoimmunity caused by germline STAT3 gain-of-function mutations, and that hematologic autoimmunity is a major component of this newly described disorder.
Thu Jan 22 00:00:00 UTC 2015
Regulatory T cells, inflammation, and endoplasmic reticulum stress in women with defective endometrial receptivity.
Fertility and sterility
Galgani M,Insabato L,Calì G,Della Gatta AN,Mirra P,Papaccio F,Santopaolo M,Alviggi C,Mollo A,Strina I,Matarese G,Beguinot F,De Placido G,Ulianich L
14-4777 was used in Immunohistochemistry-immunofluorescence to investigate the immunologic parameters and endoplasmic reticulum stress associated with unexplained infertility.
Mon Jun 01 00:00:00 UTC 2015
Immunoprofiling for prognostic assessment of colon cancer: a novel complement to ultrastaging.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Lavotshkin S,Jalas JR,Torisu-Itakura H,Ozao-Choy J,Lee JH,Sim MS,Stojadinovic A,Wainberg Z,Bifulco CB,Fox BA,Bilchik AJ
14-4777 was used in Flow cytometry/Cell sorting to perform initial prospective validation of immunoprofiling in patients whose colon cancer is staged with strict surgical and pathology quality measures.
Mon Jun 01 00:00:00 UTC 2015
Tumor-Infiltrating Immune Cells Are Associated With Prognosis of Gastric Cancer.
Medicine
Liu K,Yang K,Wu B,Chen H,Chen X,Chen X,Jiang L,Ye F,He D,Lu Z,Xue L,Zhang W,Li Q,Zhou Z,Mo X,Hu J
14-4777 was used in Immunohistochemistry to study the tumour-infiltrating immune cells associated with prognosis of gastric cancer.
Tue Sep 01 00:00:00 UTC 2015
Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2V617F allelic burden.
Experimental hematology & oncology
Kovacsovics-Bankowski M,Kelley TW,Efimova O,Kim SJ,Wilson A,Swierczek S,Prchal J
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Thu Oct 01 00:00:00 UTC 2020
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
Tue Oct 20 00:00:00 UTC 2015
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
Tue Oct 20 00:00:00 UTC 2015
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
Tue Oct 20 00:00:00 UTC 2015
Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases.
Oncotarget
Harter PN,Bernatz S,Scholz A,Zeiner PS,Zinke J,Kiyose M,Blasel S,Beschorner R,Senft C,Bender B,Ronellenfitsch MW,Wikman H,Glatzel M,Meinhardt M,Juratli TA,Steinbach JP,Plate KH,Wischhusen J,Weide B,Mittelbronn M
14-4777 was used in Immunohistochemistry to show that melanomas and renal cell carcinomas seem to be the most immunogenic entities for tumour infiltrating lymphocytes.
Tue Dec 01 00:00:00 UTC 2015
CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome.
Oncotarget
Huang Y,Ma C,Zhang Q,Ye J,Wang F,Zhang Y,Hunborg P,Varvares MA,Hoft DF,Hsueh EC,Peng G
14-4777 was used in Immunohistochemistry to delineate the dynamics and roles of CD4+ and CD8+ T cells in the pathogenesis of breast cancer.
Fri Jul 10 00:00:00 UTC 2015
Mismatch repair-deficient crypt foci in Lynch syndrome--molecular alterations and association with clinical parameters.
PloS one
Staffa L,Echterdiek F,Nelius N,Benner A,Werft W,Lahrmann B,Grabe N,Schneider M,Tariverdian M,von Knebel Doeberitz M,Bläker H,Kloor M
14-4777 was used in Immunohistochemistry to suggest that certain combinations of coding microsatellite mutation may contribute to the progression of MMR-deficient lesions into MMR-deficient cancers.
Fri Mar 11 00:00:00 UTC 2016
CD8+/FOXP3+-ratio in osteosarcoma microenvironment separates survivors from non-survivors: a multicenter validated retrospective study.
Oncoimmunology
Fritzsching B,Fellenberg J,Moskovszky L,Sápi Z,Krenacs T,Machado I,Poeschl J,Lehner B,Szendrõi M,Bosch AL,Bernd L,Csóka M,Mechtersheimer G,Ewerbeck V,Kinscherf R,Kunz P
14-4777 was used in Immunohistochemistry to identify that the intratumoral CD8(+)/FOXP3(+)-ratio in pretreatment biopsies separates patients with prolonged survival from non-survivors in osteosarcoma.
Sun Mar 01 00:00:00 UTC 2015
Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
Nature medicine
Schubert D,Bode C,Kenefeck R,Hou TZ,Wing JB,Kennedy A,Bulashevska A,Petersen BS,Schäffer AA,Grüning BA,Unger S,Frede N,Baumann U,Witte T,Schmidt RE,Dueckers G,Niehues T,Seneviratne S,Kanariou M,Speckmann C,Ehl S,Rensing-Ehl A,Warnatz K,Rakhmanov M,Thimme R,Hasselblatt P,Emmerich F,Cathomen T,Backofen R,Fisch P,Seidl M,May A,Schmitt-Graeff A,Ikemizu S,Salzer U,Franke A,Sakaguchi S,Walker LSK,Sansom DM,Grimbacher B
14-4777 was used in Flow cytometry/Cell sorting to demonstrate the consequences for mice with mutations in CTLA4, an essential negative regulator of immune responses.
Mon Dec 01 00:00:00 UTC 2014
Selective targeting of Toll-like receptors and OX40 inhibit regulatory T-cell function in follicular lymphoma.
International journal of cancer
Voo KS,Foglietta M,Percivalle E,Chu F,Nattamai D,Harline M,Lee ST,Bover L,Lin HY,Baladandayuthapani V,Delgado D,Luong A,Davis RE,Kwak LW,Liu YJ,Neelapu SS
14-4777 was used in Flow cytometry/Cell sorting to assess novel adjuvants that may enhance the efficacy of antitumour immunotherapeutic strategies by inhibiting Tregs.
Mon Dec 15 00:00:00 UTC 2014
CD4⁺CD25⁻Foxp3⁺ T cells: a marker for lupus nephritis?
Arthritis research & therapy
Bonelli M,Göschl L,Blüml S,Karonitsch T,Steiner CW,Steiner G,Smolen JS,Scheinecker C
14-4777 was used in Flow cytometry/Cell sorting to investigate how CD4&8314CD25−Foxp3&8314 T cells might serve as an important tool to recognise and monitor SLE patients with renal involvement.
Mon Apr 28 00:00:00 UTC 2014
Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Skogberg G,Lundberg V,Lindgren S,Gudmundsdottir J,Sandström K,Kämpe O,Annerén G,Gustafsson J,Sunnegårdh J,van der Post S,Telemo E,Berglund M,Ekwall O
Mon Sep 01 00:00:00 UTC 2014
Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Skogberg G,Lundberg V,Lindgren S,Gudmundsdottir J,Sandström K,Kämpe O,Annerén G,Gustafsson J,Sunnegårdh J,van der Post S,Telemo E,Berglund M,Ekwall O
Mon Sep 01 00:00:00 UTC 2014
Adoptive TIL transfer in the adjuvant setting for melanoma: long-term patient survival.
Journal of immunology research
Khammari A,Knol AC,Nguyen JM,Bossard C,Denis MG,Pandolfino MC,Quéreux G,Bercegeay S,Dréno B
14-4777 was used in Immunohistochemistry to confirm association of long-term patient survival with the presence of specific TILs and a decrease in Foxp3 expression.
Wed Jan 07 00:00:00 UTC 2015
FOXP3 transcription factor: a candidate marker for susceptibility and prognosis in triple negative breast cancer.
BioMed research international
Lopes LF,Guembarovski RL,Guembarovski AL,Kishima MO,Campos CZ,Oda JM,Ariza CB,de Oliveira KB,Borelli SD,Watanabe MA
14-4777 was used in Immunohistochemistry to investigate a FOXP3 promoter polymorphism and the protein expression of FOXP3 for a possible involvement in triple negative breast cancer susceptibility and prognosis.
Thu Feb 12 00:00:00 UTC 2015
Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma.
Oncotarget
Ye SB,Li ZL,Luo DH,Huang BJ,Chen YS,Zhang XS,Cui J,Zeng YX,Li J
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Wed Jul 30 00:00:00 UTC 2014
Th1 response and systemic treg deficiency in inclusion body myositis.
PloS one
Allenbach Y,Chaara W,Rosenzwajg M,Six A,Prevel N,Mingozzi F,Wanschitz J,Musset L,Charuel JL,Eymard B,Salomon B,Duyckaerts C,Maisonobe T,Dubourg O,Herson S,Klatzmann D,Benveniste O
14-4777 was used in Immunohistochemistry to characterize immune responses and regulatory T cells, considered key players in the maintenance of peripheral immune tolerance, in sIBM.
Mon Feb 09 00:00:00 UTC 2015
Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer.
Molecular therapy. Methods & clinical development
Moreau A,Vandamme C,Segovia M,Devaux M,Guilbaud M,Tilly G,Jaulin N,Le Duff J,Cherel Y,Deschamps JY,Anegon I,Moullier P,Cuturi MC,Adjali O
14-4777 was used in Flow cytometry/Cell sorting to demonstrate the critical role of the TolDC mode of injection in modulating host immunity.
Wed May 27 00:00:00 UTC 2015
Generation and in vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer.
Molecular therapy. Methods & clinical development
Moreau A,Vandamme C,Segovia M,Devaux M,Guilbaud M,Tilly G,Jaulin N,Le Duff J,Cherel Y,Deschamps JY,Anegon I,Moullier P,Cuturi MC,Adjali O
14-4777 was used in Flow cytometry/Cell sorting to demonstrate the critical role of the TolDC mode of injection in modulating host immunity.
Wed May 27 00:00:00 UTC 2015
Porphyromonas gingivalis infection reduces regulatory T cells in infected atherosclerosis patients.
PloS one
Yang J,Wu J,Liu Y,Huang J,Lu Z,Xie L,Sun W,Ji Y
14-4777 was used in Flow cytometry/Cell sorting to indicate that P.gingivalis infection is associated with Treg dysregulation in AS and type II FimA are the predominant genotype in this process.
Mon Sep 29 00:00:00 UTC 2014
Osteosarcoma microenvironment: whole-slide imaging and optimized antigen detection overcome major limitations in immunohistochemical quantification.
PloS one
Kunz P,Fellenberg J,Moskovszky L,Sápi Z,Krenacs T,Poeschl J,Lehner B,Szendrõi M,Ewerbeck V,Kinscherf R,Fritzsching B
14-4777 was used in Immunohistochemistry to ypothesize that conventional hot spot analysis is often not representative for the whole section when applied to heterogeneous tissues like osteosarcoma.
Tue Nov 04 00:00:00 UTC 2014
CD4 helper T cells, CD8 cytotoxic T cells, and FOXP3(+) regulatory T cells with respect to lethal prostate cancer.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Davidsson S,Ohlson AL,Andersson SO,Fall K,Meisner A,Fiorentino M,Andrén O,Rider JR
14-4777 was used in Immunohistochemistry to conclude that men with greater numbers of CD4(+) T(regs) in their prostate tumor environment have an increased risk of dying of prostate cancer.
Fri Mar 01 00:00:00 UTC 2013
DC-LAMP+ dendritic cells are recruited to gastric lymphoid follicles in Helicobacter pylori-infected individuals.
Infection and immunity
Hansson M,Sundquist M,Hering S,Lundin BS,Hermansson M,Quiding-Järbrink M
14-4777 was used in Immunofluorescence to investigate the presence and localisation of mature human dendritic cells in H. pylori-infected gastric mucosa.
Tue Oct 01 00:00:00 UTC 2013
Metastatic triple-negative breast cancers at first relapse have fewer tumor-infiltrating lymphocytes than their matched primary breast tumors: a pilot study.
Human pathology
Cimino-Mathews A,Ye X,Meeker A,Argani P,Emens LA
14-4777 was used in Immunohistochemistry on paraffin embedded tissues to examine tumour-infiltrating lymphocytes in surgically resected metastatic breast cancers, relative to their matched primary breast cancers.
Tue Oct 01 00:00:00 UTC 2013
HLA Class II tetramers reveal tissue-specific regulatory T cells that suppress T-cell responses in breast carcinoma patients.
Oncoimmunology
Schmidt HH,Ge Y,Hartmann FJ,Conrad H,Klug F,Nittel S,Bernhard H,Domschke C,Schuetz F,Sohn C,Beckhove P
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Sat Jun 01 00:00:00 UTC 2013
The microenvironment of human neuroblastoma supports the activation of tumor-associated T lymphocytes.
Oncoimmunology
Carlson LM,De Geer A,Sveinbjørnsson B,Orrego A,Martinsson T,Kogner P,Levitskaya J
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
Inhibition of CD4+CD25+ regulatory T cell function and conversion into Th1-like effectors by a Toll-like receptor-activated dendritic cell vaccine.
PloS one
Lee MK,Xu S,Fitzpatrick EH,Sharma A,Graves HL,Czerniecki BJ
14-4777 was used in Flow cytometry/Cell sorting to evaluate the mechanisms underlying the antigen-specific antitumour response promoted by vaccination with dendritic cells activated with LPS and IFN-γ.
Tue Jul 22 00:00:00 UTC 2014
Phenotypic characterization of leukocytes in prenatal human dermis.
The Journal of investigative dermatology
Schuster C,Vaculik C,Prior M,Fiala C,Mildner M,Eppel W,Stingl G,Elbe-Bürger A
14-4777 was used in Immunofluorescence to investigate at which time point during gestation antigen-presenting cells, T cells, and mast cells populate the human dermis.
Thu Nov 01 00:00:00 UTC 2012
IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival.
Journal of immunology (Baltimore, Md. : 1950)
Sucher R,Fischler K,Oberhuber R,Kronberger I,Margreiter C,Ollinger R,Schneeberger S,Fuchs D,Werner ER,Watschinger K,Zelger B,Tellides G,Pilat N,Pratschke J,Margreiter R,Wekerle T,Brandacher G
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Immunohistochemistry
Sun Jan 01 00:00:00 UTC 2012
Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer.
Journal of immunology (Baltimore, Md. : 1950)
Ma C,Zhang Q,Ye J,Wang F,Zhang Y,Wevers E,Schwartz T,Hunborg P,Varvares MA,Hoft DF,Hsueh EC,Peng G
14-4777 was used in Immunohistochemistry to suggest that intratumoural γδ T cells may serve as independent prognostic biomarkers, and potential therapeutic targets for human breast cancer.
Thu Nov 15 00:00:00 UTC 2012
Paradoxically increased FOXP3+ T cells in IBD do not preferentially express the isoform of FOXP3 lacking exon 2.
Digestive diseases and sciences
Lord JD,Valliant-Saunders K,Hahn H,Thirlby RC,Ziegler SF
14-4777 was used in Flow cytometry/Cell sorting to investigate whether IBD patients preferentially express the δexon2 variant of FOXP3.
Thu Nov 01 00:00:00 UTC 2012
Paradoxically increased FOXP3+ T cells in IBD do not preferentially express the isoform of FOXP3 lacking exon 2.
Digestive diseases and sciences
Lord JD,Valliant-Saunders K,Hahn H,Thirlby RC,Ziegler SF
14-4777 was used in Flow cytometry/Cell sorting to investigate whether IBD patients preferentially express the δexon2 variant of FOXP3.
Thu Nov 01 00:00:00 UTC 2012
Decrease in proportion of CD19+ CD24(hi) CD27+ B cells and impairment of their suppressive function in Graves' disease.
PloS one
Zha B,Wang L,Liu X,Liu J,Chen Z,Xu J,Sheng L,Li Y,Chu Y
14-4777 was used in Flow cytometry/Cell sorting to demonstrate that B10 cells in human peripheral blood belongs to a CD24(hi)CD27(+) B cell subpopulation.
Thu May 16 00:00:00 UTC 2013
HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals.
Retrovirology
Satou Y,Utsunomiya A,Tanabe J,Nakagawa M,Nosaka K,Matsuoka M
14-4777 was used in Flow cytometry/Cell sorting to investigate the modulation of the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals by HTLV-1.
Wed May 30 00:00:00 UTC 2012
Tissue biomarkers in melanoma patients treated with TIL.
PloS one
Knol AC,Nguyen JM,Pandolfino MC,Quéreux G,Brocard A,Peuvrel L,Saint-Jean M,Saiagh S,Khammari A,Dréno B
14-4777 was used in Immunohistochemistry to determine differences in the characteristics of TIL populations obtained from an early stage III and a more advanced stage III.
Mon Jun 17 00:00:00 UTC 2013
Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases.
Gastroenterology
Hovhannisyan Z,Treatman J,Littman DR,Mayer L
14-4777 was used in Flow cytometry/Cell sorting to investigate how Th17 and Tregs interact under chronic inflammatory conditions.
Tue Mar 01 00:00:00 UTC 2011
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.
PLoS pathogens
Satou Y,Yasunaga J,Zhao T,Yoshida M,Miyazato P,Takai K,Shimizu K,Ohshima K,Green PL,Ohkura N,Yamaguchi T,Ono M,Sakaguchi S,Matsuoka M
14-4777 was used in Immunohistochemistry on paraffin embedded tissues to investigate the effect of expression of HTLV-1 bZIP factor in CD4+ T cells.
Thu Feb 10 00:00:00 UTC 2011
Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee JH,Ulrich B,Cho J,Park J,Kim CH
14-4777 was used in Immunohistochemistry to identify a novel role of progesterone in regulation of fetal T-cell differentiation for promotion of immune tolerance.
Mon Aug 15 00:00:00 UTC 2011
Immunostaining of PD-1/PD-Ls in liver tissues of patients with hepatitis and hepatocellular carcinoma.
World journal of gastroenterology
Wang BJ,Bao JJ,Wang JZ,Wang Y,Jiang M,Xing MY,Zhang WG,Qi JY,Roggendorf M,Lu MJ,Yang DL
14-4777 was used in Immunohistochemistry to investigate the expression of PD-1, PD-L1 and PD-L2 in liver tissues in the context of chronic hepatitis and hepatocellular carcinoma.
Thu Jul 28 00:00:00 UTC 2011
The numbers of FoxP3+ lymphocytes in sentinel lymph nodes of breast cancer patients correlate with primary tumor size but not nodal status.
Cancer investigation
Gupta R,Babb JS,Singh B,Chiriboga L,Liebes L,Adams S,Demaria S
14-4777 was used in Immunohistochemistry on paraffin embedded tissues to study the presence of an immune suppressive environment in sentinel lymph nodes of larger tumours.
Fri Jul 01 00:00:00 UTC 2011
Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients.
PloS one
Fritzsching B,Haas J,König F,Kunz P,Fritzsching E,Pöschl J,Krammer PH,Brück W,Suri-Payer E,Wildemann B
14-4777 was used in Immunohistochemistry to resolve whether regulatory T cell (Treg) dysfunction in multiple sclerosis (MS) patients is limited to reduced control of peripheral T cell activation.
Fri Mar 18 00:00:00 UTC 2011
Inducing CTLA-4-dependent immune regulation by selective CD28 blockade promotes regulatory T cells in organ transplantation.
Science translational medicine
Poirier N,Azimzadeh AM,Zhang T,Dilek N,Mary C,Nguyen B,Tillou X,Wu G,Reneaudin K,Hervouet J,Martinet B,Coulon F,Allain-Launay E,Karam G,Soulillou JP,Pierson RN,Blancho G,Vanhove B
14-4777 was used in Immunohistochemistry to suggest that targeting costimulation blockade at CD28 favors CTLA-4-dependent immune regulation and promotes allograft survival.
Wed Feb 03 00:00:00 UTC 2010
CD4(+) regulatory T cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection.
The Journal of infectious diseases
Green AM,Mattila JT,Bigbee CL,Bongers KS,Lin PL,Flynn JL
Sun Aug 15 00:00:00 UTC 2010
A longitudinal, integrated, clinical, histological and mRNA profiling study of resistance exercise in myositis.
Molecular medicine (Cambridge, Mass.)
Nader GA,Dastmalchi M,Alexanderson H,Grundtman C,Gernapudi R,Esbjörnsson M,Wang Z,Rönnelid J,Hoffman EP,Nagaraju K,Lundberg IE
14-4777 was used in Immunohistochemistry to characterise, at the molecular level, the effects of resistance exercise training on muscle performance and disease progression in myositis patients.
Thu Feb 17 00:00:00 UTC 2011
Recipient NOD2/CARD15 status affects cellular infiltrates in human intestinal graft-versus-host disease.
Clinical and experimental immunology
Landfried K,Bataille F,Rogler G,Brenmoehl J,Kosovac K,Wolff D,Hilgendorf I,Hahn J,Edinger M,Hoffmann P,Obermeier F,Schoelmerich J,Andreesen R,Holler E
14-4777 was used in Immunohistochemistry to suggest a loss of protective CD4 T cells in intestinal GVHD is enhanced further by the presence of NOD2/CARD15 variants.
Fri Jan 01 00:00:00 UTC 2010
Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells.
Digestive diseases and sciences
Lord JD,Hackman RC,Moklebust A,Thompson JA,Higano CS,Chielens D,Steinbach G,McDonald GB
14-4777 was used in Immunohistochemistry to present data on the frequency of gastrointestinal symptoms, the endoscopic and histologic features of colitis, and an analysis of intramucosal FOXP3+ T cell frequency in ipilimumab recipients.
Sat May 01 00:00:00 UTC 2010
Increased quantity of tumor-infiltrating FOXP3-positive regulatory T cells is an independent predictor for improved clinical outcome in extranodal NK/T-cell lymphoma.
Annals of oncology : official journal of the European Society for Medical Oncology
Kim WY,Jeon YK,Kim TM,Kim JE,Kim YA,Lee SH,Kim DW,Heo DS,Kim CW
14-4777 was used in Immunohistochemistry to show that increased quantity of tumor-infiltrating Tregs predicted improved clinical outcome in extranodal natural killer/T-cell lymphoma patients.
Thu Oct 01 00:00:00 UTC 2009
CD49d provides access to "untouched" human Foxp3+ Treg free of contaminating effector cells.
Blood
Kleinewietfeld M,Starke M,Di Mitri D,Borsellino G,Battistini L,Rötzschke O,Falk K
14-4777 was used in Flow cytometry/Cell sorting to investigate more effective markers for the isolation of Tregs for their use in adoptive transfer.
Thu Jan 22 00:00:00 UTC 2009
Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.
Neuro-oncology
Jacobs JF,Idema AJ,Bol KF,Nierkens S,Grauer OM,Wesseling P,Grotenhuis JA,Hoogerbrugge PM,de Vries IJ,Adema GJ
14-4777 was used in Immunohistochemistry to identify regulatory T cells and the PD-1/PD-L1 pathway as immune suppressive mechanisms in malignant but not benign human brain tumours.
Sat Aug 01 00:00:00 UTC 2009
Foxp3 regulates megakaryopoiesis and platelet function.
Arteriosclerosis, thrombosis, and vascular biology
Bernard JJ,Seweryniak KE,Koniski AD,Spinelli SL,Blumberg N,Francis CW,Taubman MB,Palis J,Phipps RP
14-4777 was used in Flow cytometry/Cell sorting to study how Foxp3 is needed for proper megakaryopoiesus and plays a role in regulating platelet function.
Sun Nov 01 00:00:00 UTC 2009
Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ellestad KK,Tsutsui S,Noorbakhsh F,Warren KG,Yong VW,Pittman QJ,Power C
14-4777 was used in Immunohistochemistry to support the concept of early-life microbial exposure influencing the generation of neuroprotective regulatory T cells in relation to autoimmune diseases.
Wed Jul 01 00:00:00 UTC 2009
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Law JP,Hirschkorn DF,Owen RE,Biswas HH,Norris PJ,Lanteri MC
14-4777 was used in Flow cytometry/Cell sorting to develop a multiparameter flow cytometric panel with Foxp3 for optimal identification of Tregs.
Tue Dec 01 00:00:00 UTC 2009
Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome.
Leukemia
Krejsgaard T,Gjerdrum LM,Ralfkiaer E,Lauenborg B,Eriksen KW,Mathiesen AM,Bovin LF,Gniadecki R,Geisler C,Ryder LP,Zhang Q,Wasik MA,Odum N,Woetmann A
14-4777 was used in Western Blotting to investigate the underlying mechanism of immunodeficiency during Sézary syndrome.
Mon Dec 01 00:00:00 UTC 2008
Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome.
Leukemia
Krejsgaard T,Gjerdrum LM,Ralfkiaer E,Lauenborg B,Eriksen KW,Mathiesen AM,Bovin LF,Gniadecki R,Geisler C,Ryder LP,Zhang Q,Wasik MA,Odum N,Woetmann A
14-4777 was used in Western Blotting to investigate the underlying mechanism of immunodeficiency during Sézary syndrome.
Mon Dec 01 00:00:00 UTC 2008
Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Kasprzycka M,Zhang Q,Witkiewicz A,Marzec M,Potoczek M,Liu X,Wang HY,Milone M,Basu S,Mauger J,Choi JK,Abrams JT,Hou JS,Rook AH,Vonderheid E,Woetmann A,Odum N,Wasik MA
14-4777 was used in Immunohistochemistry to investigate the effect of gamma c-signalling cytokines on CD4+ T cells.
Fri Aug 15 00:00:00 UTC 2008
Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques.
Journal of immunology (Baltimore, Md. : 1950)
Estes JD,Gordon SN,Zeng M,Chahroudi AM,Dunham RM,Staprans SI,Reilly CS,Silvestri G,Haase AT
Thu May 15 00:00:00 UTC 2008
Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25-CD4+ T cells.
International immunology
Nagar M,Vernitsky H,Cohen Y,Dominissini D,Berkun Y,Rechavi G,Amariglio N,Goldstein I
14-4777 was used in Flow cytometry/Cell sorting to investigate the mode of de novo activation-dependent expression of FOXP3 in conventional human CD4+ T cells.
Fri Aug 01 00:00:00 UTC 2008
Foxp3 expression in human cancer cells.
Journal of translational medicine
Karanikas V,Speletas M,Zamanakou M,Kalala F,Loules G,Kerenidi T,Barda AK,Gourgoulianis KI,Germenis AE
14-4777 was used in Immunohistochemistry to show evidence that Foxp3 expression can characterizes tumor cells of various tissue origins.
Tue Apr 22 00:00:00 UTC 2008
FOXP3+ regulatory T cells in cutaneous T-cell lymphomas: association with disease stage and survival.
Leukemia
Gjerdrum LM,Woetmann A,Odum N,Burton CM,Rossen K,Skovgaard GL,Ryder LP,Ralfkiaer E
14-4777-82 was used in Immunohistochemistry to indicate that the presence of FOXP3+ Tregs in CTCL is associated with disease stage and patient survival.
Sat Dec 01 00:00:00 UTC 2007
IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients.
Blood
Ahmadzadeh M,Rosenberg SA
Published figure using FOXP3 monoclonal antibody (Product # 14-4777-82) in Flow Cytometry
Wed Mar 15 00:00:00 UTC 2006
