Product References
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology.
Nature immunology
Linnerbauer M,Lößlein L,Vandrey O,Peter A,Han Y,Tsaktanis T,Wogram E,Needhamsen M,Kular L,Nagel L,Zissler J,Andert M,Meszaros L,Hanspach J,Zuber F,Naumann UJ,Diebold M,Wheeler MA,Beyer T,Nirschl L,Cirac A,Laun FB,Günther C,Winkler J,Bäuerle T,Jagodic M,Hemmer B,Prinz M,Quintana FJ,Rothhammer V
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2024
Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance.
Inflammopharmacology
Shahine Y,El-Aal SAA,Reda AM,Sheta E,Atia NM,Abdallah OY,Ibrahim SSA
14-5773-82 was used in Immunohistochemistry to develop and characterise diosmin nanocrystals using anti-solvent precipitation technique to be used for topical treatment of psoriasis.
Thu Jun 01 00:00:00 UTC 2023
Diosmin nanocrystal gel alleviates imiquimod-induced psoriasis in rats via modulating TLR7,8/NF-κB/micro RNA-31, AKT/mTOR/P70S6K milieu, and Tregs/Th17 balance.
Inflammopharmacology
Shahine Y,El-Aal SAA,Reda AM,Sheta E,Atia NM,Abdallah OY,Ibrahim SSA
14-5773-82 was used in Immunohistochemistry to develop and characterise diosmin nanocrystals using anti-solvent precipitation technique to be used for topical treatment of psoriasis.
Thu Jun 01 00:00:00 UTC 2023
Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.
ImmunoHorizons
Arwood ML,Sun IH,Patel CH,Sun IM,Oh MH,Bettencourt IA,Claiborne MD,Chan-Li Y,Zhao L,Waickman AT,Mavrothalassitis O,Wen J,Aja S,Powell JD
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Jun 01 00:00:00 UTC 2023
Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
Journal for immunotherapy of cancer
Graziano V,Dannhorn A,Hulme H,Williamson K,Buckley H,Karim SA,Wilson M,Lee SY,Kaistha BP,Islam S,Thaventhiran JED,Richards FM,Goodwin R,Brais R,Morton JP,Dovedi SJ,Schuller AG,Eyles J,Jodrell DI
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry (Paraffin)
Tue Aug 01 00:00:00 UTC 2023
Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway.
Inflammopharmacology
Zhang ZT,Xie K,Luo RJ,Zhang DY,He ZW,Li KF,Lin SH,Xu F
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Wed Feb 01 00:00:00 UTC 2023
Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway.
Inflammopharmacology
Zhang ZT,Xie K,Luo RJ,Zhang DY,He ZW,Li KF,Lin SH,Xu F
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Wed Feb 01 00:00:00 UTC 2023
A phase I, first-in-human study to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of MRG-001 in healthy subjects.
Cell reports. Medicine
Ahmadi AR,Atiee G,Chapman B,Reynolds L,Sun J,Cameron AM,Wesson RN,Burdick JF,Sun Z
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Sep 19 00:00:00 UTC 2023
Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain.
Journal of neuroinflammation
Xu B,Shimauchi-Ohtaki H,Yoshimoto Y,Sadakata T,Ishizaki Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunocytochemistry
Tue Jan 17 00:00:00 UTC 2023
Transplanted human iPSC-derived vascular endothelial cells promote functional recovery by recruitment of regulatory T cells to ischemic white matter in the brain.
Journal of neuroinflammation
Xu B,Shimauchi-Ohtaki H,Yoshimoto Y,Sadakata T,Ishizaki Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunocytochemistry
Tue Jan 17 00:00:00 UTC 2023
Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a/β-catenin pathway in the myocardium of mice after myocardial infarction.
Phytotherapy research : PTR
Tian CX,Li MY,Shuai XX,Jiang F,Dong YL,Gui Y,Zhang ZL,Qin RJ,Kang ZY,Lin L,Sarapultsev A,Wu B,Luo SS,Hu DS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Jan 01 00:00:00 UTC 2023
Tumor-specific cholinergic CD4+ T lymphocytes guide immunosurveillance of hepatocellular carcinoma.
Nature cancer
Zheng C,Snow BE,Elia AJ,Nechanitzky R,Dominguez-Brauer C,Liu S,Tong Y,Cox MA,Focaccia E,Wakeham AC,Haight J,Tobin C,Hodgson K,Gill KT,Ma W,Berger T,Heikenwälder M,Saunders ME,Fortin J,Leung SY,Mak TW
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Oct 01 00:00:00 UTC 2023
Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4+ T cells.
Frontiers in immunology
Sandoval S,Malany K,Thongphanh K,Martinez CA,Goodson ML,Souza FDC,Lin LW,Sweeney N,Pennington J,Lein PJ,Kerkvliet NI,Ehrlich AK
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Dec 05 00:00:00 UTC 2023
Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.
Chinese medicine
Pu S,Yang Z,Zhang X,Li M,Han N,Yang X,He J,Yu G,Meng X,Jia Q,Shao H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Oct 12 00:00:00 UTC 2023
A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice.
Frontiers in immunology
Zhu X,Li Q,George V,Spanoudis C,Gilkes C,Shrestha N,Liu B,Kong L,You L,Echeverri C,Li L,Wang Z,Chaturvedi P,Muniz GJ,Egan JO,Rhode PR,Wong HC
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to find that HCW9302 exhibited a longer serum half-life with an approximately 1000-fold higher affinity for the IL-2Ra than IL-2.
Mon Feb 13 00:00:00 UTC 2023
A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice.
Frontiers in immunology
Zhu X,Li Q,George V,Spanoudis C,Gilkes C,Shrestha N,Liu B,Kong L,You L,Echeverri C,Li L,Wang Z,Chaturvedi P,Muniz GJ,Egan JO,Rhode PR,Wong HC
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to find that HCW9302 exhibited a longer serum half-life with an approximately 1000-fold higher affinity for the IL-2Ra than IL-2.
Mon Feb 13 00:00:00 UTC 2023
Hypertonic Salt Solution Enhances Inflammatory Responses in Cultured Splenic T-Cells from Dahl Salt-Sensitive Rats but Not Dahl Salt-Resistant Rats.
Journal of cardiovascular development and disease
Jang S,Kim JY,Kim CW,Kim I
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Oct 02 00:00:00 UTC 2023
The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity.
International journal of inflammation
Bourebaba L,Serwotka-Suszczak A,Bourebaba N,Zyzak M,Marycz K
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Oct 10 00:00:00 UTC 2023
SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.
Cell communication and signaling : CCS
Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Mar 02 00:00:00 UTC 2023
IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma.
The Journal of experimental medicine
Reijers ILM,Rao D,Versluis JM,Menzies AM,Dimitriadis P,Wouters MW,Spillane AJ,Klop WMC,Broeks A,Bosch LJW,Lopez-Yurda M,van Houdt WJ,Rawson RV,Grijpink-Ongering LG,Gonzalez M,Cornelissen S,Bouwman J,Sanders J,Plasmeijer E,Elshot YS,Scolyer RA,van de Wiel BA,Peeper DS,van Akkooi ACJ,Long GV,Blank CU
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon May 01 00:00:00 UTC 2023
Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance.
iScience
Que W,Ueta H,Hu X,Morita-Nakagawa M,Fujino M,Ueda D,Tokuda N,Huang W,Guo WZ,Zhong L,Li XK
14-5773-82 was used in Flow Cytometry to depict the temporal and spatial dynamics of immune cells in the spleen and liver in a murine model of spontaneous liver allograft acceptance.
Fri Sep 15 00:00:00 UTC 2023
Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche.
Nature communications
Haensel D,Daniel B,Gaddam S,Pan C,Fabo T,Bjelajac J,Jussila AR,Gonzalez F,Li NY,Chen Y,Hou J,Patel T,Aasi S,Satpathy AT,Oro AE
14-5773-82 was used in Immunohistochemistry to provide mechanistic insights into direct tumor-immune niche dynamics independent of immunosuppression, providing the basis for potential combination tumor therapies.
Wed May 10 00:00:00 UTC 2023
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Nature communications
Choi BJ,Park MH,Park KH,Han WH,Yoon HJ,Jung HY,Hong JY,Chowdhury MR,Kim KY,Lee J,Song IS,Pang M,Choi MK,Gulbins E,Reichel M,Kornhuber J,Hong CW,Kim C,Kim SH,Schuchman EH,Jin HK,Bae JS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 24 00:00:00 UTC 2023
Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA.
Frontiers in immunology
Celesti F,Gatta A,Shallak M,Chiaravalli AM,Cerati M,Sessa F,Accolla RS,Forlani G
14-5773-82 was used in Immunohistochemistry-paraffin to report unprecedented positive results in terms of protection from glioblastoma growth in an animal experimental system after vaccination with glioblastoma GL261 cells stably expressing the MHC class II transactivator CIITA.
Fri Mar 31 00:00:00 UTC 2023
Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA.
Frontiers in immunology
Celesti F,Gatta A,Shallak M,Chiaravalli AM,Cerati M,Sessa F,Accolla RS,Forlani G
14-5773-82 was used in Immunohistochemistry-paraffin to report unprecedented positive results in terms of protection from glioblastoma growth in an animal experimental system after vaccination with glioblastoma GL261 cells stably expressing the MHC class II transactivator CIITA.
Fri Mar 31 00:00:00 UTC 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2023
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 24 00:00:00 UTC 2023
Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.
Frontiers in immunology
Schwarz A,Philippsen R,Piticchio SG,Hartmann JN,Häsler R,Rose-John S,Schwarz T
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Mar 27 00:00:00 UTC 2023
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Feb 13 00:00:00 UTC 2023
Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity.
Cell research
Zhou C,Ma L,Xu H,Huo Y,Luo J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Jun 01 00:00:00 UTC 2022
Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy.
Cancer discovery
Herrera FG,Ronet C,Ochoa de Olza M,Barras D,Crespo I,Andreatta M,Corria-Osorio J,Spill A,Benedetti F,Genolet R,Orcurto A,Imbimbo M,Ghisoni E,Navarro Rodrigo B,Berthold DR,Sarivalasis A,Zaman K,Duran R,Dromain C,Prior J,Schaefer N,Bourhis J,Dimopoulou G,Tsourti Z,Messemaker M,Smith T,Warren SE,Foukas P,Rusakiewicz S,Pittet MJ,Zimmermann S,Sempoux C,Dafni U,Harari A,Kandalaft LE,Carmona SJ,Dangaj Laniti D,Irving M,Coukos G
14-5773-82 was used in Immunohistochemistry (Paraffin) to report that low-dose radiotherapy (LDRT) of murine tumors promotes T-cell infiltration and enables responsiveness to combinatorial immunotherapy in an IFN-dependent manner.
Sat Jan 01 00:00:00 UTC 2022
Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation.
The Journal of clinical investigation
Failer T,Amponsah-Offeh M,Neuwirth A,Kourtzelis I,Subramanian P,Mirtschink P,Peitzsch M,Matschke K,Tugtekin SM,Kajikawa T,Li X,Steglich A,Gembardt F,Wegner AC,Hugo C,Hajishengallis G,Chavakis T,Deussen A,Todorov V,Kopaliani I
14-5773-82 was used in Flow Cytometry to identify DEL-1 as a potential therapeutic factor.
Tue Mar 15 00:00:00 UTC 2022
Fatal cytokine release syndrome by an aberrant FLIP/STAT3 axis.
Cell death and differentiation
Musiu C,Caligola S,Fiore A,Lamolinara A,Frusteri C,Del Pizzo FD,De Sanctis F,Canè S,Adamo A,Hofer F,Barouni RM,Grilli A,Zilio S,Serafini P,Tacconelli E,Donadello K,Gottin L,Polati E,Girelli D,Polidoro I,Iezzi PA,Angelucci D,Capece A,Chen Y,Shi ZL,Murray PJ,Chilosi M,Amit I,Bicciato S,Iezzi M,Bronte V,Ugel S
14-5773-82 was used in Immunohistochemistry to show that as STAT3-targeting approaches relieved inflammation, immune disorders, and organ failures in these mice, targeted intervention towards this pathway could suppress the lethal CRS inflammatory state.
Tue Feb 01 00:00:00 UTC 2022
Trivalent chromium supplementation ameliorates adjuvant induced rheumatoid arthritis through up-regulation of FOXP3 and decrease in synovial Cathepsin G expression.
Inflammopharmacology
Hassouna SS,Sheta E,Zaki I,Harby SA,Allam EA
14-5773-82 was used in Immunohistochemistry to conclude that trivalent chromium (Cr (III)) is promising in treating RA and it lacks some side efects of accustomed immune-modulatory agents including prednisolone.
Thu Dec 01 00:00:00 UTC 2022
miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg.
Molecular biology reports
Zou Q,Liu C,Hu N,Wang W,Wang H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Apr 01 00:00:00 UTC 2022
Comparative analysis of the immune response to RFA and cryoablation in a colon cancer mouse model.
Scientific reports
Mauda-Havakuk M,Hawken NM,Owen JW,Mikhail AS,Saxena A,Karim B,Wakim PG,Pritchard WF,Karanian JW,Wood BJ
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Sat Oct 29 00:00:00 UTC 2022
Twelve-week high-fat diet for improving adverse ventricular remodeling post-myocardial infarction by alleviating local inflammation.
Annals of translational medicine
Yang J,Mai B,Su Y,Liang S,Su Z,Chen Y,Xie S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Oct 01 00:00:00 UTC 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Oct 10 00:00:00 UTC 2022
Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer.
Frontiers in immunology
Al-Saafeen BH,Al-Sbiei A,Bashir G,Mohamed YA,Masad RJ,Fernandez-Cabezudo MJ,Al-Ramadi BK
14-5773-82 was used in Immunocytochemistry and Immunohistochemistry to demonstrates that a novel combination treatment utilizing attenuated Salmonella and αPD-L1 mAb could improve the outcome of immunotherapy in colorectal cancer.
Mon Jan 09 00:00:00 UTC 2023
Attenuated Salmonella potentiate PD-L1 blockade immunotherapy in a preclinical model of colorectal cancer.
Frontiers in immunology
Al-Saafeen BH,Al-Sbiei A,Bashir G,Mohamed YA,Masad RJ,Fernandez-Cabezudo MJ,Al-Ramadi BK
14-5773-82 was used in Immunocytochemistry and Immunohistochemistry to demonstrates that a novel combination treatment utilizing attenuated Salmonella and αPD-L1 mAb could improve the outcome of immunotherapy in colorectal cancer.
Mon Jan 09 00:00:00 UTC 2023
The effect of local non-thermal plasma therapy on the cancer-immunity cycle in a melanoma mouse model.
Bioengineering & translational medicine
Lin A,De Backer J,Quatannens D,Cuypers B,Verswyvel H,De La Hoz EC,Ribbens B,Siozopoulou V,Van Audenaerde J,Marcq E,Lardon F,Laukens K,Vanlanduit S,Smits E,Bogaerts A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Thu Sep 01 00:00:00 UTC 2022
Modelling aggressive prostate cancers of young men in immune-competent mice, driven by isogenic Trp53 alterations and Pten loss.
Cell death & disease
Mejía-Hernández JO,Keam SP,Saleh R,Muntz F,Fox SB,Byrne D,Kogan A,Pang L,Huynh J,Litchfield C,Caramia F,Lozano G,He H,You JM,Sandhu S,Williams SG,Haupt Y,Haupt S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Thu Sep 08 00:00:00 UTC 2022
Oncolytic virus-mediated p53 overexpression promotes immunogenic cell death and efficacy of PD-1 blockade in pancreatic cancer.
Molecular therapy oncolytics
Araki H,Tazawa H,Kanaya N,Kajiwara Y,Yamada M,Hashimoto M,Kikuchi S,Kuroda S,Yoshida R,Umeda Y,Urata Y,Kagawa S,Fujiwara T
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Thu Dec 15 00:00:00 UTC 2022
Novel peptide-based vaccine targeting heat shock protein 90 induces effective antitumor immunity in a HER2+ breast cancer murine model.
Journal for immunotherapy of cancer
Kang J,Lee HJ,Lee J,Hong J,Hong Kim Y,Disis ML,Gim JA,Park KH
14-5773-82 was used in Immunohistochemistry to demonstrate action mechanism of HSP90 peptide vaccines in a HER2+ breast cancer murine model.
Thu Sep 01 00:00:00 UTC 2022
Novel peptide-based vaccine targeting heat shock protein 90 induces effective antitumor immunity in a HER2+ breast cancer murine model.
Journal for immunotherapy of cancer
Kang J,Lee HJ,Lee J,Hong J,Hong Kim Y,Disis ML,Gim JA,Park KH
14-5773-82 was used in Immunohistochemistry to demonstrate action mechanism of HSP90 peptide vaccines in a HER2+ breast cancer murine model.
Thu Sep 01 00:00:00 UTC 2022
Black raspberry extract inhibits regulatory T-cell activity in a murine model of head and neck squamous cell carcinoma chemoprevention.
Frontiers in immunology
Ryan NM,Lamenza FF,Upadhaya P,Pracha H,Springer A,Swingler M,Siddiqui A,Oghumu S
14-5773-82 was used in Western Blot to demonstrate the immunomodulatory potential of black raspberry extracts and support the use of black raspberry-derived phytochemicals as a complementary approach to HNSCC chemoprevention and treatment.
Mon Aug 29 00:00:00 UTC 2022
Live or Heat-Killed Lactobacillus rhamnosus Aerosolization Decreases Adenomatous Lung Cancer Development in a Mouse Carcinogen-Induced Tumor Model.
International journal of molecular sciences
Le Noci V,Bernardo G,Manenti G,Infante G,Khaleghi Hashemian D,Minoli L,Canesi S,Bianchi F,Triulzi T,Arioli S,De Cecco L,Guglielmetti S,Ambrogi F,Recordati C,Gagliano N,Tagliabue E,Sommariva M,Sfondrini L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry (Paraffin)
Sat Oct 22 00:00:00 UTC 2022
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.
Cancers
Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Aug 31 00:00:00 UTC 2022
Protocol to assess cell-intrinsic regulatory mechanisms using an ex vivo murine T cell polarization and co-culture system.
STAR protocols
Ma S,Hernandez JE,Huang WJM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Sep 16 00:00:00 UTC 2022
Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1.
JCI insight
Klaus T,Wilson AS,Vicari E,Hadaschik E,Klein M,Helbich SSC,Kamenjarin N,Hodapp K,Schunke J,Haist M,Butsch F,Probst HC,Enk AH,Mahnke K,Waisman A,Bednarczyk M,Bros M,Bopp T,Grabbe S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Dec 22 00:00:00 UTC 2022
Impact of dietary vitamin D on immunoregulation and disease pathology in lupus-prone NZB/W F1 mice.
Frontiers in immunology
Kraemer AN,Schäfer AL,Sprenger DTL,Sehnert B,Williams JP,Luo A,Riechert L,Al-Kayyal Q,Dumortier H,Fauny JD,Winter Z,Heim K,Hofmann M,Herrmann M,Heine G,Voll RE,Chevalier N
14-5773-82 was used in Flow Cytometry to reveal that low VD intake promotes lupus pathology, likely via the deviation of adaptive immunity, and suggests that the correction of VD deficiency might not only exert beneficial functions by preventing osteoporosis but also serve as an important module in prophylaxis and as an add-on in the treatment of lupus and possibly other immune-mediated diseases.
Fri Dec 16 00:00:00 UTC 2022
First Report of TTSuV1 in Domestic Swiss Pigs.
Viruses
Polster S,Lechmann J,Lienhard J,Peltzer D,Prähauser B,Bachofen C,Seehusen F
14-5773-82 was used in Immunohistochemistry to investigate the presence of Torque teno sus viruses (TTSuV1 and k2) in porcine brain tissue and other organs.
Fri Apr 22 00:00:00 UTC 2022
An immunocompetent rectal cancer model to study radiation therapy.
Cell reports methods
Kim JK,Wu C,Del Latto M,Gao Y,Choi SH,Kierstead M,Gabriel Sauvé CE,Firat C,Perez AC,Sillanpaa J,Chen CT,Lawrence KE,Paty PB,Barriga FM,Wilkinson JE,Shia J,Sawyers CL,Lowe SW,García-Aguilar J,Romesser PB,Smith JJ
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to describe a mouse model of rectal cancer (RC) involving rapid tumor organoid engraftment via orthotopic transplantation in an immunocompetent setting.
Mon Dec 19 00:00:00 UTC 2022
Stromal Reprogramming by FAK Inhibition Overcomes Radiation Resistance to Allow for Immune Priming and Response to Checkpoint Blockade.
Cancer discovery
Lander VE,Belle JI,Kingston NL,Herndon JM,Hogg GD,Liu X,Kang LI,Knolhoff BL,Bogner SJ,Baer JM,Zuo C,Borcherding NC,Lander DP,Mpoy C,Scott J,Zahner M,Rogers BE,Schwarz JK,Kim H,DeNardo DG
14-5773-82 was used in Immunohistochemistry to show that FAK inhibition allows RT to prime tumor immunity and unlock responsiveness to checkpoint immunotherapy.
Fri Dec 02 00:00:00 UTC 2022
A multi-omic single cell sequencing approach to develop a CD8 T cell specific gene signature for anti-PD1 response in solid tumors.
International journal of cancer
Kumar N,Papillon-Cavanagh S,Tang H,Wang S,Stromko C,Ho CP,Soni-Sheth S,Vasquez-Grinnell S,Broz ML,Tenney DJ,Wichroski MJ,Walsh AM,Hu Y,Benci JL
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to highlight the value of leveraging single-cell assays to dissect heterogeneous tumor and immune subsets and define cell-type specific transcriptomic biomarkers of immune checkpoint blockade (ICB) response.
Thu Dec 01 00:00:00 UTC 2022
Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis.
Cell reports. Medicine
Uceda-Castro R,Margarido AS,Cornet L,Vegna S,Hahn K,Song JY,Putavet DA,van Geldorp M,Çitirikkaya CH,de Keizer PLJ,Ter Beek LC,Borst GR,Akkari L,van Tellingen O,Broekman MLD,Vennin C,van Rheenen J
14-5773-82 was used in Immunohistochemistry to demonstrate that induction of senescence with doxorubicin improves the efficacy of immunotherapy with anti-PD1 in breast cancer brain metastasis (BCBM) in a CD8 T cell-dependent manner, thereby providing an optimized strategy to introduce immune-based treatments in this lethal disease.
Tue Nov 15 00:00:00 UTC 2022
Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis.
FEBS open bio
No authors listed
14-5773 was used in Flow cytometry/Cell sorting to suggest that Parecoxib inhibits the inflammatory response and has protective effects against sepsis in mice, and may have potential as a novel therapeutic method for treating sepsis.
Sat Jan 01 00:00:00 UTC 2022
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells.
EMBO reports
Lopez Krol A,Nehring HP,Krause FF,Wempe A,Raifer H,Nist A,Stiewe T,Bertrams W,Schmeck B,Luu M,Leister H,Chung HR,Bauer UM,Adhikary T,Visekruna A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Dec 06 00:00:00 UTC 2022
Loss of T cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages.
Cell reports
West HC,Davies J,Henderson S,Adegun OK,Ward S,Ferrer IR,Tye CA,Vallejo AF,Jardine L,Collin M,Polak ME,Bennett CL
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to demonstrate that pathology initiates dermis-specific macrophage differentiation and show that aGVHD-primed macrophages continue to dominate the dermal compartment at the relative expense of quiescent MHCIIint cells.
Tue May 17 00:00:00 UTC 2022
FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape.
Theranostics
Wu L,Xu Y,Zhao H,Zhou Y,Chen Y,Yang S,Lei J,Zhang J,Wang J,Wu Y,Li Y
14-5773-82 was used in Flow Cytometry to uncover an unrecognized regulatory role of the FcγRIIB in abnormal differentiation of MDSCs during cancer development and suggest a potential therapeutic target for anti-tumor therapy.
Thu Mar 10 00:00:00 UTC 2022
Does physical exercise improve or deteriorate treatment of multiple sclerosis with mitoxantrone? Experimental autoimmune encephalomyelitis study in rats.
BMC neuroscience
El-Emam MA,El Achy S,Abdallah DM,El-Abhar HS,Gowayed MA
14-5773-82 was used in Immunohistochemistry to show that exercise worsened the mitoxantrone effect on EAE score, Bcl2 and Bax. Mitoxantrone alone decreased EAE/demyelination/inflammation scores, Foxp3 immunoreactivity, and interleukin-6, while increased the re-myelination marker BDNF without any change in tumor necrosis factor-α.
Sat Mar 05 00:00:00 UTC 2022
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Immunity
Harb H,Benamar M,Lai PS,Contini P,Griffith JW,Crestani E,Schmitz-Abe K,Chen Q,Fong J,Marri L,Filaci G,Del Zotto G,Pishesha N,Kolifrath S,Broggi A,Ghosh S,Gelmez MY,Oktelik FB,Cetin EA,Kiykim A,Kose M,Wang Z,Cui Y,Yu XG,Li JZ,Berra L,Stephen-Victor E,Charbonnier LM,Zanoni I,Ploegh H,Deniz G,De Palma R,Chatila TA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jun 08 00:00:00 UTC 2021
Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility.
The Journal of experimental medicine
Wirasinha RC,Davies AR,Srivastava M,Sheridan JM,Sng XYX,Delmonte OM,Dobbs K,Loh KL,Miosge LA,Lee CE,Chand R,Chan A,Yap JY,Keller MD,Chen K,Rossjohn J,La Gruta NL,Vinuesa CG,Reid HH,Lionakis MS,Notarangelo LD,Gray DHD,Goodnow CC,Cook MC,Daley SR
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Feb 01 00:00:00 UTC 2021
Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells.
Genes & diseases
Yang L,Jing Y,Kang D,Jiang P,Li N,Zhou X,Chen Y,Westerberg LS,Liu C
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat May 01 00:00:00 UTC 2021
Thymic atrophy creates holes in Treg-mediated immuno-regulation via impairment of an antigen-specific clone.
Immunology
Thomas R,Oh J,Wang W,Su DM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Aug 01 00:00:00 UTC 2021
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2021
Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.
Frontiers in cell and developmental biology
Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Apr 21 00:00:00 UTC 2021
Exposure to Microbial Metabolite Butyrate Prolongs the Survival Time and Changes the Growth Pattern of Human Papillomavirus 16 E6/E7-Immortalized Keratinocytes in Vivo.
The American journal of pathology
Li M,McGhee EM,Shinno L,Lee K,Lin YL
14-5773-82 was used in Immunohistochemistry to show that butyrate treatment changed the property of HPV16 E6/E7-immortalized keratinocytes.
Fri Oct 01 00:00:00 UTC 2021
Moderate Exercise Inhibits Age-Related Inflammation, Liver Steatosis, Senescence, and Tumorigenesis.
Journal of immunology (Baltimore, Md. : 1950)
Bianchi A,Marchetti L,Hall Z,Lemos H,Vacca M,Paish H,Green K,Elliott B,Tiniakos D,Passos JF,Jurk D,Mann DA,Wilson CL
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Mon Feb 15 00:00:00 UTC 2021
SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Chen L,Bai J,Peng D,Gao Y,Cai X,Zhang J,Tang S,Niu L,Sun Y,Lou F,Zhou H,Yin Q,Wang Z,Sun L,Du X,Xu Z,Wang H,Li Q,Wang H
14-5773-82 was used in Flow Cytometry to characterise the target and mechanism of an acetylated beta-boswellic acid derivative termed SZB120, and evaluate the anti-inflammatory activities in vitro and in vivo.
Mon Mar 01 00:00:00 UTC 2021
Type of chemotherapy has substantial effects on the immune system in ovarian cancer.
Translational oncology
Vankerckhoven A,Baert T,Riva M,De Bruyn C,Thirion G,Vandenbrande K,Ceusters J,Vergote I,Coosemans A
14-5773-82 was used in Immunohistochemistry to compare six common chemotherapeutics used in ovarian cancer patients (carboplatin, paclitaxel, pegylated liposomal doxorubicin, gemcitabine, carboplatin-paclitaxel and carboplatin-gemcitabine) and studied their effects on the immune system in an ovarian cancer mouse model.
Tue Jun 01 00:00:00 UTC 2021
Type of chemotherapy has substantial effects on the immune system in ovarian cancer.
Translational oncology
Vankerckhoven A,Baert T,Riva M,De Bruyn C,Thirion G,Vandenbrande K,Ceusters J,Vergote I,Coosemans A
14-5773-82 was used in Immunohistochemistry to compare six common chemotherapeutics used in ovarian cancer patients (carboplatin, paclitaxel, pegylated liposomal doxorubicin, gemcitabine, carboplatin-paclitaxel and carboplatin-gemcitabine) and studied their effects on the immune system in an ovarian cancer mouse model.
Tue Jun 01 00:00:00 UTC 2021
Tregs-derived interleukin 35 attenuates endothelial proliferation through STAT1 in pulmonary hypertension.
Annals of translational medicine
Wan N,Rong W,Zhu W,Jia D,Bai P,Liu G,Wan Q,Lyu A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunocytochemistry
Tue Jun 01 00:00:00 UTC 2021
Tregs-derived interleukin 35 attenuates endothelial proliferation through STAT1 in pulmonary hypertension.
Annals of translational medicine
Wan N,Rong W,Zhu W,Jia D,Bai P,Liu G,Wan Q,Lyu A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunocytochemistry
Tue Jun 01 00:00:00 UTC 2021
Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model.
Cancer prevention research (Philadelphia, Pa.)
Shi Y,Xie TX,Leach DG,Wang B,Young S,Osman AA,Sikora AG,Ren X,Hartgerink JD,Myers JN,Rangel R
14-5773-82 was used in Immunohistochemistry to combine biomaterials loaded with an immunotherapeutic agent preventing oral cancer progression.
Sun Aug 01 00:00:00 UTC 2021
Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats.
BioMed research international
Kim JY,Lee E,Koo S,Kim CW,Kim I
14-5773 was used in Flow cytometry/Cell sorting to test the hypothesis that the transfer of Th17 cells from adult spontaneous hypertensive rats (SHR) accelerates the development of hypertension in juvenile SHR.
Tue May 25 00:00:00 UTC 2021
Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats.
BioMed research international
Kim JY,Lee E,Koo S,Kim CW,Kim I
14-5773 was used in Flow cytometry/Cell sorting to test the hypothesis that the transfer of Th17 cells from adult spontaneous hypertensive rats (SHR) accelerates the development of hypertension in juvenile SHR.
Tue May 25 00:00:00 UTC 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Apr 01 00:00:00 UTC 2021
Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure.
iScience
Fotheringham AK,Solon-Biet SM,Bielefeldt-Ohmann H,McCarthy DA,McMahon AC,Ruohonen K,Li I,Sullivan MA,Whiddett RO,Borg DJ,Cogger VC,Ballard WO,Turner N,Melvin RG,Raubenheimer D,Le Couteur DG,Simpson SJ,Forbes JM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunocytochemistry
Fri Nov 19 00:00:00 UTC 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 UTC 2021
Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma.
Cell reports. Medicine
Chao JL,Korzinkin M,Zhavoronkov A,Ozerov IV,Walker MT,Higgins K,Lingen MW,Izumchenko E,Savage PA
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to conclude that induction of a T cell-inflamed phenotype via therapeutic manipulation of Treg cells may trigger unexpected tumor-promoting effects in OSCC.
Tue Sep 21 00:00:00 UTC 2021
STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis.
Biomedicines
Pang L,Huynh J,Alorro MG,Li X,Ernst M,Chand AL
14-5773 was used in Immunohistochemistry to investigate the role of STAT3 in retaining epithelial barrier integrity using dextran sulfate sodium (DSS)-induced colitis in two genetically modified mouse models, to either reduce STAT1/3 activation in response to IL-6 family cytokines with a truncated gp130STAT allele (GP130STAT/+), or by inducing short hairpin-mediated knockdown of Stat3 (shStat3).
Fri Feb 12 00:00:00 UTC 2021
STAT3 Signalling via the IL-6ST/gp130 Cytokine Receptor Promotes Epithelial Integrity and Intestinal Barrier Function during DSS-Induced Colitis.
Biomedicines
Pang L,Huynh J,Alorro MG,Li X,Ernst M,Chand AL
14-5773 was used in Immunohistochemistry to investigate the role of STAT3 in retaining epithelial barrier integrity using dextran sulfate sodium (DSS)-induced colitis in two genetically modified mouse models, to either reduce STAT1/3 activation in response to IL-6 family cytokines with a truncated gp130STAT allele (GP130STAT/+), or by inducing short hairpin-mediated knockdown of Stat3 (shStat3).
Fri Feb 12 00:00:00 UTC 2021
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.
Science advances
Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat May 01 00:00:00 UTC 2021
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Frontiers in immunology
Wang Y,Gu T,Tian X,Li W,Zhao R,Yang W,Gao Q,Li T,Shim JH,Zhang C,Liu K,Lee MH
14-5773-82 was used in Immunohistochemistry to demonstrate that the PD-L1 inhibitor 1 can act to prevent T-cell exhaustion in immune checkpoint inhibition therapies using PD-L1.
Wed Sep 29 00:00:00 UTC 2021
A Small Molecule Antagonist of PD-1/PD-L1 Interactions Acts as an Immune Checkpoint Inhibitor for NSCLC and Melanoma Immunotherapy.
Frontiers in immunology
Wang Y,Gu T,Tian X,Li W,Zhao R,Yang W,Gao Q,Li T,Shim JH,Zhang C,Liu K,Lee MH
14-5773-82 was used in Immunohistochemistry to demonstrate that the PD-L1 inhibitor 1 can act to prevent T-cell exhaustion in immune checkpoint inhibition therapies using PD-L1.
Wed Sep 29 00:00:00 UTC 2021
Development of a Multiplex Immunohistochemistry Workflow to Investigate the Immune Microenvironment in Mouse Models of Inflammatory Bowel Disease and Colon Cancer.
International journal of molecular sciences
Pang L,Ernst M,Huynh J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Tue Oct 12 00:00:00 UTC 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Aug 04 00:00:00 UTC 2021
In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade response to elicit systemic antitumor immunity against intraocular melanoma and its metastasis.
Journal for immunotherapy of cancer
Kim S,Kim SA,Nam GH,Hong Y,Kim GB,Choi Y,Lee S,Cho Y,Kwon M,Jeong C,Kim S,Kim IS
14-5773-82 was used in Immunohistochemistry (Paraffin) to to conclude that immunogenic clearance induced by FIC-PDT and ROCK inhibitor combined with anti-PD-L1 antibody could be a potent immunotherapeutic strategy for UM.
Fri Jan 01 00:00:00 UTC 2021
In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade response to elicit systemic antitumor immunity against intraocular melanoma and its metastasis.
Journal for immunotherapy of cancer
Kim S,Kim SA,Nam GH,Hong Y,Kim GB,Choi Y,Lee S,Cho Y,Kwon M,Jeong C,Kim S,Kim IS
14-5773-82 was used in Immunohistochemistry (Paraffin) to to conclude that immunogenic clearance induced by FIC-PDT and ROCK inhibitor combined with anti-PD-L1 antibody could be a potent immunotherapeutic strategy for UM.
Fri Jan 01 00:00:00 UTC 2021
Systems pharmacology dissection of Epimedium targeting tumor microenvironment to enhance cytotoxic T lymphocyte responses in lung cancer.
Aging
Huang C,Li Z,Zhu J,Chen X,Hao Y,Yang R,Huang R,Zhou J,Wang Z,Xiao W,Zheng C,Wang Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Sun Jan 17 00:00:00 UTC 2021
ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.
Cell reports
Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Nov 23 00:00:00 UTC 2021
Glucose Metabolism Reprogramming of Regulatory T Cells in Concanavalin A-Induced Hepatitis.
Frontiers in pharmacology
Huang C,Shen Y,Shen M,Fan X,Men R,Ye T,Yang L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Sat Sep 18 00:00:00 UTC 2021
Treatment with the Probiotic Product Aviguard® Alleviates Inflammatory Responses during Campylobacter jejuni-Induced Acute Enterocolitis in Mice.
International journal of molecular sciences
Heimesaat MM,Weschka D,Mousavi S,Bereswill S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Tue Jun 22 00:00:00 UTC 2021
Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis.
Cancers
Bartlett AQ,Pennock ND,Klug A,Schedin P
14-5773-82 was used in Immunohistochemistry (Paraffin) to suggest that the normal postpartum liver is in an immune suppressed state, which can provide a pro-metastatic advantage to circulating breast cancer cells.
Sat Apr 03 00:00:00 UTC 2021
Immune Milieu Established by Postpartum Liver Involution Promotes Breast Cancer Liver Metastasis.
Cancers
Bartlett AQ,Pennock ND,Klug A,Schedin P
14-5773-82 was used in Immunohistochemistry (Paraffin) to suggest that the normal postpartum liver is in an immune suppressed state, which can provide a pro-metastatic advantage to circulating breast cancer cells.
Sat Apr 03 00:00:00 UTC 2021
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Frontiers in immunology
Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Oct 29 00:00:00 UTC 2021
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Jan 28 00:00:00 UTC 2022
Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Faslpr Mice.
Cells
Schmidtke L,Meineck M,Saurin S,Otten S,Gather F,Schrick K,Käfer R,Roth W,Kleinert H,Weinmann-Menke J,Pautz A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Sun Nov 14 00:00:00 UTC 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
14-5773-82 was used in Flow Cytometry to show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells.
Mon Jul 05 00:00:00 UTC 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
14-5773-82 was used in Flow Cytometry to show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells.
Mon Jul 05 00:00:00 UTC 2021
Dual Role of Interleukin-10 in Murine NZB/W F1 Lupus.
International journal of molecular sciences
Amend A,Wickli N,Schäfer AL,Sprenger DTL,Manz RA,Voll RE,Chevalier N
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Jan 29 00:00:00 UTC 2021
CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells.
iScience
Qadir AS,Guégan JP,Ginestier C,Chaibi A,Bessede A,Charafe-Jauffret E,Macario M,Lavoué V,Rouge TM,Law C,Vilker J,Wang H,Stroup E,Schipma MJ,Bridgeman B,Murmann AE,Ji Z,Legembre P,Peter ME
14-5773-82 was used in Immunohistochemistry to demonstrate that in addition to its tumor and metastasis promoting activities, CD95 expression by tumor cells can exert immune suppressive activities on NK cells, providing a new target for immune therapy.
Fri Nov 19 00:00:00 UTC 2021
Immune checkpoint blockade in triple negative breast cancer influenced by B cells through myeloid-derived suppressor cells.
Communications biology
Vito A,Salem O,El-Sayes N,MacFawn IP,Portillo AL,Milne K,Harrington D,Ashkar AA,Wan Y,Workenhe ST,Nelson BH,Bruno TC,Mossman KL
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Mon Jul 12 00:00:00 UTC 2021
Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.
Vaccines
Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Oct 27 00:00:00 UTC 2021
The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.
Journal of neuroinflammation
Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Jan 30 00:00:00 UTC 2021
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity.
Nature immunology
Hu W,Wang ZM,Feng Y,Schizas M,Hoyos BE,van der Veeken J,Verter JG,Bou-Puerto R,Rudensky AY
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Sep 01 00:00:00 UTC 2021
Combination Chemo-Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu X,Jiang J,Liao YP,Tang I,Zheng E,Qiu W,Lin M,Wang X,Ji Y,Mei KC,Liu Q,Chang CH,Wainberg ZA,Nel AE,Meng H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Mon Mar 01 00:00:00 UTC 2021
Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells.
Cell reports
Matas-Rico E,Frijlink E,van der Haar Àvila I,Menegakis A,van Zon M,Morris AJ,Koster J,Salgado-Polo F,de Kivit S,Lança T,Mazzocca A,Johnson Z,Haanen J,Schumacher TN,Perrakis A,Verbrugge I,van den Berg JH,Borst J,Moolenaar WH
14-5773-82 was used in Flow cytometry/Cell sorting to highlight an unexpected role for the pro-metastatic ATX-LPAR axis in suppressing CD8+ T cell infiltration to impede anti-tumor immunity, suggesting new therapeutic opportunities.
Tue Nov 16 00:00:00 UTC 2021
Distinct Biomarker Profiles and TCR Sequence Diversity Characterize the Response to PD-L1 Blockade in a Mouse Melanoma Model.
Molecular cancer research : MCR
El Meskini R,Atkinson D,Kulaga A,Abdelmaksoud A,Gumprecht M,Pate N,Hayes S,Oberst M,Kaplan IM,Raber P,Van Dyke T,Sharan SK,Hollingsworth R,Day CP,Merlino G,Weaver Ohler Z
14-5773-82 was used in Immunohistochemistry to suggest that an anti-PD-L1-mediated melanoma regression response requires not only an expansion of the TCR repertoire that is unique to individual mice, but also tumor access to the appropriate TCRs.
Sun Aug 01 00:00:00 UTC 2021
Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots.
Frontiers in immunology
Furesi G,Fert I,Beaufrère M,Araujo LM,Glatigny S,Baschant U,von Bonin M,Hofbauer LC,Horwood NJ,Breban M,Rauner M
14-5773-82 was used in Flow Cytometry to investigate the amount of white fat and bone marrow adipose tissue and how these link to chronic inflammatory spondyloarthritis.
Mon Oct 25 00:00:00 UTC 2021
Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots.
Frontiers in immunology
Furesi G,Fert I,Beaufrère M,Araujo LM,Glatigny S,Baschant U,von Bonin M,Hofbauer LC,Horwood NJ,Breban M,Rauner M
14-5773-82 was used in Flow Cytometry to investigate the amount of white fat and bone marrow adipose tissue and how these link to chronic inflammatory spondyloarthritis.
Mon Oct 25 00:00:00 UTC 2021
IκB Kinase-β Regulates Neutrophil Recruitment Through Activation of STAT3 Signaling in the Esophagus.
Cellular and molecular gastroenterology and hepatology
Wiles KN,Alioto CM,Hodge NB,Clevenger MH,Tsikretsis LE,Lin FTJ,Tétreault MP
14-5773-82 was used in Flow Cytometry to report that IkkβcaEEC-KI mice have increased activation of epithelial Janus kinase 2/STAT3 signaling.
Mon Mar 28 00:00:00 UTC 2022
Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model.
Gastroenterology
Gebert J,Gelincik O,Oezcan-Wahlbrink M,Marshall JD,Hernandez-Sanchez A,Urban K,Long M,Cortes E,Tosti E,Katzenmaier EM,Song Y,Elsaadi A,Deng N,Vilar E,Fuchs V,Nelius N,Yuan YP,Ahadova A,Sei S,Shoemaker RH,Umar A,Wei L,Liu S,Bork P,Edelmann W,von Knebel Doeberitz M,Lipkin SM,Kloor M
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot to test the hypothesis that recurrent FSP vaccination alone or in combination with NSAID treatment can promote anti-FSP adaptive immunity sufficiently to reduce intestinal tumor burden and prolong overall survival.
Fri Oct 01 00:00:00 UTC 2021
Anti-Pathogenic and Immune-Modulatory Effects of Peroral Treatment with Cardamom Essential Oil in Acute Murine Campylobacteriosis.
Microorganisms
Heimesaat MM,Mousavi S,Weschka D,Bereswill S
14-5773-82 was used in Immunohistochemistry to provide the first evidence that cardamom EO comprises a promising compound for the combat of acute campylobacteriosis and presumably prevention of post-infectious morbidities.
Thu Jan 14 00:00:00 UTC 2021
Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy.
Cancer cell
Wang Y,Liu S,Yang Z,Algazi AP,Lomeli SH,Wang Y,Othus M,Hong A,Wang X,Randolph CE,Jones AM,Bosenberg MW,Byrum SD,Tackett AJ,Lopez H,Yates C,Solit DB,Ribas A,Piva M,Moriceau G,Lo RS
14-5773-82 was used in Flow Cytometry to demonstrate that anti-PD-1/L1 lead-in preceding MAPKi combination optimizes response durability by promoting pro-inflammatory polarization of macrophages and clonal expansion of interferon-γhi, and CD8+ cytotoxic and proliferative T cells.
Mon Oct 11 00:00:00 UTC 2021
SPNS2 enables T cell egress from lymph nodes during an immune response.
Cell reports
Okuniewska M,Fang V,Baeyens A,Raghavan V,Lee JY,Littman DR,Schwab SR
14-5773-82 was used in Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to demonstrate that SPNS2 supplies the S1P that guides T cells out of LNs with an ongoing immune response.
Tue Jul 13 00:00:00 UTC 2021
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Cell
Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW
14-5773 was used in Immunohistochemistry-immunofluorescence to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.
Thu Apr 16 00:00:00 UTC 2020
Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance.
Cancer cell
Orgaz JL,Crosas-Molist E,Sadok A,Perdrix-Rosell A,Maiques O,Rodriguez-Hernandez I,Monger J,Mele S,Georgouli M,Bridgeman V,Karagiannis P,Lee R,Pandya P,Boehme L,Wallberg F,Tape C,Karagiannis SN,Malanchi I,Sanz-Moreno V
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Mon Jan 13 00:00:00 UTC 2020
S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.
Gastroenterology
Willers M,Ulas T,Völlger L,Vogl T,Heinemann AS,Pirr S,Pagel J,Fehlhaber B,Halle O,Schöning J,Schreek S,Löber U,Essex M,Hombach P,Graspeuntner S,Basic M,Bleich A,Cloppenborg-Schmidt K,Künzel S,Jonigk D,Rupp J,Hansen G,Förster R,Baines JF,Härtel C,Schultze JL,Forslund SK,Roth J,Viemann D
14-5773-82 was used in immunohistochemistry (frozen) to study levels of S100A8-A9 in fecal samples (also called fecal calprotectin) from newborns and during infancy, and their effects on development of the intestinal microbiota and mucosal immune system.
Tue Dec 01 00:00:00 UTC 2020
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Nature immunology
Harb H,Stephen-Victor E,Crestani E,Benamar M,Massoud A,Cui Y,Charbonnier LM,Arbag S,Baris S,Cunnigham A,Leyva-Castillo JM,Geha RS,Mousavi AJ,Guennewig B,Schmitz-Abe K,Sioutas C,Phipatanakul W,Chatila TA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Nov 01 00:00:00 UTC 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Apr 01 00:00:00 UTC 2020
Inhibiting the coregulator CoREST impairs Foxp3+ Treg function and promotes antitumor immunity.
The Journal of clinical investigation
Xiong Y,Wang L,Di Giorgio E,Akimova T,Beier UH,Han R,Trevisanut M,Kalin JH,Cole PA,Hancock WW
14-5773-80 was used in Immunocytochemistry to analyse the role in Tregs of the evolutionarily conserved CoREST complex, consisting of a scaffolding protein, Rcor1 or Rcor2, plus Hdac1 or Hdac2 and Lsd1 enzymes.
Wed Apr 01 00:00:00 UTC 2020
Metformin Abrogates Age-Associated Ovarian Fibrosis.
Clinical cancer research : an official journal of the American Association for Cancer Research
McCloskey CW,Cook DP,Kelly BS,Azzi F,Allen CH,Forsyth A,Upham J,Rayner KJ,Gray DA,Boyd RW,Murugkar S,Lo B,Trudel D,Senterman MK,Vanderhyden BC
14-5773-80 was used in Immunohistochemistry (Paraffin) to assess the effects of age and ovulation on the ovarian microenvironment underlie ovarian cancer risk.
Sat Feb 01 00:00:00 UTC 2020
Persistent IL-2 Receptor Signaling by IL-2/CD25 Fusion Protein Controls Diabetes in NOD Mice by Multiple Mechanisms.
Diabetes
Ward NC,Lui JB,Hernandez R,Yu L,Struthers M,Xie J,Santos Savio A,Dwyer CJ,Hsiung S,Yu A,Malek TR
14-5773 was used in Flow cytometry/Cell sorting to show that low-dose mouse IL-2/CD25 (mIL-2/CD25), but not an equivalent amount of IL-2, prevents the onset of diabetes in NOD mice and controls diabetes in hyperglycemic mice.
Sun Nov 01 00:00:00 UTC 2020
Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.
Immunology
Kuehlwein JM,Borsche M,Korir PJ,Risch F,Mueller AK,Hübner MP,Hildner K,Hoerauf A,Dunay IR,Schumak B
14-5773 was used in Flow cytometry/Cell sorting to investigate the inflammatory immune responses to plasmodium parasite infections which lead to cerebral malaria using a mouse model.
Sat Feb 01 00:00:00 UTC 2020
Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.
Immunology
Kuehlwein JM,Borsche M,Korir PJ,Risch F,Mueller AK,Hübner MP,Hildner K,Hoerauf A,Dunay IR,Schumak B
14-5773 was used in Flow cytometry/Cell sorting to investigate the inflammatory immune responses to plasmodium parasite infections which lead to cerebral malaria using a mouse model.
Sat Feb 01 00:00:00 UTC 2020
Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice.
Acta pharmacologica Sinica
Son SE,Park SJ,Koh JM,Im DS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Oct 01 00:00:00 UTC 2020
An Antibody-Tumor Necrosis Factor Fusion Protein that Synergizes with Oxaliplatin for Treatment of Colorectal Cancer.
Molecular cancer therapeutics
Bajic D,Chester K,Neri D
14-5773-82 was used in Immunocytochemistry to provide a rationale for the possible clinical use of oxaliplatin in combination with fully human antibody-TNF fusions.
Tue Dec 01 00:00:00 UTC 2020
Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats.
Disease models & mechanisms
Lee E,Kim N,Kang J,Yoon S,Lee HA,Jung H,Kim SH,Kim I
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that activation of pathogenic Th17 lymphocytes induces hypertension after high-fructose intake in SS rats but not SR rats.
Wed May 27 00:00:00 UTC 2020
Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats.
Disease models & mechanisms
Lee E,Kim N,Kang J,Yoon S,Lee HA,Jung H,Kim SH,Kim I
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that activation of pathogenic Th17 lymphocytes induces hypertension after high-fructose intake in SS rats but not SR rats.
Wed May 27 00:00:00 UTC 2020
Ubiquitination of MHC Class II Is Required for Development of Regulatory but Not Conventional CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Liu H,Wilson KR,Schriek P,Macri C,Blum AB,Francis L,Heinlein M,Nataraja C,Harris J,Jones SA,Gray DHD,Villadangos JA,Mintern JD
14-5773-82 was used in Immunohistochemistry to conclude that MHC II ubiquitination in specific APC types does not have a major impact on the conventional CD4+ T cell compartment but is important for Treg development.
Tue Sep 01 00:00:00 UTC 2020
A novel inhibitory role of microRNA-224 in particulate matter 2.5-induced asthmatic mice by inhibiting TLR2.
Journal of cellular and molecular medicine
Li P,Wang J,Guo F,Zheng B,Zhang X
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Mar 01 00:00:00 UTC 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Jan 01 00:00:00 UTC 2020
A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Gniadek TJ,Augustin L,Schottel J,Leonard A,Saltzman D,Greeno E,Batist G
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Sep 01 00:00:00 UTC 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Sep 28 00:00:00 UTC 2020
Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d-/- Mice Lacking NKT Cells.
Integrative cancer therapies
Takaku S,Shimizu M,Takahashi H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Mar 23 00:00:00 UTC 2020
Alcohol-Induced Immune Dysregulation in the Colon Is Diurnally Variable.
Visceral medicine
Grumish EL,Armstrong AR,Voigt RM,Forsyth CB,Bishehsari F
14-5773-82 was used in Immunocytochemistry to investigate the diurnal variation of lymphocyte infiltration in the colonic mucosa in response to alcohol.
Mon Jun 01 00:00:00 UTC 2020
Horses with equine recurrent uveitis have an activated CD4+ T-cell phenotype that can be modulated by mesenchymal stem cells in vitro.
Veterinary ophthalmology
Saldinger LK,Nelson SG,Bellone RR,Lassaline M,Mack M,Walker NJ,Borjesson DL
14-5773 was used in Flow cytometry/Cell sorting to define the lymphocyte phenotype of horses with equine recurrent uveitis(ERU) and tdetermine how mesenchymal stem cells(MSCs) alter T-cell phenotype in vitro.
Wed Jan 01 00:00:00 UTC 2020
Horses with equine recurrent uveitis have an activated CD4+ T-cell phenotype that can be modulated by mesenchymal stem cells in vitro.
Veterinary ophthalmology
Saldinger LK,Nelson SG,Bellone RR,Lassaline M,Mack M,Walker NJ,Borjesson DL
14-5773 was used in Flow cytometry/Cell sorting to define the lymphocyte phenotype of horses with equine recurrent uveitis(ERU) and tdetermine how mesenchymal stem cells(MSCs) alter T-cell phenotype in vitro.
Wed Jan 01 00:00:00 UTC 2020
Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction.
PloS one
Gladow N,Hollmann C,Ramos G,Frantz S,Kerkau T,Beyersdorf N,Hofmann U
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Jul 06 00:00:00 UTC 2020
MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.
Aging
Liu Z,Wen J,Wu C,Hu C,Wang J,Bao Q,Wang H,Wang J,Zhou Q,Wei L,Shen Y,Zhang W
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Jan 24 00:00:00 UTC 2020
Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.
Cell reports
Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunofluorescence
Tue Jan 21 00:00:00 UTC 2020
Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.
Cell reports
Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunofluorescence
Tue Jan 21 00:00:00 UTC 2020
Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.
Cell reports
Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunofluorescence
Tue Jan 21 00:00:00 UTC 2020
Pituitary Adenylate Cyclase-Activating Polypeptide Alleviates Intestinal, Extra-Intestinal and Systemic Inflammatory Responses during Acute Campylobacter jejuni-induced Enterocolitis in Mice.
Pathogens (Basel, Switzerland)
Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Tamas A,Reglodi D,Bereswill S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Wed Sep 30 00:00:00 UTC 2020
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy.
Nature communications
Baumann D,Hägele T,Mochayedi J,Drebant J,Vent C,Blobner S,Noll JH,Nickel I,Schumacher C,Boos SL,Daniel AS,Wendler S,Volkmar M,Strobel O,Offringa R
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri May 01 00:00:00 UTC 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Aug 11 00:00:00 UTC 2020
The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Klove S,Weschka D,Mousavi S,Bereswill S
14-5773-82 was used in Immunohistochemistry to survey the impact of the host-specific intestinal microbiota composition during peroral C. coli infection applying an established murine campylobacteriosis model.
Tue Sep 29 00:00:00 UTC 2020
The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Klove S,Weschka D,Mousavi S,Bereswill S
14-5773-82 was used in Immunohistochemistry to survey the impact of the host-specific intestinal microbiota composition during peroral C. coli infection applying an established murine campylobacteriosis model.
Tue Sep 29 00:00:00 UTC 2020
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
Science advances
Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H
14-5773-82 was used in Flow Cytometry to demonstrate the endogenous existence of a micropeptide encoded by a transcript annotated as "non-protein coding" and characterize a micropeptide as a regulator of antigen presentation and a suppressor of inflammatory diseases.
Fri May 01 00:00:00 UTC 2020
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
Science advances
Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H
14-5773-82 was used in Flow Cytometry to demonstrate the endogenous existence of a micropeptide encoded by a transcript annotated as "non-protein coding" and characterize a micropeptide as a regulator of antigen presentation and a suppressor of inflammatory diseases.
Fri May 01 00:00:00 UTC 2020
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Dec 16 00:00:00 UTC 2020
PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy.
Frontiers in physiology
Farini A,Villa C,Di Silvestre D,Bella P,Tripodi L,Rossi R,Sitzia C,Gatti S,Mauri P,Torrente Y
14-5773 was used in Western Blotting to suggest that cardiac levels of PTX3 might have prognostic value and potential in guiding therapy for DMD cardiomyopathy.
Mon Sep 28 00:00:00 UTC 2020
PTX3 Predicts Myocardial Damage and Fibrosis in Duchenne Muscular Dystrophy.
Frontiers in physiology
Farini A,Villa C,Di Silvestre D,Bella P,Tripodi L,Rossi R,Sitzia C,Gatti S,Mauri P,Torrente Y
14-5773 was used in Western Blotting to suggest that cardiac levels of PTX3 might have prognostic value and potential in guiding therapy for DMD cardiomyopathy.
Mon Sep 28 00:00:00 UTC 2020
FOXD3 Regulates VISTA Expression in Melanoma.
Cell reports
Rosenbaum SR,Knecht M,Mollaee M,Zhong Z,Erkes DA,McCue PA,Chervoneva I,Berger AC,Lo JA,Fisher DE,Gershenwald JE,Davies MA,Purwin TJ,Aplin AE
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jan 14 00:00:00 UTC 2020
Donor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants.
Scientific reports
Wang L,Wang Z,Han R,Samanta A,Ge G,Levin LS,Levine MH,Hancock WW
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jun 09 00:00:00 UTC 2020
A free amino acid-based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey.
Immunity, inflammation and disease
van Sadelhoff JHJ,Hogenkamp A,Wiertsema SP,Harthoorn LF,Loonstra R,Hartog A,Garssen J
14-5773-82 was used in Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (PFA fixed) to demonstrate that an amino acid-based diet can at least partially prevent allergic symptoms of cow's milk allergy in mice.
Sun Mar 01 00:00:00 UTC 2020
A free amino acid-based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey.
Immunity, inflammation and disease
van Sadelhoff JHJ,Hogenkamp A,Wiertsema SP,Harthoorn LF,Loonstra R,Hartog A,Garssen J
14-5773-82 was used in Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (PFA fixed) to demonstrate that an amino acid-based diet can at least partially prevent allergic symptoms of cow's milk allergy in mice.
Sun Mar 01 00:00:00 UTC 2020
A free amino acid-based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey.
Immunity, inflammation and disease
van Sadelhoff JHJ,Hogenkamp A,Wiertsema SP,Harthoorn LF,Loonstra R,Hartog A,Garssen J
14-5773-82 was used in Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (PFA fixed) to demonstrate that an amino acid-based diet can at least partially prevent allergic symptoms of cow's milk allergy in mice.
Sun Mar 01 00:00:00 UTC 2020
A free amino acid-based diet partially prevents symptoms of cow's milk allergy in mice after oral sensitization with whey.
Immunity, inflammation and disease
van Sadelhoff JHJ,Hogenkamp A,Wiertsema SP,Harthoorn LF,Loonstra R,Hartog A,Garssen J
14-5773-82 was used in Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (PFA fixed) to demonstrate that an amino acid-based diet can at least partially prevent allergic symptoms of cow's milk allergy in mice.
Sun Mar 01 00:00:00 UTC 2020
Preclinical Evaluation of Oral Urolithin-A for the Treatment of Acute Campylobacteriosis in Campylobacter jejuni Infected Microbiota-Depleted IL-10-/- Mice.
Pathogens (Basel, Switzerland)
Mousavi S,Weschka D,Bereswill S,Heimesaat MM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Wed Dec 23 00:00:00 UTC 2020
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
14-5773-82 was used in Immunohistochemistry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 UTC 2020
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
14-5773-82 was used in Immunohistochemistry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 UTC 2020
Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury.
Aging
Luo Y,Wang B,Liu J,Ma F,Luo D,Zheng Z,Lu Q,Zhou W,Zheng Y,Zhang C,Wang Q,Sha W,Chen H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Dec 03 00:00:00 UTC 2020
Immunopathogenesis of canine chronic ulcerative stomatitis.
PloS one
Anderson JG,Kol A,Bizikova P,Stapelton BP,Ford K,Villarreal A,Jimenez RJ,Vasilatis D,Murphy BG
14-5773-82 was used in Immunocytochemistry and Immunohistochemistry to support an autoantibody-mediated autoimmune disease process.
Mon Apr 20 00:00:00 UTC 2020
Immunopathogenesis of canine chronic ulcerative stomatitis.
PloS one
Anderson JG,Kol A,Bizikova P,Stapelton BP,Ford K,Villarreal A,Jimenez RJ,Vasilatis D,Murphy BG
14-5773-82 was used in Immunocytochemistry and Immunohistochemistry to support an autoantibody-mediated autoimmune disease process.
Mon Apr 20 00:00:00 UTC 2020
Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota.
Pathogens (Basel, Switzerland)
Kløve S,Genger C,Mousavi S,Weschka D,Bereswill S,Heimesaat MM
14-5773 was used in Immunohistochemistry-immunofluorescence to conclude that pathogenic LOS might play an important role in inducing TLR4-dependent host immune responses upon C. coli infection, which needs to be further addressed in more detail.
Mon May 18 00:00:00 UTC 2020
Toll-Like Receptor-4 Dependent Intestinal and Systemic Sequelae Following Peroral Campylobacter coli Infection of IL10 Deficient Mice Harboring a Human Gut Microbiota.
Pathogens (Basel, Switzerland)
Kløve S,Genger C,Mousavi S,Weschka D,Bereswill S,Heimesaat MM
14-5773 was used in Immunohistochemistry-immunofluorescence to conclude that pathogenic LOS might play an important role in inducing TLR4-dependent host immune responses upon C. coli infection, which needs to be further addressed in more detail.
Mon May 18 00:00:00 UTC 2020
Abnormal Eating Patterns Cause Circadian Disruption and Promote Alcohol-Associated Colon Carcinogenesis.
Cellular and molecular gastroenterology and hepatology
Bishehsari F,Engen PA,Voigt RM,Swanson G,Shaikh M,Wilber S,Naqib A,Green SJ,Shetuni B,Forsyth CB,Saadalla A,Osman A,Hamaker BR,Keshavarzian A,Khazaie K
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Wed May 05 00:00:00 UTC 2021
3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models.
Scientific reports
Kang LJ,Oh E,Cho C,Kwon H,Lee CG,Jeon J,Lee H,Choi S,Han SJ,Nam J,Song CU,Jung H,Kim HY,Park EJ,Choi EJ,Kim J,Eyun SI,Yang S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 27 00:00:00 UTC 2020
Host deficiency in ephrin-A1 inhibits breast cancer metastasis.
F1000Research
Shiuan E,Inala A,Wang S,Song W,Youngblood V,Chen J,Brantley-Sieders DM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Feb 01 00:00:00 UTC 2021
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells.
Frontiers in immunology
Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Apr 19 00:00:00 UTC 2021
Respiratory Syncytial Virus Infection Reduces Kynurenic Acid Production and Reverses Th17/Treg Balance by Modulating Indoleamine 2,3-Dioxygenase (IDO) Molecules in Plasmacytoid Dendritic Cells.
Medical science monitor : international medical journal of experimental and clinical research
Jin L,Hu Q,Hu Y,Chen Z,Liao W
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Dec 02 00:00:00 UTC 2020
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Frontiers in immunology
Wang A,Yang M,Liang R,Zhu F,Zhu F,Liu X,Han Y,Lin R,Wang X,Li D,Li H,Yuan X,Zhao H,Li B
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Apr 05 00:00:00 UTC 2021
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Frontiers in immunology
Wang A,Yang M,Liang R,Zhu F,Zhu F,Liu X,Han Y,Lin R,Wang X,Li D,Li H,Yuan X,Zhao H,Li B
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Apr 05 00:00:00 UTC 2021
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Oct 27 00:00:00 UTC 2020
Assessing IL-2-Induced STAT5 Phosphorylation in Fixed, Permeabilized Foxp3+ Treg Cells by Multiparameter Flow Cytometry.
STAR protocols
Li C,Park JH
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Dec 18 00:00:00 UTC 2020
Toll-Like Receptor-4 Is Involved in Mediating Intestinal and Extra-Intestinal Inflammation in Campylobacter coli-Infected Secondary Abiotic IL-10-/- Mice.
Microorganisms
Kløve S,Genger C,Weschka D,Mousavi S,Bereswill S,Heimesaat MM
14-5773 was used in Immunohistochemistry to provide evidence that TLR4 is involved in mediating C. coli-LOS-induced immune responses in intestinal and extra-intestinal compartments during murine campylobacteriosis.
Fri Nov 27 00:00:00 UTC 2020
Developmental Dysfunction of the Central Nervous System Lymphatics Modulates the Adaptive Neuro-Immune Response in the Perilesional Cortex in a Mouse Model of Traumatic Brain Injury.
Frontiers in immunology
Wojciechowski S,Virenque A,Vihma M,Galbardi B,Rooney EJ,Keuters MH,Antila S,Koistinaho J,Noe FM
14-5773-82 was used in Flow Cytometry to explore the role of meningeal lymphatic vessels in modulating the neuro-immune response following a traumatic brain injury.
Wed May 19 00:00:00 UTC 2021
Comprehensive Analysis of the Immune and Stromal Compartments of the CNS in EAE Mice Reveal Pathways by Which Chloroquine Suppresses Neuroinflammation.
Brain sciences
Thome R,Boehm A,Ishikawa LLW,Casella G,Munhoz J,Ciric B,Zhang GX,Rostami A
14-5773-82 was used in Flow Cytometry to analyse the CNS of experimental autoimmune encephalomyelitis mice to identify and characterize the cells that are affected by chloroquine.
Fri Jun 05 00:00:00 UTC 2020
Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer.
Oncoimmunology
Alvero AB,Hanlon D,Pitruzzello M,Filler R,Robinson E,Sobolev O,Tedja R,Ventura A,Bosenberg M,Han P,Edelson RL,Mor G
14-5773 was used in Immunohistochemistry to study the results of transimmunization in high-grade serous ovarian cancer (HGSOC) mouse models.
Wed May 13 00:00:00 UTC 2020
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Cell death & disease
Shi Y,Liu Z,Cui X,Zhao Q,Liu T
14-5773 was used in Western Blotting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.
Mon Jun 15 00:00:00 UTC 2020
T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis.
Nature communications
Napier RJ,Lee EJ,Davey MP,Vance EE,Furtado JM,Snow PE,Samson KA,Lashley SJ,Brown BR,Horai R,Mattapallil MJ,Xu B,Callegan MC,Uebelhoer LS,Lancioni CL,Vehe RK,Binstadt BA,Smith JR,Caspi RR,Rosenzweig HL
14-5773-82 was used in Flow Cytometry to reveal a non-conventional, T cell-intrinsic function for Nod2 in suppression of Th17 immunity and experimental uveitis.
Mon Oct 26 00:00:00 UTC 2020
Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system.
Oncoimmunology
Klarenbeek S,Doornebal CW,Kas SM,Bonzanni N,Bhin J,Braumuller TM,van der Heijden I,Opdam M,Schouten PC,Kersten K,de Bruijn R,Zingg D,Yemelyanenko J,Wessels LFA,de Visser KE,Jonkers J
14-5773-82 was used in Immunohistochemistry to investigate treatment response and resistance to AZD8055, an inhibitor of mammalian target of rapamycin (mTOR), in the K14-cre;Cdh1Flox/Flox;Trp53Flox/Flox (KEP) mouse model of metastatic ILC.
Wed Jul 28 00:00:00 UTC 2021
Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.
Journal of translational autoimmunity
Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Sep 28 00:00:00 UTC 2020
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Scientific reports
Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Mar 24 00:00:00 UTC 2020
The conundrum of colonization resistance against Campylobacter reloaded: The gut microbota composition in conventional mice does not prevent from Campylobacter coli infection.
European journal of microbiology & immunology
Genger C,Kløve S,Mousavi S,Bereswill S,Heimesaat MM
14-5773 was used in Immunohistochemistry to study whether this also held true for Campylobacter coli.
Fri May 01 00:00:00 UTC 2020
Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells.
JCI insight
Yang L,Shivakumar P,Kinder J,Way SS,Donnelly B,Mourya R,Luo Z,Bezerra JA
14-5773 was used in Immunohistochemistry to examine the liver gene expression pattern at diagnosis and found the top 5 enriched pathways are related to erythrocyte pathobiology in children who survived with the native liver beyond 2 years of age.
Thu Jun 04 00:00:00 UTC 2020
Tumor Size Matters-Understanding Concomitant Tumor Immunity in the Context of Hypofractionated Radiotherapy with Immunotherapy.
Cancers
Nesseler JP,Lee MH,Nguyen C,Kalbasi A,Sayre JW,Romero T,Nickers P,McBride WH,Schaue D
14-5773-82 was used in Flow Cytometry to determine the dynamic contributions of different immune cell subsets to primary and abscopal tumor regression after hypofractionated radiation therapy and the impact of anti-PD-1 therapy.
Wed Mar 18 00:00:00 UTC 2020
In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases.
Journal for immunotherapy of cancer
Clark PA,Sriramaneni RN,Jin WJ,Jagodinsky JC,Bates AM,Jaquish AA,Anderson BR,Le T,Lubin JA,Chakravarty I,Arthur IS,Heinze CM,Guy EI,Kler J,Klar KA,Carlson PM,Kim KM,Kuo JS,Morris ZS
14-5773 was used in Immunohistochemistry to test whether in situ vaccination inhibits the development of brain metastases in a murine melanoma model.
Wed Jul 01 00:00:00 UTC 2020
Microbiota composition and inflammatory immune responses upon peroral application of the commercial competitive exclusion product Aviguard® to microbiota-depleted wildtype mice.
European journal of microbiology & immunology
Heimesaat MM,Weschka D,Kløve S,Genger C,Biesemeier N,Mousavi S,Bereswill S
14-5773 was used in Immunohistochemistry to surveyed the intestinal bacterial colonization properties, potential macroscopic and microscopic inflammatory sequelae and immune responses upon peroral application of the commercial competitive exclusion product Aviguard® to wildtype mice in which the gut microbiota had been depleted by antibiotic pre-treatment.
Mon Jul 27 00:00:00 UTC 2020
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Journal for immunotherapy of cancer
Shigeta K,Matsui A,Kikuchi H,Klein S,Mamessier E,Chen IX,Aoki S,Kitahara S,Inoue K,Shigeta A,Hato T,Ramjiawan RR,Staiculescu D,Zopf D,Fiebig L,Hobbs GS,Quaas A,Dima S,Popescu I,Huang P,Munn LL,Cobbold M,Goyal L,Zhu AX,Jain RK,Duda DG
14-5773-82 was used in Flow Cytometry to conclude that judicious regorafenib/anti-PD1 combination therapy can inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T-cell infiltration through elevated CXCL10 expression in HCC cells.
Sun Nov 01 00:00:00 UTC 2020
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.
Journal for immunotherapy of cancer
Bergamaschi C,Pandit H,Nagy BA,Stellas D,Jensen SM,Bear J,Cam M,Valentin A,Fox BA,Felber BK,Pavlakis GN
14-5773-82 was used in Flow Cytometry, Immunohistochemistry to show that hetIL-15 administration enhances T cell entry into tumors, increasing the success rate of immunotherapy interventions.
Fri May 01 00:00:00 UTC 2020
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10.
Journal for immunotherapy of cancer
Bergamaschi C,Pandit H,Nagy BA,Stellas D,Jensen SM,Bear J,Cam M,Valentin A,Fox BA,Felber BK,Pavlakis GN
14-5773-82 was used in Flow Cytometry, Immunohistochemistry to show that hetIL-15 administration enhances T cell entry into tumors, increasing the success rate of immunotherapy interventions.
Fri May 01 00:00:00 UTC 2020
Inflammatory Immune Responses and Gut Microbiota Changes Following Campylobacter coli Infection of IL-10-/- Mice with Chronic Colitis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Biesemeier N,Klove S,Weschka D,Mousavi S,Bereswill S
14-5773 was used in Immunohistochemistry to study gastrointestinal colonisation properties, gut microbiota changes and pro-inflammatory sequelae changes following C. coli infection and chronic colitis using a mouse model.
Sat Jul 11 00:00:00 UTC 2020
Inflammatory Immune Responses and Gut Microbiota Changes Following Campylobacter coli Infection of IL-10-/- Mice with Chronic Colitis.
Pathogens (Basel, Switzerland)
Heimesaat MM,Genger C,Biesemeier N,Klove S,Weschka D,Mousavi S,Bereswill S
14-5773 was used in Immunohistochemistry to study gastrointestinal colonisation properties, gut microbiota changes and pro-inflammatory sequelae changes following C. coli infection and chronic colitis using a mouse model.
Sat Jul 11 00:00:00 UTC 2020
Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Bhatia S,Longino NV,Miller NJ,Kulikauskas R,Iyer JG,Ibrani D,Blom A,Byrd DR,Parvathaneni U,Twitty CG,Campbell JS,Le MH,Gargosky S,Pierce RH,Heller R,Daud AI,Nghiem P
14-5773-82 was used in Immunohistochemistry to investigate safety, efficacy, and immunologic activity of intratumoral delivery of IL12 plasmid DNA (tavo) via in vivo electroporation (i.t.-tavo-EP) in patients with Merkel cell carcinoma (MCC), an aggressive virus-associated skin cancer.
Sat Feb 01 00:00:00 UTC 2020
Immune-modulatory Properties of the Octapeptide NAP in Campylobacter jejuni Infected Mice Suffering from Acute Enterocolitis.
Microorganisms
Heimesaat MM,Mousavi S,Kløve S,Genger C,Weschka D,Giladi E,Bereswill S,Gozes I
14-5773 was used in Immunohistochemistry to provide evidence that NAP application constitutes a promising option to combat acute campylobacteriosis.
Tue May 26 00:00:00 UTC 2020
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Nature
Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed May 01 00:00:00 UTC 2019
UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma.
Cell
Wolf Y,Bartok O,Patkar S,Eli GB,Cohen S,Litchfield K,Levy R,Jiménez-Sánchez A,Trabish S,Lee JS,Karathia H,Barnea E,Day CP,Cinnamon E,Stein I,Solomon A,Bitton L,Pérez-Guijarro E,Dubovik T,Shen-Orr SS,Miller ML,Merlino G,Levin Y,Pikarsky E,Eisenbach L,Admon A,Swanton C,Ruppin E,Samuels Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Thu Sep 19 00:00:00 UTC 2019
Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.
Cell research
Zhang Y,Du X,Liu M,Tang F,Zhang P,Ai C,Fields JK,Sundberg EJ,Latinovic OS,Devenport M,Zheng P,Liu Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Aug 01 00:00:00 UTC 2019
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.
Cancer cell
Su W,Han HH,Wang Y,Zhang B,Zhou B,Cheng Y,Rumandla A,Gurrapu S,Chakraborty G,Su J,Yang G,Liang X,Wang G,Rosen N,Scher HI,Ouerfelli O,Giancotti FG
14-5773 was used in Immunohistochemistry to reveal that PRC1 coordinates stemness with immune evasion and neoangiogenesis and point to the potential clinical utility of targeting PRC1 in DNPC.
Mon Aug 12 00:00:00 UTC 2019
Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense.
Cell stem cell
Chen M,Reed RR,Lane AP
14-5773 was used in Flow cytometry/Cell sorting to establish a mechanism whereby chronic rhinosinusitis inflammation causes a functional switch of neuroepithelial stem cells from regeneration to immune defense.
Thu Oct 03 00:00:00 UTC 2019
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity.
The Journal of clinical investigation
Pai CS,Simons DM,Lu X,Evans M,Wei J,Wang YH,Chen M,Huang J,Park C,Chang A,Wang J,Westmoreland S,Beam C,Banach D,Bowley D,Dong F,Seagal J,Ritacco W,Richardson PL,Mitra S,Lynch G,Bousquet P,Mankovich J,Kingsbury G,Fong L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunofluorescence
Wed Jan 02 00:00:00 UTC 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-5773-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 UTC 2019
ICOS Costimulation at the Tumor Site in Combination with CTLA-4 Blockade Therapy Elicits Strong Tumor Immunity.
Molecular therapy : the journal of the American Society of Gene Therapy
Soldevilla MM,Villanueva H,Meraviglia-Crivelli D,Menon AP,Ruiz M,Cebollero J,Villalba M,Moreno B,Lozano T,Llopiz D,Pejenaute Á,Sarobe P,Pastor F
14-5773-82 was used in Immunohistochemistry (Paraffin) to to describe an ICOS agonistic aptamer that potentiates T cell activation and induces stronger antitumor responses when locally injected at the tumor site in combination with anti-CTLA-4 antibody in different tumor models.
Wed Nov 06 00:00:00 UTC 2019
TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.
Proceedings of the National Academy of Sciences of the United States of America
Sharma N,Vacher J,Allison JP
14-5773-82 was used in Flow Cytometry to show that this mechanism could be harnessed to modulate the clinical outcome of anti-CTLA-4 antibodies and possibly other antibody-based immunotherapies.
Tue May 21 00:00:00 UTC 2019
Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression.
Oncogene
Kim SJ,Garcia-Recio S,Creighton CJ,Perou CM,Rosen JM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunocytochemistry
Thu Aug 01 00:00:00 UTC 2019
Alterations in Wnt- and/or STAT3 signaling pathways and the immune microenvironment during metastatic progression.
Oncogene
Kim SJ,Garcia-Recio S,Creighton CJ,Perou CM,Rosen JM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunocytochemistry
Thu Aug 01 00:00:00 UTC 2019
BATF3-dependent dendritic cells drive both effector and regulatory T-cell responses in bacterially infected tissues.
PLoS pathogens
Arnold IC,Zhang X,Artola-Boran M,Fallegger A,Sander P,Johansen P,Müller A
14-5773 was used in Flow cytometry/Cell sorting to study the role of BATF3-dependent DCs in the recruitment of CXCR3+ effector and regulatory T-cells to target tissues and in their local expansion.
Sat Jun 01 00:00:00 UTC 2019
Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice.
American journal of physiology. Lung cellular and molecular physiology
Shrestha AK,Bettini ML,Menon RT,Gopal VYN,Huang S,Edwards DP,Pammi M,Barrios R,Shivanna B
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jan 01 00:00:00 UTC 2019
Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells.
Immune network
Kim JE,Sharma A,Sharma G,Lee SY,Shin HS,Rudra D,Im SH
14-5773-82 was used in Flow Cytometry to demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells.
Sun Dec 01 00:00:00 UTC 2019
CD55 Is Essential for CD103+ Dendritic Cell Tolerogenic Responses that Protect against Autoimmunity.
The American journal of pathology
Strainic MG,Liu J,An F,Bailey E,Esposito A,Hamann J,Heeger PS,Medof ME
14-5773 was used in Immuno-assay to study the importance of DAF in enabling processes that program tolerance in the gut and the eye.
Mon Jul 01 00:00:00 UTC 2019
Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.
Laboratory investigation; a journal of technical methods and pathology
Hensel JA,Khattar V,Ashton R,Ponnazhagan S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jan 01 00:00:00 UTC 2019
A Skin Rejection Grading System for Vascularized Composite Allotransplantation in a Preclinical Large Animal Model.
Transplantation
Etra JW,Grzelak MJ,Fidder SAJ,Kolegraff K,Bonawitz S,Shores J,Oh B,Cooney DS,Beck SE,Brandacher G
14-5773 was used in Immunohistochemistry to provide a standardized system for more accurate comparison of rejection in preclinical swine VCA models.
Mon Jul 01 00:00:00 UTC 2019
T Lymphocytes Attenuate Dermal Scarring by Regulating Inflammation, Neovascularization, and Extracellular Matrix Remodeling.
Advances in wound care
Wang X,Balaji S,Steen EH,Li H,Rae MM,Blum AJ,Miao Q,Butte MJ,Bollyky PL,Keswani SG
14-5773 was used in Immunohistochemistry to implicate adaptive immunity in the regulation of scarring phenotypes.
Fri Nov 01 00:00:00 UTC 2019
Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Mediators of inflammation
Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jun 11 00:00:00 UTC 2019
A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials.
Journal of mammary gland biology and neoplasia
Pénzváltó Z,Chen JQ,Tepper CG,Davis RR,Silvestrini MT,Umeh-Garcia M,Sweeney C,Borowsky AD
14-5773-82 was used in Immunohistochemistry to show that the NDLUCD cells have, so far, remained genetically and phenotypically stable over many generations, with consistent and reproducible results in immune intact preclinical cohorts.
Sat Jun 01 00:00:00 UTC 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Oct 01 00:00:00 UTC 2019
IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization.
Nature communications
Eissmann MF,Dijkstra C,Jarnicki A,Phesse T,Brunnberg J,Poh AR,Etemadi N,Tsantikos E,Thiem S,Huntington ND,Hibbs ML,Boussioutas A,Grimbaldeston MA,Buchert M,O'Donoghue RJJ,Masson F,Ernst M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Fri Jun 21 00:00:00 UTC 2019
Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.
Frontiers in immunology
Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Nov 17 00:00:00 UTC 2020
Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival.
Scientific reports
Uehara M,Li X,Sheikhi A,Zandi N,Walker B,Saleh B,Banouni N,Jiang L,Ordikhani F,Dai L,Yonar M,Vohra I,Kasinath V,Orgill DP,Khademhosseini A,Annabi N,Abdi R
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Apr 25 00:00:00 UTC 2019
Development of a new fusion-enhanced oncolytic immunotherapy platform based on herpes simplex virus type 1.
Journal for immunotherapy of cancer
Thomas S,Kuncheria L,Roulstone V,Kyula JN,Mansfield D,Bommareddy PK,Smith H,Kaufman HL,Harrington KJ,Coffin RS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunofluorescence
Sat Aug 10 00:00:00 UTC 2019
Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.
Nature communications
Kusano T,Ehirchiou D,Matsumura T,Chobaz V,Nasi S,Castelblanco M,So A,Lavanchy C,Acha-Orbea H,Nishino T,Okamoto K,Busso N
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Oct 28 00:00:00 UTC 2019
Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells.
Cell reports
Fleskens V,Minutti CM,Wu X,Wei P,Pals CEGM,McCrae J,Hemmers S,Groenewold V,Vos HJ,Rudensky A,Pan F,Li H,Zaiss DM,Coffer PJ
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunoprecipitation
Tue Mar 26 00:00:00 UTC 2019
Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function.
Cell reports
Fu Z,Ye J,Dean JW,Bostick JW,Weinberg SE,Xiong L,Oliff KN,Chen ZE,Avram D,Chandel NS,Zhou L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jul 02 00:00:00 UTC 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue May 14 00:00:00 UTC 2019
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models.
Nature communications
Martínez-Vélez N,Garcia-Moure M,Marigil M,González-Huarriz M,Puigdelloses M,Gallego Pérez-Larraya J,Zalacaín M,Marrodán L,Varela-Guruceaga M,Laspidea V,Aristu JJ,Ramos LI,Tejada-Solís S,Díez-Valle R,Jones C,Mackay A,Martínez-Climent JA,García-Barchino MJ,Raabe E,Monje M,Becher OJ,Junier MP,El-Habr EA,Chneiweiss H,Aldave G,Jiang H,Fueyo J,Patiño-García A,Gomez-Manzano C,Alonso MM
14-5773 was used in Immunohistochemistry to highlight the potential of this virus as treatment for patients with these tumors.
Tue May 28 00:00:00 UTC 2019
The oncolytic virus Delta-24-RGD elicits an antitumor effect in pediatric glioma and DIPG mouse models.
Nature communications
Martínez-Vélez N,Garcia-Moure M,Marigil M,González-Huarriz M,Puigdelloses M,Gallego Pérez-Larraya J,Zalacaín M,Marrodán L,Varela-Guruceaga M,Laspidea V,Aristu JJ,Ramos LI,Tejada-Solís S,Díez-Valle R,Jones C,Mackay A,Martínez-Climent JA,García-Barchino MJ,Raabe E,Monje M,Becher OJ,Junier MP,El-Habr EA,Chneiweiss H,Aldave G,Jiang H,Fueyo J,Patiño-García A,Gomez-Manzano C,Alonso MM
14-5773 was used in Immunohistochemistry to highlight the potential of this virus as treatment for patients with these tumors.
Tue May 28 00:00:00 UTC 2019
An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma.
Cell reports
Carper MB,Troutman S,Wagner BL,Byrd KM,Selitsky SR,Parag-Sharma K,Henry EC,Li W,Parker JS,Montgomery SA,Cleveland JL,Williams SE,Kissil JL,Hayes DN,Amelio AL
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Tue Nov 05 00:00:00 UTC 2019
Loss of TET2 and TET3 in regulatory T cells unleashes effector function.
Nature communications
Yue X,Lio CJ,Samaniego-Castruita D,Li X,Rao A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed May 01 00:00:00 UTC 2019
Vitamin D in Acute Campylobacteriosis-Results From an Intervention Study Applying a Clinical Campylobacter jejuni Induced Enterocolitis Model.
Frontiers in immunology
Mousavi S,Lobo de Sá FD,Schulzke JD,Bücker R,Bereswill S,Heimesaat MM
14-5773 was used in Immunohistochemistry to show that synthetic 25-OH-cholecalciferol injected perorally, acts as an anti-inflammatory during acute campylobacteriosis.
Mon Nov 09 00:00:00 UTC 2020
Generation of Foxp3+CD25- Regulatory T-Cell Precursors Requires c-Rel and IκBNS.
Frontiers in immunology
Schuster M,Plaza-Sirvent C,Visekruna A,Huehn J,Schmitz I
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Jun 04 00:00:00 UTC 2020
Mesenchymal Stem Cells Extract (MSCsE)-Based Therapy Alleviates Xerostomia and Keratoconjunctivitis Sicca in Sjogren's Syndrome-Like Disease.
International journal of molecular sciences
Abughanam G,Elkashty OA,Liu Y,Bakkar MO,Tran SD
14-5773 was used in Immunohistochemistry to compare the efficacy of Mesenchymal stem cells (MSCs) and MSCs extract (MSCsE) in preserving the exocrine function of salivary and lacrimal glands in a mouse model of Sjogren's Syndrome-Like Disease.
Wed Sep 25 00:00:00 UTC 2019
A20 as an immune tolerance factor can determine islet transplant outcomes.
JCI insight
Zammit NW,Walters SN,Seeberger KL,O'Connell PJ,Korbutt GS,Grey ST
14-5773 was used in Immunohistochemistry to investigate the impact of changing A20 expression levels in islet allografts as a mechanism to modify immunostimulatory thresholds and islet allograft survival.
Fri Nov 01 00:00:00 UTC 2019
A20 as an immune tolerance factor can determine islet transplant outcomes.
JCI insight
Zammit NW,Walters SN,Seeberger KL,O'Connell PJ,Korbutt GS,Grey ST
14-5773 was used in Immunohistochemistry to investigate the impact of changing A20 expression levels in islet allografts as a mechanism to modify immunostimulatory thresholds and islet allograft survival.
Fri Nov 01 00:00:00 UTC 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Oct 14 00:00:00 UTC 2020
Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.
Scientific reports
Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Dec 11 00:00:00 UTC 2019
Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice.
Nature microbiology
Wotzka SY,Kreuzer M,Maier L,Arnoldini M,Nguyen BD,Brachmann AO,Berthold DL,Zünd M,Hausmann A,Bakkeren E,Hoces D,Gül E,Beutler M,Dolowschiak T,Zimmermann M,Fuhrer T,Moor K,Sauer U,Typas A,Piel J,Diard M,Macpherson AJ,Stecher B,Sunagawa S,Slack E,Hardt WD
14-5773-82 was used in Flow Cytometry to determine whether food composition shifts enhance susceptibility to infection as diet affects microbiota composition.
Sun Dec 01 00:00:00 UTC 2019
IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury.
JCI insight
Liu Q,Dwyer GK,Zhao Y,Li H,Mathews LR,Chakka AB,Chandran UR,Demetris JA,Alcorn JF,Robinson KM,Ortiz LA,Pitt BR,Thomson AW,Fan MH,Billiar TR,Turnquist HR
14-5773 was used in Flow cytometry/Cell sorting to study the anti-inflammatory actions of interleukins and effects on shaping myeloid compartment post lung injury.
Thu Mar 21 00:00:00 UTC 2019
Mucin O-glycans facilitate symbiosynthesis to maintain gut immune homeostasis.
EBioMedicine
Yamada T,Hino S,Iijima H,Genda T,Aoki R,Nagata R,Han KH,Hirota M,Kinashi Y,Oguchi H,Suda W,Furusawa Y,Fujimura Y,Kunisawa J,Hattori M,Fukushima M,Morita T,Hase K
14-5773 was used in Flow cytometry/Cell sorting to propose that abnormal mucin utilisation may lead to reduced n-butyrate production in ulcerative colitis patients and that mucin o-glycans can facilitate symbiosynthesis of n-butyrate by gut microbiota.
Tue Oct 01 00:00:00 UTC 2019
Multidrug-Resistant Pseudomonas aeruginosa Accelerate Intestinal, Extra-Intestinal, and Systemic Inflammatory Responses in Human Microbiota-Associated Mice With Subacute Ileitis.
Frontiers in immunology
Heimesaat MM,Escher U,Grunau A,Kühl AA,Bereswill S
14-5773 was used in Immunohistochemistry to study the factors facilitating gastrointestinal Pseudomonas aeruginosa-acquisition by the vertebrate host and subsequently induced inflammatory sequelae.
Fri Dec 20 00:00:00 UTC 2019
CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells.
Journal of neuroinflammation
Yang CL,Zhang P,Liu RT,Zhang N,Zhang M,Li H,Du T,Li XL,Dou YC,Duan RS
14-5773-82 was used in Flow Cytometry to investigate the function of NK cells in experimental autoimmune myasthenia gravis in vivo.
Sun Dec 29 00:00:00 UTC 2019
miR-511-3p protects against cockroach allergen-induced lung inflammation by antagonizing CCL2.
JCI insight
Do DC,Mu J,Ke X,Sachdeva K,Qin Z,Wan M,Ishmael FT,Gao P
14-5773 was used in Flow cytometry/Cell sorting to identify how miR-511-3p regulates allergic inflammation and macrophage polarisation by inhibiting Ccl2 and its downstream Ccr2/RhoA downstream axis.
Thu Oct 17 00:00:00 UTC 2019
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-5773 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 UTC 2021
Hepatic Stellate Cells Enhance Liver Cancer Progression by Inducing Myeloid-Derived Suppressor Cells through Interleukin-6 Signaling.
International journal of molecular sciences
Hsieh CC,Hung CH,Chiang M,Tsai YC,He JT
14-5773-82 was used in Flow Cytometry to provide in vitro and in vivo evidences that HSCs induce the generation of MDSCs to promote hepatocellular carcinoma (HCC) progression through interleukin (IL)-6 secretion.
Sun Oct 13 00:00:00 UTC 2019
The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability.
Frontiers in immunology
Ronin E,Lubrano di Ricco M,Vallion R,Divoux J,Kwon HK,Grégoire S,Collares D,Rouers A,Baud V,Benoist C,Salomon BL
14-5773-82 was used in Flow Cytometry to show that RelA, a key member of the NF-κB complex, is critical for Treg biology as it promotes both the generation of their effector phenotype and the maintenance of their identity.
Thu Oct 29 00:00:00 UTC 2020
Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
JCI insight
Kono M,Maeda K,Stocton-Gavanescu I,Pan W,Umeda M,Katsuyama E,Burbano C,Orite SYK,Vukelic M,Tsokos MG,Yoshida N,Tsokos GC
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that CaMK4 binds to PKM2 and promotes its activity, which is requisite for Th1 and Th17 differentiation.
Thu Jun 20 00:00:00 UTC 2019
A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Oncoimmunology
Lévesque S,Le Naour J,Pietrocola F,Paillet J,Kremer M,Castoldi F,Baracco EE,Wang Y,Vacchelli E,Stoll G,Jolly A,De La Grange P,Zitvogel L,Kroemer G,Pol JG
14-5773-82 was used in In Vivo to point to the possibility of synergistic interactions among distinct classes of anticancer agents.
Sat Jul 20 00:00:00 UTC 2024
Complementary Roles of GCN5 and PCAF in Foxp3+ T-Regulatory Cells.
Cancers
Liu Y,Bao C,Wang L,Han R,Beier UH,Akimova T,Cole PA,Dent SYR,Hancock WW
14-5773 was used in Immunocytochemistry to show that two prototypical GNAT family members, GCN5 (general control nonrepressed-protein 5, lysine acetyltransferase (KAT)2a) and p300/CBP-associated factor (p300/CBP-associated factor (PCAF), Kat2b) contribute to Treg functions through partially distinct and partially overlapping mechanisms.
Thu Apr 18 00:00:00 UTC 2019
Delta-24-RGD combined with radiotherapy exerts a potent antitumor effect in diffuse intrinsic pontine glioma and pediatric high grade glioma models.
Acta neuropathologica communications
Martinez-Velez N,Marigil M,García-Moure M,Gonzalez-Huarriz M,Aristu JJ,Ramos-García LI,Tejada S,Díez-Valle R,Patiño-García A,Becher OJ,Gomez-Manzano C,Fueyo J,Alonso MM
14-5773-82 was used in Immunohistochemistry to evaluate the feasibility, safety and therapeutic efficacy of Delta-24-RGD, a genetically engineered tumor-selective adenovirus, in combination with radiotherapy in pediatric high grade glioma and diffuse intrinsic pontine glioma models.
Mon Apr 29 00:00:00 UTC 2019
90Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin's Lymphoma.
Communications biology
Hernandez R,Walker KL,Grudzinski JJ,Aluicio-Sarduy E,Patel R,Zahm CD,Pinchuk AN,Massey CF,Bitton AN,Brown RJ,Sondel PM,Morris ZS,Engle JW,Capitini CM,Weichert JP
Wed Apr 22 00:00:00 UTC 2020
The Aged Microenvironment Influences the Tumorigenic Potential of Malignant Prostate Epithelial Cells.
Molecular cancer research : MCR
Bianchi-Frias D,Damodarasamy M,Hernandez SA,Gil da Costa RM,Vakar-Lopez F,Coleman IM,Reed MJ,Nelson PS
14-5773-82 was used in Immunohistochemistry to demonstrate the importance of age-associated tumor microenvironment alterations in regulating key aspects of prostate cancer progression.
Tue Jan 01 00:00:00 UTC 2019
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Jun 28 00:00:00 UTC 2018
The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment.
Immunity
Mollaoglu G,Jones A,Wait SJ,Mukhopadhyay A,Jeong S,Arya R,Camolotto SA,Mosbruger TL,Stubben CJ,Conley CJ,Bhutkar A,Vahrenkamp JM,Berrett KC,Cessna MH,Lane TE,Witt BL,Salama ME,Gertz J,Jones KB,Snyder EL,Oliver TG
14-5773 was used in Immunohistochemistry to identify that SOX2 and NKX2-1 lineage-defining transcription factors regulate tumour immune microenvironment and determine lung cancer cell fate.
Tue Oct 16 00:00:00 UTC 2018
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.
Cancer cell
Zappasodi R,Budhu S,Hellmann MD,Postow MA,Senbabaoglu Y,Manne S,Gasmi B,Liu C,Zhong H,Li Y,Huang AC,Hirschhorn-Cymerman D,Panageas KS,Wherry EJ,Merghoub T,Wolchok JD
14-5773-82 was used in Flow Cytometry to provide evidence that mouse and human circulating and intra-tumor 4PD1hi inhibit T cell functions in a PD-1/PD-L1 dependent fashion and resemble follicular helper T cell (TFH)-like cells.
Mon Jun 11 00:00:00 UTC 2018
Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.
The Journal of clinical investigation
Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM
Mon Jul 02 00:00:00 UTC 2018
Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.
The Journal of clinical investigation
Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM
Mon Jul 02 00:00:00 UTC 2018
Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.
The Journal of clinical investigation
Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM
Mon Jul 02 00:00:00 UTC 2018
PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.
The Journal of clinical investigation
Kraakman MJ,Liu Q,Postigo-Fernandez J,Ji R,Kon N,Larrea D,Namwanje M,Fan L,Chan M,Area-Gomez E,Fu W,Creusot RJ,Qiang L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Jun 01 00:00:00 UTC 2018
Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response.
The Journal of clinical investigation
Ubil E,Caskey L,Holtzhausen A,Hunter D,Story C,Earp HS
14-5773 was used in Immunohistochemistry to demonstrate that tumour-secreted protein S, a Mer/Tyro3 ligand, decreases macrophage M1 cytokine expression in vitro and in vivo.
Fri Jun 01 00:00:00 UTC 2018
Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells.
The Journal of experimental medicine
Delpoux A,Michelini RH,Verma S,Lai CY,Omilusik KD,Utzschneider DT,Redwood AJ,Goldrath AW,Benedict CA,Hedrick SM
14-5773 was used in Flow cytometry/Cell sorting to show that FOXO1 is continuously required for all the phenotypic characteristics of memory-effector T cells.
Mon Feb 05 00:00:00 UTC 2018
Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion.
The Journal of experimental medicine
Lynch JP,Werder RB,Loh Z,Sikder MAA,Curren B,Zhang V,Rogers MJ,Lane K,Simpson J,Mazzone SB,Spann K,Hayball J,Diener K,Everard ML,Blyth CC,Forstner C,Dennis PG,Murtaza N,Morrison M,Ó Cuív P,Zhang P,Haque A,Hill GR,Sly PD,Upham JW,Phipps S
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to identify that transient plasmacytoid dendritic cell depletion during primary Pneumovirus infection alone predisposes to severe bronchiolitis in early life and subsequent asthma in later life after reinfection.
Mon Feb 05 00:00:00 UTC 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-5773 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 UTC 2018
The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.
The Journal of experimental medicine
Balbinot C,Armant O,Elarouci N,Marisa L,Martin E,De Clara E,Onea A,Deschamps J,Beck F,Freund JN,Duluc I
14-5773 was used in Immunohistochemistry-immunofluorescence to study the mechanisms by which the Cdx25 homeobox gene suppresses intestinal tumourigenesis.
Mon Mar 05 00:00:00 UTC 2018
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells.
The Journal of experimental medicine
Seki A,Rutz S
14-5773 was used in Flow cytometry/Cell sorting to develop an optimised approach for Cas9/RNP transfection of primary mouse and human T cells without TCR stimulation, that results in near complete loss of target gene expression at the population level.
Mon Mar 05 00:00:00 UTC 2018
IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN.
Journal of the American Society of Nephrology : JASN
Diefenhardt P,Nosko A,Kluger MA,Richter JV,Wegscheid C,Kobayashi Y,Tiegs G,Huber S,Flavell RA,Stahl RAK,Steinmetz OM
14-5773 was used in Immunohistochemistry to identify and characterize mechanisms responsible for generation, activation, and functional differentiation of Tregs.
Sun Jul 01 00:00:00 UTC 2018
Elective Nodal Irradiation Attenuates the Combinatorial Efficacy of Stereotactic Radiation Therapy and Immunotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Marciscano AE,Ghasemzadeh A,Nirschl TR,Theodros D,Kochel CM,Francica BJ,Muroyama Y,Anders RA,Sharabi AB,Velarde E,Mao W,Chaudhary KR,Chaimowitz MG,Wong J,Selby MJ,Thudium KB,Korman AJ,Ulmert D,Thorek DLJ,DeWeese TL,Drake CG
14-5773 was used in Flow cytometry/Cell sorting to study the effects of elective novel irradiation on the adaptive immune system and if this increases its antitumour effects.
Mon Oct 15 00:00:00 UTC 2018
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Autophagy
Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 22 00:00:00 UTC 2019
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy
Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Apr 04 00:00:00 UTC 2018
Bryostatin-1 alleviates experimental multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Feb 27 00:00:00 UTC 2018
MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis.
Proceedings of the National Academy of Sciences of the United States of America
Suarez-Lopez L,Sriram G,Kong YW,Morandell S,Merrick KA,Hernandez Y,Haigis KM,Yaffe MB
14-5773 was used in Immunohistochemistry to show that p38/MAPKAP Kinase 2 activity in the myeloid compartment promotes tumour progression by supporting tumour neoangiogenesis in vivo.
Tue May 01 00:00:00 UTC 2018
Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.
PLoS biology
Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B
14-5773 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.
Tue May 01 00:00:00 UTC 2018
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.
British journal of pharmacology
Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.
British journal of pharmacology
Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Apr 01 00:00:00 UTC 2018
Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology
LaMothe RA,Kolte PN,Vo T,Ferrari JD,Gelsinger TC,Wong J,Chan VT,Ahmed S,Srinivasan A,Deitemeyer P,Maldonado RA,Kishimoto TK
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Mar 21 00:00:00 UTC 2019
CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.
Frontiers in immunology
Cobbold SP,Adams E,Howie D,Waldmann H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Jan 31 00:00:00 UTC 2022
Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions.
Mucosal immunology
Varanasi SK,Rajasagi NK,Jaggi U,Rouse BT
14-5773 was used in Flow cytometry/Cell sorting to investigate IL-18's mechanisms to control of inflammatory lesions in the cornea caused by the herpes infection.
Thu Nov 01 00:00:00 UTC 2018
Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.
Immunology
Yap JY,Wirasinha RC,Chan A,Howard DR,Goodnow CC,Daley SR
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Jul 01 00:00:00 UTC 2018
TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tsutsui M,Hirase R,Miyamura S,Nagayasu K,Nakagawa T,Mori Y,Shirakawa H,Kaneko S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Sep 26 00:00:00 UTC 2018
Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Sprouse ML,Shevchenko I,Scavuzzo MA,Joseph F,Lee T,Blum S,Borowiak M,Bettini ML,Bettini M
14-5773 was used in Flow cytometry/Cell sorting to reveal a role for both high- and low-affinity Tregs in the control of autoimmunity.
Thu Feb 01 00:00:00 UTC 2018
Cleavage of TL1A Differentially Regulates Its Effects on Innate and Adaptive Immune Cells.
Journal of immunology (Baltimore, Md. : 1950)
Ferdinand JR,Richard AC,Meylan F,Al-Shamkhani A,Siegel RM
14-5773 was used in Flow cytometry/Cell sorting to suggest differential roles for membrane and soluble TL1A on adaptive and innate immune cells and have implications for the consequences of blocking these two forms of TL1A.
Thu Feb 15 00:00:00 UTC 2018
FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma.
International journal of molecular medicine
Skarmoutsou E,Bevelacqua V,D' Amico F,Russo A,Spandidos DA,Scalisi A,Malaponte G,Guarneri C
14-5773 was used in Western Blotting to demonstrate that NOTCH1 is a central mediator of TGF-β-mediated FOXP3 expression and NOTCH1 inhibition reduces melanoma cell proliferation and viability.
Sun Jul 01 00:00:00 UTC 2018
Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas.
Journal of neuro-oncology
Filley A,Henriquez M,Bhowmik T,Tewari BN,Rao X,Wan J,Miller MA,Liu Y,Bentley RT,Dey M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in In Situ Hybridization (ISH)
Tue May 01 00:00:00 UTC 2018
CTLA4Ig Improves Murine iTreg Induction via TGFβ and Suppressor Function In Vitro.
Journal of immunology research
Pilat N,Mahr B,Gattringer M,Baranyi U,Wekerle T
14-5773 was used in Flow cytometry/Cell sorting to investigate the compatibility of CTLA4lg with regulatory T cells by evaluating direct effects of CTLA4lg on murine Treg generation and function in vitro.
Mon Nov 05 00:00:00 UTC 2018
Modulated electro-hyperthermia induced loco-regional and systemic tumor destruction in colorectal cancer allografts.
Journal of Cancer
Vancsik T,Kovago C,Kiss E,Papp E,Forika G,Benyo Z,Meggyeshazi N,Krenacs T
14-5773 was used in Immunohistochemistry to test the modulated electro-hyperthermia induced stress and immune responses, in C26 colorectal cancer allografts.
Thu Oct 01 00:00:00 UTC 2020
PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani.
Infection and immunity
Habib S,El Andaloussi A,Elmasry K,Handoussa A,Azab M,Elsawey A,Al-Hendy A,Ismail N
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Jun 01 00:00:00 UTC 2018
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model.
EJNMMI research
Tomita M,Yasui H,Higashikawa K,Nakajima K,Takakura H,Shiga T,Kuge Y,Ogawa M
14-5773-82 was used in Flow Cytometry to show that anti PD-1 therapy increases glucose metabolism in cancer cells.
Thu Aug 16 00:00:00 UTC 2018
Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.
Oncology letters
Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Sep 01 00:00:00 UTC 2018
Combined treatment with simvastatin and rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells.
Experimental and therapeutic medicine
Liu Y,Sun L,Chen W,Chuai J,Shang Y,Zhang D,Fu B,Tian H,Jiang S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Feb 01 00:00:00 UTC 2018
Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma.
Experimental and therapeutic medicine
Wei Y,Zhang Z,Wang F,Zhou S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Jan 01 00:00:00 UTC 2018
Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.
Scientific reports
Quan S,Principe DR,Dean AE,Park SH,Grippo PJ,Gius D,Horikoshi N
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Nov 07 00:00:00 UTC 2018
High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice.
Scientific reports
Dar HY,Singh A,Shukla P,Anupam R,Mondal RK,Mishra PK,Srivastava RK
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Feb 06 00:00:00 UTC 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Nov 08 00:00:00 UTC 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Jan 31 00:00:00 UTC 2018
REV-ERBα Regulates TH17 Cell Development and Autoimmunity.
Cell reports
Amir M,Chaudhari S,Wang R,Campbell S,Mosure SA,Chopp LB,Lu Q,Shang J,Pelletier OB,He Y,Doebelin C,Cameron MD,Kojetin DJ,Kamenecka TM,Solt LA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Dec 26 00:00:00 UTC 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Feb 05 00:00:00 UTC 2018
Control of Treg cell homeostasis and immune equilibrium by Lkb1 in dendritic cells.
Nature communications
Chen S,Fang L,Guo W,Zhou Y,Yu G,Li W,Dong K,Liu J,Luo Y,Wang B,Li Z,Zhao C,Sun Z,Shen Y,Leng Q,Zhou D,Han Z,Huang H,Ren H,Xu G,Feng X
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Dec 13 00:00:00 UTC 2018
Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer.
Journal for immunotherapy of cancer
Pennock ND,Martinson HA,Guo Q,Betts CB,Jindal S,Tsujikawa T,Coussens LM,Borges VF,Schedin P
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to implicate beneficial prophylactic use of ibuprofen during the pro-tumorigenic window of mammary gland involution.
Mon Oct 01 00:00:00 UTC 2018
Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer.
Journal for immunotherapy of cancer
Pennock ND,Martinson HA,Guo Q,Betts CB,Jindal S,Tsujikawa T,Coussens LM,Borges VF,Schedin P
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to implicate beneficial prophylactic use of ibuprofen during the pro-tumorigenic window of mammary gland involution.
Mon Oct 01 00:00:00 UTC 2018
Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells.
Cell reports
Ogawa C,Bankoti R,Nguyen T,Hassanzadeh-Kiabi N,Nadeau S,Porritt RA,Couse M,Fan X,Dhall D,Eberl G,Ohnmacht C,Martins GA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Oct 02 00:00:00 UTC 2018
Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury.
Journal of neuroinflammation
Alizadeh A,Santhosh KT,Kataria H,Gounni AS,Karimi-Abdolrezaee S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Feb 21 00:00:00 UTC 2018
Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.
Nature communications
Chen D,Xie J,Fiskesund R,Dong W,Liang X,Lv J,Jin X,Liu J,Mo S,Zhang T,Cheng F,Zhou Y,Zhang H,Tang K,Ma J,Liu Y,Huang B
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Feb 28 00:00:00 UTC 2018
Peroral Low-Dose Toxoplasma gondii Infection of Human Microbiota-Associated Mice - A Subacute Ileitis Model to Unravel Pathogen-Host Interactions.
European journal of microbiology & immunology
Heimesaat MM,Escher U,Grunau A,Fiebiger U,Bereswill S
14-5773 was used in Immunohistochemistry to study the pathogen-host interactions of Toxoplasma gondii infection in human microbiota-associated mice.
Mon Jun 25 00:00:00 UTC 2018
Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment.
Nature communications
Wunderlich CM,Ackermann PJ,Ostermann AL,Adams-Quack P,Vogt MC,Tran ML,Nikolajev A,Waisman A,Garbers C,Theurich S,Mauer J,Hövelmeyer N,Wunderlich FT
14-5773 was used in Immunohistochemistry to investigate whether obesity-induced inflammation predisposes to colorectal cancer development.
Wed Apr 25 00:00:00 UTC 2018
Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.
Nature communications
Lopes N,Charaix J,Cédile O,Sergé A,Irla M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Mar 28 00:00:00 UTC 2018
Inflammation-induced Id2 promotes plasticity in regulatory T cells.
Nature communications
Hwang SM,Sharma G,Verma R,Byun S,Rudra D,Im SH
14-5773 was used in Flow cytometry/Cell sorting to show that pro-inflammatory cytokines enhance the expression of transcription regulator Id2, which mediates cellular plasticity of Treg into ex-Foxp3 TH17 cells.
Fri Nov 09 00:00:00 UTC 2018
Heart functional and structural compendium of cardiosplenic and cardiorenal networks in acute and chronic heart failure pathology.
American journal of physiology. Heart and circulatory physiology
Halade GV,Kain V,Ingle KA
14-5773-82 was used in Immunohistochemistry to determine comprehensive functional analysis of the LV using echocardiography in transition from acute heart failure (AHF) to progressive chronic heart failure (CHF) pathology and developed a histological compendium of the cardiosplenic and cardiorenal networks in pathological remodeling.
Thu Feb 01 00:00:00 UTC 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
14-5773 was used in Flow cytometry/Cell sorting to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.
Wed Sep 26 00:00:00 UTC 2018
CSF1R-dependent myeloid cells are required for NK‑mediated control of metastasis.
JCI insight
Beffinger M,Tallón de Lara P,Tugues S,Vermeer M,Montagnolo Y,Ohs I,Cecconi V,Lucchiari G,Gagliardi A,Misljencevic N,Sutton J,Spörri R,Becher B,Gupta A,van den Broek M
14-5773 was used in Flow cytometry/Cell sorting to reveal that neo-adjuvant treatment of mouse lung cancer with CSF1R blockade unexpectedly promoted metastasis and indirectly caused a reduction in the number of NK cells.
Thu May 17 00:00:00 UTC 2018
Respiratory Bordetella bronchiseptica Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4⁺CD25⁺ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice.
International journal of molecular sciences
Jeron A,Boehme JD,Volckmar J,Gereke M,Yevsa T,Geffers R,Guzmán CA,Schreiber J,Stegemann-Koniszewski S,Bruder D
14-5773 was used in Flow cytometry/Cell sorting to study the effects of respiratory bacterial carriage on the immune system and its implications for secondary responses.
Sat Sep 01 00:00:00 UTC 2018
Accumulation of IL-17+ Vγ6+ γδ T cells in pregnant mice is not associated with spontaneous abortion.
Clinical & translational immunology
Polese B,Gridelet V,Perrier d'Hauterive S,Renard C,Munaut C,Martens H,Vermijlen D,King IL,Jacobs N,Geenen V
14-5773 was used in Flow cytometry/Cell sorting to define the kinetics and cellular source of IL-17A in the uterus during healthy and abortion-prone murine pregnancy.
Wed Sep 30 00:00:00 UTC 2020
Induction of immunosuppressive functions and NF-κB by FLIP in monocytes.
Nature communications
Fiore A,Ugel S,De Sanctis F,Sandri S,Fracasso G,Trovato R,Sartoris S,Solito S,Mandruzzato S,Vascotto F,Hippen KL,Mondanelli G,Grohmann U,Piro G,Carbone C,Melisi D,Lawlor RT,Scarpa A,Lamolinara A,Iezzi M,Fassan M,Bicciato S,Blazar BR,Sahin U,Murray PJ,Bronte V
14-5773 was used in Immunohistochemistry to demonstrate that low-dose cytotoxic chemotherapy agents cause apoptosis linked to c-FLIP down-regulation selectively in monocytes.
Wed Dec 05 00:00:00 UTC 2018
An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis.
Scientific reports
Yamashita T,Lakota K,Taniguchi T,Yoshizaki A,Sato S,Hong W,Zhou X,Sodin-Semrl S,Fang F,Asano Y,Varga J
14-5773 was used in Flow cytometry/Cell sorting to study the effectiveness of AdipoRon, an orally active adiponectin receptor agonist, in treatment of systemic sclerosis in mice.
Tue Aug 07 00:00:00 UTC 2018
Intact interleukin-10 receptor signaling protects from hippocampal damage elicited by experimental neurotropic virus infection of SJL mice.
Scientific reports
Uhde AK,Ciurkiewicz M,Herder V,Khan MA,Hensel N,Claus P,Beckstette M,Teich R,Floess S,Baumgärtner W,Jung K,Huehn J,Beineke A
14-5773 was used in Immunohistochemistry to study IL-10R signaling following virus-induced polioencephalitis in SJL mice.
Tue Apr 17 00:00:00 UTC 2018
CCL3 Promotes Germinal Center B Cells Sampling by Follicular Regulatory T Cells in Murine Lymph Nodes.
Frontiers in immunology
Benet ZL,Marthi M,Ke F,Wu R,Turner JS,Gabayre JB,Ivanitskiy MI,Sethi SS,Grigorova IL
14-5773 was used in Flow cytometry/Cell sorting to suggest that CCL3 facilitates direct interactions of foreign antigen-specific GC B cells and their negative regulation with Tfr cells in vivo.
Mon Sep 30 00:00:00 UTC 2019
Factors Produced by Macrophages Eliminating Apoptotic Cells Demonstrate Pro-Resolutive Properties and Terminate Ongoing Inflammation.
Frontiers in immunology
Bonnefoy F,Gauthier T,Vallion R,Martin-Rodriguez O,Missey A,Daoui A,Valmary-Degano S,Saas P,Couturier M,Perruche S
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that the factors produced by macrophages eliminating apoptotic cells were sufficient to reboot the resolution of inflammation in vivo, and thus definitively terminated ongoing chronic inflammation.
Thu Oct 03 00:00:00 UTC 2019
Immunomodulatory role of Keratin 76 in oral and gastric cancer.
Nature communications
Sequeira I,Neves JF,Carrero D,Peng Q,Palasz N,Liakath-Ali K,Lord GM,Morgan PR,Lombardi G,Watt FM
14-5773 was used in Flow cytometry/Cell sorting to demonstrate keratin 76 in epithelial cells regulate carcinocgenesis via communication with cells of the immune system.
Fri Aug 24 00:00:00 UTC 2018
Multidrug-resistant Pseudomonas aeruginosa aggravates inflammatory responses in murine chronic colitis.
Scientific reports
von Klitzing E,Ekmekciu I,Kühl AA,Bereswill S,Heimesaat MM
14-5773 was used in Immunohistochemistry to study whether chronic murine gut inflammation facilitates intestinal multi-drug resistant Pseudomonas aeruginosa colonisation, and whether bacterial infection subsequently worsens colonic immunopathology.
Fri Apr 27 00:00:00 UTC 2018
IL-23R Deficiency Does Not Impact Atherosclerotic Plaque Development in Mice.
Journal of the American Heart Association
Engelbertsen D,Depuydt MAC,Verwilligen RAF,Rattik S,Levinsohn E,Edsfeldt A,Kuperwaser F,Jarolim P,Lichtman AH
14-5773 was used in Flow cytometry/Cell sorting to investigate the presence of IL-23R expressing cells in the atherosclerotic aorta and it's effect on development when deficient.
Wed Apr 04 00:00:00 UTC 2018
Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity.
Cell
Overacre-Delgoffe AE,Chikina M,Dadey RE,Yano H,Brunazzi EA,Shayan G,Horne W,Moskovitz JM,Kolls JK,Sander C,Shuai Y,Normolle DP,Kirkwood JM,Ferris RL,Delgoffe GM,Bruno TC,Workman CJ,Vignali DAA
14-5773 was used in Flow cytometry/Cell sorting to identify the basis for Nrp1 dependency and the key drivers of Treg fragility to improve immunotherapy for human cancer.
Thu Jun 01 00:00:00 UTC 2017
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Cancer cell
Palazon A,Tyrakis PA,Macias D,Veliça P,Rundqvist H,Fitzpatrick S,Vojnovic N,Phan AT,Loman N,Hedenfalk I,Hatschek T,Lövrot J,Foukakis T,Goldrath AW,Bergh J,Johnson RS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Nov 13 00:00:00 UTC 2017
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity.
Cancer discovery
Loo TM,Kamachi F,Watanabe Y,Yoshimoto S,Kanda H,Arai Y,Nakajima-Takagi Y,Iwama A,Koga T,Sugimoto Y,Ozawa T,Nakamura M,Kumagai M,Watashi K,Taketo MM,Aoki T,Narumiya S,Oshima M,Arita M,Hara E,Ohtani N
14-5773 was used in Flow cytometry/Cell sorting to show that the hepatic translocation of obesity-induced lipoteichoic acid (LTA), a Gram-positive gut microbial component, promotes HCC development by creating a tumor-promoting microenvironment.
Mon May 01 00:00:00 UTC 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Wed Apr 12 00:00:00 UTC 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Apr 12 00:00:00 UTC 2017
Different molecular complexes that mediate transcriptional induction and repression by FoxP3.
Nature immunology
Kwon HK,Chen HM,Mathis D,Benoist C
14-5773 was used in Western Blotting to show that FoxP3 acts in multimodal fashion to directly activate or repress transcription, in a context- and partner-dependent manner, to govern Tregcell phenotypes.
Wed Nov 01 00:00:00 UTC 2017
The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program.
Nature immunology
Wu C,Chen Z,Dardalhon V,Xiao S,Thalhamer T,Liao M,Madi A,Franca RF,Han T,Oukka M,Kuchroo V
14-5773 was used in Flow cytometry/Cell sorting to identify the TF Musculin (MSC) as critical for iTreg development by repression of TH2 transcriptional program, using Transforming growth factor-β (TGF-β) induced regulatory T cell (iTreg) system.
Wed Mar 01 00:00:00 UTC 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Mar 01 00:00:00 UTC 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Feb 01 00:00:00 UTC 2017
Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.
The Journal of clinical investigation
Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Aug 01 00:00:00 UTC 2017
CAMKIIγ suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis.
The Journal of clinical investigation
Doran AC,Ozcan L,Cai B,Zheng Z,Fredman G,Rymond CC,Dorweiler B,Sluimer JC,Hsieh J,Kuriakose G,Tall AR,Tabas I
14-5773-82 was used in Immunohistochemistry to identify a macrophage CaMKIIγ/ATF6/LXRα/MerTK pathway as a key factor in the development of necrotic atherosclerotic plaques.
Wed Nov 01 00:00:00 UTC 2017
Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction.
The Journal of clinical investigation
Ramjee V,Li D,Manderfield LJ,Liu F,Engleka KA,Aghajanian H,Rodell CB,Lu W,Ho V,Wang T,Li L,Singh A,Cibi DM,Burdick JA,Singh MK,Jain R,Epstein JA
14-5773 was used in Immunocytochemistry-immunoflourescence to suggest that epicardial Hippo signalling plays a key role in adaptive immune regulation during the post-myocardial infarction recovery phase.
Wed Mar 01 00:00:00 UTC 2017
Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction.
The Journal of clinical investigation
Ramjee V,Li D,Manderfield LJ,Liu F,Engleka KA,Aghajanian H,Rodell CB,Lu W,Ho V,Wang T,Li L,Singh A,Cibi DM,Burdick JA,Singh MK,Jain R,Epstein JA
14-5773 was used in Immunocytochemistry-immunoflourescence to suggest that epicardial Hippo signalling plays a key role in adaptive immune regulation during the post-myocardial infarction recovery phase.
Wed Mar 01 00:00:00 UTC 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-5773 was used in Western Blotting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 UTC 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-5773 was used in Western Blotting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 UTC 2017
Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.
The Journal of clinical investigation
Chung J,Ebens CL,Perkey E,Radojcic V,Koch U,Scarpellino L,Tong A,Allen F,Wood S,Feng J,Friedman A,Granadier D,Tran IT,Chai Q,Onder L,Yan M,Reddy P,Blazar BR,Huang AY,Brennan TV,Bishop DK,Ludewig B,Siebel CW,Radtke F,Luther SA,Maillard I
14-5773 was used in Flow cytometry/Cell sorting to reveal what we believe to be a previously unrecognised Notch-mediated immunopathogenic role for stromal cell niches in secondary lymphoid organs after allo-BMT and define a framework of early cellular and molecular interactions that regulate T cell alloimmunity.
Mon Apr 03 00:00:00 UTC 2017
PTEN drives Th17 cell differentiation by preventing IL-2 production.
The Journal of experimental medicine
Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Nov 06 00:00:00 UTC 2017
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H
14-5773 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.
Sun Jan 01 00:00:00 UTC 2017
NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.
The Journal of experimental medicine
Daley D,Mani VR,Mohan N,Akkad N,Pandian GSDB,Savadkar S,Lee KB,Torres-Hernandez A,Aykut B,Diskin B,Wang W,Farooq MS,Mahmud AI,Werba G,Morales EJ,Lall S,Wadowski BJ,Rubin AG,Berman ME,Narayanan R,Hundeyin M,Miller G
14-5773-82 was used in Flow Cytometry to suggest that targeting NLRP3 holds the promise for the immunotherapy of pancreatic ductal adenocarcinoma.
Mon Jun 05 00:00:00 UTC 2017
NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.
The Journal of experimental medicine
Daley D,Mani VR,Mohan N,Akkad N,Pandian GSDB,Savadkar S,Lee KB,Torres-Hernandez A,Aykut B,Diskin B,Wang W,Farooq MS,Mahmud AI,Werba G,Morales EJ,Lall S,Wadowski BJ,Rubin AG,Berman ME,Narayanan R,Hundeyin M,Miller G
14-5773-82 was used in Flow Cytometry to suggest that targeting NLRP3 holds the promise for the immunotherapy of pancreatic ductal adenocarcinoma.
Mon Jun 05 00:00:00 UTC 2017
Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid-Induced AKI.
Journal of the American Society of Nephrology : JASN
Martin-Sanchez D,Ruiz-Andres O,Poveda J,Carrasco S,Cannata-Ortiz P,Sanchez-Niño MD,Ruiz Ortega M,Egido J,Linkermann A,Ortiz A,Sanz AB
14-5773 was used in Immunohistochemistry to suggest that ferroptosis is the primary cause of FA-AKI and that immunogenicity secondary to ferroptosis may worsen the damage.
Sun Jan 01 00:00:00 UTC 2017
Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.
EMBO molecular medicine
Lopes N,Vachon H,Marie J,Irla M
14-5773 was used in Flow cytometry/Cell sorting to indicate that RANKL may be clinically useful to improve T-cell function recovery after bone marrow transplantation by controlling multiple facets of thymic regeneration.
Thu Jun 01 00:00:00 UTC 2017
Sarcoma Eradication by Doxorubicin and Targeted TNF Relies upon CD8+ T-cell Recognition of a Retroviral Antigen.
Cancer research
Probst P,Kopp J,Oxenius A,Colombo MP,Ritz D,Fugmann T,Neri D
14-5773 was used in Immunohistochemistry-immunofluorescence to study the use of TNF-linked antibodies to eradicate sarcomas in immunocompetent mice.
Sat Jul 01 00:00:00 UTC 2017
TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity.
Proceedings of the National Academy of Sciences of the United States of America
Lukas D,Yogev N,Kel JM,Regen T,Mufazalov IA,Tang Y,Wanke F,Reizis B,Müller W,Kurschus FC,Prinz M,Kleiter I,Clausen BE,Waisman A
14-5773 was used in Flow cytometry/Cell sorting to demonstrate the role of Smad7 in the differentiation of dendritic cells in mice and their influence on the efficient function in immunity.
Tue Feb 21 00:00:00 UTC 2017
Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.
Proceedings of the National Academy of Sciences of the United States of America
Miosge LA,Sontani Y,Chuah A,Horikawa K,Russell TA,Mei Y,Wagle MV,Howard DR,Enders A,Tscharke DC,Goodnow CC,Parish IA
14-5773 was used in Flow cytometry/Cell sorting to identify a crucial role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritise mutations in genes of unknown function with potential effects on the immune system.
Tue Jun 27 00:00:00 UTC 2017
IL-2 prevents deletion of developing T-regulatory cells in the thymus.
Cell death and differentiation
Hu DY,Wirasinha RC,Goodnow CC,Daley SR
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Jun 01 00:00:00 UTC 2017
A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis.
Gut microbes
Colpitts SL,Kasper EJ,Keever A,Liljenberg C,Kirby T,Magori K,Kasper LH,Ochoa-Repáraz J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Nov 02 00:00:00 UTC 2017
RelB+ Steady-State Migratory Dendritic Cells Control the Peripheral Pool of the Natural Foxp3+ Regulatory T Cells.
Frontiers in immunology
Döhler A,Schneider T,Eckert I,Ribechini E,Andreas N,Riemann M,Reizis B,Weih F,Lutz MB
14-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying how dendritic cells manage to keep the peripheral pool of natural Foxp3+ regulatory T cells at constant levels.
Wed Nov 20 00:00:00 UTC 2019
Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation.
The Journal of cell biology
Vander Lugt B,Riddell J,Khan AA,Hackney JA,Lesch J,DeVoss J,Weirauch MT,Singh H,Mellman I
14-5773 was used in Flow cytometry/Cell sorting to study how DCs modulate their ability to prime tolerogenic or immunogenic T cells by expressing a core antigen presentation module that is overlaid by distinctive regulatory modules to promote either tolerance or immunity.
Mon Mar 06 00:00:00 UTC 2017
Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy.
International journal of cancer
Santos JM,Havunen R,Siurala M,Cervera-Carrascon V,Tähtinen S,Sorsa S,Anttila M,Karell P,Kanerva A,Hemminki A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Oct 01 00:00:00 UTC 2017
Potency-matched Dual Cytokine-Antibody Fusion Proteins for Cancer Therapy.
Molecular cancer therapeutics
De Luca R,Soltermann A,Pretto F,Pemberton-Ross C,Pellegrini G,Wulhfard S,Neri D
14-5773 was used in Immunofluorescence in immunohistochemistry on frozen tissues to develop a novel biopharmaceutical, consisting of the F8 mAb (specific to a splice isoform of fibronectin) simultaneously fused to both TNF and IL2, for cancer therapy.
Wed Nov 01 00:00:00 UTC 2017
The Major Histocompatibility Complex Class III Haplotype Ltab-Ncr3 Regulates Adjuvant-Induced but Not Antigen-Induced Autoimmunity.
The American journal of pathology
Yau ACY,Tuncel J,Holmdahl R
14-5773 was used in Flow cytometry/Cell sorting to find that Ltab-Ncr3 is specific in regulating adjuvant-induced arthritis but not antigen-induced autoimmunity.
Mon May 01 00:00:00 UTC 2017
The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Aug 15 00:00:00 UTC 2017
Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.
Journal of immunology (Baltimore, Md. : 1950)
Leigh ND,O'Neill RE,Du W,Chen C,Qiu J,Ashwell JD,McCarthy PL,Chen GL,Cao X
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that host CD70 serves as a unique negative regulator of allogeneic T cell response by contributing to donor T cell apoptosis and inhibiting expansion of donor effector T cells.
Sat Jul 01 00:00:00 UTC 2017
Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Kyburz A,Urban S,Altobelli A,Floess S,Huehn J,Cover TL,Müller A
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Oct 01 00:00:00 UTC 2017
Overexpression of fibrinogen-like protein 2 protects against T cell-induced colitis.
World journal of gastroenterology
Bartczak A,Zhang J,Adeyi O,Amir A,Grant D,Gorczynski R,Selzner N,Chruscinski A,Levy GA
Fri Apr 21 00:00:00 UTC 2017
Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome.
Stem cells international
Aluri HS,Samizadeh M,Edman MC,Hawley DR,Armaos HL,Janga SR,Meng Z,Sendra VG,Hamrah P,Kublin CL,Hamm-Alvarez SF,Zoukhri D
14-5773 was used in Immunohistochemistry to study the potential of mouse bone marrow-derived mesenchymal stem cells in improving tear production in Sjogren's syndorme and determine the underlying mechanisms.
Tue Aug 01 00:00:00 UTC 2023
Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism.
The Journal of pharmacy and pharmacology
Makita N,Ishiguro J,Suzuki K,Nara F
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Jan 01 00:00:00 UTC 2017
miR-451 limits CD4+ T cell proliferative responses to infection in mice.
Immunologic research
Chapman LM,Ture SK,Field DJ,Morrell CN
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that miR-451 is a regulator of host immune responses to Plasmodium infection, particularly in the control of CD4+ T cell proliferation via a Myc-dependent pathway.
Tue Aug 01 00:00:00 UTC 2017
UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.
Pigment cell & melanoma research
Wang J,Perry CJ,Meeth K,Thakral D,Damsky W,Micevic G,Kaech S,Blenman K,Bosenberg M
14-5773 was used in Immunohistochemistry to study whether irradiating a mouse melanoma cell line with UVB can make it more immunogenic and induce a functional T cell response.
Sat Jul 01 00:00:00 UTC 2017
UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model.
Pigment cell & melanoma research
Wang J,Perry CJ,Meeth K,Thakral D,Damsky W,Micevic G,Kaech S,Blenman K,Bosenberg M
14-5773 was used in Immunohistochemistry to study whether irradiating a mouse melanoma cell line with UVB can make it more immunogenic and induce a functional T cell response.
Sat Jul 01 00:00:00 UTC 2017
SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance.
Molecular pharmacology
Li J,Jing J,Bai Y,Li Z,Xing R,Tan B,Ma X,Qiu WW,Du C,Du B,Yang F,Tang J,Siwko S,Liu M,Chen H,Luo J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon May 01 00:00:00 UTC 2017
Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance.
Molecular medicine reports
Li Y,Li H,Cao Y,Wu F,Ma W,Wang Y,Sun S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Dec 01 00:00:00 UTC 2017
PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.
Cancer prevention research (Philadelphia, Pa.)
Wang J,Xie T,Wang B,William WN,Heymach JV,El-Naggar AK,Myers JN,Caulin C
14-5773 was used in Immunohistochemistry-immunofluorescence to investigate whether programmed death receptor 1 blockade may control the progression of oral premalignant lesions.
Fri Dec 01 00:00:00 UTC 2017
Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs.
Oncology letters
Son CH,Bae J,Lee HR,Yang K,Park YS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon May 01 00:00:00 UTC 2017
B cells inhibit the antitumor immunity against an established murine fibrosarcoma.
Oncology letters
Maglioco A,Machuca DG,Badano MN,Nannini P,Camerano GV,Costa H,Meiss R,Ruggiero RA,Giordano M,Dran GI
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon May 01 00:00:00 UTC 2017
Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.
Oncology letters
Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Apr 01 00:00:00 UTC 2017
Treatment with Allogenic Mesenchymal Stromal Cells in a Murine Model of Systemic Lupus Erythematosus.
International journal of stem cells
Tani C,Vagnani S,Carli L,Querci F,Kühl AA,Spieckermann S,Cieluch CP,Pacini S,Fazzi R,Mosca M
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to study whether repeated administrations of 1x106/kg body weight of allogenic mesenchymal stromal cells can be effective in improving the clinical course of a murine systemic lupus erythematosus model.
Thu Nov 30 00:00:00 UTC 2017
Proteomic changes of CD4+/CD25+/forkhead box p3+ regulatory T cells in a 30-day rat model of sepsis survival.
Experimental and therapeutic medicine
Jiao Y,Tan S,Xiong J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Dec 01 00:00:00 UTC 2017
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon May 15 00:00:00 UTC 2017
The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.
BMC complementary and alternative medicine
Xie L,Zhong X,Liu D,Liu L,Xia Z
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Dec 01 00:00:00 UTC 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Feb 13 00:00:00 UTC 2017
MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.
Stem cell reports
Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue May 09 00:00:00 UTC 2017
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Oncoimmunology
Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jan 12 00:00:00 UTC 2021
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Feb 06 00:00:00 UTC 2017
Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression.
Nature communications
Lu J,Liu X,Liao YP,Salazar F,Sun B,Jiang W,Chang CH,Jiang J,Wang X,Wu AM,Meng H,Nel AE
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Mon Nov 27 00:00:00 UTC 2017
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Scientific reports
Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Sep 05 00:00:00 UTC 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
14-5773 was used in Western blot to study the effects of the loss of the functionally redundant p38 isoforms in T cells, on the induction of regulatory T cells.
Fri Feb 03 00:00:00 UTC 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
14-5773 was used in Western blot to study the effects of the loss of the functionally redundant p38 isoforms in T cells, on the induction of regulatory T cells.
Fri Feb 03 00:00:00 UTC 2017
Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.
The Journal of biological chemistry
Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM
14-5773 was used in Western blot to study the effects of the loss of the functionally redundant p38 isoforms in T cells, on the induction of regulatory T cells.
Fri Feb 03 00:00:00 UTC 2017
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
PloS one
Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Aug 17 00:00:00 UTC 2017
Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.
Nature communications
Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Mar 27 00:00:00 UTC 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Apr 01 00:00:00 UTC 2017
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis.
PloS one
Bäcker V,Cheung FY,Siveke JT,Fandrey J,Winning S
14-5773 was used in Immunohistochemistry to investigate the mechanisms by which myeloid cell hypoxia-inducible factor-1a contributes to a pro-inflammatory immune response in DSS-induced colitis.
Mon Jan 08 00:00:00 UTC 2018
Knockdown of myeloid cell hypoxia-inducible factor-1α ameliorates the acute pathology in DSS-induced colitis.
PloS one
Bäcker V,Cheung FY,Siveke JT,Fandrey J,Winning S
14-5773 was used in Immunohistochemistry to investigate the mechanisms by which myeloid cell hypoxia-inducible factor-1a contributes to a pro-inflammatory immune response in DSS-induced colitis.
Mon Jan 08 00:00:00 UTC 2018
Clinical and Histopathologic Characterization of Canine Chronic Ulcerative Stomatitis.
Veterinary pathology
Anderson JG,Peralta S,Kol A,Kass PH,Murphy B
14-5773-82 was used in Immunohistochemistry to reveal that canine chronic stomatitis is clinically characterized by painful oral mucosal ulcers of varying size, pattern, appearance, and distribution, most often associated with teeth with early periodontitis.
Mon May 01 00:00:00 UTC 2017
Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells.
Oncotarget
Luu M,Jenike E,Vachharajani N,Visekruna A
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to study the requirement of c-Rel in the generation of thymic regulatory T cells.
Tue Aug 08 00:00:00 UTC 2017
Priming of lineage-specifying genes by Bcl11b is required for lineage choice in post-selection thymocytes.
Nature communications
Kojo S,Tanaka H,Endo TA,Muroi S,Liu Y,Seo W,Tenno M,Kakugawa K,Naoe Y,Nair K,Moro K,Katsuragi Y,Kanai A,Inaba T,Egawa T,Venkatesh B,Minoda A,Kominami R,Taniuchi I
14-5773 was used in Flow cytometry/Cell sorting to show that a pre-commitment event modulated by the transcription factor, Bcl11b, is required for the proper expression of ThPOK and Runx3 and correct CD4/CD8 lineage commitment.
Tue Sep 26 00:00:00 UTC 2017
HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes.
Nature communications
Mbofung RM,McKenzie JA,Malu S,Zhang M,Peng W,Liu C,Kuiatse I,Tieu T,Williams L,Devi S,Ashkin E,Xu C,Huang L,Zhang M,Talukder AH,Tripathi SC,Khong H,Satani N,Muller FL,Roszik J,Heffernan T,Allison JP,Lizee G,Hanash SM,Proia D,Amaria R,Davis RE,Hwu P
14-5773 was used in Flow cytometry to show HSP90 inhibitors can potentiate T-cell-mediated anti-tumor immune responses to enhance T-cell-mediated killing of melanoma cells.
Wed Sep 06 00:00:00 UTC 2017
Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.
eLife
Redhu NS,Bakthavatchalu V,Conaway EA,Shouval DS,Tsou A,Goettel JA,Biswas A,Wang C,Field M,Muller W,Bleich A,Li N,Gerber GK,Bry L,Fox JG,Snapper SB,Horwitz BH
14-5773 was used in Flow cytometry/Cell sorting to show that IL10R-mediated regulation of macrophage function during the early postnatal period is essential to prevent murine colitis.
Wed Jul 05 00:00:00 UTC 2017
Lactobacillus johnsonii ameliorates intestinal, extra-intestinal and systemic pro-inflammatory immune responses following murine Campylobacter jejuni infection.
Scientific reports
Bereswill S,Ekmekciu I,Escher U,Fiebiger U,Stingl K,Heimesaat MM
14-5773 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to demonstrate that immunomodulatory probiotic species might offer valuable strategies for prophylaxis and/or treatment of C. jejuni induced intestinal, extra-intestinal and systemic pro-inflammatory immune responses in vivo.
Thu May 18 00:00:00 UTC 2017
Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7.
Oncotarget
Vachharajani N,Joeris T,Luu M,Hartmann S,Pautz S,Jenike E,Pantazis G,Prinz I,Hofer MJ,Steinhoff U,Visekruna A
14-5773 was used in Flow cytometry/Cell sorting to show selective targeting of the proteasomal immunosubunit LMP7 could be used as a preventative treatment for colitis-associated cancer.
Tue Aug 01 00:00:00 UTC 2017
A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.
Nature communications
Johnston CJC,Smyth DJ,Kodali RB,White MPJ,Harcus Y,Filbey KJ,Hewitson JP,Hinck CS,Ivens A,Kemter AM,Kildemoes AO,Le Bihan T,Soares DC,Anderton SM,Brenn T,Wigmore SJ,Woodcock HV,Chambers RC,Hinck AP,McSorley HJ,Maizels RM
14-5773-82 was used in Flow Cytometry to indicate that through the helminth parasite has acquired a protein with cytokine-like function that is able to exploit an endogenous pathway of immunoregulation in the host.
Thu Nov 23 00:00:00 UTC 2017
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.
Oncoimmunology
Field CS,Hunn MK,Ferguson PM,Ruedl C,Ancelet LR,Hermans IF
14-5773 was used in Flow cytometry/Cell sorting to study the effect of the checkpoint blockade on the efficacy of responses induced with a whole tumour-cell vaccine.
Tue Jan 12 00:00:00 UTC 2021
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.
Nature medicine
Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA
14-5773 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.
Thu Sep 01 00:00:00 UTC 2016
Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses.
Nature medicine
Moynihan KD,Opel CF,Szeto GL,Tzeng A,Zhu EF,Engreitz JM,Williams RT,Rakhra K,Zhang MH,Rothschilds AM,Kumari S,Kelly RL,Kwan BH,Abraham W,Hu K,Mehta NK,Kauke MJ,Suh H,Cochran JR,Lauffenburger DA,Wittrup KD,Irvine DJ
14-5773 was used in Flow cytometry/Cell sorting to develop combined immunotherapy against established tumours.
Thu Dec 01 00:00:00 UTC 2016
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Aug 25 00:00:00 UTC 2016
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Nature genetics
Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS
14-5773 was used in Flow cytometry/Cell sorting to demonstrate the importance of TfR1 in adaptive immunity.
Fri Jan 01 00:00:00 UTC 2016
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.
Cancer cell
Pietrocola F,Pol J,Vacchelli E,Rao S,Enot DP,Baracco EE,Levesque S,Castoldi F,Jacquelot N,Yamazaki T,Senovilla L,Marino G,Aranda F,Durand S,Sica V,Chery A,Lachkar S,Sigl V,Bloy N,Buque A,Falzoni S,Ryffel B,Apetoh L,Di Virgilio F,Madeo F,Maiuri MC,Zitvogel L,Levine B,Penninger JM,Kroemer G
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Mon Jul 11 00:00:00 UTC 2016
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Nature immunology
Xing S,Li F,Zeng Z,Zhao Y,Yu S,Shan Q,Li Y,Phillips FC,Maina PK,Qi HH,Liu C,Zhu J,Pope RM,Musselman CA,Zeng C,Peng W,Xue HH
14-5773 was used in Flow cytometry/Cell sorting to reveal that sequence-specific transcription factors can utilise intrinsic HDAC activity to guard cell identity by repressing lineage-inappropriate genes.
Wed Jun 01 00:00:00 UTC 2016
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
The Journal of clinical investigation
Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS
14-5773 was used in Flow cytometry/Cell sorting to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.
Tue Nov 01 00:00:00 UTC 2016
FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.
The Journal of clinical investigation
Lexmond WS,Goettel JA,Lyons JJ,Jacobse J,Deken MM,Lawrence MG,DiMaggio TH,Kotlarz D,Garabedian E,Sackstein P,Nelson CC,Jones N,Stone KD,Candotti F,Rings EH,Thrasher AJ,Milner JD,Snapper SB,Fiebiger E
14-5773 was used in Flow cytometry/Cell sorting to investigate the mechanism by which FOXP3+ T regulatory cells and WASP protein together restrain Th-2 mediated food allergy.
Mon Oct 03 00:00:00 UTC 2016
Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection.
The Journal of experimental medicine
Liu H,Jain R,Guan J,Vuong V,Ishido S,La Gruta NL,Gray DH,Villadangos JA,Mintern JD
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that the ligase MARCH 8 is responsible for regulating surface MHC II in thymic epithelial cells (TECs).
Mon Aug 22 00:00:00 UTC 2016
Migratory CD103+ dendritic cells suppress helminth-driven type 2 immunity through constitutive expression of IL-12.
The Journal of experimental medicine
Everts B,Tussiwand R,Dreesen L,Fairfax KC,Huang SC,Smith AM,O'Neill CM,Lam WY,Edelson BT,Urban JF,Murphy KM,Pearce EJ
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of CD8α+ and CD103+ dendritic cells in suppressing helminth-driven type 2 immune responses.
Mon Jan 11 00:00:00 UTC 2016
pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation.
Journal of autoimmunity
Duraes FV,Lippens C,Steinbach K,Dubrot J,Brighouse D,Bendriss-Vermare N,Issazadeh-Navikas S,Merkler D,Hugues S
14-5773 was used in Flow cytometry/Cell sorting to investigate novel pDC-based cell therapies in autoimmune diseases, aiming at specifically modulating pathogenic cells that induce and sustain autoimmune inflammation.
Mon Feb 01 00:00:00 UTC 2016
A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase-Akt pathway activation.
The Journal of allergy and clinical immunology
Matsushita T,Le Huu D,Kobayashi T,Hamaguchi Y,Hasegawa M,Naka K,Hirao A,Muramatsu M,Takehara K,Fujimoto M
14-5773 was used in Immunohistochemistry to investigate the signaling mechanisms and a novel phenotypic parameter of B10 cells in mice.
Sat Oct 01 00:00:00 UTC 2016
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Autophagy
Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Aug 02 00:00:00 UTC 2016
Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer.
Cancer research
Lastwika KJ,Wilson W,Li QK,Norris J,Xu H,Ghazarian SR,Kitagawa H,Kawabata S,Taube JM,Yao S,Liu LN,Gills JJ,Dennis PA
14-5773 was used in Immunohistochemistry to suggest that oncogenic activation of the AKT-mTOR pathway promotes immune escape by driving expression of PD-L1.
Fri Jan 15 00:00:00 UTC 2016
p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
European journal of immunology
Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Jan 01 00:00:00 UTC 2016
B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.
European journal of immunology
Carrascal J,Carrillo J,Arpa B,Egia-Mendikute L,Rosell-Mases E,Pujol-Autonell I,Planas R,Mora C,Mauricio D,Ampudia RM,Vives-Pi M,Verdaguer J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Mar 01 00:00:00 UTC 2016
Concomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.
Cancer immunology, immunotherapy : CII
Kroon P,Gadiot J,Peeters M,Gasparini A,Deken MA,Yagita H,Verheij M,Borst J,Blank CU,Verbrugge I
14-5773 was used in Immunohistochemistry to examine the extent to which T cell co-stimulation and/or stereotactic body radiation therapy could enhance the therapeutic efficacy of T cell checkpoint blockade.
Wed Jun 01 00:00:00 UTC 2016
Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells.
Cancer immunology, immunotherapy : CII
Foy SP,Mandl SJ,dela Cruz T,Cote JJ,Gordon EJ,Trent E,Delcayre A,Breitmeyer J,Franzusoff A,Rountree RB
14-5773 was used in Flow cytometry/Cell sorting to help elucidate evidence of enhanced clinical benefit from combining CTLA-4 blockade with poxvirus-based active immunotherapy.
Sun May 01 00:00:00 UTC 2016
Apoptotic cell infusion treats ongoing collagen-induced arthritis, even in the presence of methotrexate, and is synergic with anti-TNF therapy.
Arthritis research & therapy
Bonnefoy F,Daoui A,Valmary-Degano S,Toussirot E,Saas P,Perruche S
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that apoptotic-cell-based therapy is efficient in treating ongoing CIA, compatible with current RA treatments, and needs to be evaluated in humans in the treatment of RA.
Thu Aug 11 00:00:00 UTC 2016
Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.
Journal of immunology (Baltimore, Md. : 1950)
Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunofluorescence
Sun May 01 00:00:00 UTC 2016
IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod).
Journal of immunology (Baltimore, Md. : 1950)
Jirmo AC,Daluege K,Happle C,Albrecht M,Dittrich AM,Busse M,Habener A,Skuljec J,Hansen G
14-5773 was used in Flow cytometry/Cell sorting to study the mechanisms by which resiquimod mediates its therapeutic effects in experimental allergic asthma.
Thu Dec 01 00:00:00 UTC 2016
A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen LC,Nicholson YT,Rosborough BR,Thomson AW,Raimondi G
14-5773 was used in Flow cytometry/Cell sorting to provide a framework for how the migratory behaviour of Treg and Tconv might be differentially regulated for therapeutic purposes.
Mon Aug 15 00:00:00 UTC 2016
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Poczobutt JM,Nguyen TT,Hanson D,Li H,Sippel TR,Weiser-Evans MC,Gijon M,Murphy RC,Nemenoff RA
14-5773 was used in Flow cytometry/Cell sorting to reveal an antitumorigenic role for 5-LO products in the microenvironment during lung cancer progression through T cell regulation.
Fri Jan 15 00:00:00 UTC 2016
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
Journal of immunology (Baltimore, Md. : 1950)
Harakal J,Rival C,Qiao H,Tung KS
14-5773-82 was used in Flow Cytometry to suggest that Tregs maintain physiological tolerance to clinically relevant gastric autoantigens, and Th2 responses can be a pathogenic mechanism in AIG.
Fri Jul 01 00:00:00 UTC 2016
Differential T Cell Cytokine Receptivity and Not Signal Quality Distinguishes IL-6 and IL-10 Signaling during Th17 Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jones LL,Alli R,Li B,Geiger TL
14-5773 was used in Flow cytometry/Cell sorting to demonstrate a key role for the regulation of receptor expression in differentiating the functional outcomes of IL-6 and IL-10 signalling.
Fri Apr 01 00:00:00 UTC 2016
Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3-/- Mice.
Mediators of inflammation
Hirota SA,Ueno A,Tulk SE,Becker HM,Schenck LP,Potentier MS,Li Y,Ghosh S,Muruve DA,MacDonald JA,Beck PL
14-5773 was used in Flow cytometry/Cell sorting to suggest that the NLRP3 inflammasome can regulate intestinal inflammation through noncanonical mechanisms.
Mon Jun 05 00:00:00 UTC 2017
Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity.
Genes and immunity
Bearoff F,Del Rio R,Case LK,Dragon JA,Nguyen-Vu T,Lin CY,Blankenhorn EP,Teuscher C,Krementsov DN
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Dec 01 00:00:00 UTC 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun May 01 00:00:00 UTC 2016
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.
Molecular medicine reports
Gu L,Deng WS,Sun XF,Zhou H,Xu Q
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Aug 01 00:00:00 UTC 2016
Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.
Autoimmunity
Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Aug 01 00:00:00 UTC 2016
Pretreatment of donor islets with papain improves allograft survival without systemic immunosuppression in mice.
Islets
Kumano K,Nishinakamura H,Mera T,Itoh T,Takahashi H,Fujiwara T,Kodama S
Fri Sep 02 00:00:00 UTC 2016
Pretreatment of donor islets with papain improves allograft survival without systemic immunosuppression in mice.
Islets
Kumano K,Nishinakamura H,Mera T,Itoh T,Takahashi H,Fujiwara T,Kodama S
Fri Sep 02 00:00:00 UTC 2016
Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.
Veterinary immunology and immunopathology
Wang Z,Navarro-Alvarez N,Shah JA,Zhang H,Huang Q,Zheng Q,Madsen JC,Sachs DH,Huang CA,Wang Z
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Dec 01 00:00:00 UTC 2016
Narrow-Band Ultraviolet B Phototherapy Ameliorates Acute Graft-Versus-Host Disease of the Intestine by Expansion of Regulatory T Cells.
PloS one
Hashimoto A,Sato T,Iyama S,Yoshida M,Ibata S,Tatekoshi A,Kamihara Y,Horiguchi H,Murase K,Kawano Y,Takada K,Miyanishi K,Kobune M,Ichimiya S,Kato J
14-5773 was used in Immunohistochemistry to demonstrate that NB-UVB phototherapy has the ability to ameliorate intestinal aGVHD through the expansion of Treg cells.
Mon Aug 08 00:00:00 UTC 2016
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.
Nature communications
Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Jun 08 00:00:00 UTC 2016
Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice.
Clinical and molecular allergy : CMA
Petrarca C,Clemente E,Amato V,Gatta A,Cortese S,Lamolinara A,Rossi C,Zanotta S,Mistrello G,Paganelli R,Di Gioacchino M
Mon Aug 08 00:00:00 UTC 2016
Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice.
Clinical and molecular allergy : CMA
Petrarca C,Clemente E,Amato V,Gatta A,Cortese S,Lamolinara A,Rossi C,Zanotta S,Mistrello G,Paganelli R,Di Gioacchino M
Mon Aug 08 00:00:00 UTC 2016
Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.
JCI insight
Federico G,Meister M,Mathow D,Heine GH,Moldenhauer G,Popovic ZV,Nordström V,Kopp-Schneider A,Hielscher T,Nelson PJ,Schaefer F,Porubsky S,Fliser D,Arnold B,Gröne HJ
Thu Jan 21 00:00:00 UTC 2016
Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.
JCI insight
Federico G,Meister M,Mathow D,Heine GH,Moldenhauer G,Popovic ZV,Nordström V,Kopp-Schneider A,Hielscher T,Nelson PJ,Schaefer F,Porubsky S,Fliser D,Arnold B,Gröne HJ
Thu Jan 21 00:00:00 UTC 2016
NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.
Scientific reports
Zang C,Luyten A,Chen J,Liu XS,Shivdasani RA
14-5773 was used in Western Blotting to elucidate the involvement of three transcription factors: NF-E2, FLI1, and RUNX1, during terminal megakaryocyte maturation.
Tue Jul 26 00:00:00 UTC 2016
Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.
Nature communications
Du C,Duan Y,Wei W,Cai Y,Chai H,Lv J,Du X,Zhu J,Xie X
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Apr 04 00:00:00 UTC 2016
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Jul 11 00:00:00 UTC 2016
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.
Nature communications
Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Aug 08 00:00:00 UTC 2016
Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.
PloS one
Uhde AK,Herder V,Akram Khan M,Ciurkiewicz M,Schaudien D,Teich R,Floess S,Baumgärtner W,Huehn J,Beineke A
14577382 was used in flow cytometry and immunohistochemistry - paraffin section to study the effect of IL-10 signaling in infectious neurological diseases
Fri Aug 25 00:00:00 UTC 2017
Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.
PloS one
Uhde AK,Herder V,Akram Khan M,Ciurkiewicz M,Schaudien D,Teich R,Floess S,Baumgärtner W,Huehn J,Beineke A
14577382 was used in flow cytometry and immunohistochemistry - paraffin section to study the effect of IL-10 signaling in infectious neurological diseases
Fri Aug 25 00:00:00 UTC 2017
Restrained Th17 response and myeloid cell infiltration into the central nervous system by human decidua-derived mesenchymal stem cells during experimental autoimmune encephalomyelitis.
Stem cell research & therapy
Bravo B,Gallego MI,Flores AI,Bornstein R,Puente-Bedia A,Hernández J,de la Torre P,García-Zaragoza E,Perez-Tavarez R,Grande J,Ballester A,Ballester S
14-5773 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of DMSCs for treatment of autoimmune disorders.
Thu Mar 17 00:00:00 UTC 2016
Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerization.
JCI insight
Pilat N,Mahr B,Unger L,Hock K,Schwarz C,Farkas AM,Baranyi U,Wrba F,Wekerle T
14-5773 was used in Flow cytometry/Cell sorting to suggest that deletion of donor-reactive T cells for specificities expressed on hematopoietic cells preclude the expansion of donor-specific Tregs.
Thu May 19 00:00:00 UTC 2016
A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma.
PloS one
Gossmann J,Stolte M,Lohoff M,Yu P,Moll R,Finkernagel F,Garn H,Brendel C,Bittner A,Neubauer A,Huynh MQ
14-5773 was used in Immunohistochemistry to demonstrate a correlation between a reduced immune response against H. felis, and protection from developing gastric mucosa-associated lymphoid tissue lymphomas.
Fri Nov 04 00:00:00 UTC 2016
Rotavirus acceleration of type 1 diabetes in non-obese diabetic mice depends on type I interferon signalling.
Scientific reports
Pane JA,Fleming FE,Graham KL,Thomas HE,Kay TW,Coulson BS
14-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms of diabetes acceleration by rotaviruses.
Wed Jul 13 00:00:00 UTC 2016
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression.
Clinical & translational immunology
Li K,Baird M,Yang J,Jackson C,Ronchese F,Young S
14-5773 was used in Flow cytometry/Cell sorting to provide valuable data for further research into in vitro expansion of CD4(+) Th1-like cells, with potential applications to cancer treatment involving ACT.
Mon Aug 01 00:00:00 UTC 2016
Preclinical Development of Ipilimumab and Nivolumab Combination Immunotherapy: Mouse Tumor Models, In Vitro Functional Studies, and Cynomolgus Macaque Toxicology.
PloS one
Selby MJ,Engelhardt JJ,Johnston RJ,Lu LS,Han M,Thudium K,Yao D,Quigley M,Valle J,Wang C,Chen B,Cardarelli PM,Blanset D,Korman AJ
14-5773 was used in Flow cytometry/Cell sorting to exhibit a preclinical strategy for the identification and development of highly effective antitumour combination immunotherapies.
Fri Aug 25 00:00:00 UTC 2017
Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.
Oncoimmunology
Kleinpeter P,Fend L,Thioudellet C,Geist M,Sfrontato N,Koerper V,Fahrner C,Schmitt D,Gantzer M,Remy-Ziller C,Brandely R,Villeval D,Rittner K,Silvestre N,Erbs P,Zitvogel L,Quéméneur E,Préville X,Marchand JB
14-5773 was used in Flow cytometry/Cell sorting to develop a method to vectorise a hamster monoclonal IgG against murine PD-1 in Western Reserve oncolytic vaccina virus.
Tue Jan 12 00:00:00 UTC 2021
Liver sinusoidal endothelial cells induce tolerance of autoreactive CD4+ recent thymic emigrants.
Scientific reports
Xu X,Jin R,Li M,Wang K,Zhang S,Hao J,Sun X,Zhang Y,Wu H,Zhang J,Ge Q
14-5773 was used in Flow cytometry/Cell sorting to investigate the tolerance of liver-persisting CD4(+) recent thymic emigrants.
Fri Jan 22 00:00:00 UTC 2016
CD301b+ dendritic cells suppress T follicular helper cells and antibody responses to protein antigens.
eLife
Kumamoto Y,Hirai T,Wong PW,Kaplan DH,Iwasaki A
14-5773 was used in Flow cytometry/Cell sorting to demonstrate a novel function of CD301b+ dendritic cells in negatively regulating antibody responses and preventing autoantibody formation.
Thu Sep 22 00:00:00 UTC 2016
Stat3 Is Important for Follicular Regulatory T Cell Differentiation.
PloS one
Wu H,Xie MM,Liu H,Dent AL
14-5773 was used in Flow cytometry/Cell sorting to uncover unique roles of Stat3 in Tfr cell differentiation and the regulation of the antibody response.
Mon Jul 10 00:00:00 UTC 2017
Balancing intestinal and systemic inflammation through cell type-specific expression of the aryl hydrocarbon receptor repressor.
Scientific reports
Brandstätter O,Schanz O,Vorac J,König J,Mori T,Maruyama T,Korkowski M,Haarmann-Stemmann T,von Smolinski D,Schultze JL,Abel J,Esser C,Takeyama H,Weighardt H,Förster I
14-5773 was used in Flow cytometry/Cell sorting to highlight the physiologic importance of cell-type specific balancing of AhR/AhRR expression in response to microbial, nutritional and other environmental stimuli.
Tue May 17 00:00:00 UTC 2016
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Nature communications
Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG
14-5773 was used in Flow cytometry/Cell sorting to study how immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner, and involves alterations in intracellular cyclic AMP formation.
Wed May 18 00:00:00 UTC 2016
Immune homeostasis enforced by co-localized effector and regulatory T cells.
Nature
Liu Z,Gerner MY,Van Panhuys N,Levine AG,Rudensky AY,Germain RN
14-5773 was used in Immunofluorescence to reveal autoreactive T cells are activated to cytokine production, with co-clustering T cell receptor-stimulated Treg cells causing negative feedback, maintaining immune homeostasis.
Thu Dec 10 00:00:00 UTC 2015
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
Nature biotechnology
Chen HJ,Sun J,Huang Z,Hou H,Arcilla M,Rakhilin N,Joe DJ,Choi J,Gadamsetty P,Milsom J,Nandakumar G,Longman R,Zhou XK,Edwards R,Chen J,Chen KY,Bu P,Wang L,Xu Y,Munroe R,Abratte C,Miller AD,Gümüş ZH,Shuler M,Nishimura N,Edelmann W,Shen X,Lipkin SM
14-5773 was used in Flow cytometry/Cell sorting to create chemokine-targeted mouse models that recapitulate the majority of common human somatic CRC mutations.
Mon Jun 01 00:00:00 UTC 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
14-5773-82 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.
Tue Dec 15 00:00:00 UTC 2015
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue.
Nature immunology
Lynch L,Michelet X,Zhang S,Brennan PJ,Moseman A,Lester C,Besra G,Vomhof-Dekrey EE,Tighe M,Koay HF,Godfrey DI,Leadbetter EA,Sant'Angelo DB,von Andrian U,Brenner MB
14-5773 was used in Flow cytometry/Cell sorting to report a unique transcriptional program of iNKT cells in adipose tissue, making them unique regulators of immunological homeostasis.
Thu Jan 01 00:00:00 UTC 2015
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Nature immunology
Finkin S,Yuan D,Stein I,Taniguchi K,Weber A,Unger K,Browning JL,Goossens N,Nakagawa S,Gunasekaran G,Schwartz ME,Kobayashi M,Kumada H,Berger M,Pappo O,Rajewsky K,Hoshida Y,Karin M,Heikenwalder M,Ben-Neriah Y,Pikarsky E
14-5773 was used in Immunofluorescence-paraffin to reveal the function of ectopic lymphoid-like structures in cancer.
Tue Dec 01 00:00:00 UTC 2015
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.
The Journal of clinical investigation
Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Mar 02 00:00:00 UTC 2015
FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.
The Journal of clinical investigation
Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Mar 02 00:00:00 UTC 2015
Podoplanin negatively regulates CD4+ effector T cell responses.
The Journal of clinical investigation
Peters A,Burkett PR,Sobel RA,Buckley CD,Watson SP,Bettelli E,Kuchroo VK
14-5773 was used in Flow cytometry/Cell sorting to investigate the effect of podoplanin on CD4+ effector T cell responses in mice.
Thu Jan 01 00:00:00 UTC 2015
Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis.
The Journal of clinical investigation
Nagy N,Kaber G,Johnson PY,Gebe JA,Preisinger A,Falk BA,Sunkari VG,Gooden MD,Vernon RB,Bogdani M,Kuipers HF,Day AJ,Campbell DJ,Wight TN,Bollyky PL
14-5773 was used in Immunohistochemistry to demonstrate that hyaluronan synthesis is critical for the pathogenesis of autoimmune diabetes.
Thu Oct 01 00:00:00 UTC 2015
STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection.
The Journal of clinical investigation
Desvignes L,Weidinger C,Shaw P,Vaeth M,Ribierre T,Liu M,Fergus T,Kozhaya L,McVoy L,Unutmaz D,Ernst JD,Feske S
14-5773 was used in Flow cytometry/Cell sorting to study the role of the activator stromal interaction molecule 1 (STIM1) on T cell regulation during chronic Mycobacterium tuberculosis infection.
Mon Jun 01 00:00:00 UTC 2015
Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.
The Journal of clinical investigation
Bolton HA,Zhu E,Terry AM,Guy TV,Koh WP,Tan SY,Power CA,Bertolino P,Lahl K,Sparwasser T,Shklovskaya E,Fazekas de St Groth B
14-5773 was used in Flow cytometry/Cell sorting to indicate that achieving optimal recovery from lymphopenia should aim to improve early Treg reconstitution to increase the relative number of Tregs to DCs inhibiting spontaneous oligoclonal T cell proliferation.
Tue Sep 01 00:00:00 UTC 2015
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers.
The Journal of experimental medicine
Rahimpour A,Koay HF,Enders A,Clanchy R,Eckle SB,Meehan B,Chen Z,Whittle B,Liu L,Fairlie DP,Goodnow CC,McCluskey J,Rossjohn J,Uldrich AP,Pellicci DG,Godfrey DI
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that mucosal-associated invariant T cells (MAIT cells) are detectable in a broad range of tissues in C57BL/6 and BALB/c mice.
Mon Jun 29 00:00:00 UTC 2015
Towards programming immune tolerance through geometric manipulation of phosphatidylserine.
Biomaterials
Roberts RA,Eitas TK,Byrne JD,Johnson BM,Short PJ,McKinnon KP,Reisdorf S,Luft JC,DeSimone JM,Ting JP
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Dec 01 00:00:00 UTC 2015
IL-2 is a critical regulator of group 2 innate lymphoid cell function during pulmonary inflammation.
The Journal of allergy and clinical immunology
Roediger B,Kyle R,Tay SS,Mitchell AJ,Bolton HA,Guy TV,Tan SY,Forbes-Blom E,Tong PL,Köller Y,Shklovskaya E,Iwashima M,McCoy KD,Le Gros G,Fazekas de St Groth B,Weninger W
14-5773 was used in Immunohistochemistry to show that IL-2 signalling serves two distinct functions in lung group 2 innate lymphoid cells.
Tue Dec 01 00:00:00 UTC 2015
Commensal microbiota influence systemic autoimmune responses.
The EMBO journal
Van Praet JT,Donovan E,Vanassche I,Drennan MB,Windels F,Dendooven A,Allais L,Cuvelier CA,van de Loo F,Norris PS,Kruglov AA,Nedospasov SA,Rabot S,Tito R,Raes J,Gaboriau-Routhiau V,Cerf-Bensussan N,Van de Wiele T,Eberl G,Ware CF,Elewaut D
14-5773 was used in Flow cytometry/Cell sorting to indicate that neonatal colonization of gut microbiota influences generalized autoimmunity in adult life.
Thu Feb 12 00:00:00 UTC 2015
Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Dai M,Yip YY,Hellstrom I,Hellstrom KE
14-5773 was used in Flow cytometry/Cell sorting to assess immunologic and anti-tumour responses to the administration of various antibodies to various cancers.
Sun Mar 01 00:00:00 UTC 2015
β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.
Cancer research
Hong Y,Manoharan I,Suryawanshi A,Majumdar T,Angus-Hill ML,Koni PA,Manicassamy B,Mellor AL,Munn DH,Manicassamy S
14-5773 was used in Flow cytometry/Cell sorting to show that dendritic cells in the tumour microenvironment acquire the ability to metabolise vitamin A to produce retinoic acid, driving immune tolerance.
Sun Feb 15 00:00:00 UTC 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Dec 29 00:00:00 UTC 2015
Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice.
Hypertension (Dallas, Tex. : 1979)
Yodoi K,Yamashita T,Sasaki N,Kasahara K,Emoto T,Matsumoto T,Kita T,Sasaki Y,Mizoguchi T,Sparwasser T,Hirata K
14-5773 was used in Immunohistochemistry to suggest that Foxp3(+) Tregs may play a protective role in abdominal aortic aneurysm formation.
Wed Apr 01 00:00:00 UTC 2015
Repeated Injections of IL-2 Break Renal Allograft Tolerance Induced via Mixed Hematopoietic Chimerism in Monkeys.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Yamada Y,Nadazdin O,Boskovic S,Lee S,Zorn E,Smith RN,Colvin RB,Madsen JC,Cosimi AB,Kawai T,Benichou G
14-5773-82 was used in immunohistochemistry (paraffin) to investigate the effect of repeated IL-2 injections on renal allograft tolerance in monkeys.
Tue Dec 01 00:00:00 UTC 2015
Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.
Mucosal immunology
Jiang TT,Chaturvedi V,Ertelt JM,Xin L,Clark DR,Kinder JM,Way SS
14-5773 was used in Flow cytometry/Cell sorting to study susceptibility against Candida albicans fungal infectiong following eradication of commensal enteric bacteria, showing loss of commensal bacteria enhances antifungal immunity through robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, suggesting that enteric bacteria restrains activation of some immune components.
Wed Jul 01 00:00:00 UTC 2015
Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.
Mucosal immunology
Bertin S,Lozano-Ruiz B,Bachiller V,García-Martínez I,Herdman S,Zapater P,Francés R,Such J,Lee J,Raz E,González-Navajas JM
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that DUSP6 regulates CD4+ T-cell activation and differentiation by inhibiting TCR-dependent ERK1/2 activation.
Fri May 01 00:00:00 UTC 2015
Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway.
Mucosal immunology
Park J,Kim M,Kang SG,Jannasch AH,Cooper B,Patterson J,Kim CH
14-5773 was used in Flow cytometry/Cell sorting to show that short-chain fatty acids promote T-cell differentiation to promote either immunity or immune tolerance.
Thu Jan 01 00:00:00 UTC 2015
Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.
PLoS pathogens
Hewitson JP,Filbey KJ,Esser-von Bieren J,Camberis M,Schwartz C,Murray J,Reynolds LA,Blair N,Robertson E,Harcus Y,Boon L,Huang SC,Yang L,Tu Y,Miller MJ,Voehringer D,Le Gros G,Harris N,Maizels RM
14-5773 was used in Flow cytometry/Cell sorting to show that vaccine-induced immunity to intestinal helminths involves both IgG1 antibodies and IL-25-dependent Type 2 myeloid effector populations.
Sun Mar 01 00:00:00 UTC 2015
Interferon-γ Promotes Inflammation and Development of T-Cell Lymphoma in HTLV-1 bZIP Factor Transgenic Mice.
PLoS pathogens
Mitagami Y,Yasunaga J,Kinosada H,Ohshima K,Matsuoka M
14-5773 was used in Flow cytometry/Cell sorting to investigate the effect of interferon-γ on inflammation and T-cell lymphoma development in HTLV-1 bZIP factor transgenic mice.
Sat Aug 01 00:00:00 UTC 2015
Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine.
Cancer science
Ohshio Y,Teramoto K,Hanaoka J,Tezuka N,Itoh Y,Asai T,Daigo Y,Ogasawara K
14-5773 was used in Immunohistochemistry on frozen tissues to study the immunosuppressive trait of CAFs, and systematically explore the alteration of tumour-associated immune responses by CAF-targeted therapy.
Sun Feb 01 00:00:00 UTC 2015
Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.
Molecular medicine (Cambridge, Mass.)
Li CH,Lin MH,Chu SH,Tu PH,Fang CC,Yen CH,Liang PI,Huang JC,Su YC,Sytwu HK,Chen YM
14-5773 was used in Immunocytochemistry to investigate whether glycine N-methyltransferase plays an immunomodulatory role in the pathogenesis of experimental autoimmune encephalomyelitis.
Tue Mar 24 00:00:00 UTC 2015
Down-regulation of survivin alleviates experimental arthritis.
Journal of leukocyte biology
Andersson KM,Svensson MN,Erlandsson MC,Jonsson IM,Bokarewa MI
14-5773 was used in Flow cytometry/Cell sorting to show that inhibition of survivin is sufficient to reduce joint inflammation and bone damage in preclinical models of arthritis.
Thu Jan 01 00:00:00 UTC 2015
Enhancement of the proapoptotic properties of newcastle disease virus promotes tumor remission in syngeneic murine cancer models.
Molecular cancer therapeutics
Cuadrado-Castano S,Ayllon J,Mansour M,de la Iglesia-Vicente J,Jordan S,Tripathi S,García-Sastre A,Villar E
14-5773 was used in Flow cytometry/Cell sorting to demonstrate an augmented agent for cancer therapy which exploits the oncolytic properties of Newcastle disease virus.
Fri May 01 00:00:00 UTC 2015
Intrapulmonary Delivery of CpG Microparticles Eliminates Lung Tumors.
Molecular cancer therapeutics
Sato T,Shimosato T,Ueda A,Ishigatsubo Y,Klinman DM
14-5773 was used in Immunohistochemistry to examine the effect of instilling CpG oligonucleotides into the lungs of mice with non-small cell lung cancer.
Thu Oct 01 00:00:00 UTC 2015
Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.
International journal of obesity (2005)
Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Nov 01 00:00:00 UTC 2015
Leptin receptor signaling in T cells is required for Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Jun 01 00:00:00 UTC 2015
IRF-1 promotes liver transplant ischemia/reperfusion injury via hepatocyte IL-15/IL-15Rα production.
Journal of immunology (Baltimore, Md. : 1950)
Yokota S,Yoshida O,Dou L,Spadaro AV,Isse K,Ross MA,Stolz DB,Kimura S,Du Q,Demetris AJ,Thomson AW,Geller DA
14-5773 was used in Flow cytometry/Cell sorting to determine the role of IRF-1 during ischemia/reperfusion injury following allogeneic liver transplant, showing that it promotes injury via hepatocyte IL-15/IL-15Rα production.
Mon Jun 15 00:00:00 UTC 2015
PD-1 upregulated on regulatory T cells during chronic virus infection enhances the suppression of CD8+ T cell immune response via the interaction with PD-L1 expressed on CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Park HJ,Park JS,Jeong YH,Son J,Ban YH,Lee BH,Chen L,Chang J,Chung DH,Choi I,Ha SJ
14-5773 was used in Flow cytometry/Cell sorting to define PD-1 upregulated on Treg cells and its interaction with PD-1 ligand on effector T cells as one cause for the potent T cell suppression.
Mon Jun 15 00:00:00 UTC 2015
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H
14-5773 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.
Sat Aug 15 00:00:00 UTC 2015
Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Krishnamoorthy N,Burkett PR,Dalli J,Abdulnour RE,Colas R,Ramon S,Phipps RP,Petasis NA,Kuchroo VK,Serhan CN,Levy BD
14-5773 was used in Flow cytometry/Cell sorting to reveal that lung MaR1 augments de novo Treg generation, and that both Tregs and MaR1 inhibit ILC2s to restrain allergic lung inflammation.
Sun Feb 01 00:00:00 UTC 2015
The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.
Journal of immunology (Baltimore, Md. : 1950)
Presa M,Chen YG,Grier AE,Leiter EH,Brehm MA,Greiner DL,Shultz LD,Serreze DV
14-5773 was used in Flow cytometry/Cell sorting to indicate NSG recipients might be efficiently employed to test the activity of T1D patient-derived β cell-autoreactive T cell clones and lines.
Thu Oct 01 00:00:00 UTC 2015
Regulatory T cells require TCR signaling for their suppressive function.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt AM,Lu W,Sindhava VJ,Huang Y,Burkhardt JK,Yang E,Riese MJ,Maltzman JS,Jordan MS,Kambayashi T
14-5773 was used in Flow cytometry/Cell sorting to reveal that T cell receptor-mediated PLCγ activation is required for Tregs to inhibit Tconv proliferation.
Fri May 01 00:00:00 UTC 2015
Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
Journal of immunology (Baltimore, Md. : 1950)
Suryawanshi A,Manoharan I,Hong Y,Swafford D,Majumdar T,Taketo MM,Manicassamy B,Koni PA,Thangaraju M,Sun Z,Mellor AL,Munn DH,Manicassamy S
14-5773 was used in Flow cytometry/Cell sorting to study the factors in the tissue microenvironment and signalling networks critical for programming dendritic cells to control chronic inflammation and promote tolerance, showing that Th1/Th17 responses are regulated by canonical Wnt signalling in dendritic cells and suppresses autoimmune neuroinflammation.
Wed Apr 01 00:00:00 UTC 2015
Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S
14-5773-82 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.
Sun Mar 15 00:00:00 UTC 2015
Inhibition of System Xc(-) Transporter Attenuates Autoimmune Inflammatory Demyelination.
Journal of immunology (Baltimore, Md. : 1950)
Evonuk KS,Baker BJ,Doyle RE,Moseley CE,Sestero CM,Johnston BP,De Sarno P,Tang A,Gembitsky I,Hewett SJ,Weaver CT,Raman C,DeSilva TM
14-5773 was used in Flow cytometry/Cell sorting to investigate the link between inflammation and glutamate dysregulation in EAE, showing that inhibition of system Xc(-) transporter attenuates autoimmune inflammatory demyelination.
Wed Jul 15 00:00:00 UTC 2015
Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance.
Transplantation
Lal G,Nakayama Y,Sethi A,Singh AK,Burrell BE,Kulkarni N,Brinkman CC,Iwami D,Zhang T,Bromberg JS
14577382 was used in flow cytometry and immunohistochemistry to determine if specific B cell subsets or if B cell-derived interleukin-10 contributes to tolerance
Tue Sep 01 00:00:00 UTC 2015
Cytotoxic T lymphocyte-associated antigen 4 inhibition increases the antitumor activity of adoptive T-cell therapy when carried out with naïve rather than differentiated T cells.
Oncology reports
Ishikawa T,Adachi S,Okayama T,Kokura S,Mizushima K,Doi T,Matsuyama T,Sakamoto N,Katada K,Kamada K,Uchiyama K,Handa O,Takagi T,Naito Y,Itoh Y,Yoshikawa T
14-5773 was used in Immunohistochemistry to explore the effect of combination therapy with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) inhibition and adoptive T-cell therapy in a clinical setting.
Fri May 01 00:00:00 UTC 2015
Introduction of Zinc-salt Fixation for Effective Detection of Immune Cell-related Markers by Immunohistochemistry.
Toxicologic pathology
Mori H,Soonsawad P,Schuetter L,Chen Q,Hubbard NE,Cardiff RD,Borowsky AD
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Sat Aug 01 00:00:00 UTC 2015
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.
Nature communications
Baruch K,Rosenzweig N,Kertser A,Deczkowska A,Sharif AM,Spinrad A,Tsitsou-Kampeli A,Sarel A,Cahalon L,Schwartz M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Aug 18 00:00:00 UTC 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Sep 29 00:00:00 UTC 2015
Injectable cryogel-based whole-cell cancer vaccines.
Nature communications
Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Aug 12 00:00:00 UTC 2015
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.
Oncoimmunology
Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sun Mar 01 00:00:00 UTC 2015
Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.
Scientific reports
Guo A,He D,Xu HB,Geng CA,Zhao J
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Sep 15 00:00:00 UTC 2015
MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.
Nature communications
Pratama A,Srivastava M,Williams NJ,Papa I,Lee SK,Dinh XT,Hutloff A,Jordan MA,Zhao JL,Casellas R,Athanasopoulos V,Vinuesa CG
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 06 00:00:00 UTC 2015
Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer.
Oncotarget
Patel MR,Jacobson BA,Ji Y,Drees J,Tang S,Xiong K,Wang H,Prigge JE,Dash AS,Kratzke AK,Mesev E,Etchison R,Federspiel MJ,Russell SJ,Kratzke RA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Oct 20 00:00:00 UTC 2015
Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer.
Journal for immunotherapy of cancer
Liao JB,Ovenell KJ,Curtis EE,Cecil DL,Koehnlein MR,Rastetter LR,Gad EA,Disis ML
14577382 was used in immunohistochemistry to determine the immune profile of a murine ovarian cancer model.
Wed May 20 00:00:00 UTC 2015
Preventing Allograft Rejection by Targeting Immune Metabolism.
Cell reports
Lee CF,Lo YC,Cheng CH,Furtmüller GJ,Oh B,Andrade-Oliveira V,Thomas AG,Bowman CE,Slusher BS,Wolfgang MJ,Brandacher G,Powell JD
14-5773-82 was used in Flow Cytometry to study whether inhibition of glycolysis and glutamine metabolism prevents graft rejection by inhibiting effector generation and function and promoting regulatory T cell generation.
Tue Oct 27 00:00:00 UTC 2015
Interleukin-35 administration counteracts established murine type 1 diabetes--possible involvement of regulatory T cells.
Scientific reports
Singh K,Kadesjö E,Lindroos J,Hjort M,Lundberg M,Espes D,Carlsson PO,Sandler S,Thorvaldson L
14-5773 was used in Flow cytometry/Cell sorting to suggest that insufficient IL-35 levels play a pivotal role in the development of T1D and that treatment with IL-35 should be investigated in treatment of T1D and other autoimmune diseases.
Thu Jul 30 00:00:00 UTC 2015
Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance.
PloS one
Houlden A,Hayes KS,Bancroft AJ,Worthington JJ,Wang P,Grencis RK,Roberts IS
14-5773 was used in Flow cytometry/Cell sorting to investigate the effects of T. muris infection on the faecal microbiota of mice.
Wed Apr 06 00:00:00 UTC 2016
FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration.
PloS one
Castiglioni A,Corna G,Rigamonti E,Basso V,Vezzoli M,Monno A,Almada AE,Mondino A,Wagers AJ,Manfredi AA,Rovere-Querini P
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that regulatory T-cells are critical in effective skeletal muscle regeneration.
Sun May 01 00:00:00 UTC 2016
All-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-β.
BMC immunology
Wang X,Wang W,Xu J,Wu S,Le Q
14-5773 was used in Flow cytometry/Cell sorting to investigate the potential effect of the application of ATRA and TGF-β on immunological tolerance and the treatment of posttransplant rejection.
Thu Mar 19 00:00:00 UTC 2015
Preventive Anti-CD2 Treatment does not Impair Parasite Control in a Murine Toxoplasmosis Model.
European journal of microbiology & immunology
Erben U,Pawlowski NN,Heimesaat MM,Loddenkemper C,Doerfel K,Spieckermann S,Siegmund B,Kühl AA
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to investigate whether the anti-CD2 monoclonal antibody CB.219 has adverse effects on infection control.
Tue Dec 01 00:00:00 UTC 2015
Latent virus infection upregulates CD40 expression facilitating enhanced autoimmunity in a model of multiple sclerosis.
Scientific reports
Casiraghi C,Márquez AC,Shanina I,Horwitz MS
14-5773 was used in Flow cytometry/Cell sorting to investigate the cause of enhanced experimental autoimmune encephalomyelitis following infection with murine γ-herpesvirus 68.
Thu Sep 10 00:00:00 UTC 2015
Doxil synergizes with cancer immunotherapies to enhance antitumor responses in syngeneic mouse models.
Neoplasia (New York, N.Y.)
Rios-Doria J,Durham N,Wetzel L,Rothstein R,Chesebrough J,Holoweckyj N,Zhao W,Leow CC,Hollingsworth R
14-5773 was used in Flow cytometry/Cell sorting to investigate the ability of doxorubicin and liposomal doxorubicin to enhance the antitumor response of different cancer immunotherapies in mouse models.
Sat Aug 01 00:00:00 UTC 2015
Cellular size as a means of tracking mTOR activity and cell fate of CD4+ T cells upon antigen recognition.
PloS one
Pollizzi KN,Waickman AT,Patel CH,Sun IH,Powell JD
14-5773 was used in Flow cytometry/Cell sorting to characterise the metabolism and immunologic functions of distinct clonal populations of activated T cells.
Fri Mar 25 00:00:00 UTC 2016
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 UTC 2015
Higher Sensitivity of Foxp3+ Treg Compared to Foxp3- Conventional T Cells to TCR-Independent Signals for CD69 Induction.
PloS one
Bremser A,Brack M,Izcue A
14-5773 was used in Flow cytometry/Cell sorting to investigate the effects of TCR signals on T cells through studying the expression of T cell activation marker CD69.
Tue May 24 00:00:00 UTC 2016
Matrix Metalloproteinase-2 Mediates Intestinal Immunopathogenesis in Campylobacter Jejuni-Infected Infant Mice.
European journal of microbiology & immunology
Alutis ME,Grundmann U,Hagen U,Fischer A,Kühl AA,Göbel UB,Bereswill S,Heimesaat MM
14-5773 was used in Immunohistochemistry to suggest an important role of MMP-2 in mediating Campylobacter jejuni-induced intestinal immunopathogenesis.
Tue Sep 01 00:00:00 UTC 2015
The Role of Regulatory CD4 T Cells in Maintaining Tolerance in a Mouse Model of Autoimmune Hepatitis.
PloS one
An Haack I,Derkow K,Riehn M,Rentinck MN,Kühl AA,Lehnardt S,Schott E
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to add to the evidence for an important role of Treg in autoimmune hepatitis and show that Treg reduce the severity of T-cell mediated hepatitis in vivo.
Mon Jun 20 00:00:00 UTC 2016
Anti-Inflammatory Properties of NAP in Acute Toxoplasma Gondii-Induced Ileitis in Mice.
European journal of microbiology & immunology
Heimesaat MM,Fischer A,Kühl AA,Göbel UB,Gozes I,Bereswill S
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to investigate potential anti-inflammatory effects of the octapeptide NAP in an acute ileitis model.
Tue Sep 01 00:00:00 UTC 2015
Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice.
Journal of neuroinflammation
Djukic M,Sostmann N,Bertsch T,Mecke M,Nessler S,Manig A,Hanisch UK,Triebel J,Bollheimer LC,Sieber C,Nau R
14-5773 was used in Flow cytometry/Cell sorting to suggest a detrimental role of vitamin D deficiency in bacterial central nervous system infections.
Wed Jan 07 00:00:00 UTC 2015
Th1-Like ICOS+ Foxp3+ Treg Cells Preferentially Express CXCR3 and Home to β-Islets during Pre-Diabetes in BDC2.5 NOD Mice.
PloS one
Kornete M,Mason ES,Girouard J,Lafferty EI,Qureshi S,Piccirillo CA
14-5773 was used in Flow cytometry/Cell sorting to reveal that CXCR3-mediated trafficking of Tregs could represent a mechanism of homeostatic immunoregulation during diabetogenesis.
Mon Apr 25 00:00:00 UTC 2016
BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.
International journal of clinical and experimental pathology
Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF
14-5773 was used in Flow cytometry/Cell sorting to study the role of BLTA in ulcerative colitis, showing that the frequency Foxp3-expressing BLTA+CD4(+) T cells from the lamina propria was higher in mice with colitis, and treatment downregulated Foxp3 and IL-17 in BTLA+ cells.
Tue Mar 01 00:00:00 UTC 2016
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.
Nature medicine
Motz GT,Santoro SP,Wang LP,Garrabrant T,Lastra RR,Hagemann IS,Lal P,Feldman MD,Benencia F,Coukos G
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that tumor paracrine mechanisms establish a tumor endothelial death barrier, which is critical in establishing immune tolerance.
Sun Jun 01 00:00:00 UTC 2014
Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids.
Nature medicine
Khalifeh-Soltani A,McKleroy W,Sakuma S,Cheung YY,Tharp K,Qiu Y,Turner SM,Chawla A,Stahl A,Atabai K
14-5773 was used in Flow cytometry/Cell sorting to suggest a role of Mfge8 in regulating the absorption and storage of dietary fats, and development of obesity.
Sat Feb 01 00:00:00 UTC 2014
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
14-5773 was used in Flow cytometry/Cell sorting to investigate a T-cell-intrinsic function of the transcriptional regulator Bcl-3 in autoimmunity.
Thu Oct 16 00:00:00 UTC 2014
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
Immunity
Zigmond E,Bernshtein B,Friedlander G,Walker CR,Yona S,Kim KW,Brenner O,Krauthgamer R,Varol C,Müller W,Jung S
14-5773 was used in Flow cytometry/Cell sorting to show IL-10 as a critical homeostatic macrophage-conditioning agent in the colon and that intestinal CX3CR1(hi) macrophages determine gut health or inflammation.
Thu May 15 00:00:00 UTC 2014
Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.
Cancer cell
Xu C,Fillmore CM,Koyama S,Wu H,Zhao Y,Chen Z,Herter-Sprie GS,Akbay EA,Tchaicha JH,Altabef A,Reibel JB,Walton Z,Ji H,Watanabe H,Jänne PA,Castrillon DH,Rustgi AK,Bass AJ,Freeman GJ,Padera RF,Dranoff G,Hammerman PS,Kim CF,Wong KK
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon May 12 00:00:00 UTC 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu May 01 00:00:00 UTC 2014
The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.
Nature immunology
Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu May 01 00:00:00 UTC 2014
Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells.
Nature immunology
Arvey A,van der Veeken J,Samstein RM,Feng Y,Stamatoyannopoulos JA,Rudensky AY
14-5773 was used in Western Blotting to demonstrate that Foxp3 poises its targets for repression by facilitating the formation of repressive chromatin in Treg cells.
Sun Jun 01 00:00:00 UTC 2014
Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.
Nature immunology
Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA
14-5773 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..
Thu May 01 00:00:00 UTC 2014
Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.
Circulation research
Weirather J,Hofmann UD,Beyersdorf N,Ramos GC,Vogel B,Frey A,Ertl G,Kerkau T,Frantz S
14-5773 was used in Flow cytometry/Cell sorting to determine the mechanisms by which regulatory T cells promote an appropriate healing response after a heart attack.
Fri Jun 20 00:00:00 UTC 2014
Circulating T follicular regulatory and helper cells have memory-like properties.
The Journal of clinical investigation
Sage PT,Alvarez D,Godec J,von Andrian UH,Sharpe AH
14-5773 was used in Flow cytometry/Cell sorting to indicate circulating memory-like Tfr cells are less suppressive than LN Tfr cells and circulating memory-like Tfh cells are more potent than LN effector Tfh cells.
Mon Dec 01 00:00:00 UTC 2014
Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
The Journal of clinical investigation
Bauer CA,Kim EY,Marangoni F,Carrizosa E,Claudio NM,Mempel TR
14-5773 was used in Flow cytometry/Cell sorting to find that Tregs induce a dysfunctional state in tumor-infiltrating CTLs that resembles T cell exhaustion.
Sun Jun 01 00:00:00 UTC 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-5773 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 UTC 2014
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.
The Journal of experimental medicine
Penaloza-MacMaster P,Kamphorst AO,Wieland A,Araki K,Iyer SS,West EE,O'Mara L,Yang S,Konieczny BT,Sharpe AH,Freeman GJ,Rudensky AY,Ahmed R
14-5773 was used in Flow cytometry/Cell sorting to investigate a role for T reg cells in exhaustion of virus-specific CD8 T cells.
Mon Aug 25 00:00:00 UTC 2014
Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.
The Journal of experimental medicine
Vaeth M,Müller G,Stauss D,Dietz L,Klein-Hessling S,Serfling E,Lipp M,Berberich I,Berberich-Siebelt F
14-5773 was used in Flow cytometry/Cell sorting to highlight that NFAT2 is essential for both an adequate and nonpathological humoral immune response.
Mon Mar 10 00:00:00 UTC 2014
Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression.
The Journal of experimental medicine
Vaeth M,Müller G,Stauss D,Dietz L,Klein-Hessling S,Serfling E,Lipp M,Berberich I,Berberich-Siebelt F
14-5773 was used in Flow cytometry/Cell sorting to highlight that NFAT2 is essential for both an adequate and nonpathological humoral immune response.
Mon Mar 10 00:00:00 UTC 2014
Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kim TS,Cavnar MJ,Cohen NA,Sorenson EC,Greer JB,Seifert AM,Crawley MH,Green BL,Popow R,Pillarsetty N,Veach DR,Ku AT,Rossi F,Besmer P,Antonescu CR,Zeng S,Dematteo RP
14-5773 was used in Flow cytometry/Cell sorting to explore the ability of PLX3397 to deplete tumour-associated macrophages in gastrointestinal stromal cancer models.
Thu May 01 00:00:00 UTC 2014
Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.
Cancer research
Guéry L,Dubrot J,Lippens C,Brighouse D,Malinge P,Irla M,Pot C,Reith W,Waldburger JM,Hugues S
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of Ag-presenting CpG-activated pDCs in Th17 differentiation and antitumor immunity.
Sat Nov 15 00:00:00 UTC 2014
Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ.
Cancer research
Ho PC,Meeth KM,Tsui YC,Srivastava B,Bosenberg MW,Kaech SM
14-5773 was used in Flow cytometry/Cell sorting to investigate whether B-Raf(V600E) inhibitors promote tumor regression with the help of host immunity, showing that they rely on signaling by CD40L and IFNγ.
Sun Jun 15 00:00:00 UTC 2014
Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America
Hefetz-Sela S,Stein I,Klieger Y,Porat R,Sade-Feldman M,Zreik F,Nagler A,Pappo O,Quagliata L,Dazert E,Eferl R,Terracciano L,Wagner EF,Ben-Neriah Y,Baniyash M,Pikarsky E
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Tue Dec 09 00:00:00 UTC 2014
KLF2 is a rate-limiting transcription factor that can be targeted to enhance regulatory T-cell production.
Proceedings of the National Academy of Sciences of the United States of America
Pabbisetty SK,Rabacal W,Maseda D,Cendron D,Collins PL,Hoek KL,Parekh VV,Aune TM,Sebzda E
14-5773 was used in Flow cytometry/Cell sorting to identify the first transcription factor to distinguish between i/pTreg and tTreg ontogeny and demonstrate that KLF2 is a therapeutic target for the production of regulatory T cells.
Tue Jul 01 00:00:00 UTC 2014
Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity.
Annals of neurology
Breuer J,Schwab N,Schneider-Hohendorf T,Marziniak M,Mohan H,Bhatia U,Gross CC,Clausen BE,Weishaupt C,Luger TA,Meuth SG,Loser K,Wiendl H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu May 01 00:00:00 UTC 2014
Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products.
Environmental health perspectives
Whitehead GS,Thomas SY,Cook DN
14-5773 was used in Flow cytometry/Cell sorting to assess pulmonary cytokine production and airway inflammation following challenge with ovalbumin and LPS.
Wed Jan 01 00:00:00 UTC 2014
Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites.
Gut microbes
Reynolds LA,Smith KA,Filbey KJ,Harcus Y,Hewitson JP,Redpath SA,Valdez Y,Yebra MJ,Finlay BB,Maizels RM
14-5773 was used in Flow cytometry/Cell sorting to discover this tripartite interaction between host, bacteria and parasite has important implications for both antibiotic and anthelmintic use in endemic human populations.
Tue Jul 01 00:00:00 UTC 2014
DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Yoshida O,Kimura S,Dou L,Matta BM,Yokota S,Ross MA,Geller DA,Thomson AW
14-5773 was used in Flow cytometry/Cell sorting to show that DAP12 expression in liver grafts regulates donor mDC migration to host lymphoid tissue, alloreactive T cell responses and transplant tolerance.
Fri Aug 01 00:00:00 UTC 2014
Depletion of foxp3(+) T cells abrogates tolerance of skin and heart allografts in murine mixed chimeras without the loss of mixed chimerism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Shinoda K,Akiyoshi T,Chase CM,Farkash EA,Ndishabandi DK,Raczek CM,Sebastian DP,Pelle PD,Russell PS,Madsen JC,Colvin RB,Alessandrini A
14-5773 was used in Flow cytometry/Cell sorting to investigate the relative contribution of central and peripheral mechanisms to the generation of skin and heart allograft tolerance in murine mixed chimeras.
Wed Oct 01 00:00:00 UTC 2014
Gene targeting in NOD mouse embryos using zinc-finger nucleases.
Diabetes
Chen YG,Forsberg MH,Khaja S,Ciecko AE,Hessner MJ,Geurts AM
14-5773 was used in Flow cytometry/Cell sorting to investigate how to generate gene-targeted knockouts in a pure NOD background by using ZFNs without potential confounding factors introduced by contaminating genetic materials obtained from other strains.
Wed Jan 01 00:00:00 UTC 2014
Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment.
eLife
Han BY,Wu S,Foo CS,Horton RM,Jenne CN,Watson SR,Whittle B,Goodnow CC,Cyster JG
14-5773 was used in Flow cytometry/Cell sorting to characterise the phenotype of a mutant mouse exhibiting a mutated zinc finger protein.
Fri Oct 24 00:00:00 UTC 2014
Epigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.
eLife
Fu W,Farache J,Clardy SM,Hattori K,Mander P,Lee K,Rioja I,Weissleder R,Prinjha RK,Benoist C,Mathis D
14-5773 was used in Flow cytometry/Cell sorting to show that a short treatment with I-BET151, a small-molecule inhibitor of a family of bromodomain-containing transcriptional regulators, irreversibly suppressed development of type-1 diabetes in NOD mice.
Wed Nov 19 00:00:00 UTC 2014
Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.
European journal of immunology
Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T
14-5773 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.
Wed Oct 01 00:00:00 UTC 2014
Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.
Immunology and cell biology
Filbey KJ,Grainger JR,Smith KA,Boon L,van Rooijen N,Harcus Y,Jenkins S,Hewitson JP,Maizels RM
14-5773 was used in Flow cytometry/Cell sorting to study the differential levels of resistance to the nematode, H. polygyrus, that are observable between mouse models.
Wed Jan 07 00:00:00 UTC 2015
Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Jul 15 00:00:00 UTC 2014
IFNαR signaling in effector but not regulatory T cells is required for immune dysregulation during type I IFN-dependent inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950)
Srivastava S,Koch LK,Campbell DJ
14-5773 was used in Flow cytometry/Cell sorting to study how chronic IFN expression can drive inflammatory disease via its direct effects on effector, but not regulatory, T cells.
Mon Sep 15 00:00:00 UTC 2014
MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.
Journal of immunology (Baltimore, Md. : 1950)
Reynolds LA,Harcus Y,Smith KA,Webb LM,Hewitson JP,Ross EA,Brown S,Uematsu S,Akira S,Gray D,Gray M,MacDonald AS,Cunningham AF,Maizels RM
14-5773 was used in Flow cytometry/Cell sorting to explore the role of the MyD88 adapter protein during Heligmosomoides polygyrus infection in the C57BL/6 mice.
Mon Sep 15 00:00:00 UTC 2014
Preemptive donor apoptotic cell infusions induce IFN-γ-producing myeloid-derived suppressor cells for cardiac allograft protection.
Journal of immunology (Baltimore, Md. : 1950)
Bryant J,Lerret NM,Wang JJ,Kang HK,Tasch J,Zhang Z,Luo X
14-5773 was used in Immunohistochemistry on frozen tissues to investigate the role of MDSCs in the graft protection provided by ECDI-SPs, showing that preemptive donor apoptotic cell infusions induce IFN-γ-producing MDSCs.
Sun Jun 15 00:00:00 UTC 2014
Mode of delivery shapes gut colonization pattern and modulates regulatory immunity in mice.
Journal of immunology (Baltimore, Md. : 1950)
Hansen CH,Andersen LS,Krych L,Metzdorff SB,Hasselby JP,Skov S,Nielsen DS,Buschard K,Hansen LH,Hansen AK
14-5773 was used in Immunohistochemistry to demonstrate that mode of delivery has a major impact on the early composition of the gut microbiota in mice.
Fri Aug 01 00:00:00 UTC 2014
IL-21 receptor signalling partially mediates Th2-mediated allergic airway responses.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Lajoie S,Lewkowich I,Herman NS,Sproles A,Pesce JT,Wynn TA,Grusby MJ,Hamid Q,Wills-Karp M
14-5773 was used in Flow cytometry/Cell sorting to suggest that IL-21 plays an important role in the allergic diathesis by enhancing Th2 cytokine production through multiple mechanisms.
Tue Jul 01 00:00:00 UTC 2014
Simultaneous transplantation of hematopoietic stem cells and a vascularized composite allograft leads to tolerance.
Transplantation
Mathes DW,Chang J,Hwang B,Graves SS,Storer BE,Butts-Miwongtum T,Sale GE,Storb R
14-5773 was used in Immunohistochemistry to investigate whether tolerance to vascularised composite allograft is dependent on the prior establishment of mixed chimerism, and if it can be induced coincident with haematopoietic cell transplantation.
Sun Jul 27 00:00:00 UTC 2014
Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.
Carcinogenesis
Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB
14-5773 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.
Tue Apr 01 00:00:00 UTC 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Jan 05 00:00:00 UTC 2015
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu May 01 00:00:00 UTC 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu May 01 00:00:00 UTC 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu May 01 00:00:00 UTC 2014
Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector.
Scientific reports
Rim YA,Yi H,Kim Y,Park N,Jung H,Kim J,Jung SM,Park SH,Ju JH
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Nov 06 00:00:00 UTC 2014
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.
Nature communications
Ling GS,Bennett J,Woollard KJ,Szajna M,Fossati-Jimack L,Taylor PR,Scott D,Franzoso G,Cook HT,Botto M
14-5773 was used in Immunohistochemistry to assess the role of CD11b on regulating TLR4-signalling in dendritic cells and macrophages.
Tue Nov 24 00:00:00 UTC 2015
Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.
PloS one
Samuelson EM,Laird RM,Papillion AM,Tatum AH,Princiotta MF,Hayes SM
14-5773 was used in Flow cytometry/Cell sorting to demonstrate how BLK risk alleles confer susceptibility to systemic lupus erythematosus.
Tue Nov 11 00:00:00 UTC 2014
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
14-5773 was used in Western Blotting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 UTC 2015
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
14-5773 was used in Western Blotting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 UTC 2015
In vitro induced regulatory T cells are unique from endogenous regulatory T cells and effective at suppressing late stages of ongoing autoimmunity.
PloS one
Nguyen TL,Makhlouf NT,Anthony BA,Teague RM,DiPaolo RJ
14-5773 was used in Flow cytometry/Cell sorting to evaluate the ability of TGF-β-induced Tregs specific for the major self-antigen in autoimmune gastritis to suppress the established disease.
Mon May 11 00:00:00 UTC 2015
Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection.
Journal of neuroinflammation
Ribes S,Meister T,Ott M,Redlich S,Janova H,Hanisch UK,Nessler S,Nau R
14-5773 was used in Flow cytometry/Cell sorting to suggest that systemic administration of CpG ODN may help to prevent bacterial CNS infections in immunocompromised individuals.
Thu Jan 23 00:00:00 UTC 2014
Comparison of microbiological, histological, and immunomodulatory parameters in response to treatment with either combination therapy with prednisone and metronidazole or probiotic VSL#3 strains in dogs with idiopathic inflammatory bowel disease.
PloS one
Rossi G,Pengo G,Caldin M,Palumbo Piccionello A,Steiner JM,Cohen ND,Jergens AE,Suchodolski JS
14-5773 was used in Immunohistochemistry to compare responses to treatment with either combination therapy (prednisone and metronidazole) or probiotic strains (VSL#3) in dogs with Idiopathic inflammatory bowel disease.
Fri Jun 05 00:00:00 UTC 2015
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
PloS one
Thelemann C,Eren RO,Coutaz M,Brasseit J,Bouzourene H,Rosa M,Duval A,Lavanchy C,Mack V,Mueller C,Reith W,Acha-Orbea H
14-5773 was used in Flow cytometry/Cell sorting to investigate how epithelial MHCII expression is induced and how a deficiency in inducible epithelial MHCII expression alters susceptibility to colitis and the outcome of colon-specific immune responses.
Mon Dec 22 00:00:00 UTC 2014
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-5773 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 UTC 2015
CCR6, the sole receptor for the chemokine CCL20, promotes spontaneous intestinal tumorigenesis.
PloS one
Nandi B,Pai C,Huang Q,Prabhala RH,Munshi NC,Gold JS
14-5773 was used in Immunohistochemistry to demonstrate that interactions between CCL20 and CCR6 promote spontaneous intestinal carcinogenesis.
Thu Dec 03 00:00:00 UTC 2015
Depletion of alveolar macrophages ameliorates virus-induced disease following a pulmonary coronavirus infection.
PloS one
Hartwig SM,Holman KM,Varga SM
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that alveolar macrophages play a critical role in modulating MHV-1-induced morbidity and mortality.
Tue Dec 30 00:00:00 UTC 2014
Macrophage microRNA-155 promotes cardiac hypertrophy and failure.
Circulation
Heymans S,Corsten MF,Verhesen W,Carai P,van Leeuwen RE,Custers K,Peters T,Hazebroek M,Stöger L,Wijnands E,Janssen BJ,Creemers EE,Pinto YM,Grimm D,Schürmann N,Vigorito E,Thum T,Stassen F,Yin X,Mayr M,de Windt LJ,Lutgens E,Wouters K,de Winther MP,Zacchigna S,Giacca M,van Bilsen M,Papageorgiou AP,Schroen B
14-5773 was used in Flow cytometry/Cell sorting to investigate the therapeutic effects of microRNA-155 manipulation in hypertensive heart disease.
Tue Sep 24 00:00:00 UTC 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.
Nature immunology
Kim JS,Sklarz T,Banks LB,Gohil M,Waickman AT,Skuli N,Krock BL,Luo CT,Hu W,Pollizzi KN,Li MO,Rathmell JC,Birnbaum MJ,Powell JD,Jordan MS,Koretzky GA
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Jun 01 00:00:00 UTC 2013
The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood.
Nature immunology
Sage PT,Francisco LM,Carman CV,Sharpe AH
14-5773-82 was used in Flow Cytometry to study the mechanisms by which the PD-1 pathway regulates antibody production and reconcile inconsistencies surrounding the role of this pathway in humoural immunity.
Fri Feb 01 00:00:00 UTC 2013
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.
Nature immunology
Keating R,Hertz T,Wehenkel M,Harris TL,Edwards BA,McClaren JL,Brown SA,Surman S,Wilson ZS,Bradley P,Hurwitz J,Chi H,Doherty PC,Thomas PG,McGargill MA
14-5773 was used in Flow cytometry/Cell sorting to investigate the immunological mechanisms that promote heterosubtypic immunity, showing that mTOR modulates the antibody response to provide cross-protective immunity to lethal infection.
Sun Dec 01 00:00:00 UTC 2013
Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
Blood
Nijagal A,Derderian C,Le T,Jarvis E,Nguyen L,Tang Q,Mackenzie TC
14-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms of antigen presentation that induce a tolerant post-transplant immune response.
Thu May 30 00:00:00 UTC 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-5773-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 UTC 2013
Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.
The Journal of clinical investigation
Marabelle A,Kohrt H,Sagiv-Barfi I,Ajami B,Axtell RC,Zhou G,Rajapaksa R,Green MR,Torchia J,Brody J,Luong R,Rosenblum MD,Steinman L,Levitsky HI,Tse V,Levy R
14-5773-82 was used in Flow Cytometry to demonstrate that intratumoral coinjection of anti-CTLA-4 and anti-OX40 together with CpG depletes tumour-infiltrating regulatory T cells.
Sat Jun 01 00:00:00 UTC 2013
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
The Journal of clinical investigation
Huber M,Heink S,Pagenstecher A,Reinhard K,Ritter J,Visekruna A,Guralnik A,Bollig N,Jeltsch K,Heinemann C,Wittmann E,Buch T,Prazeres da Costa O,Brüstle A,Brenner D,Mak TW,Mittrücker HW,Tackenberg B,Kamradt T,Lohoff M
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of IL-17-producing CD8+ T cells in multiple sclerosis using a murine model.
Tue Jan 01 00:00:00 UTC 2013
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.
Kidney international
Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X
14-5773 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.
Sun Sep 01 00:00:00 UTC 2013
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation.
The Journal of experimental medicine
Zhang R,Lu G,Shen Y,Peng L,Zhu C,Cui M,Wang W,Arnaboldi P,Tang M,Gupta M,Qi CF,Jayaraman P,Zhu H,Jiang B,Chen SH,He JC,Ting AT,Zhou MM,Kuchroo VK,Morse HC,Ozato K,Sikora AG,Xiong H
14-5773 was used in Flow cytometry/Cell sorting to study the effect of inducible nitric oxide synthase on T(H)17 cell differentiation.
Mon Jul 01 00:00:00 UTC 2013
Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection.
The Journal of experimental medicine
Vom Berg J,Vrohlings M,Haller S,Haimovici A,Kulig P,Sledzinska A,Weller M,Becher B
14-5773 was used in Flow cytometry/Cell sorting to study intratumoral elicitors of T-cell mediated glioma rejection.
Mon Dec 16 00:00:00 UTC 2013
Regulatory T cell-derived IL-10 ameliorates crescentic GN.
Journal of the American Society of Nephrology : JASN
Ostmann A,Paust HJ,Panzer U,Wegscheid C,Kapffer S,Huber S,Flavell RA,Erhardt A,Tiegs G
14-5773 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to suggest the importance of Treg-derived IL-10 in ameliorating disease severity and in modulating both the Th1 and most notably Th17 immune response.
Wed May 01 00:00:00 UTC 2013
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.
Journal of autoimmunity
Podojil JR,Liu LN,Marshall SA,Chiang MY,Goings GE,Chen L,Langermann S,Miller SD
14-5773 was used in Flow cytometry/Cell sorting to investigate the inhibition of mouse and human T-cell function and treatment of EAE via IL-10/Treg-dependent mechanisms through B7-H4Ig.
Thu Aug 01 00:00:00 UTC 2013
Aire deficiency promotes TRP-1-specific immune rejection of melanoma.
Cancer research
Zhu ML,Nagavalli A,Su MA
14-5773 was used in Flow cytometry/Cell sorting to show how Aire deficiency can enhance immune responses against melanoma and offer a logical strategy to enhance immune rejection of melanoma.
Mon Apr 01 00:00:00 UTC 2013
Delicate balance among three types of T cells in concurrent regulation of tumor immunity.
Cancer research
Izhak L,Ambrosino E,Kato S,Parish ST,O'Konek JJ,Weber H,Xia Z,Venzon D,Berzofsky JA,Terabe M
14-5773 was used in Flow cytometry/Cell sorting to study the dominance of regulatory T cells and type II natural killer T cells in the colorectal and renal tumour environment.
Fri Mar 01 00:00:00 UTC 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Mar 01 00:00:00 UTC 2013
Diacylglycerol kinase ζ limits the generation of natural regulatory T cells.
Science signaling
Schmidt AM,Zou T,Joshi RP,Leichner TM,Pimentel MA,Sommers CL,Kambayashi T
14-5773 was used in Flow cytometry/Cell sorting to identify critical signal events in nT(reg) cell development, showing that diacylglycerol kinase ζ limits the generation of nT(reg) cells.
Tue Nov 26 00:00:00 UTC 2013
TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity.
Diabetes
Kota DJ,Wiggins LL,Yoon N,Lee RH
14-5773 was used in Immunohistochemistry to provide the basis for a novel therapy for the prevention of type 1 diabetes.
Sat Jun 01 00:00:00 UTC 2013
Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.
Diabetes
Wang S,Tasch J,Kheradmand T,Ulaszek J,Ely S,Zhang X,Hering BJ,Miller SD,Luo X
14-5773 was used in Immunohistochemistry to show a robust strategy for the induction of xenodonor-specific T and B-cell tolerance.
Sun Sep 01 00:00:00 UTC 2013
Host defense and recruitment of Foxp3⁺ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2.
PLoS pathogens
McBride A,Konowich J,Salgame P
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that TLR2 contributes to host resistance against chronic Mycobacterium tuberculosis infection.
Fri Jan 17 00:00:00 UTC 2014
Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
PLoS pathogens
Worthington JJ,Klementowicz JE,Rahman S,Czajkowska BI,Smedley C,Waldmann H,Sparwasser T,Grencis RK,Travis MA
14-5773 was used in Flow cytometry/Cell sorting to describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection.
Mon May 26 00:00:00 UTC 2014
T cell-derived IL-10 determines leishmaniasis disease outcome and is suppressed by a dendritic cell based vaccine.
PLoS pathogens
Schwarz T,Remer KA,Nahrendorf W,Masic A,Siewe L,Müller W,Roers A,Moll H
14-5773 was used in Flow cytometry/Cell sorting to iL-10 secretion by T-cells influences immune activation early after infection, rendering BALB/c mice susceptible to an uncontrolled Leishmania major infection.
Fri Jan 17 00:00:00 UTC 2014
Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Stubbe T,Ebner F,Richter D,Engel O,Klehmet J,Royl G,Meisel A,Nitsch R,Meisel C,Brandt C
14-5773 was used in Flow cytometry/Cell sorting to study immune cell distribution and function after middle cerebral artery occlusion.
Tue Jan 01 00:00:00 UTC 2013
Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection.
Journal of virology
Trujillo JA,Fleming EL,Perlman S
14-5773 was used in Flow cytometry/Cell sorting to examine the role of CCL2 during virus infection, showing that CCL2 expression in the CNS results in a dysregulated immune response after coronavirus infection.
Fri Mar 01 00:00:00 UTC 2013
Galectin-1 controls cardiac inflammation and ventricular remodeling during acute myocardial infarction.
The American journal of pathology
Seropian IM,Cerliani JP,Toldo S,Van Tassell BW,Ilarregui JM,González GE,Matoso M,Salloum FN,Melchior R,Gelpi RJ,Stupirski JC,Benatar A,Gómez KA,Morales C,Abbate A,Rabinovich GA
14-5773 was used in Immunofluorescence to investigate the role of Gal-1 in modulating heart pathophysiology.
Tue Jan 01 00:00:00 UTC 2013
Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice.
Arthritis research & therapy
Kidder D,Richards HE,Lyons PA,Crocker PR
14-5773 was used in Immunohistochemistry on frozen tissues to investigate a potential causative role of Sialoadhesin in lupus.
Fri Nov 01 00:00:00 UTC 2013
Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang X,Wu C,Song J,Götte M,Sorokin L
14-5773 was used in Flow cytometry/Cell sorting to investigate how the choroid plexus epithelium is a novel source of IL-6 in EAE and demonstrate that its expression negatively correlates with syndecan-1 expression at this site.
Fri Nov 01 00:00:00 UTC 2013
Suppression of inflammatory responses during myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis is regulated by AKT3 signaling.
Journal of immunology (Baltimore, Md. : 1950)
Tsiperson V,Gruber RC,Goldberg MF,Jordan A,Weinger JG,Macian F,Shafit-Zagardo B
14-5773 was used in Immunohistochemistry to indicate that AKT3 signalling contributes to the protection of mice against EAE.
Fri Feb 15 00:00:00 UTC 2013
Myeloid-derived suppressor cells play crucial roles in the regulation of mouse collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Fujii W,Ashihara E,Hirai H,Nagahara H,Kajitani N,Fujioka K,Murakami K,Seno T,Yamamoto A,Ishino H,Kohno M,Maekawa T,Kawahito Y
14-5773 was used in Flow cytometry/Cell sorting to clarify that myeloid-derived suppressor cells are crucial in regulating the proinflammatory immune response in mouse collagen-induced arthritis.
Thu Aug 01 00:00:00 UTC 2013
Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions.
Journal of immunology (Baltimore, Md. : 1950)
Kawakami T,Lichtnekert J,Thompson LJ,Karna P,Bouabe H,Hohl TM,Heinecke JW,Ziegler SF,Nelson PJ,Duffield JS
14-5773 was used in Flow cytometry/Cell sorting to show that resident kidney MPCs comprise discrete subpopulations, producing anti-inflammatory and tissue-homeostatic factors to differing degrees.
Sun Sep 15 00:00:00 UTC 2013
TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Wu X,Zhou Q,Howard OM,Netea MG,Oppenheim JJ
14-5773 was used in Flow cytometry/Cell sorting to investigate means of promoting stability of Tregs, showing that TNFR2 is critical for stabilisation in the inflammatory environment.
Fri Feb 01 00:00:00 UTC 2013
Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.
Journal of immunology (Baltimore, Md. : 1950)
Koni PA,Bolduc A,Takezaki M,Ametani Y,Huang L,Lee JR,Nutt SL,Kamanaka M,Flavell RA,Mellor AL,Tsubata T,Shimoda M
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of constitutively CD40-activated B cells in the CD8 T cell inflammatory response.
Mon Apr 01 00:00:00 UTC 2013
Differential response of regulatory and conventional CD4⁺ lymphocytes to CD3 engagement: clues to a possible mechanism of anti-CD3 action?
Journal of immunology (Baltimore, Md. : 1950)
Li L,Nishio J,van Maurik A,Mathis D,Benoist C
14-5773 was used in Flow cytometry/Cell sorting to demonstrate divergent responses of regulatory and conventional CD4+ T-cells to anti-CD3 engagement.
Tue Oct 01 00:00:00 UTC 2013
Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.
Journal of immunology (Baltimore, Md. : 1950)
Kearl TJ,Jing W,Gershan JA,Johnson BD
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that a blockade of the PD-1/PD-L1 pathway yields positive antitumour results.
Sat Jun 01 00:00:00 UTC 2013
Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Saligrama N,Case LK,del Rio R,Noubade R,Teuscher C
14-5773 was used in Flow cytometry/Cell sorting to explore the contributions of different histamine receptors to the pathogenesis of experimental allergic encephalomyelitis.
Mon Jul 15 00:00:00 UTC 2013
Examining T cells at vaccine sites of tumor-bearing hosts provides insights to dysfunctional T-cell immunity.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Barr KM,Jing W,Hallett WH,Gershan JA,Johnson BD
14-5773 was used in Flow cytometry/Cell sorting to examine immune effectors at vaccine sites to identify mechanisms responsible for the generation of ineffective antitumor immunity, providing insights to dysfunctional T-cell immunity.
Tue Jan 01 00:00:00 UTC 2013
Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes.
The Journal of endocrinology
Bogdani M,Henschel AM,Kansra S,Fuller JM,Geoffrey R,Jia S,Kaldunski ML,Pavletich S,Prosser S,Chen YG,Lernmark A,Hessner MJ
14-5773 was used in Flow cytometry/Cell sorting to find evidence of β cell dysfunction in BB rats independent of T1D progression.
Fri Feb 01 00:00:00 UTC 2013
Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.
Vaccine
Beverley P,Ronan E,Lee L,Arnold I,Bolinger B,Powrie F,Tchilian E
14-5773 was used in Flow cytometry/Cell sorting to show that exposure to environmental microorganisms can alter the protective immune response to a parenterally administered subunit vaccine.
Mon Feb 04 00:00:00 UTC 2013
PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
Tissue engineering. Part A
Graham JG,Zhang X,Goodman A,Pothoven K,Houlihan J,Wang S,Gower RM,Luo X,Shea LD
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Jun 01 00:00:00 UTC 2013
PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
Tissue engineering. Part A
Graham JG,Zhang X,Goodman A,Pothoven K,Houlihan J,Wang S,Gower RM,Luo X,Shea LD
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Sat Jun 01 00:00:00 UTC 2013
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine
Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH
14-5773 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.
Fri Nov 01 00:00:00 UTC 2013
Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.
Biochemical and biophysical research communications
Gonzalez J,Mouttalib S,Delage C,Calise D,Maoret JJ,Pradère JP,Klein J,Buffin-Meyer B,Van der Veen B,Charo IF,Heeringa P,Duchene J,Bascands JL,Schanstra JP
14-5773 was used in Immunohistochemistry to elucidate the roles of CCL7 in renal tubular interstitial fibrosis development, deleterious in early stages but beneficial during later stages.
Fri Aug 23 00:00:00 UTC 2013
Expression of Foxp3, CD25 and IL-2 in the B16F10 cancer cell line and melanoma is correlated with tumor growth in mice.
Oncology letters
Miranda-Hernández DF,Franco-Molina MA,Mendoza-Gamboa E,Zapata-Benavides P,Sierra-Rivera CA,Coronado-Cerda EE,Rosas-Taraco AG,Taméz-Guerra RS,Rodríguez-Padilla C
14-5773 was used in Flow cytometry/Cell sorting to analyse Foxp3 expression in B16F10 melanoma cells in vitro and to determine whether this expression is affected during tumour growth.
Fri Nov 01 00:00:00 UTC 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Jul 31 00:00:00 UTC 2014
The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.
PloS one
Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Thu Jan 23 00:00:00 UTC 2014
Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice.
Oncoimmunology
Bandini S,Curcio C,Macagno M,Quaglino E,Arigoni M,Lanzardo S,Hysi A,Barutello G,Consolino L,Longo DL,Musiani P,Forni G,Iezzi M,Cavallo F
14-5773 was used in Immunohistochemistry on frozen tissues to assess the role of the complement system in the progression of carcinomas.
Sun Sep 01 00:00:00 UTC 2013
Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice.
Oncoimmunology
Bandini S,Curcio C,Macagno M,Quaglino E,Arigoni M,Lanzardo S,Hysi A,Barutello G,Consolino L,Longo DL,Musiani P,Forni G,Iezzi M,Cavallo F
14-5773 was used in Immunohistochemistry on frozen tissues to assess the role of the complement system in the progression of carcinomas.
Sun Sep 01 00:00:00 UTC 2013
Regulatory T cells are protective in systemic inflammation response syndrome induced by zymosan in mice.
PloS one
Jia W,Cao L,Yang S,Dong H,Zhang Y,Wei H,Jing W,Hou L,Wang C
14-5773 was used in Western Blotting to examine the immune mechanisms underlying the development of systemic inflammation response syndrome (SIRS).
Tue Dec 17 00:00:00 UTC 2013
Regulatory T cells are protective in systemic inflammation response syndrome induced by zymosan in mice.
PloS one
Jia W,Cao L,Yang S,Dong H,Zhang Y,Wei H,Jing W,Hou L,Wang C
14-5773 was used in Western Blotting to examine the immune mechanisms underlying the development of systemic inflammation response syndrome (SIRS).
Tue Dec 17 00:00:00 UTC 2013
Combined TIM-3 blockade and CD137 activation affords the long-term protection in a murine model of ovarian cancer.
Journal of translational medicine
Guo Z,Cheng D,Xia Z,Luan M,Wu L,Wang G,Zhang S
14-5773 was used in Flow cytometry/Cell sorting to investigate the effects of anti-TIM-3/CD137 combined mAb in a murine ovarian cancer model.
Tue Sep 17 00:00:00 UTC 2013
Costimulation blockade induces foxp3(+) regulatory T cells to human embryonic stem cells.
BioResearch open access
Ljung K,Simonson OE,Felldin U,Wärdell E,Ibarra C,Antonsson L,Kumagai-Braesch M,Hovatta O,Lampela R,Grinnemo KH,Corbascio M
14-5773 was used in Immunohistochemistry to show that Foxp3(+) T-cells induce tolerance to hESC transplants in mouse kidneys after immunosuppressive costimulation blockade.
Sun Dec 01 00:00:00 UTC 2013
Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1.
PloS one
Chopra M,Lang I,Salzmann S,Pachel C,Kraus S,Bäuerlein CA,Brede C,Garrote AL,Mattenheimer K,Ritz M,Schwinn S,Graf C,Schäfer V,Frantz S,Einsele H,Wajant H,Beilhack A
14-5773 was used in Immunofluorescence to assess the mechanisms underlying the contribution of tumour necrosis factor to carcinogenesis.
Mon May 12 00:00:00 UTC 2014
Myeloablative temozolomide enhances CD8⁺ T-cell responses to vaccine and is required for efficacy against brain tumors in mice.
PloS one
Sanchez-Perez LA,Choi BD,Archer GE,Cui X,Flores C,Johnson LA,Schmittling RJ,Snyder D,Herndon JE,Bigner DD,Mitchell DA,Sampson JH
14-5773 was used in Flow cytometry/Cell sorting to show that, in a murine model of cancer, vaccination-induced immunity in the setting of myeloablative temozolomide led to significantly prolonged survival.
Fri Sep 27 00:00:00 UTC 2013
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.
The Journal of biological chemistry
Zhong MC,Veillette A
14-5773 was used in Flow cytometry/Cell sorting to investigate how SAP plays an essential role in CIA because of Fyn-independent and Fyn-dependent effects on TFH cells and, possibly, other T cell types.
Fri Nov 01 00:00:00 UTC 2013
Foxp3 protein stability is regulated by cyclin-dependent kinase 2.
The Journal of biological chemistry
Morawski PA,Mehra P,Chen C,Bhatti T,Wells AD
14-5773 was used in Western Blotting to indicate that CDK2 negatively regulates the stability and activity of Foxp3.
Fri Aug 23 00:00:00 UTC 2013
Commensal microbiota drive proliferation of conventional and Foxp3(+) regulatory CD4(+) T cells in mesenteric lymph nodes and Peyer's patches.
European journal of microbiology & immunology
Cording S,Fleissner D,Heimesaat MM,Bereswill S,Loddenkemper C,Uematsu S,Akira S,Hamann A,Huehn J
14-5773 was used in Immunohistochemistry to better understand the contribution of commensal microbiota and TLR signalling in the homeostasis of conventional CD4(+) T cells and Foxp3(+) Tregs.
Fri Mar 01 00:00:00 UTC 2013
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.
PloS one
Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B
14-5773 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.
Tue Aug 12 00:00:00 UTC 2014
Lactobacillus reuteri DSM 17938 changes the frequency of Foxp3+ regulatory T cells in the intestine and mesenteric lymph node in experimental necrotizing enterocolitis.
PloS one
Liu Y,Fatheree NY,Dingle BM,Tran DQ,Rhoads JM
14-5773 was used in Flow cytometry/Cell sorting to suggest that factors in breast milk may enhance the early immunomodulatory effects of LR17938.
Tue Sep 10 00:00:00 UTC 2013
FoxP3⁺ regulatory T cells attenuate experimental necrotizing enterocolitis.
PloS one
Dingle BM,Liu Y,Fatheree NY,Min J,Rhoads JM,Tran DQ
14-5773 was used in Flow cytometry/Cell sorting to investigate how the number of Tregs in the intestines might be insufficient to dampen the excessive inflammatory state in NEC.
Wed Oct 08 00:00:00 UTC 2014
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.
PloS one
Barron L,Smith AM,El Kasmi KC,Qualls JE,Huang X,Cheever A,Borthwick LA,Wilson MS,Murray PJ,Wynn TA
14-5773 was used in Flow cytometry/Cell sorting to investigate the contribution of arginase 1 to asthma pathogenesis.
Mon Dec 09 00:00:00 UTC 2013
Defining the transcriptional and cellular landscape of type 1 diabetes in the NOD mouse.
PloS one
Carrero JA,Calderon B,Towfic F,Artyomov MN,Unanue ER
14-5773 was used in Flow cytometry/Cell sorting to examine autoimmune diabetes and its disease progression markers.
Mon Sep 30 00:00:00 UTC 2013
Novel Foxo1-dependent transcriptional programs control T(reg) cell function.
Nature
Ouyang W,Liao W,Luo CT,Yin N,Huse M,Kim MV,Peng M,Chan P,Ma Q,Mo Y,Meijer D,Zhao K,Rudensky AY,Atwal G,Zhang MQ,Li MO
14-5773 was used in Immunofluorescence to show that the evolutionarily ancient Akt-Foxo1 signalling module controls a novel genetic program indispensable for Treg cell function.
Thu Nov 22 00:00:00 UTC 2012
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.
Immunity
Darce J,Rudra D,Li L,Nishio J,Cipolletta D,Rudensky AY,Mathis D,Benoist C
14-5773 was used in Western blotting following immunoprecipitation to report that a commonly used insertional mutant of FoxP3 transcription factor-(GFP-Foxp3), modifies its molecular interactions, blocking Hif1a but increasing Irf4 interactions.
Fri May 25 00:00:00 UTC 2012
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes.
Immunity
Darce J,Rudra D,Li L,Nishio J,Cipolletta D,Rudensky AY,Mathis D,Benoist C
14-5773 was used in Western blotting following immunoprecipitation to report that a commonly used insertional mutant of FoxP3 transcription factor-(GFP-Foxp3), modifies its molecular interactions, blocking Hif1a but increasing Irf4 interactions.
Fri May 25 00:00:00 UTC 2012
Cytokine therapy with interleukin-2/anti-interleukin-2 monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis.
Circulation
Dinh TN,Kyaw TS,Kanellakis P,To K,Tipping P,Toh BH,Bobik A,Agrotis A
14-5773 was used in Immunohistochemistry to examine the capacity of a modified IL-2/anti-IL-2 monoclonal antibody treatment to expand Tregs and attenuate atherosclerosis in mice.
Tue Sep 04 00:00:00 UTC 2012
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Nature immunology
Fu W,Ergun A,Lu T,Hill JA,Haxhinasto S,Fassett MS,Gazit R,Adoro S,Glimcher L,Chan S,Kastner P,Rossi D,Collins JJ,Mathis D,Benoist C
14-5773 was used in Immunoprecipitation to characterise the contribution of different transcription factors in the production of the characteristic regulatory T cell signature.
Mon Oct 01 00:00:00 UTC 2012
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Nature immunology
Fu W,Ergun A,Lu T,Hill JA,Haxhinasto S,Fassett MS,Gazit R,Adoro S,Glimcher L,Chan S,Kastner P,Rossi D,Collins JJ,Mathis D,Benoist C
14-5773 was used in Immunoprecipitation to characterise the contribution of different transcription factors in the production of the characteristic regulatory T cell signature.
Mon Oct 01 00:00:00 UTC 2012
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.
The Journal of experimental medicine
Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D
14-5773 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.
Mon May 07 00:00:00 UTC 2012
TGF-β and αvβ6 integrin act in a common pathway to suppress pancreatic cancer progression.
Cancer research
Hezel AF,Deshpande V,Zimmerman SM,Contino G,Alagesan B,O'Dell MR,Rivera LB,Harper J,Lonning S,Brekken RA,Bardeesy N
14-5773 was used in Immunohistochemistry to indicate that αvβ6 and TGF-β act in a common tumor suppressor pathway, and their pharmacologic inactivation promotes pancreatic cancer progression in mice.
Sat Sep 15 00:00:00 UTC 2012
Mitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.
Cancer research
Hurez V,Daniel BJ,Sun L,Liu AJ,Ludwig SM,Kious MJ,Thibodeaux SR,Pandeswara S,Murthy K,Livi CB,Wall S,Brumlik MJ,Shin T,Zhang B,Curiel TJ
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that aged anti-tumor effector T-cell function can be improved by reducing age-related immune dysfunction.
Sun Apr 15 00:00:00 UTC 2012
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Cancer research
Woo SR,Turnis ME,Goldberg MV,Bankoti J,Selby M,Nirschl CJ,Bettini ML,Gravano DM,Vogel P,Liu CL,Tangsombatvisit S,Grosso JF,Netto G,Smeltzer MP,Chaux A,Utz PJ,Workman CJ,Pardoll DM,Korman AJ,Drake CG,Vignali DA
14-5773 was used in Immunohistochemistry-immunofluorescence to study the extensive coexpression of PD-1 and LAG-3 on tumour-infiltrating CD4(+) and CD8(+) T cells in three distinct transplantable tumours.
Wed Feb 15 00:00:00 UTC 2012
Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3+ regulatory T cells.
Proceedings of the National Academy of Sciences of the United States of America
Vaeth M,Schliesser U,Müller G,Reissig S,Satoh K,Tuettenberg A,Jonuleit H,Waisman A,Müller MR,Serfling E,Sawitzki BS,Berberich-Siebelt F
14-5773 was used in Chromatin immunoprecipitation to investigate the impact of NFAT on Foxp3 expression.
Tue Oct 02 00:00:00 UTC 2012
Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.
Journal of controlled release : official journal of the Controlled Release Society
Jhunjhunwala S,Balmert SC,Raimondi G,Dons E,Nichols EE,Thomson AW,Little SR
14-5773 was used in Flow cytometry/Cell sorting to investigate alternative strategies to achieve an in situ increase in regulatory T cell abundance.
Tue Apr 10 00:00:00 UTC 2012
Transcutaneous vaccination via laser microporation.
Journal of controlled release : official journal of the Controlled Release Society
Weiss R,Hessenberger M,Kitzmüller S,Bach D,Weinberger EE,Krautgartner WD,Hauser-Kronberger C,Malissen B,Boehler C,Kalia YN,Thalhamer J,Scheiblhofer S
14-5773 was used in Flow cytometry/Cell sorting to investigate the potential of transcutaneous immunisation via laser-generated micropores for induction of specific immune responses.
Mon Sep 10 00:00:00 UTC 2012
Deleterious effect of CTLA4-Ig on a Treg-dependent transplant model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Riella LV,Liu T,Yang J,Chock S,Shimizu T,Mfarrej B,Batal I,Xiao X,Sayegh MH,Chandraker A
14-5773 was used in Immunohistochemistry to investigate the consequences of B7:CD28 blockade by hCTLA4Ig on regulator T cell generation in different major histocompatibility complex mismatch transplant models.
Sun Apr 01 00:00:00 UTC 2012
CD8α⁺β⁻ and CD8α⁺β⁺ plasmacytoid dendritic cells induce Foxp3⁺ regulatory T cells and prevent the induction of airway hyper-reactivity.
Mucosal immunology
Lombardi V,Speak AO,Kerzerho J,Szely N,Akbari O
14-5773 was used in Immunocytochemistry to reveal three functional and phenotypically distinct populations of mice plasmacytoid dendritic cells.
Sun Jul 01 00:00:00 UTC 2012
Probiotics are effective for the prevention and treatment of Citrobacter rodentium-induced colitis in mice.
The Journal of infectious diseases
Rodrigues DM,Sousa AJ,Johnson-Henry KC,Sherman PM,Gareau MG
14-5773 was used in Immunohistochemistry to provide evidence that probiotics can prevent illness and treat disease in an animal model of infectious colitis.
Sun Jul 01 00:00:00 UTC 2012
Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.
PLoS pathogens
Broadhurst MJ,Leung JM,Lim KC,Girgis NM,Gundra UM,Fallon PG,Premenko-Lanier M,McKerrow JH,McCune JM,Loke P
14-5773 was used in Flow cytometry/Cell sorting to show that retinal dehydrogenases are induced during a retinoid-dependent type-2 immune response elicited by Schistosoma mansoni infection.
Mon Dec 17 00:00:00 UTC 2012
Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system.
European journal of immunology
Saligrama N,Noubade R,Case LK,del Rio R,Teuscher C
14-5773 was used in Flow cytometry/Cell sorting to generate histamine H1-H2 and H3-H4 receptor knockout mice and study them for susceptibility to experimental allergic encephalomyelitis.
Fri Jun 01 00:00:00 UTC 2012
Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Mineharu Y,Muhammad AK,Yagiz K,Candolfi M,Kroeger KM,Xiong W,Puntel M,Liu C,Levy E,Lugo C,Kocharian A,Allison JP,Curran MA,Lowenstein PR,Castro MG
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Oct 01 00:00:00 UTC 2012
A2A adenosine receptor signaling in lymphocytes and the central nervous system regulates inflammation during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Mills JH,Kim DG,Krenz A,Chen JF,Bynoe MS
14-5773 was used in Immunohistochemistry to study lymphocyte infiltration to the CNS during experimental autoimmune encephalomyelitis induction experiments.
Fri Jun 01 00:00:00 UTC 2012
Arsenic trioxide exerts antitumor activity through regulatory T cell depletion mediated by oxidative stress in a murine model of colon cancer.
Journal of immunology (Baltimore, Md. : 1950)
Thomas-Schoemann A,Batteux F,Mongaret C,Nicco C,Chéreau C,Annereau M,Dauphin A,Goldwasser F,Weill B,Lemare F,Alexandre J
14-5773 was used in Flow cytometry/Cell sorting to examine the potential for As(2)O(3) to enhance adoptive immunotherapy strategies in human cancer.
Sat Dec 01 00:00:00 UTC 2012
The E3 ubiquitin ligase adaptor Ndfip1 regulates Th17 differentiation by limiting the production of proinflammatory cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Ramon HE,Beal AM,Liu Y,Worthen GS,Oliver PM
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of the E3 ubiquitin ligase adaptor Ndfip1 on Th17 differentiation in mice.
Sun Apr 15 00:00:00 UTC 2012
Foxp3 expression is required for the induction of therapeutic tissue tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Regateiro FS,Chen Y,Kendal AR,Hilbrands R,Adams E,Cobbold SP,Ma J,Andersen KG,Betz AG,Zhang M,Madhiwalla S,Roberts B,Waldmann H,Nolan KF,Howie D
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3 in tissue tolerance by coreceptor blockade.
Mon Oct 15 00:00:00 UTC 2012
STAT6-dependent regulation of Th9 development.
Journal of immunology (Baltimore, Md. : 1950)
Goswami R,Jabeen R,Yagi R,Pham D,Zhu J,Goenka S,Kaplan MH
14-5773 was used in Immunocytochemistry to demonstrate how combinations of cytokine signals generate cytokine-secreting potential by altering the expression of a panel of transcription factors.
Wed Feb 01 00:00:00 UTC 2012
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function.
Journal of immunology (Baltimore, Md. : 1950)
Sawant DV,Sehra S,Nguyen ET,Jadhav R,Englert K,Shinnakasu R,Hangoc G,Broxmeyer HE,Nakayama T,Perumal NB,Kaplan MH,Dent AL
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of Bcl6 in Treg function.
Thu Nov 15 00:00:00 UTC 2012
Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17.
Journal of immunology (Baltimore, Md. : 1950)
Lobo PI,Bajwa A,Schlegel KH,Vengal J,Lee SJ,Huang L,Ye H,Deshmukh U,Wang T,Pei H,Okusa MD
14-5773 was used in Immunofluorescence to investigate whether physiologic doses of IgM anti-leukocyte autoantibodies are able to regulate the inflammatory response in mice.
Wed Feb 15 00:00:00 UTC 2012
NK cells are required for costimulatory blockade induced tolerance to vascularized allografts.
Transplantation
van der Touw W,Burrell B,Lal G,Bromberg JS
14-5773 was used in Immunohistochemistry on frozen tissues to investigate the role of NK cells in allograft tolerance, showing that they are required for costimulatory blockade induced tolerance to vascularised allografts.
Thu Sep 27 00:00:00 UTC 2012
Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis.
World journal of gastroenterology
van der Marel S,Majowicz A,Kwikkers K,van Logtenstein R,te Velde AA,De Groot AS,Meijer SL,van Deventer SJ,Petry H,Hommes DW,Ferreira V
14-5773 was used in Flow cytometry/Cell sorting to explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of regulatory T-cell epitopes in a mouse model of experimental colitis.
Tue Aug 28 00:00:00 UTC 2012
Th2 type inflammation promotes the gradual progression of HPV-infected cervical cells to cervical carcinoma.
Gynecologic oncology
Feng Q,Wei H,Morihara J,Stern J,Yu M,Kiviat N,Hellstrom I,Hellstrom KE
14-5773 was used in Flow cytometry/Cell sorting to study the effect of Th2 inflammation upon the tumorigenesis of cervical cancer in human papillomavirus infected women.
Thu Nov 01 00:00:00 UTC 2012
T cells localized to the androgen-deprived prostate are TH1 and TH17 biased.
The Prostate
Morse MD,McNeel DG
14-5773 was used in Flow cytometry/Cell sorting to investigate the nature and timing of the T cell response in the prostate following castration.
Wed Aug 01 00:00:00 UTC 2012
Immunohistochemical investigation of Foxp3 expression in the intestine in healthy and diseased dogs.
Veterinary research
Junginger J,Schwittlick U,Lemensieck F,Nolte I,Hewicker-Trautwein M
14-5773 was used in Immunohistochemistry to suggest that a defect in Treg homeostasis may be involved in the pathogenesis of canine Inflammatory Bowel Disease.
Thu Mar 22 00:00:00 UTC 2012
Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice.
Evidence-based complementary and alternative medicine : eCAM
Jin X,Uchiyama M,Zhang Q,Hirai T,Niimi M
14-5773 was used in Flow cytometry/Cell sorting to investigate the effects of Inchingorei-san (TJ-117) on alloimmune responses in murine cardiac allograft transplantation.
Thu Aug 23 00:00:00 UTC 2012
The utility of immunohistochemistry for the identification of hematopoietic and lymphoid cells in normal tissues and interpretation of proliferative and inflammatory lesions of mice and rats.
Toxicologic pathology
Rehg JE,Bush D,Ward JM
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to identify antigens expressed in normal tissues and in proliferative and inflammatory lesions in formalin-fixed, paraffin-embedded (FFPE) murine specimens.
Thu Aug 30 00:00:00 UTC 2012
The Aryl Hydrocarbon Receptor Influences Transplant Outcomes in Response to Environmental Signals.
Toxicological and environmental chemistry
Pauly SK,Fechner JH,Zhang X,Torrealba J,Bradfield CA,Mezrich JD
14-5773 was used in Flow cytometry/Cell sorting to create a model which will be useful to further delineate direct effects of the environment on the immune system and outcomes of organ transplantation.
Thu Oct 21 00:00:00 UTC 2021
CD4(+) CD25(+) FoxP3(+) regulatory T cells suppress cytotoxicity of CD8(+) effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level.
Journal of neuroinflammation
Göbel K,Bittner S,Melzer N,Pankratz S,Dreykluft A,Schuhmann MK,Meuth SG,Wiendl H
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Feb 28 00:00:00 UTC 2012
Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments.
BMC cancer
Nguyen L,Fifis T,Malcontenti-Wilson C,Chan LS,Costa PN,Nikfarjam M,Muralidharan V,Christophi C
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Thu Nov 15 00:00:00 UTC 2012
Role of donor-specific regulatory T cells in long-term acceptance of rat hind limb allograft.
PloS one
Wang Y,Zheng Z,Wang Y,Liu J,Li N,Hu X,Han F,Liu Y,Hu D
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Feb 19 00:00:00 UTC 2013
Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sjögren's-like disease.
PloS one
Khalili S,Liu Y,Kornete M,Roescher N,Kodama S,Peterson A,Piccirillo CA,Tran SD
Fri Dec 07 00:00:00 UTC 2012
Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sjögren's-like disease.
PloS one
Khalili S,Liu Y,Kornete M,Roescher N,Kodama S,Peterson A,Piccirillo CA,Tran SD
Fri Dec 07 00:00:00 UTC 2012
Comprehensive postmortem analyses of intestinal microbiota changes and bacterial translocation in human flora associated mice.
PloS one
Heimesaat MM,Boelke S,Fischer A,Haag LM,Loddenkemper C,Kühl AA,Göbel UB,Bereswill S
14-5773 was used in Immunohistochemistry to conclude that kinetics of ileal overgrowth with enterobacteria and enterococci can identify the time of death under defined ambient conditions.
Thu Jan 10 00:00:00 UTC 2013
Involvement of CD4⁺ Foxp3⁺ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice.
PLoS neglected tropical diseases
Tiwananthagorn S,Iwabuchi K,Ato M,Sakurai T,Kato H,Katakura K
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to investigate the mechanisms of L. donovani persistence in immunocompromised conditions.
Thu Jan 03 00:00:00 UTC 2013
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression.
PloS one
Gao X,Zhu Y,Li G,Huang H,Zhang G,Wang F,Sun J,Yang Q,Zhang X,Lu B
14-5773 was used in Flow cytometry/Cell sorting to reveal a new role for TIM-3 as an important immune regulator in the tumour microenvironment.
Fri Jun 29 00:00:00 UTC 2012
Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells.
PloS one
Schallenberg S,Petzold C,Tsai PY,Sparwasser T,Kretschmer K
14-5773 was used in Flow cytometry/Cell sorting to perform a comparative analysis of thymic Treg cell development and peripheral compartments of mature Treg cells in various transgenic Foxp3-fluorochrome reporter mouse strains.
Thu Jan 10 00:00:00 UTC 2013
Disease-dependent local IL-10 production ameliorates collagen induced arthritis in mice.
PloS one
Henningsson L,Eneljung T,Jirholt P,Tengvall S,Lidberg U,van den Berg WB,van de Loo FA,Gjertsson I
14-5773 was used in Flow cytometry/Cell sorting to study how inflammation-dependent IL-10 therapy suppresses experimental autoimmune arthritis and is a promising candidate in the development of novel treatments for RA.
Thu Jun 20 00:00:00 UTC 2013
The synthetic hydroxyproline-containing collagen analogue (Gly-Pro-Hyp)10 ameliorates acute DSS colitis.
European journal of microbiology & immunology
Heimesaat MM,Heilmann K,Kühl AA,Erben U,Rühl M,Fischer A,Farndale RW,Bereswill S,Göbel UB,Zeitz M,Somasundaram R,Freise C
14-5773 was used in Immunohistochemistry to propose (GPO)10 as an effective and safe treatment option of intestinal and extra-intestinal inflammatory conditions in humans.
Sat Sep 01 00:00:00 UTC 2012
Sequential induction of effector function, tissue migration and cell death during polyclonal activation of mouse regulatory T-cells.
PloS one
Langenhorst D,Gogishvili T,Ribechini E,Kneitz S,McPherson K,Lutz MB,Hünig T
14-5773 was used in Flow cytometry/Cell sorting to investigate the origin and fate of IL-10 producing Tregs.
Mon May 20 00:00:00 UTC 2013
Regulation of Toll-like receptor 5 gene expression and function on mucosal dendritic cells.
PloS one
Feng T,Cong Y,Alexander K,Elson CO
14-5773 was used in Flow cytometry/Cell sorting to indicate that bacterial and host factors differentially regulate DC TLR5 expression.
Mon Aug 27 00:00:00 UTC 2012
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis.
Nature
Qian BZ,Li J,Zhang H,Kitamura T,Zhang J,Campion LR,Kaiser EA,Snyder LA,Pollard JW
14-5773 was used in Flow cytometry/Cell sorting to provide the mechanistic link between these two clinical associations and indicate new therapeutic targets for treating metastatic breast cancer.
Wed Jun 08 00:00:00 UTC 2011
Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.
Immunity
Chen Y,Haines CJ,Gutcher I,Hochweller K,Blumenschein WM,McClanahan T,Hämmerling G,Li MO,Cua DJ,McGeachy MJ
14-5773 was used in Flow cytometry/Cell sorting to study how Treg cell depletion resulted in a reduced frequency of antigen-specific IL-17 producers in draining lymph nodes and blood, correlating with reduced inflammatory skin responses.
Fri Mar 25 00:00:00 UTC 2011
Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.
Gastroenterology
Païdassi H,Acharya M,Zhang A,Mukhopadhyay S,Kwon M,Chow C,Stuart LM,Savill J,Lacy-Hulbert A
14-5773 was used in Western Blotting to investigate the ability of CD103(+) dendritic cells to promote Treg generation through activation of TGF-β by preferential expression of αvβ8.
Tue Nov 01 00:00:00 UTC 2011
Preferential expression of integrin αvβ8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells.
Gastroenterology
Païdassi H,Acharya M,Zhang A,Mukhopadhyay S,Kwon M,Chow C,Stuart LM,Savill J,Lacy-Hulbert A
14-5773 was used in Western Blotting to investigate the ability of CD103(+) dendritic cells to promote Treg generation through activation of TGF-β by preferential expression of αvβ8.
Tue Nov 01 00:00:00 UTC 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-5773 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 UTC 2011
Endogenous foxp3(+) T-regulatory cells suppress anti-glomerular basement membrane nephritis.
Kidney international
Ooi JD,Snelgrove SL,Engel DR,Hochheiser K,Ludwig-Portugall I,Nozaki Y,O'Sullivan KM,Hickey MJ,Holdsworth SR,Kurts C,Kitching AR
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to discover that endogenous foxp3(+) cells have increased suppressive capacity after immune stimuli.
Sun May 01 00:00:00 UTC 2011
Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis.
Kidney international
Paust HJ,Ostmann A,Erhardt A,Turner JE,Velden J,Mittrücker HW,Sparwasser T,Panzer U,Tiegs G
14-5773 was used in Immunohistochemistry to analyze the role of endogenous Tregs in a T cell-dependent glomerulonephritis model of nephrotoxic nephritis.
Fri Jul 01 00:00:00 UTC 2011
Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
The Journal of experimental medicine
Wei J,Loke P,Zang X,Allison JP
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of B7x in maintaining peripheral tolerance and protecting from CD4 T cell-mediated autoimmunity.
Mon Aug 01 00:00:00 UTC 2011
Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions.
Biomaterials
Kheradmand T,Wang S,Gibly RF,Zhang X,Holland S,Tasch J,Graham JG,Kaufman DB,Miller SD,Shea LD,Luo X
14-5773 was used in Immunohistochemistry to examine the use of islet-loaded microporous poly(lactide-co-glycolide) in allogeneic islet transplantation and determine whether transplant tolerance could be induced to protect the islets.
Fri Jul 01 00:00:00 UTC 2011
Analysis of the T-cell receptor repertoires of tumor-infiltrating conventional and regulatory T cells reveals no evidence for conversion in carcinogen-induced tumors.
Cancer research
Hindley JP,Ferreira C,Jones E,Lauder SN,Ladell K,Wynn KK,Betts GJ,Singh Y,Price DA,Godkin AJ,Dyson J,Gallimore A
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to evaluate the conversion of conventional T cells into Tregs in vivo, as a mechanism underpinning intratumoral accumulation of Tregs.
Tue Feb 01 00:00:00 UTC 2011
Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4(+) and CD8(+) T cells.
Cancer research
González-Martín A,Gómez L,Lustgarten J,Mira E,Mañes S
14-5773 was used in Immunofluorescence to investigate the relevance of the chemokine receptor CCR5 in tumoural immune control.
Mon Aug 15 00:00:00 UTC 2011
Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis.
Annals of neurology
Blankenhorn EP,Butterfield R,Case LK,Wall EH,del Rio R,Diehl SA,Krementsov DN,Saligrama N,Teuscher C
14-5773 was used in Flow cytometry/Cell sorting to support the polygenic model of MS/EAE, requiring MHC susceptibility, confirming dependence on CD4 T(H)-cell differentiation and function.
Thu Dec 01 00:00:00 UTC 2011
Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Nakajima K,Yamashita T,Kita T,Takeda M,Sasaki N,Kasahara K,Shinohara M,Rikitake Y,Ishida T,Yokoyama M,Hirata K
14-5773 was used in Immunohistochemistry to investigate the effect of the administration of EPA on the regression of atherosclerosis.
Thu Sep 01 00:00:00 UTC 2011
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo.
PLoS pathogens
Satou Y,Yasunaga J,Zhao T,Yoshida M,Miyazato P,Takai K,Shimizu K,Ohshima K,Green PL,Ohkura N,Yamaguchi T,Ono M,Sakaguchi S,Matsuoka M
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to investigate the effect of expression of HTLV-1 bZIP factor in CD4+ T cells.
Thu Feb 10 00:00:00 UTC 2011
MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.
Journal of immunology (Baltimore, Md. : 1950)
McPhee CG,Sproule TJ,Shin DM,Bubier JA,Schott WH,Steinbuck MP,Avenesyan L,Morse HC,Roopenian DC
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Tue Nov 01 00:00:00 UTC 2011
The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Yang J,Riella LV,Chock S,Liu T,Zhao X,Yuan X,Paterson AM,Watanabe T,Vanguri V,Yagita H,Azuma M,Blazar BR,Freeman GJ,Rodig SJ,Sharpe AH,Chandraker A,Sayegh MH
14-5773 was used in Immunohistochemistry to indicate that PDL1 interaction with B7.1 plays an important role in the inhibition of alloimmune responses in vivo.
Mon Aug 01 00:00:00 UTC 2011
Rescue of tumor-infiltrating lymphocytes from activation-induced cell death enhances the antitumor CTL response in CD5-deficient mice.
Journal of immunology (Baltimore, Md. : 1950)
Tabbekh M,Franciszkiewicz K,Haouas H,Lécluse Y,Benihoud K,Raman C,Mami-Chouaib F
14-5773 was used in Immunocytochemistry-immunoflourescence to compare the T cell response to the B16F10 melanoma engrafted into CD5-deficient and wild-type C57BL/6 mice.
Fri Jul 01 00:00:00 UTC 2011
Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection.
Journal of immunology (Baltimore, Md. : 1950)
Weiss KA,Christiaansen AF,Fulton RB,Meyerholz DK,Varga SM
14-5773 was used in Flow cytometry/Cell sorting to evaluate the role of IL-10 in the modulation of the respiratory syncytial virus-specific immune response.
Thu Sep 15 00:00:00 UTC 2011
Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu.
Journal of immunology (Baltimore, Md. : 1950)
Divekar AA,Dubey S,Gangalum PR,Singh RR
14-5773 was used in Flow cytometry/Cell sorting to investigate mechanisms of potential Treg cell defects in systemic lupus erythematosus.
Sat Jan 15 00:00:00 UTC 2011
Hepatic stellate cells function as regulatory bystanders.
Journal of immunology (Baltimore, Md. : 1950)
Ichikawa S,Mucida D,Tyznik AJ,Kronenberg M,Cheroutre H
14-5773 was used in Flow cytometry/Cell sorting to suggest that HSC can function as regulatory bystanders, and therefore, by promoting Tregs and suppressing Th17 differentiation, they might represent key players in the mechanism that drives liver-induced tolerance.
Sun May 15 00:00:00 UTC 2011
Absence of β2 integrins impairs regulatory T cells and exacerbates CD4+ T cell-dependent autoimmune carditis.
Journal of immunology (Baltimore, Md. : 1950)
Haasken S,Auger JL,Binstadt BA
14-5773 was used in Immunohistochemistry to investigate the contribution of CD4(+) T cells and β(2) integrins in the pathogenesis of autoimmune arthritis and endocarditis.
Thu Sep 01 00:00:00 UTC 2011
Absence of β2 integrins impairs regulatory T cells and exacerbates CD4+ T cell-dependent autoimmune carditis.
Journal of immunology (Baltimore, Md. : 1950)
Haasken S,Auger JL,Binstadt BA
14-5773 was used in Immunohistochemistry to investigate the contribution of CD4(+) T cells and β(2) integrins in the pathogenesis of autoimmune arthritis and endocarditis.
Thu Sep 01 00:00:00 UTC 2011
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Chen YG,Scheuplein F,Driver JP,Hewes AA,Reifsnyder PC,Leiter EH,Serreze DV
14-5773 was used in Flow cytometry/Cell sorting to demonstrate the presence of a T1D resistance gene closely linked to the ablated Cd38 allele in the previously reported NOD stock also lacking ART2.
Fri Apr 01 00:00:00 UTC 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-5773 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 UTC 2011
Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.
Journal of immunology (Baltimore, Md. : 1950)
Atibalentja DF,Murphy KM,Unanue ER
14-5773 was used in Flow cytometry/Cell sorting to evaluate the presentation of blood-derived protein Ags by antigen presenting cells in the thymus.
Tue Feb 01 00:00:00 UTC 2011
Tolerance to vascularized composite allografts in canine mixed hematopoietic chimeras.
Transplantation
Mathes DW,Hwang B,Graves SS,Edwards J,Chang J,Storer BE,Butts-Miwongtum T,Sale GE,Nash RA,Storb R
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Tue Dec 27 00:00:00 UTC 2011
Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells.
Molecular and cellular biology
de Zoeten EF,Wang L,Butler K,Beier UH,Akimova T,Sai H,Bradner JE,Mazitschek R,Kozikowski AP,Matthias P,Hancock WW
14-5773 was used in Immunofluorescence to demonstrate that histone/protein deacetylase 6 targeting promotes the suppressive functions of Foxp3+ Tregs, and that targeting of heat shock protein 9 produces comparable effects.
Sun May 01 00:00:00 UTC 2011
Interleukin-33 prolongs allograft survival during chronic cardiac rejection.
Transplant international : official journal of the European Society for Organ Transplantation
Brunner SM,Schiechl G,Falk W,Schlitt HJ,Geissler EK,Fichtner-Feigl S
14-5773 was used in Immunohistochemistry to examine the effects of IL-33 on allografted heart tissue in a chronic cardiac rejection model, including analysis of the peripheral myeloid and lymphoid compartments.
Sat Oct 01 00:00:00 UTC 2011
Coinfection with Enterohepatic Helicobacter species can ameliorate or promote Helicobacter pylori-induced gastric pathology in C57BL/6 mice.
Infection and immunity
Ge Z,Feng Y,Muthupalani S,Eurell LL,Taylor NS,Whary MT,Fox JG
14-5773 was used in Immunohistochemistry to assess the effects of Helicobacter pylori infection on murine stomach health.
Sat Oct 01 00:00:00 UTC 2011
Experimental infection with Schistosoma mansoni in CCR5-deficient mice is associated with increased disease severity, as CCR5 plays a role in controlling granulomatous inflammation.
Infection and immunity
Souza AL,Souza PR,Pereira CA,Fernandes A,Guabiraba R,Russo RC,Vieira LQ,Corrêa A,Teixeira MM,Negrão-Corrêa D
14-5773 was used in Immunohistochemistry to discover that CCR5 deletion is deleterious to Schistosoma mansoni infected mice, which is associated with enhanced fibrosis and granulomatous inflammation.
Fri Apr 01 00:00:00 UTC 2011
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Cancer prevention research (Philadelphia, Pa.)
Maier CR,Hollander MC,Hobbs EA,Dogan I,Linnoila RI,Dennis PA
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to show that nicotine replacement therapies do not enhance lung cancer risk in former smokers.
Tue Nov 01 00:00:00 UTC 2011
Rapamycin combined with anti-CD45RB mAb and IL-10 or with G-CSF induces tolerance in a stringent mouse model of islet transplantation.
PloS one
Gagliani N,Gregori S,Jofra T,Valle A,Stabilini A,Rothstein DM,Atkinson M,Roncarolo MG,Battaglia M
14-5773 was used in an ELISA assay to demonstrate that the anti-CD45RB mAb+rapamycin+IL-10 combined protocol promotes an IL-10-dependent state of tolerance.
Mon Apr 23 00:00:00 UTC 2012
Alcohol facilitates CD1d loading, subsequent activation of NKT cells, and reduces the incidence of diabetes in NOD mice.
PloS one
Buschard K,Hansen AK,Jensen K,Lindenbergh-Kortleve DJ,de Ruiter LF,Krohn TC,Hufeldt MR,Vogensen FK,Aasted B,Osterbye T,Roep BO,de Haar C,Nieuwenhuis EE
14-5773 was used in Immunohistochemistry to study the role of alcohol in facilitating the uptake of glycolipids and the stimulation of natural killer T cells.
Fri Apr 01 00:00:00 UTC 2011
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer.
Nature communications
Haabeth OA,Lorvik KB,Hammarström C,Donaldson IM,Haraldsen G,Bogen B,Corthay A
14-5773 was used in Flow cytometry/Cell sorting to investigate the nature of protective anti-tumour immunity.
Mon Aug 01 00:00:00 UTC 2011
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PloS one
Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R
14-5773 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.
Fri Oct 14 00:00:00 UTC 2011
SHIP-deficient dendritic cells, unlike wild type dendritic cells, suppress T cell proliferation via a nitric oxide-independent mechanism.
PloS one
Antignano F,Hamilton M,Patterson S,Ho V,Cohen C,Levings MK,Krystal G
14-5773 was used in Flow cytometry/Cell sorting to examine SHIP's role in dendritic cell-induced T cell suppression.
Wed Nov 09 00:00:00 UTC 2011
N-acetylglucosamine inhibits T-helper 1 (Th1)/T-helper 17 (Th17) cell responses and treats experimental autoimmune encephalomyelitis.
The Journal of biological chemistry
Grigorian A,Araujo L,Naidu NN,Place DJ,Choudhury B,Demetriou M
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that oral GlcNAc inhibits T-helper 1 and 17 responses, suppressing experimental autoimmune encephalomyelitis progression.
Fri Nov 18 00:00:00 UTC 2011
What you eat is what you get: Novel Campylobacter models in the quadrangle relationship between nutrition, obesity, microbiota and susceptibility to infection.
European journal of microbiology & immunology
Bereswill S,Plickert R,Fischer A,Kühl AA,Loddenkemper C,Batra A,Siegmund B,Göbel UB,Heimesaat MM
14-5773 was used in Immunohistochemistry to investigate the role of nutrition and obesity in susceptibility to Campylobacter jejuni infection.
Thu Sep 01 00:00:00 UTC 2011
Interplay between Depressive-Like Behavior and the Immune System in an Animal Model of Prenatal Dexamethasone Administration.
Frontiers in behavioral neuroscience
Roque S,Oliveira TG,Nobrega C,Barreira-Silva P,Nunes-Alves C,Sousa N,Palha JA,Correia-Neves M
14-5773 was used in Flow cytometry/Cell sorting to investigate the long-term impact of prenatal dexamethasone administration in depressive-like behavior and the immune system.
Thu Jul 14 00:00:00 UTC 2011
Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.
PloS one
McFarland AP,Savan R,Wagage S,Addison A,Ramakrishnan K,Karwan M,Duong T,Young HA
14-5773 was used in Flow cytometry/Cell sorting to identify a correlation between the loss/down-regulation of IFNAR1 on DCs and exacerbation of colitis.
Fri Feb 18 00:00:00 UTC 2011
The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell-mediated peripheral T cell unresponsiveness.
Nature immunology
Hawiger D,Wan YY,Eynon EE,Flavell RA
14-5773 was used in Flow cytometry/Cell sorting to study the role of the homeodomain-only protein (Hopx) in induced regulatory T cells (iT(regs)).
Fri Oct 01 00:00:00 UTC 2010
The post sepsis-induced expansion and enhanced function of regulatory T cells create an environment to potentiate tumor growth.
Blood
Cavassani KA,Carson WF,Moreira AP,Wen H,Schaller MA,Ishii M,Lindell DM,Dou Y,Lukacs NW,Keshamouni VG,Hogaboam CM,Kunkel SL
14-5773 was used in Flow cytometry/Cell sorting to investigate the contribution of regulatory T cells to post sepsis immune defects and tumour growth.
Thu Jun 03 00:00:00 UTC 2010
Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance.
Blood
Fukaya T,Takagi H,Sato Y,Sato K,Eizumi K,Taya H,Shin T,Chen L,Dong C,Azuma M,Yagita H,Malissen B,Sato K
14-5773 was used in Flow cytometry/Cell sorting to suggest that B7-H1 and B7-DC expressed on mesenteric lymph node DCs are essential for establishing oral tolerance.
Thu Sep 30 00:00:00 UTC 2010
Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints.
The Journal of experimental medicine
Nishio J,Feuerer M,Wong J,Mathis D,Benoist C
14-5773 was used in Flow cytometry/Cell sorting to investigate the involvement of regulatory T cells in anti-CD3 treatment for autoimmune diabetes.
Mon Aug 30 00:00:00 UTC 2010
IL-10 production differentially influences the magnitude, quality, and protective capacity of Th1 responses depending on the vaccine platform.
The Journal of experimental medicine
Darrah PA,Hegde ST,Patel DT,Lindsay RW,Chen L,Roederer M,Seder RA
14-5773 was used in Flow cytometry/Cell sorting to delineate distinct mechanisms by which vaccines elicit protective Th1 responses and underscore the importance of multifunctional CD4(+) T cells.
Mon Jul 05 00:00:00 UTC 2010
Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma.
The Journal of experimental medicine
Xie Y,Akpinarli A,Maris C,Hipkiss EL,Lane M,Kwon EK,Muranski P,Restifo NP,Antony PA
14-5773 was used in Flow cytometry/Cell sorting to study the regression of tumours due to naive tumor-specific CD4(+) T cell differentiation.
Mon Mar 15 00:00:00 UTC 2010
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway.
The Journal of experimental medicine
Hubert S,Rissiek B,Klages K,Huehn J,Sparwasser T,Haag F,Koch-Nolte F,Boyer O,Seman M,Adriouch S
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that NAD(+) influences survival, phenotype, and function of Treg cells.
Mon Nov 22 00:00:00 UTC 2010
Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.
Brain : a journal of neurology
Linker RA,Lee DH,Demir S,Wiese S,Kruse N,Siglienti I,Gerhardt E,Neumann H,Sendtner M,Lühder F,Gold R
14-5773 was used in Flow cytometry/Cell sorting to study the neuroprotective effects of brain-derived neurotrophic factor in experimental autoimmune encephalomyelitis (EAE).
Sun Aug 01 00:00:00 UTC 2010
Toll-like receptor 3-mediated suppression of TRAMP prostate cancer shows the critical role of type I interferons in tumor immune surveillance.
Cancer research
Chin AI,Miyahira AK,Covarrubias A,Teague J,Guo B,Dempsey PW,Cheng G
14-5773 was used in Immunohistochemistry to delineate the importance of IFNAR-dependent functions in TLR3-mediated tumour suppression.
Thu Apr 01 00:00:00 UTC 2010
In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice.
Cancer research
Akins EJ,Moore ML,Tang S,Willingham MC,Tooze JA,Dubey P
14-5773 was used in Immunofluorescence on frozen tissues to assess the acute and chronic effect of androgen ablation on the localisation of T-cell subsets within castration-resistant murine prostate cancer.
Sat May 01 00:00:00 UTC 2010
Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery.
Plant biotechnology journal
Davoodi-Semiromi A,Schreiber M,Nalapalli S,Verma D,Singh ND,Banks RK,Chakrabarti D,Daniell H
14-5773 was used in Flow cytometry/Cell sorting to further investigate use of chloroplast-derived vaccines against major diseases.
Mon Feb 01 00:00:00 UTC 2010
Targeting improves MSC treatment of inflammatory bowel disease.
Molecular therapy : the journal of the American Society of Gene Therapy
Ko IK,Kim BG,Awadallah A,Mikulan J,Lin P,Letterio JJ,Dennis JE
14-5773 was used in Immunohistochemistry to develop a new method to coat mesenchymal stem cells with antibodies against addressins to enhance their delivery to the colon and thereby increase the therapeutic effectiveness.
Thu Jul 01 00:00:00 UTC 2010
Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A.
European journal of immunology
Joffre OP,Sancho D,Zelenay S,Keller AM,Reis e Sousa C
14-5773 was used in Flow cytometry/Cell sorting to show that antigen targeting to DNGR-1 is a versatile approach for inducing functionally distinct CD4+ T-cell responses.
Sat May 01 00:00:00 UTC 2010
3-Methylcholanthrene-induced transforming growth factor-beta-producing carcinomas, but not sarcomas, are refractory to regulatory T cell-depletion therapy.
Cancer science
Chamoto K,Wakita D,Ohkuri T,Uchinami Y,Matsushima K,Kitamura H,Nishimura T
14-5773 was used in Immunohistochemistry-immunofluorescence to examine the distinct regulation of regulatory T cell-mediated immunosuppression between carcinomas and sarcomas.
Thu Apr 01 00:00:00 UTC 2010
CD4+ regulatory T cells generated in vitro with IFN-{gamma} and allogeneic APC inhibit transplant arteriosclerosis.
The American journal of pathology
Warnecke G,Feng G,Goto R,Nadig SN,Francis R,Wood KJ,Bushell A
14-5773 was used in Flow cytometry/Cell sorting to illustrate the potential of ex vivo generated regulatory T cells for the inhibition of transplant-associated vasculopathy.
Thu Jul 01 00:00:00 UTC 2010
TIM-3: a novel regulatory molecule of alloimmune activation.
Journal of immunology (Baltimore, Md. : 1950)
Boenisch O,D'Addio F,Watanabe T,Elyaman W,Magee CN,Yeung MY,Padera RF,Rodig SJ,Murayama T,Tanaka K,Yuan X,Ueno T,Jurisch A,Mfarrej B,Akiba H,Yagita H,Najafian N
Mon Nov 15 00:00:00 UTC 2010
TIM-3: a novel regulatory molecule of alloimmune activation.
Journal of immunology (Baltimore, Md. : 1950)
Boenisch O,D'Addio F,Watanabe T,Elyaman W,Magee CN,Yeung MY,Padera RF,Rodig SJ,Murayama T,Tanaka K,Yuan X,Ueno T,Jurisch A,Mfarrej B,Akiba H,Yagita H,Najafian N
Mon Nov 15 00:00:00 UTC 2010
Antigen aggregation decides the fate of the allergic immune response.
Journal of immunology (Baltimore, Md. : 1950)
Zaborsky N,Brunner M,Wallner M,Himly M,Karl T,Schwarzenbacher R,Ferreira F,Achatz G
14-5773 was used in Flow cytometry/Cell sorting to elucidate the molecular background of hypoallergenicity using Betula verrucosa.
Fri Jan 15 00:00:00 UTC 2010
IL-1β-mediated signals preferentially drive conversion of regulatory T cells but not conventional T cells into IL-17-producing cells.
Journal of immunology (Baltimore, Md. : 1950)
Li L,Kim J,Boussiotis VA
14-5773 was used in Flow cytometry/Cell sorting to examine the role of regulatory T-cells on IL-17 production in the absence of exogenous cytokines and insults.
Fri Oct 01 00:00:00 UTC 2010
Combination therapy of established tumors by antibodies targeting immune activating and suppressing molecules.
Journal of immunology (Baltimore, Md. : 1950)
Takeda K,Kojima Y,Uno T,Hayakawa Y,Teng MW,Yoshizawa H,Yagita H,Gejyo F,Okumura K,Smyth MJ
14-5773 was used in Immunohistochemistry-immunofluorescence to assess the efficacy of a combination monoclonal antibody-based therapy targeting immune activating and suppressing molecules in the treatment of established tumours.
Sat May 15 00:00:00 UTC 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-5773 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 UTC 2010
Identification and characterization of a lupus suppressor 129 locus on chromosome 3.
Journal of immunology (Baltimore, Md. : 1950)
Carlucci F,Fossati-Jimack L,Dumitriu IE,Heidari Y,Walport MJ,Szajna M,Baruah P,Garden OA,Cook HT,Botto M
14-5773 was used in Flow cytometry/Cell sorting to identify that 129-Sle18 represents a novel, non-MHC lupus-suppressor locus, likely functionally modifying B cells, leading to lupus resistance.
Tue Jun 01 00:00:00 UTC 2010
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Matsushita T,Horikawa M,Iwata Y,Tedder TF
14-5773 was used in Flow cytometry/Cell sorting to investigate how the regulatory functions of B10 cells and FoxP3(+) Tregs overlap or influence EAE immunopathogenesis independently.
Sun Aug 15 00:00:00 UTC 2010
Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Hamano R,Subleski JJ,Hurwitz AA,Howard OM,Oppenheim JJ
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of TNFR2 signalling in the function of conventional T cells.
Thu Jul 01 00:00:00 UTC 2010
Regulatory T cells protect from local and systemic bone destruction in arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Zaiss MM,Frey B,Hess A,Zwerina J,Luther J,Nimmerjahn F,Engelke K,Kollias G,Hünig T,Schett G,David JP
14-5773 was used in Immunohistochemistry to demonstrate that increasing Treg cell numbers improve clinical signs of arthritis and suppress local and systemic bone destruction.
Tue Jun 15 00:00:00 UTC 2010
Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.
The Journal of pharmacology and experimental therapeutics
Wang DW,Zhou RB,Yao YM,Zhu XM,Yin YM,Zhao GJ,Dong N,Sheng ZY
14-5773 was used in Western Blotting to reveal α7 nAChR to be a critical regulator for immunosuppressive function of CD4(+)CD25(+) Tregs.
Wed Dec 01 00:00:00 UTC 2010
Stimulation of α7 nicotinic acetylcholine receptor by nicotine increases suppressive capacity of naturally occurring CD4+CD25+ regulatory T cells in mice in vitro.
The Journal of pharmacology and experimental therapeutics
Wang DW,Zhou RB,Yao YM,Zhu XM,Yin YM,Zhao GJ,Dong N,Sheng ZY
14-5773 was used in Western Blotting to reveal α7 nAChR to be a critical regulator for immunosuppressive function of CD4(+)CD25(+) Tregs.
Wed Dec 01 00:00:00 UTC 2010
Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.
Gene therapy
Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Wed Sep 01 00:00:00 UTC 2010
Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.
Veterinary immunology and immunopathology
Gerner W,Stadler M,Hammer SE,Klein D,Saalmüller A
Mon Nov 15 00:00:00 UTC 2010
Low-dose cyclophosphamide synergizes with dendritic cell-based immunotherapy in antitumor activity.
Journal of biomedicine & biotechnology
Veltman JD,Lambers ME,van Nimwegen M,de Jong S,Hendriks RW,Hoogsteden HC,Aerts JG,Hegmans JP
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Mon Sep 10 00:00:00 UTC 2012
Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.
Self/nonself
Capurso NA,Look M,Jeanbart L,Nowyhed H,Abraham C,Craft J,Fahmy TM
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Fri Oct 01 00:00:00 UTC 2010
Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases.
BMC cancer
Grimm M,Gasser M,Bueter M,Strehl J,Wang J,Nichiporuk E,Meyer D,Germer CT,Waaga-Gasser AM,Thalheimer A
14-5773 was used in Immunofluorescence to analyse tumour immune escape mechanisms in a murine colorectal liver metastases model throughout tumour growth.
Sun Mar 07 00:00:00 UTC 2010
CD28 down-regulation on circulating CD4 T-cells is associated with poor prognoses of patients with idiopathic pulmonary fibrosis.
PloS one
Gilani SR,Vuga LJ,Lindell KO,Gibson KF,Xue J,Kaminski N,Valentine VG,Lindsay EK,George MP,Steele C,Duncan SR
14-5773 was used in Flow cytometry/Cell sorting to show that T-cell responses to antigen resulting in CD28 down-regulation are associated with manifestation of idiopathic pulmonary fibrosis.
Fri Jan 29 00:00:00 UTC 2010
Identification of gp96 as a novel target for treatment of autoimmune disease in mice.
PloS one
Han JM,Kwon NH,Lee JY,Jeong SJ,Jung HJ,Kim HR,Li Z,Kim S
14-5773 was used in Flow cytometry/Cell sorting to suggest that surface translocation of gp96 can be chemically controlled and gp96 as a potential therapeutic autoimmune disease treatment.
Tue Mar 23 00:00:00 UTC 2010
Peripheral blood T regulatory cell counts may not predict transplant rejection.
BMC immunology
Huang Y,Shan J,Zhang C,Zhang J,Feng L,Li S,Li Y
14-5773 was used in Immunohistochemistry to examine the frequency and cytokine profile of Foxp3+ Tregs in rat recipients of cardiac allografts following a dose of Rapamycin.
Thu Jul 15 00:00:00 UTC 2010
Temporal pattern of ICAM-I mediated regulatory T cell recruitment to sites of inflammation in adoptive transfer model of multiple sclerosis.
PloS one
Doerck S,Göbel K,Weise G,Schneider-Hohendorf T,Reinhardt M,Hauff P,Schwab N,Linker R,Mäurer M,Meuth SG,Wiendl H
14-5773 was used in Flow cytometry/Cell sorting to explore the migration of pro-inflammatory and regulatory T cells towards target organs in an in vivo model of multiple sclerosis.
Mon Nov 15 00:00:00 UTC 2010
How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets.
Immunity
Feuerer M,Shen Y,Littman DR,Benoist C,Mathis D
14-5773 was used in Flow cytometry/Cell sorting to explore when, where and how regulatory T cells exert their influence to control the progression of autoimmune disorders.
Fri Oct 16 00:00:00 UTC 2009
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology
Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ
14-5773 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.
Mon Jun 01 00:00:00 UTC 2009
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo.
Nature immunology
McGeachy MJ,Chen Y,Tato CM,Laurence A,Joyce-Shaikh B,Blumenschein WM,McClanahan TK,O'Shea JJ,Cua DJ
14-5773 was used in Flow cytometry/Cell sorting to investigate the requirement for IL-23 signaling in the development and function of T(H)-17 cells in autoimmunity, inflammation and infection.
Sun Mar 01 00:00:00 UTC 2009
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammation.
Nature immunology
Marks BR,Nowyhed HN,Choi JY,Poholek AC,Odegard JM,Flavell RA,Craft J
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that T(H)-17 cells, like Treg cells, can be selected by self antigens in the thymus.
Thu Oct 01 00:00:00 UTC 2009
Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment.
Blood
Swee LK,Bosco N,Malissen B,Ceredig R,Rolink A
14-5773 was used in Flow cytometry/Cell sorting to show unique aspects in the regulation of Treg homeostasis by DCs and reinforce the relevance of FLT3L treatment in GVHD.
Thu Jun 18 00:00:00 UTC 2009
Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion.
Blood
Houot R,Goldstein MJ,Kohrt HE,Myklebust JH,Alizadeh AA,Lin JT,Irish JM,Torchia JA,Kolstad A,Chen L,Levy R
14-5773 was used in Flow cytometry/Cell sorting to demonstrate the antitumor effect of anti-CD137 therapy, mediated by natural killer (NK) and CD8 T cells inducing long-lasting immunity.
Thu Oct 15 00:00:00 UTC 2009
Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury.
Kidney international
Gandolfo MT,Jang HR,Bagnasco SM,Ko GJ,Agreda P,Satpute SR,Crow MT,King LS,Rabb H
14-5773 was used in Immunohistochemistry to characterise kidney infiltrating T lymphocytes during healing from renal ischaemic-reperfusion injury in mice, and identify subsets that may mediate repair.
Thu Oct 01 00:00:00 UTC 2009
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.
The Journal of experimental medicine
Darrasse-Jèze G,Deroubaix S,Mouquet H,Victora GD,Eisenreich T,Yao KH,Masilamani RF,Dustin ML,Rudensky A,Liu K,Nussenzweig MC
14-5773 was used in Flow cytometry/Cell sorting to demonstrate the existence of a feedback regulatory loop between DCs and T reg cells.
Mon Aug 31 00:00:00 UTC 2009
Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice.
Diabetes
Emamaullee JA,Davis J,Merani S,Toso C,Elliott JF,Thiesen A,Shapiro AM
14-5773 was used in Immunofluorescence to suggest that Th17 cells are involved in the pathogenesis of autoimmune diabetes.
Mon Jun 01 00:00:00 UTC 2009
Castration induces autoantibody and T cell responses that correlate with inferior outcomes in an androgen-dependent murine tumor model.
International journal of cancer
Hahn S,Nesslinger NJ,Drapala RJ,Bowden M,Rennie PS,Pai HH,Ludgate C,Nelson BH
14-5773 was used in Immunohistochemistry to demonstrate that castration-induced immune responses are associated with inferior outcomes in the Shionogi carcinoma model.
Tue Dec 15 00:00:00 UTC 2009
CCR7-deficient mice develop atypically persistent germinal centers in response to thymus-independent type 2 antigens.
Journal of leukocyte biology
Achtman AH,Höpken UE,Bernert C,Lipp M
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Immunohistochemistry
Sun Mar 01 00:00:00 UTC 2009
Role of regulatory T cells in a new mouse model of experimental autoimmune myositis.
The American journal of pathology
Allenbach Y,Solly S,Grégoire S,Dubourg O,Salomon B,Butler-Browne G,Musset L,Herson S,Klatzmann D,Benveniste O
14-5773 was used in Flow cytometry/Cell sorting to develop a reproducible experimental autoimmune myositis model of polymyositis in mice and to analyze how Tregs regulate myositis in vivo.
Sun Mar 01 00:00:00 UTC 2009
Expansion of antigen-specific regulatory T cells with the topical vitamin d analog calcipotriol.
Journal of immunology (Baltimore, Md. : 1950)
Ghoreishi M,Bach P,Obst J,Komba M,Fleet JC,Dutz JP
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that exposure of the skin to calcipotriol before transcutaneous immunization with OVA protein and CpG adjuvant prevents Ag-specific CD8(+) T cell priming coincident with Langerhans cell depletion in the skin.
Fri May 15 00:00:00 UTC 2009
Lymphocytes with aberrant expression of Fas or Fas ligand attenuate immune bone marrow failure in a mouse model.
Journal of immunology (Baltimore, Md. : 1950)
Omokaro SO,Desierto MJ,Eckhaus MA,Ellison FM,Chen J,Young NS
14-5773 was used in Flow cytometry/Cell sorting to demonstrate that abnormal Fas or FasL expression interferes with the development of pancytopenia and marrow hypoplasia.
Sun Mar 15 00:00:00 UTC 2009
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice.
Journal of immunology (Baltimore, Md. : 1950)
Kim J,Lahl K,Hori S,Loddenkemper C,Chaudhry A,deRoos P,Rudensky A,Sparwasser T
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to test whether the expression of Foxp3 in epithelial cells is the cause for disease development in mice.
Tue Dec 15 00:00:00 UTC 2009
Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival.
Journal of immunology (Baltimore, Md. : 1950)
D'Elia R,Behnke JM,Bradley JE,Else KJ
14-5773 was used in Immunohistochemistry on frozen tissues to demonstrate that regulatory T cells protect the host from worm-driven intestinal pathology.
Sun Feb 15 00:00:00 UTC 2009
Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis.
Experimental and molecular pathology
Saouaf SJ,Li B,Zhang G,Shen Y,Furuuchi N,Hancock WW,Greene MI
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to show that clinically approved Histone/protein deacetylase inhibitors may limit autoimmune disease in vivo through FOXP3(+) Treg cell modulation.
Thu Oct 01 00:00:00 UTC 2009
Deacetylase inhibition increases regulatory T cell function and decreases incidence and severity of collagen-induced arthritis.
Experimental and molecular pathology
Saouaf SJ,Li B,Zhang G,Shen Y,Furuuchi N,Hancock WW,Greene MI
14-5773 was used in Immunohistochemistry on paraffin embedded tissues to show that clinically approved Histone/protein deacetylase inhibitors may limit autoimmune disease in vivo through FOXP3(+) Treg cell modulation.
Thu Oct 01 00:00:00 UTC 2009
Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice.
Reproduction (Cambridge, England)
Roca V,Calafat M,Larocca L,Ramhorst R,Farina M,Franchi AM,Leirós CP
14-5773 was used in Flow cytometry/Cell sorting to explore the participation of vasoactive intestinal peptide in the implantation sites of normal and pregnant prediabetic nonobese diabetic female mice.
Thu Oct 01 00:00:00 UTC 2009
Potential immunomodulatory role of VIP in the implantation sites of prediabetic nonobese diabetic mice.
Reproduction (Cambridge, England)
Roca V,Calafat M,Larocca L,Ramhorst R,Farina M,Franchi AM,Leirós CP
14-5773 was used in Flow cytometry/Cell sorting to explore the participation of vasoactive intestinal peptide in the implantation sites of normal and pregnant prediabetic nonobese diabetic female mice.
Thu Oct 01 00:00:00 UTC 2009
Three distinct domains contribute to nuclear transport of murine Foxp3.
PloS one
Hancock WW,Ozkaynak E
Wed Nov 18 00:00:00 UTC 2009
Foxp3 processing by proprotein convertases and control of regulatory T cell function.
The Journal of biological chemistry
de Zoeten EF,Lee I,Wang L,Chen C,Ge G,Wells AD,Hancock WW,Ozkaynak E
14-5773 was used in Western Blotting to investigate Foxp3 processing in Tregs.
Fri Feb 27 00:00:00 UTC 2009
A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses.
Immunity
Yanaba K,Bouaziz JD,Haas KM,Poe JC,Fujimoto M,Tedder TF
14-5773 was used in Flow cytometry/Cell sorting to identify that CD1d(hi)CD5(+) B cells represent a unique subset of potent regulatory B cells.
Thu May 01 00:00:00 UTC 2008
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.
Immunity
Gri G,Piconese S,Frossi B,Manfroi V,Merluzzi S,Tripodo C,Viola A,Odom S,Rivera J,Colombo MP,Pucillo CE
14-5773 was used in Immunohistochemistry to explore whether Treg cells influence the immediate hypersensitivity response of mast cells.
Fri Nov 14 00:00:00 UTC 2008
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Blood
Ahonen CL,Wasiuk A,Fuse S,Turk MJ,Ernstoff MS,Suriawinata AA,Gorham JD,Kedl RM,Usherwood EJ,Noelle RJ
14-5773 was used in Flow cytometry/Cell sorting to report the therapeutic effects of combinatorial use of CD40 and TLR agonists as a cancer vaccine.
Sat Mar 15 00:00:00 UTC 2008
Organ-derived dendritic cells have differential effects on alloreactive T cells.
Blood
Kim TD,Terwey TH,Zakrzewski JL,Suh D,Kochman AA,Chen ME,King CG,Borsotti C,Grubin J,Smith OM,Heller G,Liu C,Murphy GF,Alpdogan O,van den Brink MR
14-5773 was used in Flow cytometry/Cell sorting to study the induction of specific organ-homing phenotypes in alloreactive T cells.
Sat Mar 01 00:00:00 UTC 2008
Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development.
Proceedings of the National Academy of Sciences of the United States of America
Spence PJ,Green EA
14-5773 was used in Flow cytometry/Cell sorting to investigate Foxp3+ Treg development, showing that CD154 is critical during thymic development of Foxp3+ Tregs.
Tue Jan 22 00:00:00 UTC 2008
Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity.
The British journal of dermatology
Anthoni M,Fyhrquist-Vanni N,Wolff H,Alenius H,Lauerma A
14-5773 was used in Immunohistochemistry to examine the role of Smad3 in a murine model of contact hypersensitivity.
Mon Sep 01 00:00:00 UTC 2008
IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.
PLoS pathogens
Couper KN,Blount DG,Wilson MS,Hafalla JC,Belkaid Y,Kamanaka M,Flavell RA,de Souza JB,Riley EM
14-5773 was used in Flow cytometry/Cell sorting to investigate the cellular source of IL-10 and TGF-beta during malaria infection, showing that IL-10 from CD4+CD25-Foxp3-CD127- adaptive Tregs modulates parasite clearance and pathology.
Fri Feb 29 00:00:00 UTC 2008
Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells.
European journal of immunology
Feng G,Gao W,Strom TB,Oukka M,Francis RS,Wood KJ,Bushell A
14-5773 was used in Flow cytometry/Cell sorting to indicate how IFN-gamma could be used to shape beneficial immune responses ex vivo for possible cell therapy.
Mon Sep 01 00:00:00 UTC 2008
Regulatory role of B cells in a murine model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950)
Singh A,Carson WF,Secor ER,Guernsey LA,Flavell RA,Clark RB,Thrall RS,Schramm CM
14-5773 was used in Flow cytometry/Cell sorting to investigate the role of B cells in the resolution of allergic airway disease and induction of local inhalational tolerance.
Sun Jun 01 00:00:00 UTC 2008
Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Chen X,Subleski JJ,Kopf H,Howard OM,Männel DN,Oppenheim JJ
14-5773 was used in Flow cytometry/Cell sorting to characterise the phenotype and function of TNFR2(+) Tregs in peripheral lymphoid tissues, showing that expression defines a suppressive subset of Tregs that accumulate intratumourally.
Thu May 15 00:00:00 UTC 2008
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Chen ML,Yan BS,Bando Y,Kuchroo VK,Weiner HL
14-5773 was used in Flow cytometry/Cell sorting to characterise a novel subset of CD4(+)CD25(+) regulatory T cells that express latency-associated peptide (LAP) on their cell surface.
Sun Jun 01 00:00:00 UTC 2008
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
PloS one
Hase K,Takahashi D,Ebisawa M,Kawano S,Itoh K,Ohno H
14-5773 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying autoimmunity associated with AID mutations, showing that AID is a negative regulator of autoreactive B cells.
Thu Aug 21 00:00:00 UTC 2008
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.
Blood
Borsellino G,Kleinewietfeld M,Di Mitri D,Sternjak A,Diamantini A,Giometto R,Höpner S,Centonze D,Bernardi G,Dell'Acqua ML,Rossini PM,Battistini L,Rötzschke O,Falk K
14-5773 was used in Flow cytometry/Cell sorting to investigate the expression of CD39 in immune cells.
Wed Aug 15 00:00:00 UTC 2007
Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis.
The Journal of clinical investigation
Humblet-Baron S,Sather B,Anover S,Becker-Herman S,Kasprowicz DJ,Khim S,Nguyen T,Hudkins-Loya K,Alpers CE,Ziegler SF,Ochs H,Torgerson T,Campbell DJ,Rawlings DJ
14-5773 was used in Flow cytometry/Cell sorting to investigate whether alterations in Treg function might explain Wiskott-Aldrich syndrome pathology, showing that WASp is required for Treg homeostasis.
Thu Feb 01 00:00:00 UTC 2007
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-5773 was used in Immunohistochemistry to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 UTC 2007
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
The Journal of experimental medicine
Lahl K,Loddenkemper C,Drouin C,Freyer J,Arnason J,Eberl G,Hamann A,Wagner H,Huehn J,Sparwasser T
14-5773 was used in Immunohistochemistry to investigate whether dysfunction or a lack of T reg cells is etiologically involved in scurfy pathogenesis, showing that selective depletion of Foxp3+ Tregs leads to scurfy.
Mon Jan 22 00:00:00 UTC 2007
An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2.
The Journal of experimental medicine
Cho JH,Boyman O,Kim HO,Hahm B,Rubinstein MP,Ramsey C,Kim DM,Surh CD,Sprent J
14-5773 was used in Flow cytometry/Cell sorting to describe a novel form of homeostatic proliferation that occurs when naive T cells encounter raised levels of IL-2 and IL-15 in vivo.
Mon Aug 06 00:00:00 UTC 2007
Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function.
Clinical cancer research : an official journal of the American Association for Cancer Research
Fecci PE,Ochiai H,Mitchell DA,Grossi PM,Sweeney AE,Archer GE,Cummings T,Allison JP,Bigner DD,Sampson JH
14-5773 was used in Flow cytometry/Cell sorting to investigate the effects of systemic CTLA-4 blockade in a murine glioma model.
Sun Apr 01 00:00:00 UTC 2007
Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family.
Cancer research
Garlanda C,Riva F,Veliz T,Polentarutti N,Pasqualini F,Radaelli E,Sironi M,Nebuloni M,Zorini EO,Scanziani E,Mantovani A
14-5773 was used in Immunohistochemistry to demonstrate that TIR8 plays a role in the control of the protumor activity of chronic inflammation in the gut.
Sun Jul 01 00:00:00 UTC 2007
Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells.
Proceedings of the National Academy of Sciences of the United States of America
Gray M,Miles K,Salter D,Gray D,Savill J
14-5773 was used in Flow cytometry/Cell sorting to show that apoptotic cells have a significant influence on the adaptive immune response by generating CD19(+) regulatory B cells.
Tue Aug 28 00:00:00 UTC 2007
CCR7 mediates the migration of Foxp3+ regulatory T cells to the paracortical areas of peripheral lymph nodes through high endothelial venules.
Journal of leukocyte biology
Ueha S,Yoneyama H,Hontsu S,Kurachi M,Kitabatake M,Abe J,Yoshie O,Shibayama S,Sugiyama T,Matsushima K
14-5773 was used in Flow cytometry/Cell sorting to provide the evidence that CCR7 mediates nTreg migration to the paracortical areas of lymph nodes under steady-state conditions, but also takes place in the medulla.
Thu Nov 01 00:00:00 UTC 2007
Peroxisome proliferator-activated receptor gamma is required for regulatory CD4+ T cell-mediated protection against colitis.
Journal of immunology (Baltimore, Md. : 1950)
Hontecillas R,Bassaganya-Riera J
14-5773-82 was used in Functional assay to suggest that endogenous PPAR-gamma activation represents a Treg intrinsic mechanism of down-regulation of effector CD4+ T cell function and prevention of colitis.
Thu Mar 01 00:00:00 UTC 2007
Novel exosome-targeted CD4+ T cell vaccine counteracting CD4+25+ regulatory T cell-mediated immune suppression and stimulating efficient central memory CD8+ CTL responses.
Journal of immunology (Baltimore, Md. : 1950)
Hao S,Liu Y,Yuan J,Zhang X,He T,Wu X,Wei Y,Sun D,Xiang J
14-5773 was used in Flow cytometry/Cell sorting to study the effects of a novel exosome-targeted CD4+ T cell vaccine.
Sat Sep 01 00:00:00 UTC 2007
Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma.
Carcinogenesis
Poutahidis T,Haigis KM,Rao VP,Nambiar PR,Taylor CL,Ge Z,Watanabe K,Davidson A,Horwitz BH,Fox JG,Erdman SE
14-5773 was used in Flow cytometry/Cell sorting to provide insights into etiopathogenesis of inflammation-associated epithelial invasion and maintenance of epithelial homeostasis.
Sat Dec 01 00:00:00 UTC 2007
N-glycan processing deficiency promotes spontaneous inflammatory demyelination and neurodegeneration.
The Journal of biological chemistry
Lee SU,Grigorian A,Pawling J,Chen IJ,Gao G,Mozaffar T,McKerlie C,Demetriou M
14-5773 was used in Flow cytometry/Cell sorting to identify hypomorphic Golgi processing as an inherited trait that determines susceptibility to EAE and provides a unique spontaneous model of MS.
Fri Nov 16 00:00:00 UTC 2007
Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.
Circulation
Gotsman I,Grabie N,Gupta R,Dacosta R,MacConmara M,Lederer J,Sukhova G,Witztum JL,Sharpe AH,Lichtman AH
14-5773 was used in Immunohistochemistry on frozen tissues to investigate the influence of ICOS on atherosclerosis and associated immune responses.
Tue Nov 07 00:00:00 UTC 2006
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production.
Blood
Zeiser R,Nguyen VH,Beilhack A,Buess M,Schulz S,Baker J,Contag CH,Negrin RS
14-5773 was used in Immunocytochemistry-immunoflourescence to find rapamycin and mycophenolate mofetil rather than cyclosporine A preserve function of regulatory T cells in pathologic immune responses such as graft-versus-host disease without weakening the graft-versus-tumour effect.
Sat Jul 01 00:00:00 UTC 2006
Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells.
International immunology
Mohamood AS,Trujillo CJ,Zheng D,Jie C,Murillo FM,Schneck JP,Hamad AR
14-5773 was used in Immunofluorescence to provide a strong cellular and molecular basis for understanding why impaired Fas pathway prevents an important subset of T cell-mediated autoimmune diseases.
Tue Aug 01 00:00:00 UTC 2006
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation.
The Journal of biological chemistry
Chen C,Rowell EA,Thomas RM,Hancock WW,Wells AD
14-5773-82 was used in Immunocytochemistry to investigate how ectopic Foxp3 expression enforces repression of IL-2 and IFNgamma and induction of CD25, GITR and CTLA-4.
Fri Dec 01 00:00:00 UTC 2006
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation.
The Journal of biological chemistry
Chen C,Rowell EA,Thomas RM,Hancock WW,Wells AD
14-5773-82 was used in Immunocytochemistry to investigate how ectopic Foxp3 expression enforces repression of IL-2 and IFNgamma and induction of CD25, GITR and CTLA-4.
Fri Dec 01 00:00:00 UTC 2006
Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation.
The Journal of biological chemistry
Chen C,Rowell EA,Thomas RM,Hancock WW,Wells AD
14-5773-82 was used in Immunocytochemistry to investigate how ectopic Foxp3 expression enforces repression of IL-2 and IFNgamma and induction of CD25, GITR and CTLA-4.
Fri Dec 01 00:00:00 UTC 2006
Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells.
The Journal of experimental medicine
Ko K,Yamazaki S,Nakamura K,Nishioka T,Hirota K,Yamaguchi T,Shimizu J,Nomura T,Chiba T,Sakaguchi S
Published figure using FOXP3 monoclonal antibody (Product # 14-5773-82) in Flow Cytometry
Mon Oct 03 00:00:00 UTC 2005
