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Invitrogen
FPR1 Polyclonal Antibody
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FPR1 Antibody (PA1-41398) in WB
Western blot analysis of FPR1 in 0.5 mg/mL Mouse Liver lysate. Samples were incubated in FPR1 polyclonal antibody (Product # PA1-41398). This experiment was performed under reducing conditions using the 12-230 kDa separation system. * Non-specific interaction with the 230 kDa Simple Western standard may be seen with this antibody.
Product Details
PA1-41398
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues 176-190 of human FPR1.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2247097
Product Specific Information
Suggested positive control: human liver protein, liver lysate.
Target Information
FPR1 is a member of chemoattractant/chemokine GPCRs expressed mainly on leukocytes, neutrophils and monocytes. FPR1 is a seven transmembrane pertussis toxin-sensitive GPCR and binds to formylated peptides generated by bacteria resulting in leukocyte trafficking to the site of inflammation. Ligand binding to FPR results in activation of multiple effectors including phospholipase C leading to calcium mobilization and PKC activation. Other implications of FPR signaling include polarization of actin cytoskeleton, activation of various integrins, increased cell migration, phagocytosis, degranulation and release of reactive oxygen intermediates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: fMet-Leu-Phe receptor; fMLP receptor; FPR; Fpr receptor; FPR-1; lipoxin A4 receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor
Gene Aliases: fMLF-R; FMLP; FPR; FPR1; LXA4R
UniProt ID: (Human) P21462, (Mouse) P33766
Entrez Gene ID: (Human) 2357, (Mouse) 14293
activation of MAPK activity
movement of cell or subcellular component
chemotaxis
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
nitric oxide mediated signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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