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Invitrogen
FREM1 Polyclonal Antibody
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FREM1 Antibody (PA5-109737) in WB
Western blot analysis of FREM1 in extracts of various cell lines. Samples were incubated with FREM1 Polyclonal antibody (Product # PA5-109737) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
Product Details
PA5-109737
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1880-2179 of human FREM1 (NP_659403.4).
Conjugate
Form
Liquid
Concentration
1.12 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2855148
Product Specific Information
Immunogen sequence: GSSSSTTSGS FHLERRPLPS SMQLAVIRGD TLRGFDSTDL SQRKLRTRGN GKTVRPSSVY RNGTDIIYNY HGIVSLKLED DSFPTHKRKA KVSIISQPQK TIKVAELPQA DKVESTTDSH FPRQDQLPSF PKNCTLELKG LFHFEEGIQK LYQCNGIAWK AWSPQTKDVE DKSCPAGWHQ HSGYCHILIT EQKGTWNAAA QACREQYLGN LVTVFSRQHM RWLWDIGGRK SFWIGLNDQV HAGHWEWIGG EPVAFTNGRR GPSQRSKLGK SCVLVQRQGK WQTKDCRRAK PHNYVCSRKL
Target Information
FREM1 is a member of the FRAS1-related extracellular matrix protein family and is thought to play a role in craniofacial and renal development. FREM1 functions as an extracellular matrix protein that is essential for epidermal adhesion during embryogenesis and may also participate in epidermal differentiation. It is recognized by cells in the embryonic skin and hair follicles through different members of the integrin family. Deficiency in the Fras1/Frem genes gives rise to the bleb phenotype, which is equivalent to the human hereditary disorder Fraser syndrome.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: extracellular matrix protein QBRICK; FRAS1-related extracellular matrix protein 1; Protein QBRICK; RP11-265B7.2
Gene Aliases:
BC037594; BNAR; C9orf143; C9orf145; C9orf154; crf11; D430009N09; D630008K06; eye
UniProt ID: (Human) Q5H8C1, (Mouse) Q684R7
Entrez Gene ID: (Human) 158326, (Rat) 298185, (Mouse) 329872
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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