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FRY Antibody (PA5-143851) in IHC (P)
Immunohistochemistry analysis of FRY in paraffin-embedded section of human liver cancer tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with FRY Polyclonal antibody (Product # PA5-143851) using a dilution of 5 μg/mL overnight at 4°C. DyLight®550 Conjugated Goat Anti-Rabbit Ig... View More
Product Details
PA5-143851
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human FRY recombinant protein (Position: E11-L3013).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3075065
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human RT4 whole cell, human Caco-2 whole cell, rat brain tissue, rat lung tissue, mouse brain tissue, mouse lung tissue. IHC: human colorectal adenocarcinoma tissue, human liver cancer tissue, human lung cancer tissue, human ovarian cancer tissue, human penis squamous cell carcinoma tissue. Flow: SiHa cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The FRY gene encodes a protein known as furry homolog (FRY), a gene that is highly conserved across species and plays vital roles in cell division and differentiation. FRY is involved in the regulation of mitotic spindle orientation and cellular polarity, crucial for proper cell division and tissue organization. It is found within various tissues and has implications in neurodevelopment and cancer biology, where it influences cell structural properties and signaling pathways. Alterations in FRY expression or mutations can disrupt normal cell function, leading to aberrant cellular morphogenesis and developmental defects. In cancer studies, FRY is associated with tumor suppression, where loss of function contributes to uncontrolled cell proliferation. This gene interacts with other cellular components, such as the cytoskeleton and signaling proteins, orchestrating complex cellular processes essential for maintaining homeostasis and development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: furry homolog; Protein furry homolog; WUGSC:H_2G3A.1
Gene Aliases: 13CDNA73; 214K23.2; 9330186A19Rik; AF346502; AI462658; bA207N4.2; bA37E23.1; C13orf14; C87180; CG003; D930046M03; FRY; Kiaa4143; mKIAA4143; RGD1307034
UniProt ID: (Human) Q5TBA9, (Mouse) E9Q8I9
Entrez Gene ID: (Human) 10129, (Mouse) 320365, (Rat) 304244
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