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Product Details
MA5-38525
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3D5G9
Immunogen
Purified recombinant fragment of human FSHR (aa: extra 18-366) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2898438
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
Follicle-Stimulating Hormone Receptor (FSHR) expression has been reported in ovary, uterus, and testis. ESTs have been isolated from testis libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This turn-off activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Follicle-stimulating hormone receptor; Follitropin receptor; FSH receptor; FSH-R
Gene Aliases: FSHR; FSHR1; FSHRO; LGR1; ODG1
UniProt ID: (Human) P23945
Entrez Gene ID: (Human) 2492
primary ovarian follicle growth
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
spermatogenesis
female gamete generation
gonad development
male gonad development
female gonad development
hormone-mediated signaling pathway
regulation of protein kinase A signaling
positive regulation of phosphatidylinositol 3-kinase signaling
follicle-stimulating hormone signaling pathway
regulation of osteoclast differentiation
positive regulation of ERK1 and ERK2 cascade
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