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Bioss
FUBP1/2 Polyclonal Antibody
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FIGURE: 1 / 1
FUBP1/2 Antibody (BS-13224R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Mouse intestine; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with FBP1 Polyclonal Antibody, Unconjugated (bs-13224R) at 1:200 overnight at 4°C, DAB staining.
Product Details
BS-13224R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FUBP1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA helicase V; far upstream element (FUSE) binding protein 1; far upstream element (FUSE) binding protein 4; Far upstream element-binding protein 1; far upstream element-binding protein 1 {ECO:0000250|UniProtKB:Q96AE4, ECO:0000312|EMBL:AAI07943.1}; Far upstream element-binding protein 2; FBP; FBP {ECO:0000250|UniProtKB:Q96AE4}; fubp1 {ECO:0000312|EMBL:AAI07943.1, ECO:0000312|RGD:1591892}; FUSE binding protein 1; FUSE binding protein 2; FUSE-binding protein 1; FUSE-binding protein 1 {ECO:0000250|UniProtKB:Q96AE4}; FUSE-binding protein 2; hDH V; KH type-splicing regulatory protein; KSRP; MAP2 RNA trans-acting protein 1; MAP2 RNA trans-acting protein MARTA1; p75
Gene Aliases: 6330409F21Rik; 9530027K12Rik; D3Ertd330e; FBP; FBP2; FUBP; FUBP1; FUBP2; Fubp4; hDH V; KHSRP; KSRP; Marta1
UniProt ID: (Human) Q96AE4, (Rat) Q32PX7, (Human) Q92945, (Mouse) Q3U0V1
Entrez Gene ID: (Human) 8880, (Rat) 654496, (Mouse) 51886, (Human) 8570, (Rat) 171137, (Mouse) 16549
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of gene expression
transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
mRNA processing
mRNA catabolic process
RNA splicing
mRNA transport
regulation of miRNA metabolic process
transport
RNA splicing, via transesterification reactions
regulation of mRNA stability
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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