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Invitrogen
FUZ Polyclonal Antibody
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Product Details
PA5-31699
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human FUZ. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 1% BSA, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2549172
Product Specific Information
Recommended positive controls: HCT116.
Predicted reactivity: Mouse (88%), Bovine (87%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FUZ is the human homolog of Drosophila fy protein and belongs to the fuzzy family. The fy gene of Drosophila encodes a novel four-pass transmembrane protein that plays two roles in the development of hairs on the Drosophila wing. The first is to specify the correct orientation of the hair by restricting its initiation to the distal vertex of the cell. The second role is to permit the development of just a single cell hair by maintaining the integrity of the F-actin and microtubule arrays that are required for hair development. In humans, the protein is involved in cytoskeleton function and cell polarity in epithelial cells. The human fuz gene is localized on chromosome 19q13.33.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fuzzy homolog; Protein fuzzy homolog
Gene Aliases: FUZ; FY; NTD; RGD1310608
UniProt ID: (Human) Q9BT04, (Rat) Q3B756
Entrez Gene ID: (Human) 80199, (Rat) 308577
establishment of planar polarity
neural tube closure
hair follicle development
negative regulation of cell proliferation
regulation of smoothened signaling pathway
embryonic body morphogenesis
protein transport
negative regulation of cell migration
nonmotile primary cilium assembly
cilium assembly
positive regulation of cilium assembly
embryonic skeletal system morphogenesis
negative regulation of canonical Wnt signaling pathway
negative regulation of neural crest formation
negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
spinal cord dorsal/ventral patterning
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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