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Invitrogen
FUZ Polyclonal Antibody
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Product Details
PA5-59909
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human FUZ. Recombinant protein control fragment (Product #RP-98851).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2641791
Product Specific Information
Immunogen sequence: GDSELIGDLT QCVDCVIPPE GSLLQEALSG FAEAAGTTFV SLVVSGRVVA ATEGWWRLGT PEAVLLPWLV GSLPPQTARD YPVYL
Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 88%.
Target Information
FUZ is the human homolog of Drosophila fy protein and belongs to the fuzzy family. The fy gene of Drosophila encodes a novel four-pass transmembrane protein that plays two roles in the development of hairs on the Drosophila wing. The first is to specify the correct orientation of the hair by restricting its initiation to the distal vertex of the cell. The second role is to permit the development of just a single cell hair by maintaining the integrity of the F-actin and microtubule arrays that are required for hair development. In humans, the protein is involved in cytoskeleton function and cell polarity in epithelial cells. The human fuz gene is localized on chromosome 19q13.33.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fuzzy homolog; Protein fuzzy homolog
Gene Aliases: FUZ; FY; NTD
UniProt ID: (Human) Q9BT04
Entrez Gene ID: (Human) 80199
establishment of planar polarity
neural tube closure
hair follicle development
negative regulation of cell proliferation
regulation of smoothened signaling pathway
embryonic body morphogenesis
protein transport
negative regulation of cell migration
nonmotile primary cilium assembly
cilium assembly
positive regulation of cilium assembly
embryonic skeletal system morphogenesis
negative regulation of canonical Wnt signaling pathway
negative regulation of neural crest formation
negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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