Proteintech

FXR1 Polyclonal Antibody

FXR1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

FXR1 Antibody (13194-1-AP) in ICC/IF

Immunofluorescent analysis of Ethacrynic acid treated HepG2 cells using 13194-1-AP (FXR1 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

FXR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FXR1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13194-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:12,000

View 11 publications 11 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

RNA Immunoprecipitation (RIP)

View 2 publications 2 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

FXR1 Fusion Protein Ag3873 (1-353 aa encoded by BC028983)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAELTVEVR GSNGAFYKGF IKDVHEDSLT VVFENNWQPE RQVPFNEVRL PPPPDIKKEI SEGDEVEVYS RANDQEPCGW WLAKVRMMKG EFYVIEYAAC DATYNEIVTF ERLRPVNQNK TVKKNTFFKC TVDVPEDLRE ACANENAHKD FKKAVGACRI FYHPETTQLM ILSASEATVK RVNILSDMHL RSIRTKLMLM SRNEEATKHL ECTKQLAAAF HEEFVVREDL MGLAIGTHGS NIQQARKVPG VTAIELDEDT GTFRIYGESA DAVKKARGFL EFVEDFIQVP RNLVGKVIGK NGKVIQEIVD KSGVVRVRIE GDNENKLPRE DGMVPFVFVG TKESIGNVQV LLEY (1-353 aa encoded by BC028983)

Target Information

FXR1 is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. It may regulate intracellular transport and local transltion of certain mRNAs. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. FXR1 is required for embryonic and postnatal development of muscle tissue. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.

The international journal of biochemistry & cell biology

Wen C,Li Y,Huang Y,Wang N,He S,Bao M,Zhou H,Wu L

Sun Jan 01 00:00:00 UTC 2023

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.

The international journal of biochemistry & cell biology

Wen C,Li Y,Huang Y,Wang N,He S,Bao M,Zhou H,Wu L

Sun Jan 01 00:00:00 UTC 2023

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

iScience

Hsu YH,Pintacuda G,Liu R,Nacu E,Kim A,Tsafou K,Petrossian N,Crotty W,Suh JM,Riseman J,Martin JM,Biagini JC,Mena D,Ching JKT,Malolepsza E,Li T,Singh T,Ge T,Egri SB,Tanenbaum B,Stanclift CR,Apffel AM,Carr SA,Schenone M,Jaffe J,Fornelos N,Huang H,Eggan KC,Lage K

Fri May 19 00:00:00 UTC 2023

FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.

Scientific reports

Shimizu H,Hohjoh H

Thu Feb 02 00:00:00 UTC 2023

FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome system.

Scientific reports

Shimizu H,Hohjoh H

Thu Feb 02 00:00:00 UTC 2023

Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.

Frontiers in pharmacology

He J,Yang Y,Zhang F,Li Y,Li X,Pu X,He X,Zhang M,Yang X,Yu Q,Qi Y,Li X,Yu J

Mon Jun 05 00:00:00 UTC 2023

Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.

Science advances

Datta C,Truesdell SS,Wu KQ,Bukhari SIA,Ngue H,Buchanan B,Le Tonqueze O,Lee S,Kollu S,Granovetter MA,Boukhali M,Kreuzer J,Batool MS,Balaj L,Haas W,Vasudevan S

Fri Oct 28 00:00:00 UTC 2022

Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.

Science advances

Datta C,Truesdell SS,Wu KQ,Bukhari SIA,Ngue H,Buchanan B,Le Tonqueze O,Lee S,Kollu S,Granovetter MA,Boukhali M,Kreuzer J,Batool MS,Balaj L,Haas W,Vasudevan S

Fri Oct 28 00:00:00 UTC 2022

Intestinal epithelial β Klotho is a critical protective factor in alcohol-induced intestinal barrier dysfunction and liver injury.

EBioMedicine

Hou Z,Ding Q,Li Y,Zhao Z,Yan F,Li Y,Wang X,Xu J,Chen W,Wu G,Ruan X,Zhao L

Mon Aug 01 00:00:00 UTC 2022

Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.

Food & function

Bai X,Fu R,Duan Z,Liu Y,Zhu C,Fan D

Wed Apr 07 00:00:00 UTC 2021

Microtubule-based transport is essential to distribute RNA and nascent protein in skeletal muscle.

Nature communications

Denes LT,Kelley CP,Wang ET

Wed Oct 27 00:00:00 UTC 2021

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.

Cell reports

George J,Li Y,Kadamberi IP,Parashar D,Tsaih SW,Gupta P,Geethadevi A,Chen C,Ghosh C,Sun Y,Mittal S,Ramchandran R,Rui H,Lopez-Berestein G,Rodriguez-Aguayo C,Leone G,Rader JS,Sood AK,Dey M,Pradeep S,Chaluvally-Raghavan P

Tue Nov 02 00:00:00 UTC 2021

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site.

Cell reports

Tue Nov 02 00:00:00 UTC 2021

Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization.

Cell

Sanders DW,Kedersha N,Lee DSW,Strom AR,Drake V,Riback JA,Bracha D,Eeftens JM,Iwanicki A,Wang A,Wei MT,Whitney G,Lyons SM,Anderson P,Jacobs WM,Ivanov P,Brangwynne CP

Thu Apr 16 00:00:00 UTC 2020

Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.

iScience

Valdez-Sinon AN,Lai A,Shi L,Lancaster CL,Gokhale A,Faundez V,Bassell GJ

Fri May 22 00:00:00 UTC 2020

The Tudor SND1 protein is an m⁶A RNA reader essential for replication of Kaposi's sarcoma-associated herpesvirus.

eLife

Baquero-Perez B,Antanaviciute A,Yonchev ID,Carr IM,Wilson SA,Whitehouse A

Thu Oct 24 00:00:00 UTC 2019

FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG.

Journal of experimental & clinical cancer research : CR

Cao S,Zheng J,Liu X,Liu Y,Ruan X,Ma J,Liu L,Wang D,Yang C,Cai H,Li Z,Feng Z,Xue Y

Mon Jan 28 00:00:00 UTC 2019

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Nature communications

Estañ MC,Fernández-Núñez E,Zaki MS,Esteban MI,Donkervoort S,Hawkins C,Caparros-Martin JA,Saade D,Hu Y,Bolduc V,Chao KR,Nevado J,Lamuedra A,Largo R,Herrero-Beaumont G,Regadera J,Hernandez-Chico C,Tizzano EF,Martinez-Glez V,Carvajal JJ,Zong R,Nelson DL,Otaify GA,Temtamy S,Aglan M,Issa M,Bönnemann CG,Lapunzina P,Yoon G,Ruiz-Perez VL

Fri Feb 15 00:00:00 UTC 2019

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy.

Nature communications

Fri Feb 15 00:00:00 UTC 2019

Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.

eLife

Wang GX,Smith SJ,Mourrain P

Sat Oct 22 00:00:00 UTC 2016

Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses.

eLife

Wang GX,Smith SJ,Mourrain P

Sat Oct 22 00:00:00 UTC 2016

Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Lewkowicz P,Cwiklińska H,Mycko MP,Cichalewska M,Domowicz M,Lewkowicz N,Jurewicz A,Selmaj KW

Wed May 13 00:00:00 UTC 2015

Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Lewkowicz P,Cwiklińska H,Mycko MP,Cichalewska M,Domowicz M,Lewkowicz N,Jurewicz A,Selmaj KW

Wed May 13 00:00:00 UTC 2015

Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.

Neuron

Wang GX,Smith SJ,Mourrain P

Wed Dec 17 00:00:00 UTC 2014

Fmr1 KO and fenobam treatment differentially impact distinct synapse populations of mouse neocortex.

Neuron

Wang GX,Smith SJ,Mourrain P

Wed Dec 17 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: FMR1 autosomal homolog 1; fragile X mental retardation autosomal homolog variant p1K; fragile X mental retardation autosomal homolog variant p2K; fragile X mental retardation autosomal homolog variant p4K; fragile X mental retardation autosomal homolog variant p5FK; fragile X mental retardation gene, autosomal homolog; fragile X mental retardation syndrome-related protein 1; fragile X mental retardation, autosomal homolog 1; fragile X mental retardation-related protein 1; fragile-X-related protein 1; FXR1P; hFXR1p; mFxr1p; RNA-binding protein FXR1

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Gene Aliases: 1110050J02Rik; 9530073J07Rik; AI851072; FXR1; Fxr1h; FXR1P

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UniProt ID: (Human) P51114, (Rat) Q5XI81, (Mouse) Q61584

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Entrez Gene ID: (Human) 8087, (Rat) 361927, (Mouse) 14359

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Function(s)

G-quadruplex RNA binding RNA binding mRNA binding mRNA 3'-UTR binding protein binding RNA strand annealing activity protein homodimerization activity poly(A) RNA binding protein heterodimerization activity nucleic acid binding

Process(es)

apoptotic process muscle organ development negative regulation of translation cell differentiation positive regulation of gene silencing by miRNA multicellular organism development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FXR1 Polyclonal Antibody

FXR1 Antibody (13194-1-AP) in ICC/IF

Product Details

13194-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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