Proteintech

FYN Monoclonal Antibody (1G4B1)

FYN Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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FYN Antibody (66606-1-IG) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human tonsillitis tissue slide using (Product # 66606-1-Ig) FYN antibody at dilution of 1:5,000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

66606-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000

Flow Cytometry (Flow)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1G4B1

Immunogen

FYN Fusion Protein Ag11127 (231-483 aa encoded by BC032496)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: YSGTWNGNT KVAIKTLKPG TMSPESFLEE AQIMKKLKHD KLVQLYAVVS EEPIYIVTEY MNKGSLLDFL KDGEGRALKL PNLVDMAAQV AAGMAYIERM NYIHRDLRSA NILVGNGLIC KIADFGLARL IEDNEYTARQ GAKFPIKWTA PEAALYGRFT IKSDVWSFGI LLTELVTKGR VPYPGMNNRE VLEQVERGYR MPCPQDCPIS LHELMIHCWK KDPEERPTFE YLQSFLEDYF TATEPQYQPG ENL (231-483 aa encoded by BC032496)

Target Information

FYN is a SRC-related kinase expressed in brain, skeletal muscle and adipose tissues. Fyn functions in a large number of pathways and has been shown to play a role in memory. FYN is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Chen M,Dong Y,Tian L,Zhou J,Zhu E,Yuan H,Li X,Wang B

Sat Apr 01 00:00:00 UTC 2023

Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer.

Journal of experimental & clinical cancer research : CR

Zhou F,Gao H,Shang L,Li J,Zhang M,Wang S,Li R,Ye L,Yang S

Mon Jun 19 00:00:00 UTC 2023

MIR31HG Expression Predicts Poor Prognosis and Promotes Colorectal Cancer Progression.

Cancer management and research

Wang J,Liu B,Cao J,Zhao L,Wang G

Sat Jul 16 00:00:00 UTC 2022

A four oxidative stress gene prognostic model and integrated immunity-analysis in pancreatic adenocarcinoma.

Frontiers in oncology

Wang H,Tian RF,Liang X,Fan J,Duan ZC,Fan XY,Zhang JJ,Yao DS,Chen ZN,Li L

Thu Feb 02 00:00:00 UTC 2023

BP5 alleviates endotoxemia-induced acute lung injury by activating Nrf2 via dual regulation of the Keap1-Nrf2 interaction and the Akt (Ser473)/GSK3β (Ser9)/Fyn pathway.

Free radical biology & medicine

Li T,Geng Z,Zhang J,Xu L,Zhu X

Sun Nov 20 00:00:00 UTC 2022

Src-mediated Tyr353 phosphorylation of IP3R1 promotes its stability and causes apoptosis in palmitic acid-treated hepatocytes.

Experimental cell research

Yu T,Zheng E,Li Y,Li Y,Xia J,Ding Q,Hou Z,Ruan XZ,Zhao L,Chen Y

Mon Feb 15 00:00:00 UTC 2021

PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.

Biochemical pharmacology

Sun M,Sheng H,Wu T,Song J,Sun H,Wang Y,Wang J,Li Z,Zhao H,Tan J,Li Y,Chen G,Huang Q,Zhang Y,Lan B,Liu S,Shan C,Zhang S

Fri Oct 01 00:00:00 UTC 2021

Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.

Medical science monitor : international medical journal of experimental and clinical research

Niu Q,Sun W,Chen Q,Long Y,Cao W,Wen S,Li A,Dong F,Shi H

Mon Jul 20 00:00:00 UTC 2020

Biallelic mutations in LAMA5 disrupts a skeletal noncanonical focal adhesion pathway and produces a distinct bent bone dysplasia.

EBioMedicine

Barad M,Csukasi F,Bosakova M,Martin JH,Zhang W,Paige Taylor S,Lachman RS,Zieba J,Bamshad M,Nickerson D,Chong JX,Cohn DH,Krejci P,Krakow D,Duran I

Tue Dec 01 00:00:00 UTC 2020

Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.

EBioMedicine

Luo X,Li Y,Yang P,Chen Y,Wei L,Yu T,Xia J,Ruan XZ,Zhao L,Chen Y

Mon Jun 01 00:00:00 UTC 2020

ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.

Experimental cell research

Yuan H,Zhou W,Yang Y,Xue L,Liu L,Song Y

Fri Jun 01 00:00:00 UTC 2018

ISG15 promotes esophageal squamous cell carcinoma tumorigenesis via c-MET/Fyn/β-catenin signaling pathway.

Experimental cell research

Yuan H,Zhou W,Yang Y,Xue L,Liu L,Song Y

Fri Jun 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: C syn protooncogene; c-syn protooncogene; EC 2.7.10.2; FYN oncogene related to SRC, FGR, YES; fyn {ECO:0000312|RGD:2641}; kinase Fyn; MGC45350; OKT3-induced calcium influx regulator; OTTHUMP00000017916; OTTHUMP00000017917; P59 p59-Fyn; p59-Fyn; Proto-oncogene c-Fyn; Proto-oncogene Syn; proto-oncogene tyrosine-protein kinase Fyn; Protooncogene Syn; RP1-66H14.1; SLK; Src Kinase p59; Src like kinase; Src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); Tyrosine-protein kinase Fyn

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Gene Aliases: AI448320; AW552119; FYN; p59-FYN; SLK; SYN

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UniProt ID: (Human) P06241, (Rat) Q62844, (Mouse) P39688

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Entrez Gene ID: (Human) 2534, (Rat) 25150, (Mouse) 14360

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Function(s)

G-protein coupled receptor binding glycoprotein binding protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding tubulin binding T cell receptor binding CD4 receptor binding CD8 receptor binding phosphatidylinositol 3-kinase binding ion channel binding metal ion binding ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity peptide hormone receptor binding growth factor receptor binding protein kinase activity receptor binding protein complex binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

MAPK cascade neuron migration stimulatory C-type lectin receptor signaling pathway adaptive immune response protein phosphorylation calcium ion transport transmembrane receptor protein tyrosine kinase signaling pathway axon guidance central nervous system development blood coagulation learning feeding behavior regulation of cell shape negative regulation of gene expression positive regulation of neuron projection development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling viral process cell migration peptidyl-tyrosine phosphorylation cell differentiation platelet activation forebrain development T cell costimulation negative regulation of protein ubiquitination intracellular signal transduction cellular response to platelet-derived growth factor stimulus peptidyl-tyrosine autophosphorylation Fc-gamma receptor signaling pathway involved in phagocytosis T cell activation regulation of cell proliferation negative regulation of protein catabolic process response to drug positive regulation of tyrosine phosphorylation of Stat5 protein regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of neuron apoptotic process positive regulation of GTPase activity innate immune response response to ethanol phosphatidylinositol phosphorylation vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling dendrite morphogenesis regulation of defense response to virus by virus activated T cell proliferation T cell receptor signaling pathway leukocyte migration detection of mechanical stimulus involved in sensory perception of pain cellular response to peptide hormone stimulus cellular response to transforming growth factor beta stimulus positive regulation of protein localization to nucleus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand cell surface receptor signaling pathway ionotropic glutamate receptor signaling pathway protein autophosphorylation cellular response to growth factor stimulus immune system process multicellular organism development phosphorylation myelination

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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FYN Monoclonal Antibody (1G4B1)

FYN Antibody (66606-1-IG) in IHC (P)

Product Details

66606-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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