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Invitrogen
FZD7 Polyclonal Antibody
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FZD7 Antibody (PA5-92165) in WB
Western blot was performed using Anti-FZD7 Polyclonal Antibody (Product # PA5-92165) and a 70 kDa band corresponding to Frizzled-7 was observed across the cell lines tested except SK-BR-3 which is reported to be negative. Membrane enriched extracts (30 µg lysate) of Hep G2 (Lane 1), SW480 (Lane 2), HCT 116 (Lane 3), HT-29 (Lane 4), MDA-MB-231 (Lane 5), SK-BR-3 (Lane 6), HeLa (Lane 7) and MKN-45 (Lane 8) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0302BOX). Resolved proteins were then transferred onto a Nitrocel... View More
Product Details
PA5-92165
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human FZD7 (NP_0034981)
Conjugate
Form
Liquid
Concentration
0.52 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806397
Product Specific Information
Immunogen sequence: MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ PISIPLCTDI AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLDQAIPPC RSLCERARQG CEALMNKFGF QWPERLRCEN FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP TAPYLPDLPF TALPPGASDG RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN GLMYFKEEER RFARLWVGVW; Positive Samples: SW480, Mouse kidney; Cellular Location: Cell membrane, Membrane, Multi-pass membrane protein
Target Information
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; Frizzled, drosophila, homolog of, 7; Frizzled-7; Fz-7; FzE3; hFz7; mFz7; rizzled 7
Gene Aliases: Fz7; FZD7; FzE3
UniProt ID: (Human) O75084, (Mouse) Q61090
Entrez Gene ID: (Human) 8324, (Mouse) 14369
regulation of transcription, DNA-templated
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
multicellular organism development
negative regulation of cell-substrate adhesion
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
Wnt signaling pathway
stem cell population maintenance
T cell differentiation in thymus
substrate adhesion-dependent cell spreading
regulation of catenin import into nucleus
non-canonical Wnt signaling pathway
non-canonical Wnt signaling pathway via JNK cascade
positive regulation of phosphorylation
negative regulation of ectodermal cell fate specification
positive regulation of transcription, DNA-templated
somatic stem cell division
positive regulation of epithelial cell proliferation involved in wound healing
canonical Wnt signaling pathway
mesenchymal to epithelial transition
neuron differentiation
positive regulation of JNK cascade
Wnt signaling pathway, planar cell polarity pathway
cellular response to retinoic acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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