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Invitrogen
FZD8 Polyclonal Antibody
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Product Details
PA5-50589
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human frizzled family receptor 8
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2636042
Product Specific Information
The antibody detects endogenous levels of total FZD8 / Frizzled 8 protein.
Target Information
Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: frizzled 8, seven transmembrane spanning receptor; frizzled family receptor 8; frizzled homolog 8; Frizzled-8; Fz-8; HGNC:4046
Gene Aliases: FZ-8; Fz8; FZD8; hFZ8
UniProt ID: (Human) Q9H461, (Mouse) Q61091, (Rat) Q498S8
Entrez Gene ID: (Human) 8325, (Mouse) 14370, (Rat) 364754
negative regulation of transcription from RNA polymerase II promoter
angiogenesis
positive regulation of protein phosphorylation
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
multicellular organism development
Wnt signaling pathway
T cell differentiation in thymus
non-canonical Wnt signaling pathway
positive regulation of JUN kinase activity
positive regulation of transcription from RNA polymerase II promoter
canonical Wnt signaling pathway
neuron differentiation
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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