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Product Details
66753-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3D3F11
Immunogen
Factor X Fusion Protein Ag11664 (140-488 aa encoded by BC046125)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CHEEQNSVV CSCARGYTLA DNGKACIPTG PYPCGKQTLE RRKRSVAQAT SSSGEAPDSI TWKPYDAADL DPTENPFDLL DFNQTQPERG DNNLTRIVGG QECKDGECPW QALLINEENE GFCGGTILSE FYILTAAHCL YQAKRFKVRV GDRNTEQEEG GEAVHEVEVV IKHNRFTKET YDFDIAVLRL KTPITFRMNV APACLPERDW AESTLMTQKT GIVSGFGRTH EKGRQSTRLK MLEVPYVDRN SCKLSSSFII TQNMFCAGYD TKQEDACQGD SGGPHVTRFK DTYFVTGIVS WGEGCARKGK YGIYTKVTAF LKWIDRSMKT RGLPKAKSHA PEVITSSPLK (140-488 aa encoded by BC046125)
Target Information
F10 undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Coagulation factor X; Factor 10; factor Xa; Factor10; prothrombinase; RP11-98F14.9; Stuart factor; Stuart-Prower factor
Gene Aliases: F10; FX; FXA
UniProt ID: (Human) P00742
Entrez Gene ID: (Human) 2159
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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