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Proteintech
Factor XIIIa Monoclonal Antibody (2D2B2)
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Product Details
66325-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2D2B2
Immunogen
Factor XIIIa Fusion Protein Ag11105 (383-732 aa encoded by BC027963)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RPDLPVGFG GWQAVDSTPQ ENSDGMYRCG PASVQAIKHG HVCFQFDAPF VFAEVNSDLI YITAKKDGTH VVENVDATHI GKLIVTKQIG GDGMMDITDT YKFQEGQEEE RLALETALMY GAKKPLNTEG VMKSRSNVDM DFEVENAVLG KDFKLSITFR NNSHNRYTIT AYLSANITFY TGVPKAEFKK ETFDVTLEPL SFKKEAVLIQ AGEYMGQLLE QASLHFFVTA RINETRDVLA KQKSTVLTIP EIIIKVRGTQ VVGSDMTVIV EFTNPLKETL RNVWVHLDGP GVTRPMKKMF REIRPNSTVQ WEEVCRPWVS GHRKLIASMS SDSLRHVYGE LDVQIQRRPS M (383-732 aa encoded by BC027963)
Target Information
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bA525O21.1 (coagulation factor XIII, A1 polypeptide); Coagulation factor XIII A chain; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; coagulation factor XIII, alpha subunit; Coagulation factor XIIIa; factor viiia; Factor XIIIA; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; Protein-glutamine gamma-glutamyltransferase A chain; RP11-232H4.1; TGase; Transglutaminase A chain; transglutaminase. plasma
Gene Aliases: 1200014I03Rik; AI462306; F13A; F13A1
UniProt ID: (Human) P00488, (Mouse) Q8BH61
Entrez Gene ID: (Human) 2162, (Mouse) 74145
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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