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          • Primary Antibodies ›
          • FceR1 alpha Antibodies
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          Invitrogen

          FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), eBioscience™

          1 Published Figure
          9 References
          View all (78) FceR1 alpha antibodies

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          Cite FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), eBioscience™

          • Antibody Testing Data (1)
          • Published Figures (1)
          FceR1 alpha Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.
          FceR1 alpha Antibody in Flow Cytometry (Flow)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          FceR1 alpha Antibody (14-5899-80) in Flow

          Staining of normal human peripheral blood cells with Mouse IgG2b kappa Isotype Control Purified (Product # 14-4732-82) (green histogram) or Anti-Human Fc epsilon Receptor I a (FcepsilonR1) Purified (blue histogram) followed by Anti-Mouse IgG Biotin (Product # 13-4013-85) and Streptavidin PE (Product # 12-4317-87). Cells in the lymphocyte gate were used for analysis. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
          Published figure supplied by benchsci-logo
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          FceR1 alpha Antibody in Flow Cytometry (Flow)
          FceR1 alpha Antibody in Flow Cytometry (Flow)

          Product Details

          14-5899-80

          Applications
          Tested Dilution
          Publications

          Immunohistochemistry (IHC)

          -
          View 1 publication 1 publication

          Immunocytochemistry (ICC/IF)

          -
          View 1 publication 1 publication

          Flow Cytometry (Flow)

          1 µg/test
          View 5 publications 5 publications

          Neutralization (Neu)

          -
          View 1 publication 1 publication

          Functional Assay (Functional)

          -
          View 1 publication 1 publication
          Product Specifications

          Published species

          Human, Rat

          Host/Isotype

          Mouse / IgG2b, kappa

          Class

          Monoclonal

          Type

          Antibody

          Clone

          AER-37 (CRA1)

          Conjugate

          Unconjugated Unconjugated Unconjugated
          • APC 
          • Biotin 
          • Brilliant Violet 786
          • eFluor 450
          • FITC
          • Functional Grade
          • NovaFluor Blue 610-70S
          • NovaFluor Blue 660-120S
          • NovaFluor Yellow 570
          • NovaFluor Yellow 610
          • NovaFluor Yellow 660
          • PE 
          • PE-Cyanine7
          • PE-eFluor 610
          • PerCP-eFluor 710
          • Super Bright 436
          • Super Bright 600
          • Super Bright 780
          • Request custom conjugation

          Form

          Liquid

          Concentration

          0.5 mg/mL

          Storage conditions

          4°C

          Shipping conditions

          Wet ice

          RRID

          AB_467709

          Product Specific Information

          Description: The AER-37 monoclonal antibody reacts with the FcεRIalpha subunit, an IgE-binding subunit lacking signal-transducing ability. FcεRIalpha is expressed on mast and basophil cells and is upregulated by the presence of IgE. FcεRIalpha forms a tetrameric complex with one beta and two gamma subunits. The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). The FcεRI complex plays an important role in triggering IgE-mediated allergic reactions.

          Applications Reported: The AER-37 (CRA1) antibody has been reported for use in flow cytometric analysis. It has been reported to not block IgE binding.

          Applications Tested: The AER-37 (CRA1) antibody has been tested by flow cytometric analysis of peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

          Purity: Greater than 90%, as determined by SDS-PAGE.

          Aggregation: Less than 10%, as determined by HPLC.

          Filtration: 0.2 µm post-manufacturing filtered.

          Target Information

          Fc epsilon RI alpha, also known as FceR1 alpha, is a subunit of the high-affinity receptor for IgE, primarily expressed on mast cells and basophils. Its expression is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits, which are essential for signal transduction. The beta and gamma subunits contain immunoreceptor tyrosine-based activation motifs (ITAMs). The Fc epsilon RI complex plays a crucial role in triggering IgE-mediated allergic reactions. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, it leads to the release of mediators such as histamine, which are responsible for allergy symptoms. This process couples allergens and mast cells to initiate inflammatory responses characteristic of allergic disorders like hay fever and asthma. The release of histamine and proteases also leads to the synthesis of prostaglandins and leukotrienes, which are potent effectors of the hypersensitivity response.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          It has to be done as per old AB suggested Products section.
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